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Cutaneous Hematopoietic and Lymphoid Cell Neoplasm

MedGen UID:
317553
•Concept ID:
C1707548
•
Neoplastic Process

Definition

A myeloid or lymphoid cell neoplasm involving the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Hematopoietic and Lymphoid Cell Neoplasm

Professional guidelines

PubMed

Systemic mastocytosis in adults: 2021 Update on diagnosis, risk stratification and management.
Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Diagnosis and treatment of lymphomas in the era of epigenetics.
Chebly A, Chouery E, Ropio J, Kourie HR, Beylot-Barry M, Merlio JP, Tomb R, Chevret E
Blood Rev 2021 Jul;48:100782. Epub 2020 Nov 17 doi: 10.1016/j.blre.2020.100782. PMID: 33229141
Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers.
Pritchard AL, Johansson PA, Nathan V, Howlie M, Symmons J, Palmer JM, Hayward NK
PLoS One 2018;13(4):e0194098. Epub 2018 Apr 11 doi: 10.1371/journal.pone.0194098. PMID: 29641532Free PMC Article

Recent clinical studies

Etiology

North American Blastic Plasmacytoid Dendritic Cell Neoplasm Consortium: position on standards of care and areas of need.
Pemmaraju N, Kantarjian H, Sweet K, Wang E, Senapati J, Wilson NR, Konopleva M, Frankel AE, Gupta V, Mesa R, Ulrickson M, Gorak E, Bhatia S, Budak-Alpdogan T, Mason J, Garcia-Romero MT, Lopez-Santiago N, Cesarman-Maus G, Vachhani P, Lee S, Bhatt VR, Blum W, Walter RB, Bixby D, Gojo I, Duvic M, Rampal RK, de Lima M, Foran J, Fathi AT, Hall AC, Jacoby MA, Lancet J, Mannis G, Stein AS, Mims A, Rizzieri D, Olin R, Perl A, Schiller G, Shami P, Stone RM, Strickland S, Wieduwilt MJ, Daver N, Ravandi F, Vasu S, Guzman M, Roboz GJ, Khoury J, Qazilbash M, Aung PP, Cuglievan B, Madanat Y, Kharfan-Dabaja MA, Pawlowska A, Taylor J, Tallman M, Dhakal P, Lane AA
Blood 2023 Feb 9;141(6):567-578. doi: 10.1182/blood.2022017865. PMID: 36399715
New Insights into the Pathogenesis of Mastocytosis: Emerging Concepts in Diagnosis and Therapy.
Valent P, Akin C, Sperr WR, Horny HP, Arock M, Metcalfe DD, Galli SJ
Annu Rev Pathol 2023 Jan 24;18:361-386. Epub 2022 Oct 21 doi: 10.1146/annurev-pathmechdis-031521-042618. PMID: 36270293
Systemic mastocytosis in adults: 2021 Update on diagnosis, risk stratification and management.
Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Epidemiology and clinical manifestations of mucormycosis.
Petrikkos G, Skiada A, Lortholary O, Roilides E, Walsh TJ, Kontoyiannis DP
Clin Infect Dis 2012 Feb;54 Suppl 1:S23-34. doi: 10.1093/cid/cir866. PMID: 22247442
WHO-EORTC classification for cutaneous lymphomas.
Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, Ralfkiaer E, Chimenti S, Diaz-Perez JL, Duncan LM, Grange F, Harris NL, Kempf W, Kerl H, Kurrer M, Knobler R, Pimpinelli N, Sander C, Santucci M, Sterry W, Vermeer MH, Wechsler J, Whittaker S, Meijer CJ
Blood 2005 May 15;105(10):3768-85. Epub 2005 Feb 3 doi: 10.1182/blood-2004-09-3502. PMID: 15692063

