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Gain of Chromosome 11q13

MedGen UID:
317710
•Concept ID:
C1708165
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 11q13

Professional guidelines

PubMed

Genome-wide screening for genetic alterations in esophageal cancer by aCGH identifies 11q13 amplification oncogenes associated with nodal metastasis.
Ying J, Shan L, Li J, Zhong L, Xue L, Zhao H, Li L, Langford C, Guo L, Qiu T, Lu N, Tao Q
PLoS One 2012;7(6):e39797. Epub 2012 Jun 25 doi: 10.1371/journal.pone.0039797. PMID: 22761904Free PMC Article
Genomic alterations in human malignant glioma cells associate with the cell resistance to the combination treatment with tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy.
Li YC, Tzeng CC, Song JH, Tsia FJ, Hsieh LJ, Liao SJ, Tsai CH, Van Meir EG, Hao C, Lin CC
Clin Cancer Res 2006 May 1;12(9):2716-29. doi: 10.1158/1078-0432.CCR-05-1980. PMID: 16675563
Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors.
Paris PL, Andaya A, Fridlyand J, Jain AN, Weinberg V, Kowbel D, Brebner JH, Simko J, Watson JE, Volik S, Albertson DG, Pinkel D, Alers JC, van der Kwast TH, Vissers KJ, Schroder FH, Wildhagen MF, Febbo PG, Chinnaiyan AM, Pienta KJ, Carroll PR, Rubin MA, Collins C, van Dekken H
Hum Mol Genet 2004 Jul 1;13(13):1303-13. Epub 2004 May 11 doi: 10.1093/hmg/ddh155. PMID: 15138198

Recent clinical studies

Etiology

Molecular heterogeneity in human papillomavirus-dependent and -independent vulvar carcinogenesis.
Swarts DRA, Voorham QJM, van Splunter AP, Wilting SM, Sie D, Pronk D, van Beurden M, Heideman DAM, Snijders PJF, Meijer CJLM, Steenbergen RDM, Bleeker MCG
Cancer Med 2018 Sep;7(9):4542-4553. Epub 2018 Jul 20 doi: 10.1002/cam4.1633. PMID: 30030907Free PMC Article
Copy number gain of 11q13.3 genes associates with pathological stage in hypopharyngeal squamous cell carcinoma.
Pattle SB, Utjesanovic N, Togo A, Wells L, Conn B, Monaghan H, Junor E, Johannessen I, Cuschieri K, Talbot S
Genes Chromosomes Cancer 2017 Mar;56(3):185-198. Epub 2016 Nov 21 doi: 10.1002/gcc.22425. PMID: 27750372
Clinical Follow-up of Atypical Spitzoid Tumors Analyzed by Fluorescence In Situ Hybridization.
Egnatios GL, Ferringer TC
Am J Dermatopathol 2016 Apr;38(4):289-96. doi: 10.1097/DAD.0000000000000440. PMID: 26999339
Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications.
Klussmann JP, Mooren JJ, Lehnen M, Claessen SM, Stenner M, Huebbers CU, Weissenborn SJ, Wedemeyer I, Preuss SF, Straetmans JM, Manni JJ, Hopman AH, Speel EJ
Clin Cancer Res 2009 Mar 1;15(5):1779-86. Epub 2009 Feb 17 doi: 10.1158/1078-0432.CCR-08-1463. PMID: 19223504
Aberrations of 11q13 in laryngeal squamous cell lines and their prognostic significance.
Jarmuz M, Grenman R, Golusinski W, Szyfter K
Cancer Genet Cytogenet 2005 Jul 1;160(1):82-8. doi: 10.1016/j.cancergencyto.2004.12.006. PMID: 15949577

