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PPARG Gene Rearrangement

MedGen UID:
317999
•Concept ID:
C1709419
•
Cell or Molecular Dysfunction
Synonym: PPAR-gamma Rearrangement

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPPARG Gene Rearrangement

Recent clinical studies

Etiology

Molecular testing of thyroid fine-needle aspirations improves presurgical diagnosis and supports the histologic identification of minimally invasive follicular thyroid carcinomas.
Eszlinger M, Piana S, Moll A, Bösenberg E, Bisagni A, Ciarrocchi A, Ragazzi M, Paschke R
Thyroid 2015 Apr;25(4):401-9. Epub 2015 Feb 26 doi: 10.1089/thy.2014.0362. PMID: 25629769
Optimizing detection of RET and PPARg rearrangements in thyroid neoplastic cells using a home-brew tetracolor probe.
Caria P, Frau DV, Dettori T, Boi F, Lai ML, Mariotti S, Vanni R
Cancer Cytopathol 2014 May;122(5):377-85. Epub 2014 Feb 7 doi: 10.1002/cncy.21397. PMID: 24510380Free PMC Article
Impact of molecular screening for point mutations and rearrangements in routine air-dried fine-needle aspiration samples of thyroid nodules.
Eszlinger M, Krogdahl A, Münz S, Rehfeld C, Precht Jensen EM, Ferraz C, Bösenberg E, Drieschner N, Scholz M, Hegedüs L, Paschke R
Thyroid 2014 Feb;24(2):305-13. Epub 2013 Oct 29 doi: 10.1089/thy.2013.0278. PMID: 23837487
Genetic alterations in thyroid tumors from patients irradiated in childhood for tinea capitis treatment.
Boaventura P, Pereira D, Celestino R, Mendes A, Nakasawa T, Teixeira-Gomes J, Sobrinho-Simões M, Soares P
Eur J Endocrinol 2013 Nov;169(5):673-9. Epub 2013 Oct 3 doi: 10.1530/EJE-13-0543. PMID: 23966419
Detection of PAX8/PPARG and RET/PTC rearrangements is feasible in routine air-dried fine needle aspiration smears.
Ferraz C, Rehfeld C, Krogdahl A, Precht Jensen EM, Bösenberg E, Narz F, Hegedüs L, Paschke R, Eszlinger M
Thyroid 2012 Oct;22(10):1025-30. doi: 10.1089/thy.2011.0391. PMID: 23025542Free PMC Article

Diagnosis

Molecular pathology and thyroid FNA.
Poller DN, Glaysher S
Cytopathology 2017 Dec;28(6):475-481. doi: 10.1111/cyt.12492. PMID: 29165888
Molecular testing for oncogenic gene mutations in thyroid lesions: a case-control validation study in 413 postsurgical specimens.
Giordano TJ, Beaudenon-Huibregtse S, Shinde R, Langfield L, Vinco M, Laosinchai-Wolf W, Labourier E
Hum Pathol 2014 Jul;45(7):1339-47. Epub 2014 Apr 4 doi: 10.1016/j.humpath.2014.03.010. PMID: 24830619
Optimizing detection of RET and PPARg rearrangements in thyroid neoplastic cells using a home-brew tetracolor probe.
Caria P, Frau DV, Dettori T, Boi F, Lai ML, Mariotti S, Vanni R
Cancer Cytopathol 2014 May;122(5):377-85. Epub 2014 Feb 7 doi: 10.1002/cncy.21397. PMID: 24510380Free PMC Article
Impact of molecular screening for point mutations and rearrangements in routine air-dried fine-needle aspiration samples of thyroid nodules.
Eszlinger M, Krogdahl A, Münz S, Rehfeld C, Precht Jensen EM, Ferraz C, Bösenberg E, Drieschner N, Scholz M, Hegedüs L, Paschke R
Thyroid 2014 Feb;24(2):305-13. Epub 2013 Oct 29 doi: 10.1089/thy.2013.0278. PMID: 23837487
Detection of PAX8/PPARG and RET/PTC rearrangements is feasible in routine air-dried fine needle aspiration smears.
Ferraz C, Rehfeld C, Krogdahl A, Precht Jensen EM, Bösenberg E, Narz F, Hegedüs L, Paschke R, Eszlinger M
Thyroid 2012 Oct;22(10):1025-30. doi: 10.1089/thy.2011.0391. PMID: 23025542Free PMC Article

Therapy

Genetic alterations in thyroid tumors from patients irradiated in childhood for tinea capitis treatment.
Boaventura P, Pereira D, Celestino R, Mendes A, Nakasawa T, Teixeira-Gomes J, Sobrinho-Simões M, Soares P
Eur J Endocrinol 2013 Nov;169(5):673-9. Epub 2013 Oct 3 doi: 10.1530/EJE-13-0543. PMID: 23966419

Prognosis

Clinicopathological significance of major fusion oncogenes in papillary thyroid carcinoma: An individual patient data meta-analysis.
Vuong HG, Le HT, Le TTB, Le T, Hassell L, Kakudo K
Pathol Res Pract 2022 Dec;240:154180. Epub 2022 Oct 21 doi: 10.1016/j.prp.2022.154180. PMID: 36306725
Molecular pathology and thyroid FNA.
Poller DN, Glaysher S
Cytopathology 2017 Dec;28(6):475-481. doi: 10.1111/cyt.12492. PMID: 29165888
Molecular testing of thyroid fine-needle aspirations improves presurgical diagnosis and supports the histologic identification of minimally invasive follicular thyroid carcinomas.
Eszlinger M, Piana S, Moll A, Bösenberg E, Bisagni A, Ciarrocchi A, Ragazzi M, Paschke R
Thyroid 2015 Apr;25(4):401-9. Epub 2015 Feb 26 doi: 10.1089/thy.2014.0362. PMID: 25629769
Molecular testing for oncogenic gene mutations in thyroid lesions: a case-control validation study in 413 postsurgical specimens.
Giordano TJ, Beaudenon-Huibregtse S, Shinde R, Langfield L, Vinco M, Laosinchai-Wolf W, Labourier E
Hum Pathol 2014 Jul;45(7):1339-47. Epub 2014 Apr 4 doi: 10.1016/j.humpath.2014.03.010. PMID: 24830619
Optimizing detection of RET and PPARg rearrangements in thyroid neoplastic cells using a home-brew tetracolor probe.
Caria P, Frau DV, Dettori T, Boi F, Lai ML, Mariotti S, Vanni R
Cancer Cytopathol 2014 May;122(5):377-85. Epub 2014 Feb 7 doi: 10.1002/cncy.21397. PMID: 24510380Free PMC Article

Clinical prediction guides

Insight into the cellular effects of nitrated phospholipids: Evidence for pleiotropic mechanisms of action.
Duarte S, Melo T, Domingues R, de Dios Alché J, Pérez-Sala D
Free Radic Biol Med 2019 Nov 20;144:192-202. Epub 2019 Jun 12 doi: 10.1016/j.freeradbiomed.2019.06.003. PMID: 31199965
Molecular testing of thyroid fine-needle aspirations improves presurgical diagnosis and supports the histologic identification of minimally invasive follicular thyroid carcinomas.
Eszlinger M, Piana S, Moll A, Bösenberg E, Bisagni A, Ciarrocchi A, Ragazzi M, Paschke R
Thyroid 2015 Apr;25(4):401-9. Epub 2015 Feb 26 doi: 10.1089/thy.2014.0362. PMID: 25629769

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