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Minimal change nephrotic syndrome

MedGen UID:
316454
Concept ID:
C1704321
Disease or Syndrome
Synonyms: Minimal Change Nephrotic Syndrome; Nephrotic Syndrome, Minimal Change
SNOMED CT: Minimal change nephrotic syndrome (44785005); MCNS - Minimal change nephrotic syndrome (44785005)

Definition

A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by an inflammatory reaction in the glomerular capillaries and the effacement of the surrounding epithelial cell foot processes worsening protein leakage. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMinimal change nephrotic syndrome

Professional guidelines

PubMed

Wada T, Shimizu S, Koizumi M, Sofue T, Nishiwaki H, Sasaki S, Nakaya I, Oe Y, Ishimoto T, Furuichi K, Okada H, Kurita N
Clin Exp Nephrol 2023 Sep;27(9):767-775. Epub 2023 Jun 13 doi: 10.1007/s10157-023-02366-6. PMID: 37310570
Rovin BH, Adler SG, Barratt J, Bridoux F, Burdge KA, Chan TM, Cook HT, Fervenza FC, Gibson KL, Glassock RJ, Jayne DRW, Jha V, Liew A, Liu ZH, Mejía-Vilet JM, Nester CM, Radhakrishnan J, Rave EM, Reich HN, Ronco P, Sanders JF, Sethi S, Suzuki Y, Tang SCW, Tesar V, Vivarelli M, Wetzels JFM, Lytvyn L, Craig JC, Tunnicliffe DJ, Howell M, Tonelli MA, Cheung M, Earley A, Floege J
Kidney Int 2021 Oct;100(4):753-779. doi: 10.1016/j.kint.2021.05.015. PMID: 34556300
Shigidi MM
Saudi J Kidney Dis Transpl 2011 Jan;22(1):10-7. PMID: 21196608

Recent clinical studies

Etiology

Hsu CY, Chang C, Chen HY, Ou SH, Chou KJ, Fang HC, Chen CL, Huang CW, Ho TY, Lee PT
Nephrology (Carlton) 2022 Dec;27(12):953-961. Epub 2022 Oct 19 doi: 10.1111/nep.14119. PMID: 36209374
Meyrier A, Niaudet P
Kidney Int 2018 Nov;94(5):861-869. Epub 2018 Jul 3 doi: 10.1016/j.kint.2018.04.024. PMID: 29980292
Sugimoto K, Miyazawa T, Miyazaki K, Yanagida H, Enya T, Nishi H, Wada N, Okada M, Takemura T
Clin Exp Nephrol 2017 Aug;21(4):665-670. Epub 2016 Nov 4 doi: 10.1007/s10157-016-1325-1. PMID: 27812762
Cho MH, Hong EH, Lee TH, Ko CW
Nephrology (Carlton) 2007 Dec;12 Suppl 3:S11-4. doi: 10.1111/j.1440-1797.2007.00875.x. PMID: 17995521
Nanjundaswamy HM, Phadke KD
Indian J Pediatr 2002 Dec;69(12):1059-63. doi: 10.1007/BF02724388. PMID: 12557960

Diagnosis

Kuno H, Kanzaki G, Sasaki T, Haruhara K, Okabe M, Yokote S, Koike K, Tsuboi N, Yokoo T
Kidney360 2023 Jun 1;4(6):e787-e795. Epub 2023 May 10 doi: 10.34067/KID.0000000000000143. PMID: 37166949Free PMC Article
Horigome M, Kobayashi R, Hanaoka M, Kinguchi S, Kanaoka T, Toya Y, Wakui H, Tamura K
CEN Case Rep 2021 Aug;10(3):315-319. Epub 2021 Jan 6 doi: 10.1007/s13730-020-00568-5. PMID: 33405175Free PMC Article
Tsuji K, Kitamura S, Wada J
Int J Mol Sci 2020 Dec 23;22(1) doi: 10.3390/ijms22010088. PMID: 33374848Free PMC Article
Eddy AA, Symons JM
Lancet 2003 Aug 23;362(9384):629-39. doi: 10.1016/S0140-6736(03)14184-0. PMID: 12944064
Nanjundaswamy HM, Phadke KD
Indian J Pediatr 2002 Dec;69(12):1059-63. doi: 10.1007/BF02724388. PMID: 12557960

