U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Amyloidogenesis

MedGen UID:
317372
Concept ID:
C1706803
Cell or Molecular Dysfunction

Definition

Amyloidogenesis is the formation or growth of amyloid structures, implicated in many human diseases including Alzheimer s disease (AD), Parkinson s disease (PD), type II diabetes, and spongiform encephalopathies. In these disease states, normally soluble proteins aggregate as amyloidogenic insoluble fibrils that accumulate in affected tissues or organs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmyloidogenesis

Professional guidelines

PubMed

Dohrn MF, Ihne S, Hegenbart U, Medina J, Züchner SL, Coelho T, Hahn K
J Neurochem 2021 Mar;156(6):802-818. Epub 2020 Dec 3 doi: 10.1111/jnc.15233. PMID: 33155274
Tosca Cuquerella J, Bosca-Watts MM, Anton Ausejo R, Tejedor Alonso S, Mora De Miguel F, Minguez Perez M
J Crohns Colitis 2016 Oct;10(10):1245-53. Epub 2016 Apr 7 doi: 10.1093/ecco-jcc/jjw080. PMID: 27056947
Dai Y, Kamal MA
CNS Neurol Disord Drug Targets 2014 Mar;13(2):271-82. doi: 10.2174/18715273113126660134. PMID: 24059324

Recent clinical studies

Etiology

Escudero-Pérez B, Lalande A, Mathieu C, Lawrence P
Viruses 2023 Feb 22;15(3) doi: 10.3390/v15030599. PMID: 36992308Free PMC Article
Yin F
FEBS J 2023 Mar;290(6):1420-1453. Epub 2022 Jan 18 doi: 10.1111/febs.16344. PMID: 34997690Free PMC Article
Alhowail A, Alsikhan R, Alsaud M, Aldubayan M, Rabbani SI
Drug Des Devel Ther 2022;16:2919-2931. Epub 2022 Aug 31 doi: 10.2147/DDDT.S367229. PMID: 36068789Free PMC Article
Maurer MS, Schwartz JH, Gundapaneni B, Elliott PM, Merlini G, Waddington-Cruz M, Kristen AV, Grogan M, Witteles R, Damy T, Drachman BM, Shah SJ, Hanna M, Judge DP, Barsdorf AI, Huber P, Patterson TA, Riley S, Schumacher J, Stewart M, Sultan MB, Rapezzi C; ATTR-ACT Study Investigators
N Engl J Med 2018 Sep 13;379(11):1007-1016. Epub 2018 Aug 27 doi: 10.1056/NEJMoa1805689. PMID: 30145929
Ghetti B, Piccardo P, Frangione B, Bugiani O, Giaccone G, Young K, Prelli F, Farlow MR, Dlouhy SR, Tagliavini F
Brain Pathol 1996 Apr;6(2):127-45. doi: 10.1111/j.1750-3639.1996.tb00796.x. PMID: 8737929

Diagnosis

Kozin SA
Biochemistry (Mosc) 2023 Jan;88(Suppl 1):S75-S87. doi: 10.1134/S0006297923140055. PMID: 37069115
Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M
Int J Nanomedicine 2019;14:5541-5554. Epub 2019 Jul 19 doi: 10.2147/IJN.S200490. PMID: 31410002Free PMC Article
Galant NJ, Westermark P, Higaki JN, Chakrabartty A
Clin Sci (Lond) 2017 Mar 1;131(5):395-409. doi: 10.1042/CS20160413. PMID: 28213611
Marin R, Fabelo N, Fernández-Echevarría C, Canerina-Amaro A, Rodríguez-Barreto D, Quinto-Alemany D, Mesa-Herrera F, Díaz M
Curr Alzheimer Res 2016;13(9):973-84. doi: 10.2174/1567205013666160314150017. PMID: 26971937
Sui X, Liu J, Yang X
Neurosci Bull 2014 Apr;30(2):233-42. Epub 2014 Apr 15 doi: 10.1007/s12264-013-1412-1. PMID: 24733653Free PMC Article