Diagnosis

Blastic Plasmacytoid Dendritic Cell Neoplasm.
Jain A, Sweet K
J Natl Compr Canc Netw 2023 May;21(5):515-521. doi: 10.6004/jnccn.2023.7026. PMID: 37156483
New Insights into the Pathogenesis of Mastocytosis: Emerging Concepts in Diagnosis and Therapy.
Valent P, Akin C, Sperr WR, Horny HP, Arock M, Metcalfe DD, Galli SJ
Annu Rev Pathol 2023 Jan 24;18:361-386. Epub 2022 Oct 21 doi: 10.1146/annurev-pathmechdis-031521-042618. PMID: 36270293
Primary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC.
Olsen EA, Whittaker S, Willemze R, Pinter-Brown L, Foss F, Geskin L, Schwartz L, Horwitz S, Guitart J, Zic J, Kim YH, Wood GS, Duvic M, Ai W, Girardi M, Gru A, Guenova E, Hodak E, Hoppe R, Kempf W, Kim E, Lechowicz MJ, Ortiz-Romero P, Papadavid E, Quaglino P, Pittelkow M, Prince HM, Sanches JA, Sugaya M, Vermeer M, Zain J, Knobler R, Stadler R, Bagot M, Scarisbrick J
Blood 2022 Aug 4;140(5):419-437. doi: 10.1182/blood.2021012057. PMID: 34758074Free PMC Article
Systemic mastocytosis in adults: 2021 Update on diagnosis, risk stratification and management.
Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Mastocytosis.
Tzankov A, Duncavage E, Craig FE, Kelemen K, King RL, Orazi A, Quintanilla-Martinez L, Reichard KK, Rimsza LM, Wang SA, Horny HP, George TI
Am J Clin Pathol 2021 Feb 4;155(2):239-266. doi: 10.1093/ajcp/aqaa183. PMID: 33313644

Therapy

Blastic Plasmacytoid Dendritic Cell Neoplasm.
Jain A, Sweet K
J Natl Compr Canc Netw 2023 May;21(5):515-521. doi: 10.6004/jnccn.2023.7026. PMID: 37156483
Primary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC.
Olsen EA, Whittaker S, Willemze R, Pinter-Brown L, Foss F, Geskin L, Schwartz L, Horwitz S, Guitart J, Zic J, Kim YH, Wood GS, Duvic M, Ai W, Girardi M, Gru A, Guenova E, Hodak E, Hoppe R, Kempf W, Kim E, Lechowicz MJ, Ortiz-Romero P, Papadavid E, Quaglino P, Pittelkow M, Prince HM, Sanches JA, Sugaya M, Vermeer M, Zain J, Knobler R, Stadler R, Bagot M, Scarisbrick J
Blood 2022 Aug 4;140(5):419-437. doi: 10.1182/blood.2021012057. PMID: 34758074Free PMC Article
Systemic mastocytosis in adults: 2021 Update on diagnosis, risk stratification and management.
Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Mastocytosis.
Tzankov A, Duncavage E, Craig FE, Kelemen K, King RL, Orazi A, Quintanilla-Martinez L, Reichard KK, Rimsza LM, Wang SA, Horny HP, George TI
Am J Clin Pathol 2021 Feb 4;155(2):239-266. doi: 10.1093/ajcp/aqaa183. PMID: 33313644
Epidemiology and clinical manifestations of mucormycosis.
Petrikkos G, Skiada A, Lortholary O, Roilides E, Walsh TJ, Kontoyiannis DP
Clin Infect Dis 2012 Feb;54 Suppl 1:S23-34. doi: 10.1093/cid/cir866. PMID: 22247442

Prognosis

Blastic Plasmacytoid Dendritic Cell Neoplasm.
Jain A, Sweet K
J Natl Compr Canc Netw 2023 May;21(5):515-521. doi: 10.6004/jnccn.2023.7026. PMID: 37156483
New Insights into the Pathogenesis of Mastocytosis: Emerging Concepts in Diagnosis and Therapy.
Valent P, Akin C, Sperr WR, Horny HP, Arock M, Metcalfe DD, Galli SJ
Annu Rev Pathol 2023 Jan 24;18:361-386. Epub 2022 Oct 21 doi: 10.1146/annurev-pathmechdis-031521-042618. PMID: 36270293
Primary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC.
Olsen EA, Whittaker S, Willemze R, Pinter-Brown L, Foss F, Geskin L, Schwartz L, Horwitz S, Guitart J, Zic J, Kim YH, Wood GS, Duvic M, Ai W, Girardi M, Gru A, Guenova E, Hodak E, Hoppe R, Kempf W, Kim E, Lechowicz MJ, Ortiz-Romero P, Papadavid E, Quaglino P, Pittelkow M, Prince HM, Sanches JA, Sugaya M, Vermeer M, Zain J, Knobler R, Stadler R, Bagot M, Scarisbrick J
Blood 2022 Aug 4;140(5):419-437. doi: 10.1182/blood.2021012057. PMID: 34758074Free PMC Article
Systemic mastocytosis in adults: 2021 Update on diagnosis, risk stratification and management.
Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Mastocytosis.
Tzankov A, Duncavage E, Craig FE, Kelemen K, King RL, Orazi A, Quintanilla-Martinez L, Reichard KK, Rimsza LM, Wang SA, Horny HP, George TI
Am J Clin Pathol 2021 Feb 4;155(2):239-266. doi: 10.1093/ajcp/aqaa183. PMID: 33313644

