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Bronchial Mixed Squamous Cell and Glandular Papilloma

MedGen UID:
317850
•Concept ID:
C1708774
•
Neoplastic Process
Synonyms: Lung Mixed Squamous and Glandular Papilloma; Lung Mixed Squamous Cell and Glandular Papilloma

Definition

An exceedingly rare benign endobronchial neoplasm characterized by the presence of fibrovascular cores which are lined by both squamous and glandular epithelium. Patients present with obstructive symptoms. Complete resection is curative. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBronchial Mixed Squamous Cell and Glandular Papilloma

Recent clinical studies

Etiology

Solitary pulmonary papillomas in adults: a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature.
Flieder DB, Koss MN, Nicholson A, Sesterhenn IA, Petras RE, Travis WD
Am J Surg Pathol 1998 Nov;22(11):1328-42. doi: 10.1097/00000478-199811000-00003. PMID: 9808125

Diagnosis

Endobronchial Glandular Papilloma With Atypical Histologic Characteristics: A Case Report and Literature Review.
Yang L, Tomashefski JF Jr, Keskin T, Santoscoy TG, Abramovich C
Int J Surg Pathol 2024 May;32(3):632-640. Epub 2023 Jul 24 doi: 10.1177/10668969231188420. PMID: 37488137
Mucous Gland Adenoma of the Lung: A Neoplastic Counterpart of Mucinous Bronchial Glands.
Sasaki E, Masago K, Kogure Y, Fujita S, Iwakoshi A, Kuroda H, Tsuzuki T, Tsuta K, Matsushita H, Oki M
Mod Pathol 2023 Jun;36(6):100182. Epub 2023 Apr 5 doi: 10.1016/j.modpat.2023.100182. PMID: 37028599
Sialadenoma Papilliferum of the Bronchus: An Unrecognized Bronchial Counterpart of the Salivary Gland Tumor With Frequent BRAF V600E Mutations.
Nakaguro M, Mino-Kenudson M, Urano M, Ogawa I, Honda Y, Hirai H, Tanigawa M, Sukeda A, Kajiwara N, Ohira T, Ikeda N, Mikami Y, Tada Y, Ikeda JI, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 May 1;45(5):662-671. doi: 10.1097/PAS.0000000000001657. PMID: 33443864Free PMC Article
Pleomorphic (spindle and squamous cell) carcinoma arising in a peripheral mixed squamous and glandular papilloma in a 70-year-old man.
Lagana SM, Hanna RF, Borczuk AC
Arch Pathol Lab Med 2011 Oct;135(10):1353-6. doi: 10.5858/arpa.2010-0420-CR. PMID: 21970492
Cytological findings of mixed squamous cell and glandular papilloma in the lung.
Kadota K, Haba R, Katsuki N, Hayashi T, Miyai Y, Bando K, Shibuya S, Kushida Y
Diagn Cytopathol 2010 Dec;38(12):913-7. doi: 10.1002/dc.21334. PMID: 20301213

Prognosis

Sialadenoma Papilliferum of the Bronchus: An Unrecognized Bronchial Counterpart of the Salivary Gland Tumor With Frequent BRAF V600E Mutations.
Nakaguro M, Mino-Kenudson M, Urano M, Ogawa I, Honda Y, Hirai H, Tanigawa M, Sukeda A, Kajiwara N, Ohira T, Ikeda N, Mikami Y, Tada Y, Ikeda JI, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 May 1;45(5):662-671. doi: 10.1097/PAS.0000000000001657. PMID: 33443864Free PMC Article
Cytological findings of mixed squamous cell and glandular papilloma in the lung.
Kadota K, Haba R, Katsuki N, Hayashi T, Miyai Y, Bando K, Shibuya S, Kushida Y
Diagn Cytopathol 2010 Dec;38(12):913-7. doi: 10.1002/dc.21334. PMID: 20301213
Solitary pulmonary papillomas in adults: a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature.
Flieder DB, Koss MN, Nicholson A, Sesterhenn IA, Petras RE, Travis WD
Am J Surg Pathol 1998 Nov;22(11):1328-42. doi: 10.1097/00000478-199811000-00003. PMID: 9808125

Clinical prediction guides

Sialadenoma Papilliferum of the Bronchus: An Unrecognized Bronchial Counterpart of the Salivary Gland Tumor With Frequent BRAF V600E Mutations.
Nakaguro M, Mino-Kenudson M, Urano M, Ogawa I, Honda Y, Hirai H, Tanigawa M, Sukeda A, Kajiwara N, Ohira T, Ikeda N, Mikami Y, Tada Y, Ikeda JI, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 May 1;45(5):662-671. doi: 10.1097/PAS.0000000000001657. PMID: 33443864Free PMC Article
Solitary pulmonary papillomas in adults: a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature.
Flieder DB, Koss MN, Nicholson A, Sesterhenn IA, Petras RE, Travis WD
Am J Surg Pathol 1998 Nov;22(11):1328-42. doi: 10.1097/00000478-199811000-00003. PMID: 9808125

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