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Gain of Chromosome 13q

MedGen UID:
317712
•Concept ID:
C1708167
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 13q

Professional guidelines

PubMed

Cytogenetics in the management of chronic lymphocytic leukemia: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Nguyen-Khac F, Balogh Z, Chauzeix J, Veronese L, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103410. Epub 2023 Sep 17 doi: 10.1016/j.retram.2023.103410. PMID: 38039634
Evaluation of genetic patterns in different tumor areas of intermediate-grade prostatic adenocarcinomas by high-resolution genomic array analysis.
van Dekken H, Paris PL, Albertson DG, Alers JC, Andaya A, Kowbel D, van der Kwast TH, Pinkel D, Schröder FH, Vissers KJ, Wildhagen MF, Collins C
Genes Chromosomes Cancer 2004 Mar;39(3):249-56. doi: 10.1002/gcc.20001. PMID: 14732926
Molecular cytogenetic analysis of prostatic adenocarcinomas from screening studies : early cancers may contain aggressive genetic features.
Alers JC, Krijtenburg PJ, Vis AN, Hoedemaeker RF, Wildhagen MF, Hop WC, van Der Kwast TT, Schröder FH, Tanke HJ, van Dekken H
Am J Pathol 2001 Feb;158(2):399-406. doi: 10.1016/s0002-9440(10)63983-1. PMID: 11159178Free PMC Article

Recent clinical studies

Etiology

Presentation and outcomes of patients with multiple myeloma harboring gain or amplification of 1q21 and receiving novel agent therapies: results from a single-center study.
Chen H, Zhou N, Shi H, Yu W, Wu L, Zhou F
Hematology 2023 Dec;28(1):2177979. doi: 10.1080/16078454.2023.2177979. PMID: 36794720
Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma.
DeSisto J, Lucas JT Jr, Xu K, Donson A, Lin T, Sanford B, Wu G, Tran QT, Hedges D, Hsu CY, Armstrong GT, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Schüller U, Venkataraman S, Hoffman LM, Dorris K, Mulcahy Levy JM, Hankinson TC, Handler M, Liu AK, Foreman N, Vibhakar R, Jones K, Allen S, Zhang J, Baker SJ, Merchant TE, Orr BA, Green AL
Nat Commun 2021 Sep 20;12(1):5531. doi: 10.1038/s41467-021-25709-x. PMID: 34545084Free PMC Article
Identification and monitoring of Copy Number Variants (CNV) in monoclonal gammopathy.
Sallustio F, Curci C, Solimando AG, Leone P, Pontrelli P, Gesualdo L, Vacca A, Racanelli V, Gallone A
Cancer Biol Ther 2021 Jun 3;22(5-6):404-412. Epub 2021 Jul 21 doi: 10.1080/15384047.2021.1946458. PMID: 34288806Free PMC Article
Heterogeneity within the PF-EPN-B ependymoma subgroup.
Cavalli FMG, Hübner JM, Sharma T, Luu B, Sill M, Zapotocky M, Mack SC, Witt H, Lin T, Shih DJH, Ho B, Santi M, Emery L, Hukin J, Dunham C, McLendon RE, Lipp ES, Gururangan S, Grossbach A, French P, Kros JM, van Veelen MC, Rao AAN, Giannini C, Leary S, Jung S, Faria CC, Mora J, Schüller U, Alonso MM, Chan JA, Klekner A, Chambless LB, Hwang EI, Massimino M, Eberhart CG, Karajannis MA, Lu B, Liau LM, Zollo M, Ferrucci V, Carlotti C, Tirapelli DPC, Tabori U, Bouffet E, Ryzhova M, Ellison DW, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Pfister SM, Taylor MD, Aldape K, Pajtler KW, Kool M, Ramaswamy V
Acta Neuropathol 2018 Aug;136(2):227-237. Epub 2018 Jul 17 doi: 10.1007/s00401-018-1888-x. PMID: 30019219Free PMC Article
Genetic and epigenetic alterations during renal carcinogenesis.
Arai E, Kanai Y
Int J Clin Exp Pathol 2010 Dec 13;4(1):58-73. PMID: 21228928Free PMC Article

