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Thyroid Gland Follicular Adenoma with Papillary Hyperplasia

MedGen UID:
313775
•Concept ID:
C1710412
•
Neoplastic Process

Definition

A thyroid gland adenoma characterized by the presence of papillae lined by cells that range from cuboidal to columnar. The papillae are usually cystic and non-branching. Aggregates of follicles may be found within the papillary structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Follicular Adenoma with Papillary Hyperplasia

Professional guidelines

PubMed

Clinical value of Cyclin D1 and P21 in the differential diagnosis of papillary thyroid carcinoma.
Wang CC, Lu DD, Shen MH, Chen RL, Zhang ZH, Lv JH
Diagn Pathol 2023 Nov 11;18(1):123. doi: 10.1186/s13000-023-01410-z. PMID: 37951919Free PMC Article
Thyroid tumors with a follicular growth pattern: problems in differential diagnosis.
Suster S
Arch Pathol Lab Med 2006 Jul;130(7):984-8. doi: 10.5858/2006-130-984-TTWAFG. PMID: 16831055
Pathogenesis, diagnosis and management of thyroid nodules in children.
Niedziela M
Endocr Relat Cancer 2006 Jun;13(2):427-53. doi: 10.1677/erc.1.00882. PMID: 16728572

Recent clinical studies

Etiology

Incidentally discovered papillary thyroid microcarcinoma in patients undergoing thyroid surgery for benign disease.
de Carlos J, Ernaga A, Irigaray A, Pineda JJ, Echegoyen A, Salvador P, Anda E
Endocrine 2022 Aug;77(2):325-332. Epub 2022 May 31 doi: 10.1007/s12020-022-03089-6. PMID: 35639243
Preoperatively Predicting the Central Lymph Node Metastasis for Papillary Thyroid Cancer Patients With Hashimoto's Thyroiditis.
Min Y, Huang Y, Wei M, Wei X, Chen H, Wang X, Chen J, Xiang K, Feng Y, Yin G
Front Endocrinol (Lausanne) 2021;12:713475. Epub 2021 Jul 22 doi: 10.3389/fendo.2021.713475. PMID: 34367075Free PMC Article
Poorly differentiated thyroid carcinoma: A hospital-based clinicopathological study and review of literature.
Win TT, Othman NH, Mohamad I
Indian J Pathol Microbiol 2017 Apr-Jun;60(2):167-171. doi: 10.4103/IJPM.IJPM_457_16. PMID: 28631629
Molecular pathogenesis of nodular goiter.
Paschke R
Langenbecks Arch Surg 2011 Dec;396(8):1127-36. Epub 2011 Apr 14 doi: 10.1007/s00423-011-0788-5. PMID: 21487943
Follicular neoplasms of the thyroid: what to recommend.
Carling T, Udelsman R
Thyroid 2005 Jun;15(6):583-7. doi: 10.1089/thy.2005.15.583. PMID: 16029125

Diagnosis

Top 10 Nested Pattern Head and Neck Lesions to Notice.
Lott Limbach A, Chute DJ
Head Neck Pathol 2023 Mar;17(1):119-131. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01534-0. PMID: 36928740Free PMC Article
Impact of Transoral Endoscopic Vestibular Approach Thyroidectomy on Pathologic Assessment.
Smith SM, Ahmed M, Carling T, Udelsman R, Adeniran AJ, Gilani S, Prasad ML, Barbieri AL
Arch Pathol Lab Med 2022 Jul 1;146(7):879-885. doi: 10.5858/arpa.2021-0082-OA. PMID: 34669921
Preoperatively Predicting the Central Lymph Node Metastasis for Papillary Thyroid Cancer Patients With Hashimoto's Thyroiditis.
Min Y, Huang Y, Wei M, Wei X, Chen H, Wang X, Chen J, Xiang K, Feng Y, Yin G
Front Endocrinol (Lausanne) 2021;12:713475. Epub 2021 Jul 22 doi: 10.3389/fendo.2021.713475. PMID: 34367075Free PMC Article
Five Top Stories in Thyroid Pathology.
Moghaddam PA, Virk R, Sakhdari A, Prasad ML, Cosar EF, Khan A
Arch Pathol Lab Med 2016 Feb;140(2):158-70. doi: 10.5858/arpa.2014-0468-RA. PMID: 26910221
Pitfalls in the diagnosis of follicular epithelial proliferations of the thyroid.
Mete O, Asa SL
Adv Anat Pathol 2012 Nov;19(6):363-73. doi: 10.1097/PAP.0b013e318271a5ac. PMID: 23060062

Therapy

Fine-Needle Aspiration Biopsy Findings of the Thyroid Gland in Renal Transplant Patients.
Yılmaz Akçay E, Tepeoğlu M, Ok Atilgan A, Yağcı S, Özdemir BH, Haberal M
Exp Clin Transplant 2023 Sep;21(9):717-721. doi: 10.6002/ect.2023.0117. PMID: 37885286
Thresholds of Basal- and Calcium-Stimulated Calcitonin for Diagnosis of Thyroid Malignancy.
Băetu M, Olariu CA, Stancu C, Caragheorgheopol A, Ioachim D, Moldoveanu G, Corneci C, Badiu C
Horm Metab Res 2021 Dec;53(12):779-786. Epub 2021 Oct 22 doi: 10.1055/a-1661-4420. PMID: 34687025
Yonsei Experience of 5000 Gasless Transaxillary Robotic Thyroidectomies.
Kim MJ, Nam KH, Lee SG, Choi JB, Kim TH, Lee CR, Lee J, Kang SW, Jeong JJ, Chung WY
World J Surg 2018 Feb;42(2):393-401. doi: 10.1007/s00268-017-4209-y. PMID: 28879559
Development of RET kinase inhibitors for targeted cancer therapy.
Mologni L
Curr Med Chem 2011;18(2):162-75. doi: 10.2174/092986711794088308. PMID: 21110809
Surgical and pathological changes after percutaneous ethanol injection therapy of thyroid nodules.
Monzani F, Caraccio N, Basolo F, Iacconi P, LiVolsi V, Miccoli P
Thyroid 2000 Dec;10(12):1087-92. doi: 10.1089/thy.2000.10.1087. PMID: 11201854

