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c-MET Gene Amplification

MedGen UID:
318452
•Concept ID:
C1711106
•
Cell or Molecular Dysfunction
Synonyms: c-Met Gene Amplification; Hepatocyte Growth Factor Receptor Gene Amplification; HGFR Gene Amplification; MET Amplification; MET Gene Amplification; Met Proto-Oncogene (Hepatocyte Growth Factor Receptor) Gene Amplification; MET Proto-Oncogene, Receptor Tyrosine Kinase Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of the MET gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVc-MET Gene Amplification

Professional guidelines

PubMed

Overcoming erlotinib resistance with tailored treatment regimen in patient-derived xenografts from naïve Asian NSCLC patients.
Yang M, Shan B, Li Q, Song X, Cai J, Deng J, Zhang L, Du Z, Lu J, Chen T, Wery JP, Chen Y, Li Q
Int J Cancer 2013 Jan 15;132(2):E74-84. Epub 2012 Oct 3 doi: 10.1002/ijc.27813. PMID: 22948846

Recent clinical studies

Etiology

A Prospective Observational Study Evaluating the Correlation of c-MET Expression and EGFR Gene Mutation with Response to Erlotinib as Second-Line Treatment for Patients with Advanced/Metastatic Non-Small-Cell Lung Cancer.
Park CK, Oh IJ, Choi YD, Jang TW, Lee JE, Ryu JS, Lee SY, Kim YC
Oncology 2018;94(6):373-382. Epub 2018 Mar 2 doi: 10.1159/000486896. PMID: 29502124
Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation?
Watermann I, Schmitt B, Stellmacher F, Müller J, Gaber R, Kugler Ch, Reinmuth N, Huber RM, Thomas M, Zabel P, Rabe KF, Jonigk D, Warth A, Vollmer E, Reck M, Goldmann T
Diagn Pathol 2015 Jul 28;10:130. doi: 10.1186/s13000-015-0362-5. PMID: 26215852Free PMC Article
Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs.
Ogi S, Fujita H, Kashihara M, Yamamoto C, Sonoda K, Okamoto I, Nakagawa K, Ohdo S, Tanaka Y, Kuwano M, Ono M
Cancer Sci 2013 May;104(5):573-83. Epub 2013 Mar 8 doi: 10.1111/cas.12117. PMID: 23360489Free PMC Article
Amplification of the c-met, c-erbB-2 and epidermal growth factor receptor gene in human gastric cancers: correlation to clinical features.
Tsugawa K, Yonemura Y, Hirono Y, Fushida S, Kaji M, Miwa K, Miyazaki I, Yamamoto H
Oncology 1998 Sep-Oct;55(5):475-81. doi: 10.1159/000011898. PMID: 9732228

Diagnosis

Gastric cancer patient with c-MET amplification treated with crizotinib after failed multi-line treatment: A case report and literature review.
Hou GX, Song BB
Math Biosci Eng 2019 Jun 25;16(5):5923-5930. doi: 10.3934/mbe.2019296. PMID: 31499745
Protein overexpression and gene amplification of cellular mesenchymal-epithelial transition factor is associated with poor prognosis in micropapillary-predominant subtype pulmonary adenocarcinoma.
Zhang J, Sun J, Zhang Z, Liang X, Luo Y, Wu S, Liang Z
Hum Pathol 2018 Feb;72:59-65. Epub 2017 Nov 9 doi: 10.1016/j.humpath.2017.10.031. PMID: 29128478
Comparison of the c-MET gene amplification between primary tumor and metastatic lymph nodes in non-small cell lung cancer.
Xu CW, Wang WX, Wu MJ, Zhu YC, Zhuang W, Lin G, Du KQ, Huang YJ, Chen YP, Chen G, Fang MY
Thorac Cancer 2017 Sep;8(5):417-422. Epub 2017 Jun 7 doi: 10.1111/1759-7714.12455. PMID: 28590585Free PMC Article
Soluble c-Met Levels Correlated With Tissue c-Met Protein Expression in Patients With Advanced Non-Small-Cell Lung Cancer.
Gao HF, Li AN, Yang JJ, Chen ZH, Xie Z, Zhang XC, Su J, Lou NN, Yan HH, Han JF, Wu YL
Clin Lung Cancer 2017 Jan;18(1):85-91. Epub 2016 Jun 23 doi: 10.1016/j.cllc.2016.06.008. PMID: 27461774
Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation?
Watermann I, Schmitt B, Stellmacher F, Müller J, Gaber R, Kugler Ch, Reinmuth N, Huber RM, Thomas M, Zabel P, Rabe KF, Jonigk D, Warth A, Vollmer E, Reck M, Goldmann T
Diagn Pathol 2015 Jul 28;10:130. doi: 10.1186/s13000-015-0362-5. PMID: 26215852Free PMC Article