Therapy

Bhalla S, Mehan S, Khan A, Rehman MU
Neurosci Biobehav Rev 2022 Nov;142:104896. Epub 2022 Oct 1 doi: 10.1016/j.neubiorev.2022.104896. PMID: 36191807
Alhowail A, Alsikhan R, Alsaud M, Aldubayan M, Rabbani SI
Drug Des Devel Ther 2022;16:2919-2931. Epub 2022 Aug 31 doi: 10.2147/DDDT.S367229. PMID: 36068789Free PMC Article
Maurer MS, Schwartz JH, Gundapaneni B, Elliott PM, Merlini G, Waddington-Cruz M, Kristen AV, Grogan M, Witteles R, Damy T, Drachman BM, Shah SJ, Hanna M, Judge DP, Barsdorf AI, Huber P, Patterson TA, Riley S, Schumacher J, Stewart M, Sultan MB, Rapezzi C; ATTR-ACT Study Investigators
N Engl J Med 2018 Sep 13;379(11):1007-1016. Epub 2018 Aug 27 doi: 10.1056/NEJMoa1805689. PMID: 30145929
Dennison SR, Harris F, Mura M, Phoenix DA
Curr Protein Pept Sci 2018;19(8):823-838. doi: 10.2174/1389203719666180226155035. PMID: 29484989
Hammer ND, Wang X, McGuffie BA, Chapman MR
J Alzheimers Dis 2008 May;13(4):407-19. doi: 10.3233/jad-2008-13406. PMID: 18487849Free PMC Article

Prognosis

Escudero-Pérez B, Lalande A, Mathieu C, Lawrence P
Viruses 2023 Feb 22;15(3) doi: 10.3390/v15030599. PMID: 36992308Free PMC Article
Nyström S, Hammarström P
J Am Chem Soc 2022 May 25;144(20):8945-8950. Epub 2022 May 17 doi: 10.1021/jacs.2c03925. PMID: 35579205Free PMC Article
Gonzalez-Duarte A, Ulloa-Aguirre A
Int J Mol Sci 2021 Dec 6;22(23) doi: 10.3390/ijms222313158. PMID: 34884963Free PMC Article
Bi TM, Daggett V
Yale J Biol Med 2018 Sep;91(3):247-255. Epub 2018 Sep 21 PMID: 30258312Free PMC Article
Marin R, Fabelo N, Fernández-Echevarría C, Canerina-Amaro A, Rodríguez-Barreto D, Quinto-Alemany D, Mesa-Herrera F, Díaz M
Curr Alzheimer Res 2016;13(9):973-84. doi: 10.2174/1567205013666160314150017. PMID: 26971937

Clinical prediction guides

Escudero-Pérez B, Lalande A, Mathieu C, Lawrence P
Viruses 2023 Feb 22;15(3) doi: 10.3390/v15030599. PMID: 36992308Free PMC Article
Maurer MS, Schwartz JH, Gundapaneni B, Elliott PM, Merlini G, Waddington-Cruz M, Kristen AV, Grogan M, Witteles R, Damy T, Drachman BM, Shah SJ, Hanna M, Judge DP, Barsdorf AI, Huber P, Patterson TA, Riley S, Schumacher J, Stewart M, Sultan MB, Rapezzi C; ATTR-ACT Study Investigators
N Engl J Med 2018 Sep 13;379(11):1007-1016. Epub 2018 Aug 27 doi: 10.1056/NEJMoa1805689. PMID: 30145929
Zhao Y, Lukiw WJ
Mol Neurobiol 2018 Dec;55(12):9100-9107. Epub 2018 Apr 10 doi: 10.1007/s12035-018-1015-y. PMID: 29637444
Nizynski B, Dzwolak W, Nieznanski K
Protein Sci 2017 Nov;26(11):2126-2150. Epub 2017 Sep 13 doi: 10.1002/pro.3275. PMID: 28833749Free PMC Article
Marin R, Fabelo N, Fernández-Echevarría C, Canerina-Amaro A, Rodríguez-Barreto D, Quinto-Alemany D, Mesa-Herrera F, Díaz M
Curr Alzheimer Res 2016;13(9):973-84. doi: 10.2174/1567205013666160314150017. PMID: 26971937

Recent systematic reviews

Dohrn MF, Ihne S, Hegenbart U, Medina J, Züchner SL, Coelho T, Hahn K
J Neurochem 2021 Mar;156(6):802-818. Epub 2020 Dec 3 doi: 10.1111/jnc.15233. PMID: 33155274
Tosca Cuquerella J, Bosca-Watts MM, Anton Ausejo R, Tejedor Alonso S, Mora De Miguel F, Minguez Perez M
J Crohns Colitis 2016 Oct;10(10):1245-53. Epub 2016 Apr 7 doi: 10.1093/ecco-jcc/jjw080. PMID: 27056947

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...