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Low Grade Lung Neuroendocrine Neoplasm

MedGen UID:
317843
•Concept ID:
C1708750
•
Neoplastic Process

Definition

A low grade malignant neoplasm with neuroendocrine differentiation that arises from the lung. This category includes typical carcinoid tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Lung Neuroendocrine Neoplasm

Professional guidelines

PubMed

Immunotherapy and potential predictive biomarkers in the treatment of neuroendocrine neoplasia.
Xu G, Wang Y, Zhang H, She X, Yang J
Future Oncol 2021 Mar;17(9):1069-1081. Epub 2020 Nov 2 doi: 10.2217/fon-2020-0703. PMID: 33136448
Advanced typical and atypical carcinoid tumours of the lung: management recommendations.
Melosky B
Curr Oncol 2018 Jun;25(Suppl 1):S86-S93. Epub 2018 Jun 13 doi: 10.3747/co.25.3808. PMID: 29910651Free PMC Article
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Recent clinical studies

Etiology

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors.
Patel SP, Othus M, Chae YK, Giles FJ, Hansel DE, Singh PP, Fontaine A, Shah MH, Kasi A, Baghdadi TA, Matrana M, Gatalica Z, Korn WM, Hayward J, McLeod C, Chen HX, Sharon E, Mayerson E, Ryan CW, Plets M, Blanke CD, Kurzrock R
Clin Cancer Res 2020 May 15;26(10):2290-2296. Epub 2020 Jan 22 doi: 10.1158/1078-0432.CCR-19-3356. PMID: 31969335Free PMC Article
Advanced typical and atypical carcinoid tumours of the lung: management recommendations.
Melosky B
Curr Oncol 2018 Jun;25(Suppl 1):S86-S93. Epub 2018 Jun 13 doi: 10.3747/co.25.3808. PMID: 29910651Free PMC Article
Molecular alterations of neuroendocrine tumours of the lung.
Rossi G, Bertero L, Marchiò C, Papotti M
Histopathology 2018 Jan;72(1):142-152. doi: 10.1111/his.13394. PMID: 29239031
Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease.
Hendifar AE, Marchevsky AM, Tuli R
J Thorac Oncol 2017 Mar;12(3):425-436. Epub 2016 Nov 24 doi: 10.1016/j.jtho.2016.11.2222. PMID: 27890494
Pulmonary preinvasive neoplasia.
Kerr KM
J Clin Pathol 2001 Apr;54(4):257-71. doi: 10.1136/jcp.54.4.257. PMID: 11304841Free PMC Article

Diagnosis

Neuroendocrine Tumors of the Lung.
Randhawa S, Trikalinos N, Patterson GA
Thorac Surg Clin 2021 Nov;31(4):469-476. doi: 10.1016/j.thorsurg.2021.05.005. PMID: 34696859
Therapeutic options in lung neuroendocrine tumors: between established concepts and new hopes.
Brighi N, Lamberti G, Manuzzi L, Maggio I, Campana D
Anticancer Drugs 2019 Aug;30(7):e0784. doi: 10.1097/CAD.0000000000000784. PMID: 30896503
Cyto-histology in NET: what is necessary today and what is the future?
Inzani F, Petrone G, Fadda G, Rindi G
Rev Endocr Metab Disord 2017 Dec;18(4):381-391. doi: 10.1007/s11154-017-9428-x. PMID: 28871510
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Pathology and diagnosis of neuroendocrine tumors: lung neuroendocrine.
Travis WD
Thorac Surg Clin 2014 Aug;24(3):257-66. doi: 10.1016/j.thorsurg.2014.04.001. PMID: 25065926

Therapy

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors.
Patel SP, Othus M, Chae YK, Giles FJ, Hansel DE, Singh PP, Fontaine A, Shah MH, Kasi A, Baghdadi TA, Matrana M, Gatalica Z, Korn WM, Hayward J, McLeod C, Chen HX, Sharon E, Mayerson E, Ryan CW, Plets M, Blanke CD, Kurzrock R
Clin Cancer Res 2020 May 15;26(10):2290-2296. Epub 2020 Jan 22 doi: 10.1158/1078-0432.CCR-19-3356. PMID: 31969335Free PMC Article
Therapeutic options in lung neuroendocrine tumors: between established concepts and new hopes.
Brighi N, Lamberti G, Manuzzi L, Maggio I, Campana D
Anticancer Drugs 2019 Aug;30(7):e0784. doi: 10.1097/CAD.0000000000000784. PMID: 30896503
Current Treatment Options in Gastroenteropancreatic Neuroendocrine Carcinoma.
Thomas KEH, Voros BA, Boudreaux JP, Thiagarajan R, Woltering EA, Ramirez RA
Oncologist 2019 Aug;24(8):1076-1088. Epub 2019 Jan 11 doi: 10.1634/theoncologist.2018-0604. PMID: 30635447Free PMC Article
Neuroendocrine Tumors of the Lung: Current Challenges and Advances in the Diagnosis and Management of Well-Differentiated Disease.
Hendifar AE, Marchevsky AM, Tuli R
J Thorac Oncol 2017 Mar;12(3):425-436. Epub 2016 Nov 24 doi: 10.1016/j.jtho.2016.11.2222. PMID: 27890494
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Prognosis

