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Basaloid carcinoma

MedGen UID:
316439
•Concept ID:
C1704216
•
Neoplastic Process
Synonyms: Basaloid Carcinoma; basaloid carcinoma
SNOMED CT: Basaloid carcinoma (5843004)
 
Monarch Initiative: MONDO:0006102

Definition

A malignant epithelial neoplasm characterized by the presence of neoplastic cells with hyperchromatic nuclei, small amount of cytoplasm, and peripheral nuclear palisading. [from NCI]

Professional guidelines

PubMed

Detection of variable genotypes in common human papillomavirus-associated invasive penile squamous cell carcinomas: a study of 177 human papillomavirus-positive cases.
Sanchez DF, Fernández-Nestosa MJ, Alemany L, Cañete-Portillo S, Lloveras B, Clavero O, Rodríguez I, Quint W, Muñoz N, de Sanjosé S, Bosch FX, Cubilla AL; HPV VVAP Study Group
Hum Pathol 2023 Sep;139:65-72. Epub 2023 Jul 8 doi: 10.1016/j.humpath.2023.07.001. PMID: 37429448
A reappraisal of "basaloid carcinoma" of the cervix, and the differential diagnosis of basaloid cervical neoplasms.
Grayson W, Cooper K
Adv Anat Pathol 2002 Sep;9(5):290-300. doi: 10.1097/00125480-200209000-00003. PMID: 12195218
Basaloid squamous cell carcinoma of the head and neck: clinicopathological features and differential diagnosis.
Barnes L, Ferlito A, Altavilla G, MacMillan C, Rinaldo A, Doglioni C
Ann Otol Rhinol Laryngol 1996 Jan;105(1):75-82. doi: 10.1177/000348949610500115. PMID: 8546432

Recent clinical studies

Etiology

Long-Term Outcomes of Endoscopic Submucosal Dissection for Special Type of Esophageal Cancer.
Suzuki Y, Nomura K, Matsui A, Kikuchi D, Ohashi K, Hoteya S
Dig Dis 2023;41(4):533-542. Epub 2023 Feb 9 doi: 10.1159/000529590. PMID: 36758528
CYLD-mutant cylindroma-like basaloid carcinoma of the anus: a genetically and morphologically distinct class of HPV-related anal carcinoma.
Williams EA, Montesion M, Sharaf R, Corines J, Patel PJ, Gillespie BJ, Pavlick DC, Sokol ES, Alexander BM, Williams KJ, Elvin JA, Ross JS, Ramkissoon SH, Hemmerich AC, Tse JY, Mochel MC
Mod Pathol 2020 Dec;33(12):2614-2625. Epub 2020 May 27 doi: 10.1038/s41379-020-0584-2. PMID: 32461623Free PMC Article
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Pulmonary preneoplasia--sequential molecular carcinogenetic events.
Lantuéjoul S, Salameire D, Salon C, Brambilla E
Histopathology 2009 Jan;54(1):43-54. doi: 10.1111/j.1365-2559.2008.03182.x. PMID: 19187179
Basaloid salivary carcinoma.
Batsakis JG, Luna MA
Ann Otol Rhinol Laryngol 1991 Sep;100(9 Pt 1):785-7. doi: 10.1177/000348949110000918. PMID: 1952675

Diagnosis

Esophageal basaloid squamous cell carcinoma presenting as a subepithelial lesion.
Shiratori Y, Kanomata N, Takagi K, Fukuda K
Clin J Gastroenterol 2021 Oct;14(5):1324-1328. Epub 2021 Jul 5 doi: 10.1007/s12328-021-01449-9. PMID: 34224084
NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Large cell carcinoma of lung: On the verge of extinction?
Weissferdt A
Semin Diagn Pathol 2014 Jul;31(4):278-88. Epub 2014 Jun 12 doi: 10.1053/j.semdp.2014.06.005. PMID: 25023633
A reappraisal of "basaloid carcinoma" of the cervix, and the differential diagnosis of basaloid cervical neoplasms.
Grayson W, Cooper K
Adv Anat Pathol 2002 Sep;9(5):290-300. doi: 10.1097/00125480-200209000-00003. PMID: 12195218
Basaloid salivary carcinoma.
Batsakis JG, Luna MA
Ann Otol Rhinol Laryngol 1991 Sep;100(9 Pt 1):785-7. doi: 10.1177/000348949110000918. PMID: 1952675

