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Minimal change nephrotic syndrome

MedGen UID:
316454
•Concept ID:
C1704321
•
Disease or Syndrome
Synonyms: Minimal Change Nephrotic Syndrome; Nephrotic Syndrome, Minimal Change
SNOMED CT: Minimal change nephrotic syndrome (44785005); MCNS - Minimal change nephrotic syndrome (44785005)

Definition

A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by an inflammatory reaction in the glomerular capillaries and the effacement of the surrounding epithelial cell foot processes worsening protein leakage. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMinimal change nephrotic syndrome

Professional guidelines

PubMed

Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases.
Rovin BH, Adler SG, Barratt J, Bridoux F, Burdge KA, Chan TM, Cook HT, Fervenza FC, Gibson KL, Glassock RJ, Jayne DRW, Jha V, Liew A, Liu ZH, Mejía-Vilet JM, Nester CM, Radhakrishnan J, Rave EM, Reich HN, Ronco P, Sanders JF, Sethi S, Suzuki Y, Tang SCW, Tesar V, Vivarelli M, Wetzels JFM, Lytvyn L, Craig JC, Tunnicliffe DJ, Howell M, Tonelli MA, Cheung M, Earley A, Floege J
Kidney Int 2021 Oct;100(4):753-779. doi: 10.1016/j.kint.2021.05.015. PMID: 34556300
Minimal change nephrotic syndrome of childhood: current concepts in management.
Yap HK, Murugasu B
J Singapore Paediatr Soc 1990;32(1-2):18-22. PMID: 2259191
Immunoregulatory treatment for minimal change nephrotic syndrome.
Miller PF
Arch Dis Child 1986 Jul;61(7):718-9. doi: 10.1136/adc.61.7.718-a. PMID: 2943233Free PMC Article

Recent clinical studies

Etiology

Acute kidney injury complicating nephrotic syndrome of minimal change disease.
Meyrier A, Niaudet P
Kidney Int 2018 Nov;94(5):861-869. Epub 2018 Jul 3 doi: 10.1016/j.kint.2018.04.024. PMID: 29980292
Acute renal failure and tubular dysfunction associated with minimal change nephrotic syndrome.
Praga M, Martinez MA, Andres A, Alvarez de Buergo M, Bello I, Millet VG, Morales JM
Nephrol Dial Transplant 1989;4(10):914-6. doi: 10.1093/ndt/4.10.914. PMID: 2515498
Steroid-sensitive minimal change nephrotic syndrome. Long-term follow-up.
Lewis MA, Baildom EM, Davies N, Houston IB, Postlethwaite RJ
Contrib Nephrol 1988;67:226-8. doi: 10.1159/000415405. PMID: 3208531
Morphological transition in minimal change nephrotic syndrome.
Tejani A
Nephron 1985;39(3):157-9. doi: 10.1159/000183363. PMID: 3974779
Long-term outcome for children with minimal-change nephrotic syndrome.
Trompeter RS, Lloyd BW, Hicks J, White RH, Cameron JS
Lancet 1985 Feb 16;1(8425):368-70. doi: 10.1016/s0140-6736(85)91387-x. PMID: 2857421

Diagnosis

Iliac Arterial Thrombosis in Minimal Change Nephrotic Syndrome.
Nagayama Y, Kashimura S, Ichikura-Iida A, Inoue T
Intern Med 2023 Apr 15;62(8):1243-1244. Epub 2022 Sep 6 doi: 10.2169/internalmedicine.0294-22. PMID: 36070947Free PMC Article
Abdominal involvement in minimal change nephrotic syndrome.
Kagaya S, Nagasawa T
Clin Exp Nephrol 2018 Apr;22(2):481-482. Epub 2017 Jul 21 doi: 10.1007/s10157-017-1446-1. PMID: 28733945
Minimal change (steroid sensitive) nephrotic syndrome in children: new aspects on pathogenesis and treatment.
Oh J, Kemper MJ
Minerva Pediatr 2012 Apr;64(2):197-204. PMID: 22495193
Nephrotic syndrome in childhood.
Eddy AA, Symons JM
Lancet 2003 Aug 23;362(9384):629-39. doi: 10.1016/S0140-6736(03)14184-0. PMID: 12944064
Steroid-sensitive minimal change nephrotic syndrome. Long-term follow-up.
Lewis MA, Baildom EM, Davies N, Houston IB, Postlethwaite RJ
Contrib Nephrol 1988;67:226-8. doi: 10.1159/000415405. PMID: 3208531