Diagnosis

Gain of CCND1 May Occur Too Infrequently in Cutaneous Melanoma, and Too Late in Melanomagenesis, to Be Diagnostically Useful: Genomic Analysis of 88 Cases.
McFadden JR, Chaudhari AS, Stevanovic M, Tsongalis GJ, Hughes EG, Sriharan A
Am J Dermatopathol 2023 May 1;45(5):311-319. Epub 2023 Mar 20 doi: 10.1097/DAD.0000000000002420. PMID: 36939129Free PMC Article
Molecular heterogeneity in human papillomavirus-dependent and -independent vulvar carcinogenesis.
Swarts DRA, Voorham QJM, van Splunter AP, Wilting SM, Sie D, Pronk D, van Beurden M, Heideman DAM, Snijders PJF, Meijer CJLM, Steenbergen RDM, Bleeker MCG
Cancer Med 2018 Sep;7(9):4542-4553. Epub 2018 Jul 20 doi: 10.1002/cam4.1633. PMID: 30030907Free PMC Article
Clinical Follow-up of Atypical Spitzoid Tumors Analyzed by Fluorescence In Situ Hybridization.
Egnatios GL, Ferringer TC
Am J Dermatopathol 2016 Apr;38(4):289-96. doi: 10.1097/DAD.0000000000000440. PMID: 26999339
The diagnostic value of 11q13 amplification and protein expression in the detection of nodal metastasis from oral squamous cell carcinoma: a systematic review and meta-analysis.
Noorlag R, van Kempen PM, Stegeman I, Koole R, van Es RJ, Willems SM
Virchows Arch 2015 Apr;466(4):363-73. Epub 2015 Feb 7 doi: 10.1007/s00428-015-1719-6. PMID: 25663615Free PMC Article
Aberrations of 11q13 in laryngeal squamous cell lines and their prognostic significance.
Jarmuz M, Grenman R, Golusinski W, Szyfter K
Cancer Genet Cytogenet 2005 Jul 1;160(1):82-8. doi: 10.1016/j.cancergencyto.2004.12.006. PMID: 15949577

Therapy

Recurrent oligodendroglioma with changed 1p/19q status.
Barresi V, Mafficini A, Calicchia M, Piredda ML, Musumeci A, Ghimenton C, Scarpa A
Neuropathology 2022 Apr;42(2):160-166. Epub 2022 Feb 10 doi: 10.1111/neup.12789. PMID: 35144313Free PMC Article
Genomic alterations identified by array comparative genomic hybridization as prognostic markers in tamoxifen-treated estrogen receptor-positive breast cancer.
Han W, Han MR, Kang JJ, Bae JY, Lee JH, Bae YJ, Lee JE, Shin HJ, Hwang KT, Hwang SE, Kim SW, Noh DY
BMC Cancer 2006 Apr 12;6:92. doi: 10.1186/1471-2407-6-92. PMID: 16608533Free PMC Article
Genetic analysis of lithium-associated parathyroid tumors.
Dwight T, Kytölä S, Teh BT, Theodosopoulos G, Richardson AL, Philips J, Twigg S, Delbridge L, Marsh DJ, Nelson AE, Larsson C, Robinson BG
Eur J Endocrinol 2002 May;146(5):619-27. doi: 10.1530/eje.0.1460619. PMID: 11980616
Multiple myeloma: an update on biology and treatment.
Ludwig H, Meran J, Zojer N
Ann Oncol 1999;10 Suppl 6:31-43. PMID: 10676551
Molecular cytogenetic abnormalities in multiple myeloma and plasma cell leukemia measured using comparative genomic hybridization.
Avet-Loiseau H, Andree-Ashley LE, Moore D 2nd, Mellerin MP, Feusner J, Bataille R, Pallavicini MG
Genes Chromosomes Cancer 1997 Jun;19(2):124-33. doi: 10.1002/(sici)1098-2264(199706)19:2<124::aid-gcc8>3.0.co;2-0. PMID: 9172003