Prognosis

Preoperatively Predicting the Central Lymph Node Metastasis for Papillary Thyroid Cancer Patients With Hashimoto's Thyroiditis.
Min Y, Huang Y, Wei M, Wei X, Chen H, Wang X, Chen J, Xiang K, Feng Y, Yin G
Front Endocrinol (Lausanne) 2021;12:713475. Epub 2021 Jul 22 doi: 10.3389/fendo.2021.713475. PMID: 34367075Free PMC Article
Downregulation of SMOC2 expression in papillary thyroid carcinoma and its prognostic significance.
Kim HS, Choi JH, Lee JY, Kang J, Myung JK, Kim WH, Jang BG
Sci Rep 2020 Mar 17;10(1):4853. doi: 10.1038/s41598-020-61828-z. PMID: 32184420Free PMC Article
Poorly differentiated thyroid carcinoma: A hospital-based clinicopathological study and review of literature.
Win TT, Othman NH, Mohamad I
Indian J Pathol Microbiol 2017 Apr-Jun;60(2):167-171. doi: 10.4103/IJPM.IJPM_457_16. PMID: 28631629
Molecular pathogenesis of nodular goiter.
Paschke R
Langenbecks Arch Surg 2011 Dec;396(8):1127-36. Epub 2011 Apr 14 doi: 10.1007/s00423-011-0788-5. PMID: 21487943
Papillary carcinoma.
Vickery AL Jr, Carcangiu ML, Johannessen JV, Sobrinho-Simoes M
Semin Diagn Pathol 1985 May;2(2):90-100. PMID: 3843693

Clinical prediction guides

Clinical value of Cyclin D1 and P21 in the differential diagnosis of papillary thyroid carcinoma.
Wang CC, Lu DD, Shen MH, Chen RL, Zhang ZH, Lv JH
Diagn Pathol 2023 Nov 11;18(1):123. doi: 10.1186/s13000-023-01410-z. PMID: 37951919Free PMC Article
Raman Spectroscopy as a Potential Adjunct of Thyroid Nodule Evaluation: A Systematic Review.
Kujdowicz M, Januś D, Taczanowska-Niemczuk A, Lankosz MW, Adamek D
Int J Mol Sci 2023 Oct 13;24(20) doi: 10.3390/ijms242015131. PMID: 37894812Free PMC Article
Preoperatively Predicting the Central Lymph Node Metastasis for Papillary Thyroid Cancer Patients With Hashimoto's Thyroiditis.
Min Y, Huang Y, Wei M, Wei X, Chen H, Wang X, Chen J, Xiang K, Feng Y, Yin G
Front Endocrinol (Lausanne) 2021;12:713475. Epub 2021 Jul 22 doi: 10.3389/fendo.2021.713475. PMID: 34367075Free PMC Article
Poorly differentiated thyroid carcinoma: A hospital-based clinicopathological study and review of literature.
Win TT, Othman NH, Mohamad I
Indian J Pathol Microbiol 2017 Apr-Jun;60(2):167-171. doi: 10.4103/IJPM.IJPM_457_16. PMID: 28631629
Expression of Mcl-1 and Ki-67 in Papillary Thyroid Carcinomas.
Maia FF, Vassallo J, Pinto GA, Pavin EJ, Matos PS, Zantut-Wittmann DE
Exp Clin Endocrinol Diabetes 2016 Apr;124(4):209-14. Epub 2016 Apr 28 doi: 10.1055/s-0035-1569363. PMID: 27123780

Recent systematic reviews

Raman Spectroscopy as a Potential Adjunct of Thyroid Nodule Evaluation: A Systematic Review.
Kujdowicz M, Januś D, Taczanowska-Niemczuk A, Lankosz MW, Adamek D
Int J Mol Sci 2023 Oct 13;24(20) doi: 10.3390/ijms242015131. PMID: 37894812Free PMC Article
Causes of misdiagnoses by thyroid fine-needle aspiration cytology (FNAC): our experience and a systematic review.
Zhu Y, Song Y, Xu G, Fan Z, Ren W
Diagn Pathol 2020 Jan 3;15(1):1. doi: 10.1186/s13000-019-0924-z. PMID: 31900180Free PMC Article
Defining the value of CD56, CK19, Galectin 3 and HBME-1 in diagnosis of follicular cell derived lesions of thyroid with systematic review of literature.
Dunđerović D, Lipkovski JM, Boričic I, Soldatović I, Božic V, Cvejić D, Tatić S
Diagn Pathol 2015 Oct 26;10:196. doi: 10.1186/s13000-015-0428-4. PMID: 26503236Free PMC Article

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