Diagnosis

Identification and monitoring of Copy Number Variants (CNV) in monoclonal gammopathy.
Sallustio F, Curci C, Solimando AG, Leone P, Pontrelli P, Gesualdo L, Vacca A, Racanelli V, Gallone A
Cancer Biol Ther 2021 Jun 3;22(5-6):404-412. Epub 2021 Jul 21 doi: 10.1080/15384047.2021.1946458. PMID: 34288806Free PMC Article
Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia.
Fabbri M, Bottoni A, Shimizu M, Spizzo R, Nicoloso MS, Rossi S, Barbarotto E, Cimmino A, Adair B, Wojcik SE, Valeri N, Calore F, Sampath D, Fanini F, Vannini I, Musuraca G, Dell'Aquila M, Alder H, Davuluri RV, Rassenti LZ, Negrini M, Nakamura T, Amadori D, Kay NE, Rai KR, Keating MJ, Kipps TJ, Calin GA, Croce CM
JAMA 2011 Jan 5;305(1):59-67. doi: 10.1001/jama.2010.1919. PMID: 21205967Free PMC Article
Genetic and epigenetic alterations during renal carcinogenesis.
Arai E, Kanai Y
Int J Clin Exp Pathol 2010 Dec 13;4(1):58-73. PMID: 21228928Free PMC Article
Gain of chromosome 3 and loss of 13q are frequent alterations in pituitary adenomas.
Fan X, Paetau A, Aalto Y, Välimäki M, Sane T, Poranen A, Castresana JS, Knuutila S
Cancer Genet Cytogenet 2001 Jul 15;128(2):97-103. doi: 10.1016/s0165-4608(01)00398-3. PMID: 11463446
Cytogenetic analysis in the examination of solid tumors in children.
Mertens F, Mandahl N, Mitelman F, Heim S
Pediatr Hematol Oncol 1994 Jul-Aug;11(4):361-77. doi: 10.3109/08880019409140536. PMID: 7947009

Therapy

Gain of 1q21 is an adverse prognostic factor for multiple myeloma patients treated by autologous stem cell transplantation: A multicenter study in China.
Gao W, Jian Y, Du J, Li X, Zhou H, Zhang Z, Yang G, Wang G, Tian Y, Li Y, Wu Y, Fu W, Li J, Chen W
Cancer Med 2020 Nov;9(21):7819-7829. Epub 2020 Sep 2 doi: 10.1002/cam4.3254. PMID: 32881351Free PMC Article
Clinical Characteristics and Prognosis of MAF Deletion in Chinese Patients With Multiple Myeloma.
Wang Y, Li Q, Xing S, Zhang H, Li D
Clin Lymphoma Myeloma Leuk 2019 Sep;19(9):e545-e550. Epub 2019 May 29 doi: 10.1016/j.clml.2019.05.016. PMID: 31262667
Heterogeneity within the PF-EPN-B ependymoma subgroup.
Cavalli FMG, Hübner JM, Sharma T, Luu B, Sill M, Zapotocky M, Mack SC, Witt H, Lin T, Shih DJH, Ho B, Santi M, Emery L, Hukin J, Dunham C, McLendon RE, Lipp ES, Gururangan S, Grossbach A, French P, Kros JM, van Veelen MC, Rao AAN, Giannini C, Leary S, Jung S, Faria CC, Mora J, Schüller U, Alonso MM, Chan JA, Klekner A, Chambless LB, Hwang EI, Massimino M, Eberhart CG, Karajannis MA, Lu B, Liau LM, Zollo M, Ferrucci V, Carlotti C, Tirapelli DPC, Tabori U, Bouffet E, Ryzhova M, Ellison DW, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Pfister SM, Taylor MD, Aldape K, Pajtler KW, Kool M, Ramaswamy V
Acta Neuropathol 2018 Aug;136(2):227-237. Epub 2018 Jul 17 doi: 10.1007/s00401-018-1888-x. PMID: 30019219Free PMC Article
Proteasome inhibitors and IMiDs can overcome some high-risk cytogenetics in multiple myeloma but not gain 1q21.
Nahi H, Våtsveen TK, Lund J, Heeg BM, Preiss B, Alici E, Møller MB, Wader KF, Møller HE, Grøseth LA, Østergaard B, Dai HY, Holmberg E, Gahrton G, Waage A, Abildgaard N
Eur J Haematol 2016 Jan;96(1):46-54. Epub 2015 Jun 29 doi: 10.1111/ejh.12546. PMID: 25779478
Patients with Fanconi anemia and AML have different cytogenetic clones than de novo cases of AML.
Rochowski A, Olson SB, Alonzo TA, Gerbing RB, Lange BJ, Alter BP
Pediatr Blood Cancer 2012 Nov;59(5):922-4. Epub 2012 Apr 19 doi: 10.1002/pbc.24168. PMID: 22517793Free PMC Article