Therapy

Basaloid Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case With Molecular Analysis.
Munkhdelger J, Shimooka T, Koyama Y, Ikeda S, Mikami Y, Fukuoka J, Hori T, Bychkov A
Int J Surg Pathol 2021 Oct;29(7):770-774. Epub 2021 Apr 1 doi: 10.1177/1066896921997132. PMID: 33792431
Thymic basaloid carcinoma: a rare clinical entity.
Manthri S, Rehman HH, Costello PN, Chakraborty K
BMJ Case Rep 2019 Nov 28;12(11) doi: 10.1136/bcr-2019-231980. PMID: 31780620Free PMC Article
Prevalence of human papillomavirus DNA and p16(INK4a) in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis.
Olesen TB, Sand FL, Rasmussen CL, Albieri V, Toft BG, Norrild B, Munk C, Kjær SK
Lancet Oncol 2019 Jan;20(1):145-158. Epub 2018 Dec 17 doi: 10.1016/S1470-2045(18)30682-X. PMID: 30573285
Electrochemotherapy for the treatment of recurrent head and neck cancers: preliminary results.
Mevio N, Bertino G, Occhini A, Scelsi D, Tagliabue M, Mura F, Benazzo M
Tumori 2012 May-Jun;98(3):308-13. doi: 10.1177/030089161209800305. PMID: 22825505
Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ.
Chen CH, Rowlands C, Sengupta SK, George RL, Parulekar W, Thain K, O'Malley F, Isotalo PA
Breast J 2009 Jul-Aug;15(4):409-13. doi: 10.1111/j.1524-4741.2009.00746.x. PMID: 19601946

Prognosis

Adenoid cystic carcinoma and basaloid carcinoma of the breast: A clinicopathological study.
Marco V, Garcia F, Rubio IT, Soler T, Ferrazza L, Roig I, Mendez I, Andreu X, Mínguez CG, Tresserra F
Rev Esp Patol 2021 Oct-Dec;54(4):242-249. Epub 2020 Dec 31 doi: 10.1016/j.patol.2020.09.005. PMID: 34544554
Esophageal basaloid squamous cell carcinoma presenting as a subepithelial lesion.
Shiratori Y, Kanomata N, Takagi K, Fukuda K
Clin J Gastroenterol 2021 Oct;14(5):1324-1328. Epub 2021 Jul 5 doi: 10.1007/s12328-021-01449-9. PMID: 34224084
NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Clinicopathological features of carcinoma of the distal penile urethra.
Corbishley CM, Rajab RM, Watkin NA
Semin Diagn Pathol 2015 May;32(3):238-44. Epub 2014 Dec 25 doi: 10.1053/j.semdp.2014.12.015. PMID: 25656527
HPV-related squamous cell carcinoma variants in the head and neck.
El-Mofty SK
Head Neck Pathol 2012 Jul;6 Suppl 1(Suppl 1):S55-62. Epub 2012 Jul 3 doi: 10.1007/s12105-012-0363-6. PMID: 22782224Free PMC Article

Clinical prediction guides

NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity.
Brambilla C, Laffaire J, Lantuejoul S, Moro-Sibilot D, Mignotte H, Arbib F, Toffart AC, Petel F, Hainaut P, Rousseaux S, Khochbin S, de Reyniès A, Brambilla E
Clin Cancer Res 2014 Nov 15;20(22):5777-86. Epub 2014 Sep 4 doi: 10.1158/1078-0432.CCR-14-0459. PMID: 25189482
Reproducibility of histopathological diagnosis in poorly differentiated NSCLC: an international multiobserver study.
Thunnissen E, Noguchi M, Aisner S, Beasley MB, Brambilla E, Chirieac LR, Chung JH, Dacic S, Geisinger KR, Hirsch FR, Ishikawa Y, Kerr KM, Lantejoul S, Matsuno Y, Minami Y, Moreira AL, Pelosi G, Petersen I, Roggli V, Travis WD, Wistuba I, Yatabe Y, Dziadziuszko R, Witte B, Tsao MS, Nicholson AG
J Thorac Oncol 2014 Sep;9(9):1354-62. doi: 10.1097/JTO.0000000000000264. PMID: 25122431
Alterations of expression of Rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance.
Brambilla E, Moro D, Gazzeri S, Brambilla C
J Pathol 1999 Aug;188(4):351-60. doi: 10.1002/(SICI)1096-9896(199908)188:4<351::AID-PATH385>3.0.CO;2-W. PMID: 10440744

Recent systematic reviews

Prevalence of human papillomavirus DNA and p16(INK4a) in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis.
Olesen TB, Sand FL, Rasmussen CL, Albieri V, Toft BG, Norrild B, Munk C, Kjær SK
Lancet Oncol 2019 Jan;20(1):145-158. Epub 2018 Dec 17 doi: 10.1016/S1470-2045(18)30682-X. PMID: 30573285

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