Clinical prediction guides

Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression.
Hu Z, Wei F, Su Y, Wang Y, Shen Y, Fang Y, Ding J, Chen Y
Signal Transduct Target Ther 2023 Jan 6;8(1):11. doi: 10.1038/s41392-022-01221-6. PMID: 36604412Free PMC Article
Final Overall Survival and Molecular Analysis in IMmotion151, a Phase 3 Trial Comparing Atezolizumab Plus Bevacizumab vs Sunitinib in Patients With Previously Untreated Metastatic Renal Cell Carcinoma.
Motzer RJ, Powles T, Atkins MB, Escudier B, McDermott DF, Alekseev BY, Lee JL, Suarez C, Stroyakovskiy D, De Giorgi U, Donskov F, Mellado B, Banchereau R, Hamidi H, Khan O, Craine V, Huseni M, Flinn N, Dubey S, Rini BI
JAMA Oncol 2022 Feb 1;8(2):275-280. doi: 10.1001/jamaoncol.2021.5981. PMID: 34940781Free PMC Article
Phase II study of ceralasertib (AZD6738) in combination with durvalumab in patients with advanced/metastatic melanoma who have failed prior anti-PD-1 therapy.
Kim R, Kwon M, An M, Kim ST, Smith SA, Loembé AB, Mortimer PGS, Armenia J, Lukashchuk N, Shah N, Dean E, Park WY, Lee J
Ann Oncol 2022 Feb;33(2):193-203. Epub 2021 Oct 25 doi: 10.1016/j.annonc.2021.10.009. PMID: 34710570
Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers.
Pritchard AL, Johansson PA, Nathan V, Howlie M, Symmons J, Palmer JM, Hayward NK
PLoS One 2018;13(4):e0194098. Epub 2018 Apr 11 doi: 10.1371/journal.pone.0194098. PMID: 29641532Free PMC Article
Cutaneous Reactions to Targeted Therapy.
Lee JJ, Kroshinsky D, Hoang MP
Am J Dermatopathol 2017 Feb;39(2):67-82. doi: 10.1097/DAD.0000000000000504. PMID: 28134724

Recent systematic reviews

Cutaneous-group histiocytoses associated with myeloid malignancies: A systematic review of 102 cases.
Bonometti A, Gliozzo J, Moltrasio C, Bagnoli F, Berti E
Australas J Dermatol 2021 May;62(2):e162-e169. Epub 2020 Oct 30 doi: 10.1111/ajd.13491. PMID: 33125722
A Systematic Approach to the Cutaneous Lymphoid Infiltrates: A Clinical, Morphologic, and Immunophenotypic Evaluation.
Gru AA, McHargue C, Salavaggione AL
Arch Pathol Lab Med 2019 Aug;143(8):958-979. doi: 10.5858/arpa.2018-0294-RA. PMID: 31339758
Indoor tanning and the risk of developing non-cutaneous cancers: a systematic review and meta-analysis.
O'Sullivan DE, Hillier TWR, Brenner DR, Peters CE, King WD
Cancer Causes Control 2018 Oct;29(10):937-950. Epub 2018 Aug 11 doi: 10.1007/s10552-018-1070-8. PMID: 30099630
Chemosaturation Percutaneous Hepatic Perfusion: A Systematic Review.
Vogel A, Gupta S, Zeile M, von Haken R, Brüning R, Lotz G, Vahrmeijer A, Vogl T, Wacker F
Adv Ther 2017 Jan;33(12):2122-2138. Epub 2016 Oct 31 doi: 10.1007/s12325-016-0424-4. PMID: 27798773Free PMC Article
Cutaneous Malignant Neoplasms in Hematopoietic Cell Transplant Recipients: A Systematic Review.
DePry JL, Vyas R, Lazarus HM, Caimi PF, Gerstenblith MR, Bordeaux JS
JAMA Dermatol 2015 Jul;151(7):775-82. doi: 10.1001/jamadermatol.2015.121. PMID: 25902409

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