Prognosis

Presentation and outcomes of patients with multiple myeloma harboring gain or amplification of 1q21 and receiving novel agent therapies: results from a single-center study.
Chen H, Zhou N, Shi H, Yu W, Wu L, Zhou F
Hematology 2023 Dec;28(1):2177979. doi: 10.1080/16078454.2023.2177979. PMID: 36794720
Identification and monitoring of Copy Number Variants (CNV) in monoclonal gammopathy.
Sallustio F, Curci C, Solimando AG, Leone P, Pontrelli P, Gesualdo L, Vacca A, Racanelli V, Gallone A
Cancer Biol Ther 2021 Jun 3;22(5-6):404-412. Epub 2021 Jul 21 doi: 10.1080/15384047.2021.1946458. PMID: 34288806Free PMC Article
Clinical Characteristics and Prognosis of MAF Deletion in Chinese Patients With Multiple Myeloma.
Wang Y, Li Q, Xing S, Zhang H, Li D
Clin Lymphoma Myeloma Leuk 2019 Sep;19(9):e545-e550. Epub 2019 May 29 doi: 10.1016/j.clml.2019.05.016. PMID: 31262667
Heterogeneity within the PF-EPN-B ependymoma subgroup.
Cavalli FMG, Hübner JM, Sharma T, Luu B, Sill M, Zapotocky M, Mack SC, Witt H, Lin T, Shih DJH, Ho B, Santi M, Emery L, Hukin J, Dunham C, McLendon RE, Lipp ES, Gururangan S, Grossbach A, French P, Kros JM, van Veelen MC, Rao AAN, Giannini C, Leary S, Jung S, Faria CC, Mora J, Schüller U, Alonso MM, Chan JA, Klekner A, Chambless LB, Hwang EI, Massimino M, Eberhart CG, Karajannis MA, Lu B, Liau LM, Zollo M, Ferrucci V, Carlotti C, Tirapelli DPC, Tabori U, Bouffet E, Ryzhova M, Ellison DW, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Pfister SM, Taylor MD, Aldape K, Pajtler KW, Kool M, Ramaswamy V
Acta Neuropathol 2018 Aug;136(2):227-237. Epub 2018 Jul 17 doi: 10.1007/s00401-018-1888-x. PMID: 30019219Free PMC Article
Genetic and epigenetic alterations during renal carcinogenesis.
Arai E, Kanai Y
Int J Clin Exp Pathol 2010 Dec 13;4(1):58-73. PMID: 21228928Free PMC Article

Clinical prediction guides

Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature.
Martens-de Kemp SR, Komor MA, Hegi R, Bolijn AS, Tijssen M, de Groen FLM, Depla A, van Leerdam M, Meijer GA, Fijneman RJA, Carvalho B
Neoplasia 2022 Oct;32:100820. Epub 2022 Jul 21 doi: 10.1016/j.neo.2022.100820. PMID: 35872559Free PMC Article
Identifying bifurcated paths with differential function impact in glioblastomas evolution.
Zhang Y, Xie A, Quan F, Hou X, Liao J, Zhu S, Pang L, Liang X, Zhu X, Cheng P, Li X, Xiao Y
Int J Cancer 2020 Dec 1;147(11):3139-3151. Epub 2020 Sep 12 doi: 10.1002/ijc.33276. PMID: 32875565
Clinical Characteristics and Prognosis of MAF Deletion in Chinese Patients With Multiple Myeloma.
Wang Y, Li Q, Xing S, Zhang H, Li D
Clin Lymphoma Myeloma Leuk 2019 Sep;19(9):e545-e550. Epub 2019 May 29 doi: 10.1016/j.clml.2019.05.016. PMID: 31262667
Heterogeneity within the PF-EPN-B ependymoma subgroup.
Cavalli FMG, Hübner JM, Sharma T, Luu B, Sill M, Zapotocky M, Mack SC, Witt H, Lin T, Shih DJH, Ho B, Santi M, Emery L, Hukin J, Dunham C, McLendon RE, Lipp ES, Gururangan S, Grossbach A, French P, Kros JM, van Veelen MC, Rao AAN, Giannini C, Leary S, Jung S, Faria CC, Mora J, Schüller U, Alonso MM, Chan JA, Klekner A, Chambless LB, Hwang EI, Massimino M, Eberhart CG, Karajannis MA, Lu B, Liau LM, Zollo M, Ferrucci V, Carlotti C, Tirapelli DPC, Tabori U, Bouffet E, Ryzhova M, Ellison DW, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Pfister SM, Taylor MD, Aldape K, Pajtler KW, Kool M, Ramaswamy V
Acta Neuropathol 2018 Aug;136(2):227-237. Epub 2018 Jul 17 doi: 10.1007/s00401-018-1888-x. PMID: 30019219Free PMC Article
Molecular changes during the genesis of human gliomas.
Sehgal A
Semin Surg Oncol 1998 Jan-Feb;14(1):3-12. doi: 10.1002/(sici)1098-2388(199801/02)14:1<3::aid-ssu2>3.0.co;2-f. PMID: 9407626

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