Therapy

MET inhibition downregulates DR4 expression in MET-amplified lung cancer cells with acquired resistance to EGFR inhibitors through suppressing AP-1-mediated transcription.
Deng L, Vallega KA, Zhang S, Shi P, Sun SY
Neoplasia 2021 Aug;23(8):766-774. Epub 2021 Jul 4 doi: 10.1016/j.neo.2021.06.006. PMID: 34233230Free PMC Article
MET inhibitors for targeted therapy of EGFR TKI-resistant lung cancer.
Wang Q, Yang S, Wang K, Sun SY
J Hematol Oncol 2019 Jun 21;12(1):63. doi: 10.1186/s13045-019-0759-9. PMID: 31227004Free PMC Article
MET Amplification and Response to MET Inhibitors in Stage IV Lung Adenocarcinoma.
Suryavanshi M, Shah A, Kumar D, Panigrahi MK, Metha A, Batra U
Oncol Res Treat 2017;40(4):198-202. Epub 2017 Mar 8 doi: 10.1159/000457801. PMID: 28324883
Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells.
Park CH, Cho SY, Ha JD, Jung H, Kim HR, Lee CO, Jang IY, Chae CH, Lee HK, Choi SU
BMC Cancer 2016 Jan 22;16:35. doi: 10.1186/s12885-016-2058-y. PMID: 26801760Free PMC Article
Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation?
Watermann I, Schmitt B, Stellmacher F, Müller J, Gaber R, Kugler Ch, Reinmuth N, Huber RM, Thomas M, Zabel P, Rabe KF, Jonigk D, Warth A, Vollmer E, Reck M, Goldmann T
Diagn Pathol 2015 Jul 28;10:130. doi: 10.1186/s13000-015-0362-5. PMID: 26215852Free PMC Article

Prognosis

Comparison of the c-MET gene amplification between primary tumor and metastatic lymph nodes in non-small cell lung cancer.
Xu CW, Wang WX, Wu MJ, Zhu YC, Zhuang W, Lin G, Du KQ, Huang YJ, Chen YP, Chen G, Fang MY
Thorac Cancer 2017 Sep;8(5):417-422. Epub 2017 Jun 7 doi: 10.1111/1759-7714.12455. PMID: 28590585Free PMC Article
Soluble c-Met Levels Correlated With Tissue c-Met Protein Expression in Patients With Advanced Non-Small-Cell Lung Cancer.
Gao HF, Li AN, Yang JJ, Chen ZH, Xie Z, Zhang XC, Su J, Lou NN, Yan HH, Han JF, Wu YL
Clin Lung Cancer 2017 Jan;18(1):85-91. Epub 2016 Jun 23 doi: 10.1016/j.cllc.2016.06.008. PMID: 27461774
Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma.
Kondo S, Ojima H, Tsuda H, Hashimoto J, Morizane C, Ikeda M, Ueno H, Tamura K, Shimada K, Kanai Y, Okusaka T
Int J Clin Oncol 2013 Apr;18(2):207-13. Epub 2012 Jan 5 doi: 10.1007/s10147-011-0361-9. PMID: 22218908
c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases.
Zeng ZS, Weiser MR, Kuntz E, Chen CT, Khan SA, Forslund A, Nash GM, Gimbel M, Yamaguchi Y, Culliford AT 4th, D'Alessio M, Barany F, Paty PB
Cancer Lett 2008 Jul 8;265(2):258-69. Epub 2008 Apr 18 doi: 10.1016/j.canlet.2008.02.049. PMID: 18395971Free PMC Article
Frequent amplification of the c-met gene in scirrhous type stomach cancer.
Kuniyasu H, Yasui W, Kitadai Y, Yokozaki H, Ito H, Tahara E
Biochem Biophys Res Commun 1992 Nov 30;189(1):227-32. doi: 10.1016/0006-291x(92)91548-5. PMID: 1333188

Clinical prediction guides

Comparison of the c-MET gene amplification between primary tumor and metastatic lymph nodes in non-small cell lung cancer.
Xu CW, Wang WX, Wu MJ, Zhu YC, Zhuang W, Lin G, Du KQ, Huang YJ, Chen YP, Chen G, Fang MY
Thorac Cancer 2017 Sep;8(5):417-422. Epub 2017 Jun 7 doi: 10.1111/1759-7714.12455. PMID: 28590585Free PMC Article
Soluble c-Met Levels Correlated With Tissue c-Met Protein Expression in Patients With Advanced Non-Small-Cell Lung Cancer.
Gao HF, Li AN, Yang JJ, Chen ZH, Xie Z, Zhang XC, Su J, Lou NN, Yan HH, Han JF, Wu YL
Clin Lung Cancer 2017 Jan;18(1):85-91. Epub 2016 Jun 23 doi: 10.1016/j.cllc.2016.06.008. PMID: 27461774
Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma.
Kondo S, Ojima H, Tsuda H, Hashimoto J, Morizane C, Ikeda M, Ueno H, Tamura K, Shimada K, Kanai Y, Okusaka T
Int J Clin Oncol 2013 Apr;18(2):207-13. Epub 2012 Jan 5 doi: 10.1007/s10147-011-0361-9. PMID: 22218908
c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases.
Zeng ZS, Weiser MR, Kuntz E, Chen CT, Khan SA, Forslund A, Nash GM, Gimbel M, Yamaguchi Y, Culliford AT 4th, D'Alessio M, Barany F, Paty PB
Cancer Lett 2008 Jul 8;265(2):258-69. Epub 2008 Apr 18 doi: 10.1016/j.canlet.2008.02.049. PMID: 18395971Free PMC Article
Molecular mechanism of stomach carcinogenesis.
Tahara E
J Cancer Res Clin Oncol 1993;119(5):265-72. doi: 10.1007/BF01212724. PMID: 8440743

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