Therapy

Zhao L, Cheng J, Zhou J, Wu C, Chen J
Intern Med 2015;54(17):2101-8. Epub 2015 Sep 1 doi: 10.2169/internalmedicine.54.3927. PMID: 26328632
Takei T, Nitta K
Clin Exp Nephrol 2011 Oct;15(5):641-647. Epub 2011 May 26 doi: 10.1007/s10157-011-0465-6. PMID: 21611755
Eddy AA, Symons JM
Lancet 2003 Aug 23;362(9384):629-39. doi: 10.1016/S0140-6736(03)14184-0. PMID: 12944064
Nanjundaswamy HM, Phadke KD
Indian J Pediatr 2002 Dec;69(12):1059-63. doi: 10.1007/BF02724388. PMID: 12557960
Bernstein J Jr, Edelmann CM Jr
Arch Dis Child 1982 Nov;57(11):816-7. doi: 10.1136/adc.57.11.816. PMID: 7149757Free PMC Article

Prognosis

Kuno H, Kanzaki G, Sasaki T, Haruhara K, Okabe M, Yokote S, Koike K, Tsuboi N, Yokoo T
Kidney360 2023 Jun 1;4(6):e787-e795. Epub 2023 May 10 doi: 10.34067/KID.0000000000000143. PMID: 37166949Free PMC Article
Horigome M, Kobayashi R, Hanaoka M, Kinguchi S, Kanaoka T, Toya Y, Wakui H, Tamura K
CEN Case Rep 2021 Aug;10(3):315-319. Epub 2021 Jan 6 doi: 10.1007/s13730-020-00568-5. PMID: 33405175Free PMC Article
Zhang SY, Audard V, Fan Q, Pawlak A, Lang P, Sahali D
Contrib Nephrol 2011;169:94-106. Epub 2011 Jan 20 doi: 10.1159/000313947. PMID: 21252513
Eddy AA, Symons JM
Lancet 2003 Aug 23;362(9384):629-39. doi: 10.1016/S0140-6736(03)14184-0. PMID: 12944064
Nanjundaswamy HM, Phadke KD
Indian J Pediatr 2002 Dec;69(12):1059-63. doi: 10.1007/BF02724388. PMID: 12557960

Clinical prediction guides

Grainer H, DeVita MV, Leung TM, Bijol V, Rosenstock JL
Clin Nephrol 2024 May;101(5):232-237. doi: 10.5414/CN111218. PMID: 38497684
Wada T, Shimizu S, Koizumi M, Sofue T, Nishiwaki H, Sasaki S, Nakaya I, Oe Y, Ishimoto T, Furuichi K, Okada H, Kurita N
Clin Exp Nephrol 2023 Sep;27(9):767-775. Epub 2023 Jun 13 doi: 10.1007/s10157-023-02366-6. PMID: 37310570
Kuno H, Kanzaki G, Sasaki T, Haruhara K, Okabe M, Yokote S, Koike K, Tsuboi N, Yokoo T
Kidney360 2023 Jun 1;4(6):e787-e795. Epub 2023 May 10 doi: 10.34067/KID.0000000000000143. PMID: 37166949Free PMC Article
Goto K, Kono K, Fujii H, Goto S, Nishi S
BMC Nephrol 2022 Apr 2;23(1):128. doi: 10.1186/s12882-022-02764-0. PMID: 35366840Free PMC Article
Nishide K, Nakatani S, Mori K, Morioka F, Machiba Y, Uedono H, Tsuda A, Inaba M, Ishimura E, Emoto M
Clin Exp Nephrol 2021 Mar;25(3):261-269. Epub 2020 Nov 28 doi: 10.1007/s10157-020-01992-8. PMID: 33247826

Recent systematic reviews

Jellouli M, Charfi R, Maalej B, Mahfoud A, Trabelsi S, Gargah T
J Pediatr 2018 Jun;197:191-197.e1. Epub 2018 Apr 18 doi: 10.1016/j.jpeds.2018.01.008. PMID: 29680473
Zhao L, Cheng J, Zhou J, Wu C, Chen J
Intern Med 2015;54(17):2101-8. Epub 2015 Sep 1 doi: 10.2169/internalmedicine.54.3927. PMID: 26328632

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