Therapy

Minimal change (steroid sensitive) nephrotic syndrome in children: new aspects on pathogenesis and treatment.
Oh J, Kemper MJ
Minerva Pediatr 2012 Apr;64(2):197-204. PMID: 22495193
Rapid remission of steroid and mycophenolate mofetil (mmf)-resistant minimal change nephrotic syndrome after rituximab therapy.
Yang T, Nast CC, Vo A, Jordan SC
Nephrol Dial Transplant 2008 Jan;23(1):377-80. Epub 2007 Nov 2 doi: 10.1093/ndt/gfm592. PMID: 17981884
Nephrotic syndrome in childhood.
Eddy AA, Symons JM
Lancet 2003 Aug 23;362(9384):629-39. doi: 10.1016/S0140-6736(03)14184-0. PMID: 12944064
Minimal change nephrotic syndrome and cyclophosphamide.
Trompeter RS
Arch Dis Child 1986 Aug;61(8):727-9. doi: 10.1136/adc.61.8.727. PMID: 3740921Free PMC Article
Gold-associated nephropathy.
Francis KL, Jenis EH, Jensen GE, Calcagno PL
Arch Pathol Lab Med 1984 Mar;108(3):234-8. PMID: 6365028

Prognosis

High Albumin Clearance Predicts the Minimal Change Nephrotic Syndrome Relapse.
Kuno H, Kanzaki G, Sasaki T, Haruhara K, Okabe M, Yokote S, Koike K, Tsuboi N, Yokoo T
Kidney360 2023 Jun 1;4(6):e787-e795. Epub 2023 May 10 doi: 10.34067/KID.0000000000000143. PMID: 37166949Free PMC Article
Nephrotic syndrome in childhood.
Eddy AA, Symons JM
Lancet 2003 Aug 23;362(9384):629-39. doi: 10.1016/S0140-6736(03)14184-0. PMID: 12944064
Minimal change nephrotic syndrome of childhood: current concepts in management.
Yap HK, Murugasu B
J Singapore Paediatr Soc 1990;32(1-2):18-22. PMID: 2259191
Steroid-sensitive minimal change nephrotic syndrome. Long-term follow-up.
Lewis MA, Baildom EM, Davies N, Houston IB, Postlethwaite RJ
Contrib Nephrol 1988;67:226-8. doi: 10.1159/000415405. PMID: 3208531
Morphological transition in minimal change nephrotic syndrome.
Tejani A
Nephron 1985;39(3):157-9. doi: 10.1159/000183363. PMID: 3974779

Clinical prediction guides

High Albumin Clearance Predicts the Minimal Change Nephrotic Syndrome Relapse.
Kuno H, Kanzaki G, Sasaki T, Haruhara K, Okabe M, Yokote S, Koike K, Tsuboi N, Yokoo T
Kidney360 2023 Jun 1;4(6):e787-e795. Epub 2023 May 10 doi: 10.34067/KID.0000000000000143. PMID: 37166949Free PMC Article
Clinical value of serum cholinesterase levels in Nephrotic syndrome: an observational study.
Goto K, Kono K, Fujii H, Goto S, Nishi S
BMC Nephrol 2022 Apr 2;23(1):128. doi: 10.1186/s12882-022-02764-0. PMID: 35366840Free PMC Article
Current Trends in Anti-Cancer Molecular Targeted Therapies: Renal Complications and Their Histological Features.
Tonooka A, Ohashi R
J Nippon Med Sch 2022 May 12;89(2):128-138. Epub 2021 Nov 26 doi: 10.1272/jnms.JNMS.2022_89-221. PMID: 34840210
Do circulating factors play a role in the pathogenesis of minimal change nephrotic syndrome?
Bakker WW, van Luijk WH
Pediatr Nephrol 1989 Jul;3(3):341-9. doi: 10.1007/BF00858545. PMID: 2702117
Detection of circulating soluble immune complexes in patients with various renal diseases.
Stühlinger WD, Verroust PJ, Morel-Maroger L
Immunology 1976 Jan;30(1):43-7. PMID: 1248861Free PMC Article

Recent systematic reviews

Rituximab in The Management of Pediatric Steroid-Resistant Nephrotic Syndrome: A Systematic Review.
Jellouli M, Charfi R, Maalej B, Mahfoud A, Trabelsi S, Gargah T
J Pediatr 2018 Jun;197:191-197.e1. Epub 2018 Apr 18 doi: 10.1016/j.jpeds.2018.01.008. PMID: 29680473
Enhanced Steroid Therapy in Adult Minimal Change Nephrotic Syndrome: A Systematic Review and Meta-analysis.
Zhao L, Cheng J, Zhou J, Wu C, Chen J
Intern Med 2015;54(17):2101-8. Epub 2015 Sep 1 doi: 10.2169/internalmedicine.54.3927. PMID: 26328632

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