Prognosis

Delineation of the frequency and boundary of chromosomal copy number variations in paediatric neuroblastoma.
Ho N, Peng H, Mayoh C, Liu PY, Atmadibrata B, Marshall GM, Li J, Liu T
Cell Cycle 2018;17(6):749-758. doi: 10.1080/15384101.2017.1421875. PMID: 29353549Free PMC Article
Copy number gain of 11q13.3 genes associates with pathological stage in hypopharyngeal squamous cell carcinoma.
Pattle SB, Utjesanovic N, Togo A, Wells L, Conn B, Monaghan H, Junor E, Johannessen I, Cuschieri K, Talbot S
Genes Chromosomes Cancer 2017 Mar;56(3):185-198. Epub 2016 Nov 21 doi: 10.1002/gcc.22425. PMID: 27750372
The diagnostic value of 11q13 amplification and protein expression in the detection of nodal metastasis from oral squamous cell carcinoma: a systematic review and meta-analysis.
Noorlag R, van Kempen PM, Stegeman I, Koole R, van Es RJ, Willems SM
Virchows Arch 2015 Apr;466(4):363-73. Epub 2015 Feb 7 doi: 10.1007/s00428-015-1719-6. PMID: 25663615Free PMC Article
Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma.
Takita J, Chen Y, Okubo J, Sanada M, Adachi M, Ohki K, Nishimura R, Hanada R, Igarashi T, Hayashi Y, Ogawa S
Cancer Sci 2011 Sep;102(9):1645-50. Epub 2011 Jul 3 doi: 10.1111/j.1349-7006.2011.01995.x. PMID: 21624008
Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.
Martin CL, Reshmi SC, Ried T, Gottberg W, Wilson JW, Reddy JK, Khanna P, Johnson JT, Myers EN, Gollin SM
Oral Oncol 2008 Apr;44(4):369-82. Epub 2007 Aug 2 doi: 10.1016/j.oraloncology.2007.05.003. PMID: 17681875Free PMC Article

Clinical prediction guides

Gain of CCND1 May Occur Too Infrequently in Cutaneous Melanoma, and Too Late in Melanomagenesis, to Be Diagnostically Useful: Genomic Analysis of 88 Cases.
McFadden JR, Chaudhari AS, Stevanovic M, Tsongalis GJ, Hughes EG, Sriharan A
Am J Dermatopathol 2023 May 1;45(5):311-319. Epub 2023 Mar 20 doi: 10.1097/DAD.0000000000002420. PMID: 36939129Free PMC Article
Copy number gain of 11q13.3 genes associates with pathological stage in hypopharyngeal squamous cell carcinoma.
Pattle SB, Utjesanovic N, Togo A, Wells L, Conn B, Monaghan H, Junor E, Johannessen I, Cuschieri K, Talbot S
Genes Chromosomes Cancer 2017 Mar;56(3):185-198. Epub 2016 Nov 21 doi: 10.1002/gcc.22425. PMID: 27750372
Clinical relevance of copy number profiling in oral and oropharyngeal squamous cell carcinoma.
van Kempen PM, Noorlag R, Braunius WW, Moelans CB, Rifi W, Savola S, Koole R, Grolman W, van Es RJ, Willems SM
Cancer Med 2015 Oct;4(10):1525-35. Epub 2015 Jul 21 doi: 10.1002/cam4.499. PMID: 26194878Free PMC Article
The diagnostic value of 11q13 amplification and protein expression in the detection of nodal metastasis from oral squamous cell carcinoma: a systematic review and meta-analysis.
Noorlag R, van Kempen PM, Stegeman I, Koole R, van Es RJ, Willems SM
Virchows Arch 2015 Apr;466(4):363-73. Epub 2015 Feb 7 doi: 10.1007/s00428-015-1719-6. PMID: 25663615Free PMC Article
Cytogenetic characterization of tumors of the vulva and vagina.
Micci F, Teixeira MR, Scheistrøen M, Abeler VM, Heim S
Genes Chromosomes Cancer 2003 Oct;38(2):137-48. doi: 10.1002/gcc.10263. PMID: 12939741

Recent systematic reviews

The diagnostic value of 11q13 amplification and protein expression in the detection of nodal metastasis from oral squamous cell carcinoma: a systematic review and meta-analysis.
Noorlag R, van Kempen PM, Stegeman I, Koole R, van Es RJ, Willems SM
Virchows Arch 2015 Apr;466(4):363-73. Epub 2015 Feb 7 doi: 10.1007/s00428-015-1719-6. PMID: 25663615Free PMC Article

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