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Leaflet Disruption Due To Calcification

MedGen UID:
317823
•Concept ID:
C1708667
•
Disease or Syndrome

Definition

The disturbance of a cusp of a heart valve secondary to the accumulation of calcium on the valve tissue. This most often results in stenosis of the valve. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeaflet Disruption Due To Calcification

Recent clinical studies

Etiology

Novel Surgical Technique to Prevent Left Ventricular Rupture After Mitral Valve Replacement.
Fadel M, Varghese S, Awad G, Wippermann J
Ann Thorac Surg 2021 Dec;112(6):e463-e466. Epub 2021 Mar 29 doi: 10.1016/j.athoracsur.2021.03.046. PMID: 33794159
Use of Transcatheter Valves for Open Surgical Mitral Valve Replacement. Australian Experience.
Ahmad T, Ludhani PM, Gurvitch R, Larobina M, Goldblatt J, Tatoulis J
Heart Lung Circ 2019 Mar;28(3):464-470. Epub 2018 Feb 21 doi: 10.1016/j.hlc.2018.02.008. PMID: 30170916
Fate of left-sided cardiac bioprosthesis valves in children.
Kopf GS, Geha AS, Hellenbrand WE, Kleinman CS
Arch Surg 1986 Apr;121(4):488-90. doi: 10.1001/archsurg.1986.01400040126021. PMID: 3954594
Valve failure with the Ionescu-Shiley bovine pericardial bioprosthesis: analysis of 2680 patients.
Reul GJ Jr, Cooley DA, Duncan JM, Frazier OH, Hallman GL, Livesay JJ, Ott DA, Walker WE
J Vasc Surg 1985 Jan;2(1):192-204. PMID: 3965752
Early stenosis and calcification of glutaraldehyde-preserved porcine xenografts in children.
Hellberg K, Ruschewski W, de Vivie ER
Thorac Cardiovasc Surg 1981 Dec;29(6):369-74. doi: 10.1055/s-2007-1023515. PMID: 6179219

Diagnosis

Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 1: Pluridisciplinary perspective on their hemodynamics and morphomechanics.
Pasipoularides A
J Mol Cell Cardiol 2019 Aug;133:223-232. Epub 2019 May 28 doi: 10.1016/j.yjmcc.2019.05.017. PMID: 31150733Free PMC Article
Use of Transcatheter Valves for Open Surgical Mitral Valve Replacement. Australian Experience.
Ahmad T, Ludhani PM, Gurvitch R, Larobina M, Goldblatt J, Tatoulis J
Heart Lung Circ 2019 Mar;28(3):464-470. Epub 2018 Feb 21 doi: 10.1016/j.hlc.2018.02.008. PMID: 30170916
Spontaneous rupture of atrioventricular valve tensor apparatus as late manifestation of anti-Ro/SSA antibody-mediated cardiac disease.
Cuneo BF, Fruitman D, Benson DW, Ngan BY, Liske MR, Wahren-Herlineus M, Ho SY, Jaeggi E
Am J Cardiol 2011 Mar 1;107(5):761-6. Epub 2011 Jan 19 doi: 10.1016/j.amjcard.2010.10.059. PMID: 21247531
Balloon dilatation of calcific aortic stenosis in elderly patients: postmortem, intraoperative, and percutaneous valvuloplasty studies.
McKay RG, Safian RD, Lock JE, Mandell VS, Thurer RL, Schnitt SJ, Grossman W
Circulation 1986 Jul;74(1):119-25. doi: 10.1161/01.cir.74.1.119. PMID: 2423269
Nonrheumatic mitral incompetence.
Yahini JH, Deutsch V, Miller HI, Shem-Tov A, Atlas P, Neufeld HN
Isr J Med Sci 1975 Sep;11(9):928-67. PMID: 1184367

