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Skin pigmentation disorder

MedGen UID:
316465
•Concept ID:
C1704421
•
Disease or Syndrome
Synonym: Skin pigmentation disease
SNOMED CT: Disorder of skin pigmentation (46690002); Skin pigmentation disorder (46690002)
 
Monarch Initiative: MONDO:0019288
Orphanet: ORPHA79374

Definition

A disorder of the skin characterized by loss or reduction of the skin color. It is caused by loss of melanocytes or abnormalities in melanin production. [from NCI]

Professional guidelines

PubMed

Topological Indices of Novel Drugs Used in Autoimmune Disease Vitiligo Treatment and Its QSPR Modeling.
Parveen S, Awan NUH, Farooq FB, Fanja R, Anjum QUA
Biomed Res Int 2022;2022:6045066. Epub 2022 Nov 15 doi: 10.1155/2022/6045066. PMID: 36425334Free PMC Article
An Herbal H2 Blocker in Melasma Treatment.
Mahjour M, Khoushabi A
Curr Drug Discov Technol 2020;17(3):272-277. doi: 10.2174/1570163816666190121145653. PMID: 30666910

Recent clinical studies

Etiology

The effectiveness and safety of 3% tranexamic acid cream vs. 4% hydroquinone cream for mixed-type melasma in skin of color: a double-blind, split-face, randomized controlled trial.
Yasnova N, Sirait SP, Rahmayunita G
Acta Dermatovenerol Alp Pannonica Adriat 2024 Jun;33(2):83-88. PMID: 38918942
Evaluation of efficacy and safety of vitiligo treatment with micro-needling combined with N-Acetylcysteine and micro-needling alone: A double-blinded randomized controlled clinical trial.
Atefi N, Ziaeifar E, Seirafianpour F, Sadeghzadeh-Bazargan A, Amin NG, Mozafarpoor S, Abouie A, Jafari MA, Goodarzi A
J Cosmet Dermatol 2024 Jun;23(6):2220-2230. Epub 2024 Mar 12 doi: 10.1111/jocd.16274. PMID: 38470079
Vitiligo: Not Simply a Skin Disease.
Ahluwalia J, Correa-Selm LM, Rao BK
Skinmed 2017;15(2):125-127. Epub 2017 Apr 1 PMID: 28528606

Diagnosis

Vitiligo: Not Simply a Skin Disease.
Ahluwalia J, Correa-Selm LM, Rao BK
Skinmed 2017;15(2):125-127. Epub 2017 Apr 1 PMID: 28528606

Therapy

The effectiveness and safety of 3% tranexamic acid cream vs. 4% hydroquinone cream for mixed-type melasma in skin of color: a double-blind, split-face, randomized controlled trial.
Yasnova N, Sirait SP, Rahmayunita G
Acta Dermatovenerol Alp Pannonica Adriat 2024 Jun;33(2):83-88. PMID: 38918942
Evaluation of efficacy and safety of vitiligo treatment with micro-needling combined with N-Acetylcysteine and micro-needling alone: A double-blinded randomized controlled clinical trial.
Atefi N, Ziaeifar E, Seirafianpour F, Sadeghzadeh-Bazargan A, Amin NG, Mozafarpoor S, Abouie A, Jafari MA, Goodarzi A
J Cosmet Dermatol 2024 Jun;23(6):2220-2230. Epub 2024 Mar 12 doi: 10.1111/jocd.16274. PMID: 38470079
Efficacy and Safety of Ablative Fractional Laser in Melasma: A Meta-analysis and Systematic Review.
Zhao S, Wang M, Lai X, Yan Y
Lasers Med Sci 2024 Feb 21;39(1):71. doi: 10.1007/s10103-024-03972-w. PMID: 38379033
Randomized, double-blind, placebo-controlled split-face trial of the efficacy of tranexamic acid by drug delivery through microneedling in the treatment of melasma.
Kuster Kaminski Arida D, Orso Rebellato PR, Marioto de Campos GL, Costa A, Vilaverde Schmitt J, Larocca Skare T, Rodrigues Lisboa Faucz L
J Cosmet Dermatol 2021 Dec;20(12):4005-4010. Epub 2021 Jun 18 doi: 10.1111/jocd.14257. PMID: 34077619
An Herbal H2 Blocker in Melasma Treatment.
Mahjour M, Khoushabi A
Curr Drug Discov Technol 2020;17(3):272-277. doi: 10.2174/1570163816666190121145653. PMID: 30666910

Prognosis

Topological Indices of Novel Drugs Used in Autoimmune Disease Vitiligo Treatment and Its QSPR Modeling.
Parveen S, Awan NUH, Farooq FB, Fanja R, Anjum QUA
Biomed Res Int 2022;2022:6045066. Epub 2022 Nov 15 doi: 10.1155/2022/6045066. PMID: 36425334Free PMC Article
Vitiligo: Not Simply a Skin Disease.
Ahluwalia J, Correa-Selm LM, Rao BK
Skinmed 2017;15(2):125-127. Epub 2017 Apr 1 PMID: 28528606

Clinical prediction guides

The effectiveness and safety of 3% tranexamic acid cream vs. 4% hydroquinone cream for mixed-type melasma in skin of color: a double-blind, split-face, randomized controlled trial.
Yasnova N, Sirait SP, Rahmayunita G
Acta Dermatovenerol Alp Pannonica Adriat 2024 Jun;33(2):83-88. PMID: 38918942
Evaluation of efficacy and safety of vitiligo treatment with micro-needling combined with N-Acetylcysteine and micro-needling alone: A double-blinded randomized controlled clinical trial.
Atefi N, Ziaeifar E, Seirafianpour F, Sadeghzadeh-Bazargan A, Amin NG, Mozafarpoor S, Abouie A, Jafari MA, Goodarzi A
J Cosmet Dermatol 2024 Jun;23(6):2220-2230. Epub 2024 Mar 12 doi: 10.1111/jocd.16274. PMID: 38470079
Topological Indices of Novel Drugs Used in Autoimmune Disease Vitiligo Treatment and Its QSPR Modeling.
Parveen S, Awan NUH, Farooq FB, Fanja R, Anjum QUA
Biomed Res Int 2022;2022:6045066. Epub 2022 Nov 15 doi: 10.1155/2022/6045066. PMID: 36425334Free PMC Article

Recent systematic reviews

Efficacy and Safety of Ablative Fractional Laser in Melasma: A Meta-analysis and Systematic Review.
Zhao S, Wang M, Lai X, Yan Y
Lasers Med Sci 2024 Feb 21;39(1):71. doi: 10.1007/s10103-024-03972-w. PMID: 38379033

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