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Myxoinflammatory Fibroblastic Sarcoma

MedGen UID:
317922
Concept ID:
C1709103
Neoplastic Process
Synonyms: Atypical myxoinflammatory fibroblastic tumor; Myxoinflammatory fibroblastic sarcoma
SNOMED CT: Myxoinflammatory fibroblastic sarcoma (703608004); Atypical myxoinflammatory fibroblastic tumor (703608004)

Definition

A low grade, locally aggressive, fibroblastic neoplasm that occurs primarily in the distal extremities. It is characterized by the presence of spindle-shaped fibroblasts, multivacuolated lipoblast-like cells, bizarre ganglion-like cells with inclusion-like nuclei, myxoid stroma formation, and a mixture of acute and chronic inflammatory cells. Distant metastases are very rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyxoinflammatory Fibroblastic Sarcoma

Professional guidelines

PubMed

Nishio J, Nakayama S, Aoki M
Int J Mol Sci 2024 Jan 17;25(2) doi: 10.3390/ijms25021127. PMID: 38256198Free PMC Article
Kumar R, Lefkowitz RA, Neto AD
J Comput Assist Tomogr 2017 Jan;41(1):104-115. doi: 10.1097/RCT.0000000000000490. PMID: 27560024
Tejwani A, Kobayashi W, Chen YL, Rosenberg AE, Yoon S, Raskin KA, Rosenthal DI, Nielsen GP, Hornicek FJ, Delaney TF
Cancer 2010 Dec 15;116(24):5733-9. Epub 2010 Aug 24 doi: 10.1002/cncr.25567. PMID: 20737559

Recent clinical studies

Etiology

Wu H, Laskin WB
Surg Pathol Clin 2024 Mar;17(1):83-96. Epub 2023 Aug 8 doi: 10.1016/j.path.2023.07.003. PMID: 38278610
Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448
Georgantzoglou N, Linos K
Semin Diagn Pathol 2023 Jul;40(4):295-305. Epub 2023 Apr 25 doi: 10.1053/j.semdp.2023.04.018. PMID: 37150655Free PMC Article
Kumar R, Lefkowitz RA, Neto AD
J Comput Assist Tomogr 2017 Jan;41(1):104-115. doi: 10.1097/RCT.0000000000000490. PMID: 27560024
Mangham DC, Kindblom LG
Histopathology 2014 Jan;64(1):88-100. Epub 2013 Nov 28 doi: 10.1111/his.12310. PMID: 24117966

Diagnosis

Wu H, Laskin WB
Surg Pathol Clin 2024 Mar;17(1):83-96. Epub 2023 Aug 8 doi: 10.1016/j.path.2023.07.003. PMID: 38278610
Ling MJN, Zonta M
ANZ J Surg 2023 Jan;93(1-2):367-368. Epub 2022 May 12 doi: 10.1111/ans.17774. PMID: 35560492
Wangsiricharoen S, Ali SZ, Wakely PE Jr
J Am Soc Cytopathol 2021 May-Jun;10(3):310-320. Epub 2021 Jan 9 doi: 10.1016/j.jasc.2020.12.004. PMID: 33431307
Lucas DR
Arch Pathol Lab Med 2017 Nov;141(11):1503-1507. doi: 10.5858/arpa.2017-0219-RA. PMID: 29072951
Ieremia E, Thway K
Arch Pathol Lab Med 2014 Oct;138(10):1406-11. doi: 10.5858/arpa.2013-0549-RS. PMID: 25268202

Therapy

Fagerstedt KW, Salonen T, Zhao F, Kytölä S, Böhling T, Andersson LC
Tumour Biol 2018 May;40(5):1010428318777936. doi: 10.1177/1010428318777936. PMID: 29788803
Flooks R, Vanacker A, Van Dorpe J, Smet B, Vandewiele I, De Schoenmakere G, Maes B
Transplant Proc 2009 Oct;41(8):3437-9. doi: 10.1016/j.transproceed.2009.09.023. PMID: 19857766
Fetsch JF, Laskin WB, Miettinen M
Hum Pathol 2001 Jul;32(7):704-14. doi: 10.1053/hupa.2001.25903. PMID: 11486169

Prognosis

Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448
Jain E, Kini L, Alaggio R, Ranganathan S
Int J Surg Pathol 2020 May;28(3):306-309. Epub 2019 Oct 8 doi: 10.1177/1066896919879497. PMID: 31594432
Lucas DR
Arch Pathol Lab Med 2017 Nov;141(11):1503-1507. doi: 10.5858/arpa.2017-0219-RA. PMID: 29072951
Michal M, Kazakov DV, Hadravský L, Kinkor Z, Kuroda N, Michal M
Ann Diagn Pathol 2015 Jun;19(3):157-63. Epub 2015 Apr 6 doi: 10.1016/j.anndiagpath.2015.03.012. PMID: 25886867
Ieremia E, Thway K
Arch Pathol Lab Med 2014 Oct;138(10):1406-11. doi: 10.5858/arpa.2013-0549-RS. PMID: 25268202

Clinical prediction guides

Corredor-Alonso GE, Caro-Sánchez CHS, Domínguez-Malagón HR
Ultrastruct Pathol 2024 Jan 2;48(1):75-79. Epub 2024 Jan 9 doi: 10.1080/01913123.2023.2292559. PMID: 38126325
Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448
Suster D, Michal M, Huang H, Ronen S, Springborn S, Debiec-Rychter M, Billings SD, Goldblum JR, Rubin BP, Michal M, Suster S, Mackinnon AC
Mod Pathol 2020 Dec;33(12):2520-2533. Epub 2020 Jun 8 doi: 10.1038/s41379-020-0580-6. PMID: 32514165
Jain E, Kini L, Alaggio R, Ranganathan S
Int J Surg Pathol 2020 May;28(3):306-309. Epub 2019 Oct 8 doi: 10.1177/1066896919879497. PMID: 31594432
Jurcić V, Zidar A, Montiel MD, Frković-Grazio S, Nayler SJ, Cooper K, Suster S, Lamovec J
Ann Diagn Pathol 2002 Oct;6(5):272-80. doi: 10.1053/adpa.2002.35738. PMID: 12376919

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