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Amyloidogenesis

MedGen UID:
317372
Concept ID:
C1706803
Cell or Molecular Dysfunction

Definition

Amyloidogenesis is the formation or growth of amyloid structures, implicated in many human diseases including Alzheimer s disease (AD), Parkinson s disease (PD), type II diabetes, and spongiform encephalopathies. In these disease states, normally soluble proteins aggregate as amyloidogenic insoluble fibrils that accumulate in affected tissues or organs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmyloidogenesis

Professional guidelines

PubMed

Dohrn MF, Ihne S, Hegenbart U, Medina J, Züchner SL, Coelho T, Hahn K
J Neurochem 2021 Mar;156(6):802-818. Epub 2020 Dec 3 doi: 10.1111/jnc.15233. PMID: 33155274
Tosca Cuquerella J, Bosca-Watts MM, Anton Ausejo R, Tejedor Alonso S, Mora De Miguel F, Minguez Perez M
J Crohns Colitis 2016 Oct;10(10):1245-53. Epub 2016 Apr 7 doi: 10.1093/ecco-jcc/jjw080. PMID: 27056947
Dai Y, Kamal MA
CNS Neurol Disord Drug Targets 2014 Mar;13(2):271-82. doi: 10.2174/18715273113126660134. PMID: 24059324

Recent clinical studies

Etiology

Alhowail A, Alsikhan R, Alsaud M, Aldubayan M, Rabbani SI
Drug Des Devel Ther 2022;16:2919-2931. Epub 2022 Aug 31 doi: 10.2147/DDDT.S367229. PMID: 36068789Free PMC Article
Nyström S, Hammarström P
J Am Chem Soc 2022 May 25;144(20):8945-8950. Epub 2022 May 17 doi: 10.1021/jacs.2c03925. PMID: 35579205Free PMC Article
Xu XJ, Yang MS, Zhang B, Niu F, Dong JQ, Liu BY
Chin J Traumatol 2021 Feb;24(1):5-10. Epub 2020 Nov 3 doi: 10.1016/j.cjtee.2020.10.001. PMID: 33358332Free PMC Article
Wolfe CM, Fitz NF, Nam KN, Lefterov I, Koldamova R
Int J Mol Sci 2018 Dec 26;20(1) doi: 10.3390/ijms20010081. PMID: 30587772Free PMC Article
Maurer MS, Schwartz JH, Gundapaneni B, Elliott PM, Merlini G, Waddington-Cruz M, Kristen AV, Grogan M, Witteles R, Damy T, Drachman BM, Shah SJ, Hanna M, Judge DP, Barsdorf AI, Huber P, Patterson TA, Riley S, Schumacher J, Stewart M, Sultan MB, Rapezzi C; ATTR-ACT Study Investigators
N Engl J Med 2018 Sep 13;379(11):1007-1016. Epub 2018 Aug 27 doi: 10.1056/NEJMoa1805689. PMID: 30145929

Diagnosis

Cho KH
Int J Mol Sci 2022 Apr 2;23(7) doi: 10.3390/ijms23073967. PMID: 35409326Free PMC Article
Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M
Int J Nanomedicine 2019;14:5541-5554. Epub 2019 Jul 19 doi: 10.2147/IJN.S200490. PMID: 31410002Free PMC Article
Ju Hwang C, Choi DY, Park MH, Hong JT
CNS Neurol Disord Drug Targets 2019;18(1):3-10. doi: 10.2174/1871527316666170807130011. PMID: 28782486
Galant NJ, Westermark P, Higaki JN, Chakrabartty A
Clin Sci (Lond) 2017 Mar 1;131(5):395-409. doi: 10.1042/CS20160413. PMID: 28213611
Marin R, Fabelo N, Fernández-Echevarría C, Canerina-Amaro A, Rodríguez-Barreto D, Quinto-Alemany D, Mesa-Herrera F, Díaz M
Curr Alzheimer Res 2016;13(9):973-84. doi: 10.2174/1567205013666160314150017. PMID: 26971937