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors.
Patel SP, Othus M, Chae YK, Giles FJ, Hansel DE, Singh PP, Fontaine A, Shah MH, Kasi A, Baghdadi TA, Matrana M, Gatalica Z, Korn WM, Hayward J, McLeod C, Chen HX, Sharon E, Mayerson E, Ryan CW, Plets M, Blanke CD, Kurzrock R
Clin Cancer Res 2020 May 15;26(10):2290-2296. Epub 2020 Jan 22 doi: 10.1158/1078-0432.CCR-19-3356. PMID: 31969335Free PMC Article
Therapeutic options in lung neuroendocrine tumors: between established concepts and new hopes.
Brighi N, Lamberti G, Manuzzi L, Maggio I, Campana D
Anticancer Drugs 2019 Aug;30(7):e0784. doi: 10.1097/CAD.0000000000000784. PMID: 30896503
Molecular alterations of neuroendocrine tumours of the lung.
Rossi G, Bertero L, Marchiò C, Papotti M
Histopathology 2018 Jan;72(1):142-152. doi: 10.1111/his.13394. PMID: 29239031
Classification of lung neuroendocrine tumors: lights and shadows.
Volante M, Gatti G, Papotti M
Endocrine 2015 Nov;50(2):315-9. Epub 2015 Mar 21 doi: 10.1007/s12020-015-0578-x. PMID: 25795289
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Clinical prediction guides

Strategies Towards Improving Clinical Outcomes of Peptide Receptor Radionuclide Therapy.
Minczeles NS, Hofland J, de Herder WW, Brabander T
Curr Oncol Rep 2021 Mar 15;23(4):46. doi: 10.1007/s11912-021-01037-7. PMID: 33721105Free PMC Article
Molecular alterations of neuroendocrine tumours of the lung.
Rossi G, Bertero L, Marchiò C, Papotti M
Histopathology 2018 Jan;72(1):142-152. doi: 10.1111/his.13394. PMID: 29239031
Cyto-histology in NET: what is necessary today and what is the future?
Inzani F, Petrone G, Fadda G, Rindi G
Rev Endocr Metab Disord 2017 Dec;18(4):381-391. doi: 10.1007/s11154-017-9428-x. PMID: 28871510
Classification of lung neuroendocrine tumors: lights and shadows.
Volante M, Gatti G, Papotti M
Endocrine 2015 Nov;50(2):315-9. Epub 2015 Mar 21 doi: 10.1007/s12020-015-0578-x. PMID: 25795289
Unraveling tumor grading and genomic landscape in lung neuroendocrine tumors.
Pelosi G, Papotti M, Rindi G, Scarpa A
Endocr Pathol 2014 Jun;25(2):151-64. doi: 10.1007/s12022-014-9320-0. PMID: 24771462

Recent systematic reviews

Immune-related adverse events as potential surrogates of immune checkpoint inhibitors' efficacy: a systematic review and meta-analysis of randomized studies.
Amoroso V, Gallo F, Alberti A, Paloschi D, Ferrari Bravo W, Esposito A, Cosentini D, Grisanti S, Pedersini R, Petrelli F, Berruti A
ESMO Open 2023 Apr;8(2):100787. Epub 2023 Feb 24 doi: 10.1016/j.esmoop.2023.100787. PMID: 36842300Free PMC Article
Endobronchial and surgical treatment of pulmonary carcinoid tumors: A systematic literature review.
Reuling EMBP, Dickhoff C, Plaisier PW, Bonjer HJ, Daniels JMA
Lung Cancer 2019 Aug;134:85-95. Epub 2019 Apr 15 doi: 10.1016/j.lungcan.2019.04.016. PMID: 31320001
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

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