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Hypocortisolemia

MedGen UID:
318778
•Concept ID:
C1833054
•
Finding; Finding
Synonym: Hypocortisolism

Definition

Abnormally low level of cortisol in the blood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypocortisolemia

Professional guidelines

PubMed

Diagnosis and Management of Adrenal Insufficiency in Hospitalized Patients.
Reddy P
Am J Ther 2021 Mar-Apr 01;28(2):e238-e244. doi: 10.1097/MJT.0000000000001064. PMID: 31567142
Primary hypophysitis: Experience of a Single Tertiary Center.
Korkmaz OP, Sahin S, Ozkaya HM, Apaydin T, Durmaz ES, Haliloglu O, Durcan E, Kadioglu P
Exp Clin Endocrinol Diabetes 2021 Jan;129(1):14-21. Epub 2019 Jun 24 doi: 10.1055/a-0919-4388. PMID: 31234218
Current state of the art in the diagnosis and surgical treatment of Cushing disease: early experience with a purely endoscopic endonasal technique.
Dehdashti AR, Gentili F
Neurosurg Focus 2007;23(3):E9. doi: 10.3171/foc.2007.23.3.11. PMID: 17961027

Recent clinical studies

Etiology

COVID-19 infection: from stress-related cortisol levels to adrenal glands infarction.
Popescu M, Terzea DC, Carsote M, Ghenea AE, Costache A, Popescu IAS, Biciuşcă V, Busuioc CJ, Ghemigian AM
Rom J Morphol Embryol 2022 Jan-Mar;63(1):39-48. doi: 10.47162/RJME.63.1.03. PMID: 36074666Free PMC Article
The definition of remission and recurrence of Cushing's disease.
Hinojosa-Amaya JM, Cuevas-Ramos D
Best Pract Res Clin Endocrinol Metab 2021 Jan;35(1):101485. Epub 2021 Jan 13 doi: 10.1016/j.beem.2021.101485. PMID: 33472761
Neuroendocrine changes after aneurysmal subarachnoid haemorrhage.
Karaca Z, Hacioglu A, Kelestimur F
Pituitary 2019 Jun;22(3):305-321. doi: 10.1007/s11102-018-00932-w. PMID: 30637621
Hypocortisolemia in Graves hyperthyroidism.
Karl M, Onumah BM, Cole J, Golding J, Burman KD, Wartofsky L
Endocr Pract 2009 Apr;15(3):220-4. doi: 10.4158/EP.15.3.220. PMID: 19364689
The hypothalamic-pituitary-adrenal axis in critical illness.
Johnson KL, Renn C
AACN Clin Issues 2006 Jan-Mar;17(1):39-49. doi: 10.1097/00044067-200601000-00006. PMID: 16462408

Diagnosis

Cyclic Cushing's Syndrome - A Diagnostic Challenge.
Świątkowska-Stodulska R, Berlińska A, Stefańska K, Kłosowski P, Sworczak K
Front Endocrinol (Lausanne) 2021;12:658429. Epub 2021 Apr 22 doi: 10.3389/fendo.2021.658429. PMID: 33967962Free PMC Article
The definition of remission and recurrence of Cushing's disease.
Hinojosa-Amaya JM, Cuevas-Ramos D
Best Pract Res Clin Endocrinol Metab 2021 Jan;35(1):101485. Epub 2021 Jan 13 doi: 10.1016/j.beem.2021.101485. PMID: 33472761
Diagnosis and Management of Adrenal Insufficiency in Hospitalized Patients.
Reddy P
Am J Ther 2021 Mar-Apr 01;28(2):e238-e244. doi: 10.1097/MJT.0000000000001064. PMID: 31567142
Neuroendocrine changes after aneurysmal subarachnoid haemorrhage.
Karaca Z, Hacioglu A, Kelestimur F
Pituitary 2019 Jun;22(3):305-321. doi: 10.1007/s11102-018-00932-w. PMID: 30637621
The hypothalamic-pituitary-adrenal axis in critical illness.
Johnson KL, Renn C
AACN Clin Issues 2006 Jan-Mar;17(1):39-49. doi: 10.1097/00044067-200601000-00006. PMID: 16462408