Therapy

Bhalla S, Mehan S, Khan A, Rehman MU
Neurosci Biobehav Rev 2022 Nov;142:104896. Epub 2022 Oct 1 doi: 10.1016/j.neubiorev.2022.104896. PMID: 36191807
Alhowail A, Alsikhan R, Alsaud M, Aldubayan M, Rabbani SI
Drug Des Devel Ther 2022;16:2919-2931. Epub 2022 Aug 31 doi: 10.2147/DDDT.S367229. PMID: 36068789Free PMC Article
Maurer MS, Schwartz JH, Gundapaneni B, Elliott PM, Merlini G, Waddington-Cruz M, Kristen AV, Grogan M, Witteles R, Damy T, Drachman BM, Shah SJ, Hanna M, Judge DP, Barsdorf AI, Huber P, Patterson TA, Riley S, Schumacher J, Stewart M, Sultan MB, Rapezzi C; ATTR-ACT Study Investigators
N Engl J Med 2018 Sep 13;379(11):1007-1016. Epub 2018 Aug 27 doi: 10.1056/NEJMoa1805689. PMID: 30145929
Dennison SR, Harris F, Mura M, Phoenix DA
Curr Protein Pept Sci 2018;19(8):823-838. doi: 10.2174/1389203719666180226155035. PMID: 29484989
Hammer ND, Wang X, McGuffie BA, Chapman MR
J Alzheimers Dis 2008 May;13(4):407-19. doi: 10.3233/jad-2008-13406. PMID: 18487849Free PMC Article

Prognosis

Escudero-Pérez B, Lalande A, Mathieu C, Lawrence P
Viruses 2023 Feb 22;15(3) doi: 10.3390/v15030599. PMID: 36992308Free PMC Article
Nyström S, Hammarström P
J Am Chem Soc 2022 May 25;144(20):8945-8950. Epub 2022 May 17 doi: 10.1021/jacs.2c03925. PMID: 35579205Free PMC Article
Gonzalez-Duarte A, Ulloa-Aguirre A
Int J Mol Sci 2021 Dec 6;22(23) doi: 10.3390/ijms222313158. PMID: 34884963Free PMC Article
Bi TM, Daggett V
Yale J Biol Med 2018 Sep;91(3):247-255. Epub 2018 Sep 21 PMID: 30258312Free PMC Article
Marin R, Fabelo N, Fernández-Echevarría C, Canerina-Amaro A, Rodríguez-Barreto D, Quinto-Alemany D, Mesa-Herrera F, Díaz M
Curr Alzheimer Res 2016;13(9):973-84. doi: 10.2174/1567205013666160314150017. PMID: 26971937

Clinical prediction guides

Nyström S, Hammarström P
J Am Chem Soc 2022 May 25;144(20):8945-8950. Epub 2022 May 17 doi: 10.1021/jacs.2c03925. PMID: 35579205Free PMC Article
Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, Tahirovic S, Herms J, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Grathwohl SA, Neher JJ, Holtzman DM, Meyer-Luehmann M, Haass C
Nat Neurosci 2019 Feb;22(2):191-204. Epub 2019 Jan 7 doi: 10.1038/s41593-018-0296-9. PMID: 30617257Free PMC Article
Maurer MS, Schwartz JH, Gundapaneni B, Elliott PM, Merlini G, Waddington-Cruz M, Kristen AV, Grogan M, Witteles R, Damy T, Drachman BM, Shah SJ, Hanna M, Judge DP, Barsdorf AI, Huber P, Patterson TA, Riley S, Schumacher J, Stewart M, Sultan MB, Rapezzi C; ATTR-ACT Study Investigators
N Engl J Med 2018 Sep 13;379(11):1007-1016. Epub 2018 Aug 27 doi: 10.1056/NEJMoa1805689. PMID: 30145929
Nizynski B, Dzwolak W, Nieznanski K
Protein Sci 2017 Nov;26(11):2126-2150. Epub 2017 Sep 13 doi: 10.1002/pro.3275. PMID: 28833749Free PMC Article
Marin R, Fabelo N, Fernández-Echevarría C, Canerina-Amaro A, Rodríguez-Barreto D, Quinto-Alemany D, Mesa-Herrera F, Díaz M
Curr Alzheimer Res 2016;13(9):973-84. doi: 10.2174/1567205013666160314150017. PMID: 26971937

Recent systematic reviews

Dohrn MF, Ihne S, Hegenbart U, Medina J, Züchner SL, Coelho T, Hahn K
J Neurochem 2021 Mar;156(6):802-818. Epub 2020 Dec 3 doi: 10.1111/jnc.15233. PMID: 33155274
Tosca Cuquerella J, Bosca-Watts MM, Anton Ausejo R, Tejedor Alonso S, Mora De Miguel F, Minguez Perez M
J Crohns Colitis 2016 Oct;10(10):1245-53. Epub 2016 Apr 7 doi: 10.1093/ecco-jcc/jjw080. PMID: 27056947

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