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Thyroid Gland Mixed Medullary and Papillary Carcinoma

MedGen UID:
313777
•Concept ID:
C1710414
•
Neoplastic Process
Synonym: Mixed Medullary and Papillary Thyroid Carcinoma

Definition

A primary carcinoma of the thyroid gland containing a medullary carcinoma component that is immunohistochemically positive for calcitonin, and papillary carcinoma component that is immunohistochemically positive for thyroglobulin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Mixed Medullary and Papillary Carcinoma

Recent clinical studies

Etiology

Thirty synchronous medullary and papillary thyroid carcinomas.
Zhang D, Yang M, Zhang X, Wang C, Li K, Wang H, Chi H, Sui C, Dionigi G, Sun H
Front Endocrinol (Lausanne) 2023;14:1153248. Epub 2023 Mar 31 doi: 10.3389/fendo.2023.1153248. PMID: 37065753Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Ultrasonographic characteristics of medullary thyroid carcinoma: a comparison with papillary thyroid carcinoma.
Liu MJ, Liu ZF, Hou YY, Men YM, Zhang YX, Gao LY, Liu H
Oncotarget 2017 Apr 18;8(16):27520-27528. doi: 10.18632/oncotarget.15897. PMID: 28460476Free PMC Article
Unusual malignant tumors of the thyroid gland.
Diaconescu MR, Costea I, Glod M, Grigorovici M, Diaconescu S
Chirurgia (Bucur) 2013 Jul-Aug;108(4):482-9. PMID: 23958090
Surgical therapy for thyroid carcinoma: a review of 1249 solitary thyroid nodules.
Brooks JR, Starnes HF, Brooks DC, Pelkey JN
Surgery 1988 Dec;104(6):940-6. PMID: 3194845

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Ultrasonographic characteristics of medullary thyroid carcinoma: a comparison with papillary thyroid carcinoma.
Liu MJ, Liu ZF, Hou YY, Men YM, Zhang YX, Gao LY, Liu H
Oncotarget 2017 Apr 18;8(16):27520-27528. doi: 10.18632/oncotarget.15897. PMID: 28460476Free PMC Article
Mixed medullary-papillary carcinoma of the thyroid: report of two cases and review of the literature.
Gurkan E, Gurbuz Y, Tarkun I, Canturk Z, Cetinarslan B
Indian J Pathol Microbiol 2014 Oct-Dec;57(4):598-602. doi: 10.4103/0377-4929.142684. PMID: 25308015
Unusual tumors of the thyroid gland.
Baloch ZW, LiVolsi VA
Endocrinol Metab Clin North Am 2008 Jun;37(2):297-310, vii. doi: 10.1016/j.ecl.2007.12.001. PMID: 18502328
Iodine and cancer.
Feldt-Rasmussen U
Thyroid 2001 May;11(5):483-6. doi: 10.1089/105072501300176435. PMID: 11396706

Therapy

Does percutaneous thyroid laser ablation induce mixed papillary and medullary thyroid carcinoma?
Ergul E, Gozetlik EO
Acta Chir Belg 2010 Mar-Apr;110(2):228-31. doi: 10.1080/00015458.2010.11680605. PMID: 20514841
Iodine and cancer.
Feldt-Rasmussen U
Thyroid 2001 May;11(5):483-6. doi: 10.1089/105072501300176435. PMID: 11396706

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Mixed medullary-papillary carcinoma of the thyroid: report of two cases and review of the literature.
Gurkan E, Gurbuz Y, Tarkun I, Canturk Z, Cetinarslan B
Indian J Pathol Microbiol 2014 Oct-Dec;57(4):598-602. doi: 10.4103/0377-4929.142684. PMID: 25308015
Unusual malignant tumors of the thyroid gland.
Diaconescu MR, Costea I, Glod M, Grigorovici M, Diaconescu S
Chirurgia (Bucur) 2013 Jul-Aug;108(4):482-9. PMID: 23958090
Unusual tumors of the thyroid gland.
Baloch ZW, LiVolsi VA
Endocrinol Metab Clin North Am 2008 Jun;37(2):297-310, vii. doi: 10.1016/j.ecl.2007.12.001. PMID: 18502328
Surgical therapy for thyroid carcinoma: a review of 1249 solitary thyroid nodules.
Brooks JR, Starnes HF, Brooks DC, Pelkey JN
Surgery 1988 Dec;104(6):940-6. PMID: 3194845

Clinical prediction guides

Ultrasonography-guided fine-needle aspiration cytology for thyroid nodules: an emphasis on one-sampling and biopsy techniques.
Kim DW, Choo HJ, Park JS, Lee EJ, Kim SH, Jung SJ, Ryu JH
Diagn Cytopathol 2012 May;40 Suppl 1:E48-54. Epub 2011 Mar 17 doi: 10.1002/dc.21669. PMID: 21416648
Utility of contrast-enhanced ultrasound for evaluation of thyroid nodules.
Zhang B, Jiang YX, Liu JB, Yang M, Dai Q, Zhu QL, Gao P
Thyroid 2010 Jan;20(1):51-7. doi: 10.1089/thy.2009.0045. PMID: 20067379
Medullary and mixed medullary-papillary carcinoma of the thyroid gland.
Macák J, Vaverková H, Dushová M, Perglerová I
Pathologica 1997 Jun;89(3):317-22. PMID: 9270266
Pediatric thyroid cancer after the Chernobyl disaster. Pathomorphologic study of 84 cases (1991-1992) from the Republic of Belarus.
Nikiforov Y, Gnepp DR
Cancer 1994 Jul 15;74(2):748-66. doi: 10.1002/1097-0142(19940715)74:2<748::aid-cncr2820740231>3.0.co;2-h. PMID: 8033057

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