Therapy

Diagnosis and Management of Adrenal Insufficiency in Hospitalized Patients.
Reddy P
Am J Ther 2021 Mar-Apr 01;28(2):e238-e244. doi: 10.1097/MJT.0000000000001064. PMID: 31567142
Hypocortisolemia in Graves hyperthyroidism.
Karl M, Onumah BM, Cole J, Golding J, Burman KD, Wartofsky L
Endocr Pract 2009 Apr;15(3):220-4. doi: 10.4158/EP.15.3.220. PMID: 19364689
Obesity and sleep disturbances: meaningful sub-typing of obesity.
Vgontzas AN, Bixler EO, Chrousos GP, Pejovic S
Arch Physiol Biochem 2008 Oct;114(4):224-36. doi: 10.1080/13813450802521507. PMID: 18946783
Prolonged hypocortisolemia in hydrocortisone replacement regimens in adrenocorticotrophic hormone deficiency.
Maguire AM, Ambler GR, Moore B, McLean M, Falleti MG, Cowell CT
Pediatrics 2007 Jul;120(1):e164-71. Epub 2007 Jun 18 doi: 10.1542/peds.2006-2558. PMID: 17576782
Obesity-related sleepiness and fatigue: the role of the stress system and cytokines.
Vgontzas AN, Bixler EO, Chrousos GP
Ann N Y Acad Sci 2006 Nov;1083:329-44. doi: 10.1196/annals.1367.023. PMID: 17148748

Prognosis

The definition of remission and recurrence of Cushing's disease.
Hinojosa-Amaya JM, Cuevas-Ramos D
Best Pract Res Clin Endocrinol Metab 2021 Jan;35(1):101485. Epub 2021 Jan 13 doi: 10.1016/j.beem.2021.101485. PMID: 33472761
Diagnosis and Management of Adrenal Insufficiency in Hospitalized Patients.
Reddy P
Am J Ther 2021 Mar-Apr 01;28(2):e238-e244. doi: 10.1097/MJT.0000000000001064. PMID: 31567142
Low glucocorticoids in stress-related disorders: the role of inflammation.
Sarapultsev A, Sarapultsev P, Dremencov E, Komelkova M, Tseilikman O, Tseilikman V
Stress 2020 Nov;23(6):651-661. Epub 2020 May 22 doi: 10.1080/10253890.2020.1766020. PMID: 32401103
Neuroendocrine changes after aneurysmal subarachnoid haemorrhage.
Karaca Z, Hacioglu A, Kelestimur F
Pituitary 2019 Jun;22(3):305-321. doi: 10.1007/s11102-018-00932-w. PMID: 30637621
Hypocortisolemia in Graves hyperthyroidism.
Karl M, Onumah BM, Cole J, Golding J, Burman KD, Wartofsky L
Endocr Pract 2009 Apr;15(3):220-4. doi: 10.4158/EP.15.3.220. PMID: 19364689

Clinical prediction guides

The definition of remission and recurrence of Cushing's disease.
Hinojosa-Amaya JM, Cuevas-Ramos D
Best Pract Res Clin Endocrinol Metab 2021 Jan;35(1):101485. Epub 2021 Jan 13 doi: 10.1016/j.beem.2021.101485. PMID: 33472761
Low glucocorticoids in stress-related disorders: the role of inflammation.
Sarapultsev A, Sarapultsev P, Dremencov E, Komelkova M, Tseilikman O, Tseilikman V
Stress 2020 Nov;23(6):651-661. Epub 2020 May 22 doi: 10.1080/10253890.2020.1766020. PMID: 32401103
Neuroendocrine changes after aneurysmal subarachnoid haemorrhage.
Karaca Z, Hacioglu A, Kelestimur F
Pituitary 2019 Jun;22(3):305-321. doi: 10.1007/s11102-018-00932-w. PMID: 30637621
Earlier post-operative hypocortisolemia may predict durable remission from Cushing's disease.
Ironside N, Chatain G, Asuzu D, Benzo S, Lodish M, Sharma S, Nieman L, Stratakis CA, Lonser RR, Chittiboina P
Eur J Endocrinol 2018 Mar;178(3):255-263. Epub 2018 Jan 12 doi: 10.1530/EJE-17-0873. PMID: 29330227Free PMC Article
Do anxiety and depression have a common pathophysiological mechanism?
Boyer P
Acta Psychiatr Scand Suppl 2000;(406):24-9. PMID: 11131467

Recent systematic reviews

Hydranencephaly complicated by central diabetes insipidus: report of two cases and systematic review of literature.
Omar AT 2nd, Khu KJO
Childs Nerv Syst 2019 Jul;35(7):1165-1171. Epub 2019 Mar 30 doi: 10.1007/s00381-019-04137-9. PMID: 30929071
Conservative treatment cures an elderly pituitary apoplexy patient with oculomotor paralysis and optic nerve compression: a case report and systematic review of the literature.
Fan Y, Bao X, Wang R
Clin Interv Aging 2018;13:1981-1985. Epub 2018 Oct 12 doi: 10.2147/CIA.S181109. PMID: 30349217Free PMC Article
Perinatal maternal depression and cortisol function in pregnancy and the postpartum period: a systematic literature review.
Seth S, Lewis AJ, Galbally M
BMC Pregnancy Childbirth 2016 May 31;16(1):124. doi: 10.1186/s12884-016-0915-y. PMID: 27245670Free PMC Article

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