Therapy

Novel Surgical Technique to Prevent Left Ventricular Rupture After Mitral Valve Replacement.
Fadel M, Varghese S, Awad G, Wippermann J
Ann Thorac Surg 2021 Dec;112(6):e463-e466. Epub 2021 Mar 29 doi: 10.1016/j.athoracsur.2021.03.046. PMID: 33794159
Postmortem and intraoperative balloon valvuloplasty of calcific aortic stenosis in elderly patients: mechanisms of successful dilation.
Safian RD, Mandell VS, Thurer RE, Hutchins GM, Schnitt SJ, Grossman W, McKay RG
J Am Coll Cardiol 1987 Mar;9(3):655-60. doi: 10.1016/s0735-1097(87)80061-x. PMID: 2950156
Relation of calcification to torn leaflets of spontaneously degenerated porcine bioprosthetic valves.
Stein PD, Kemp SR, Riddle JM, Lee MW, Lewis JW Jr, Magilligan DJ Jr
Ann Thorac Surg 1985 Aug;40(2):175-80. doi: 10.1016/s0003-4975(10)60014-8. PMID: 4026449
Valve failure with the Ionescu-Shiley bovine pericardial bioprosthesis: analysis of 2680 patients.
Reul GJ Jr, Cooley DA, Duncan JM, Frazier OH, Hallman GL, Livesay JJ, Ott DA, Walker WE
J Vasc Surg 1985 Jan;2(1):192-204. PMID: 3965752
The clinical life history of explanted prosthetic heart valves.
Marbarger JP Jr, Clark RE
Ann Thorac Surg 1982 Jul;34(1):22-33. doi: 10.1016/s0003-4975(10)60848-x. PMID: 7092396

Prognosis

Comparison of reoperation findings of the Carpentier-Edwards (standard) bioprosthesis and the St Jude bioimplant (formerly Liotta) in the mitral position.
Yamak B, Ozsöyler, Ulus AT, Kiziltepe U, Katircioğlu SF, Taşdemir O
Cardiovasc Surg 1999 Dec;7(7):730-4. doi: 10.1016/s0967-2109(99)00051-4. PMID: 10639048
Mitral regurgitation following mitral balloon valvotomy. Differing mechanisms for severe versus mild-to-moderate lesions.
Essop MR, Wisenbaugh T, Skoularigis J, Middlemost S, Sareli P
Circulation 1991 Oct;84(4):1669-79. doi: 10.1161/01.cir.84.4.1669. PMID: 1914106
Fate of left-sided cardiac bioprosthesis valves in children.
Kopf GS, Geha AS, Hellenbrand WE, Kleinman CS
Arch Surg 1986 Apr;121(4):488-90. doi: 10.1001/archsurg.1986.01400040126021. PMID: 3954594
Early stenosis and calcification of glutaraldehyde-preserved porcine xenografts in children.
Hellberg K, Ruschewski W, de Vivie ER
Thorac Cardiovasc Surg 1981 Dec;29(6):369-74. doi: 10.1055/s-2007-1023515. PMID: 6179219
Nonrheumatic mitral incompetence.
Yahini JH, Deutsch V, Miller HI, Shem-Tov A, Atlas P, Neufeld HN
Isr J Med Sci 1975 Sep;11(9):928-67. PMID: 1184367

Clinical prediction guides

Heart valve development, maintenance, and disease: the role of endothelial cells.
Tao G, Kotick JD, Lincoln J
Curr Top Dev Biol 2012;100:203-32. doi: 10.1016/B978-0-12-387786-4.00006-3. PMID: 22449845
Mitral regurgitation following mitral balloon valvotomy. Differing mechanisms for severe versus mild-to-moderate lesions.
Essop MR, Wisenbaugh T, Skoularigis J, Middlemost S, Sareli P
Circulation 1991 Oct;84(4):1669-79. doi: 10.1161/01.cir.84.4.1669. PMID: 1914106
Relation of calcification to torn leaflets of spontaneously degenerated porcine bioprosthetic valves.
Stein PD, Kemp SR, Riddle JM, Lee MW, Lewis JW Jr, Magilligan DJ Jr
Ann Thorac Surg 1985 Aug;40(2):175-80. doi: 10.1016/s0003-4975(10)60014-8. PMID: 4026449
Structural changes in glutaraldehyde-treated porcine heterografts used as substitute cardiac valves. Transmission and scanning electron microscopic observations in 12 patients.
Ferrans VJ, Spray TL, Billingham ME, Roberts WC
Am J Cardiol 1978 Jun;41(7):1159-84. doi: 10.1016/0002-9149(78)90873-1. PMID: 96684
Pathology of antibiotic-treated human heart valve allografts.
Gavin JB, Herdson PB, Monro JL, Barratt-Boyes BG
Thorax 1973 Jul;28(4):473-81. doi: 10.1136/thx.28.4.473. PMID: 4741451Free PMC Article

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