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DNA Degradation, Necrotic

MedGen UID:
319061
•Concept ID:
C1721093
•
Cell or Molecular Dysfunction
Synonym: Necrotic DNA Degradation

Definition

The random catabolism of DNA accompanying the irreversible damage to tissue which leads to the pathological death of one or more cells. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDNA Degradation, Necrotic

Professional guidelines

PubMed

Assessment of apoptosis and necrosis by DNA fragmentation and morphological criteria.
Zhivotosky B, Orrenius S
Curr Protoc Cell Biol 2001 Nov;Chapter 18:18.3.1-18.3.23. doi: 10.1002/0471143030.cb1803s12. PMID: 18228342
Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing.
Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF
Environ Mol Mutagen 2000;35(3):206-21. doi: 10.1002/(sici)1098-2280(2000)35:3<206::aid-em8>3.0.co;2-j. PMID: 10737956
Morphologic criteria and detection of apoptosis.
Saraste A
Herz 1999 May;24(3):189-95. doi: 10.1007/BF03044961. PMID: 10412642

Recent clinical studies

Etiology

Whole human blood DNA degradation associated with artificial ultraviolet and solar radiations as a function of exposure time.
Rahi GS, Adams JL, Yuan J, Devone DJ, Lodhi KM
Forensic Sci Int 2021 Feb;319:110674. Epub 2020 Dec 24 doi: 10.1016/j.forsciint.2020.110674. PMID: 33422800
Forensic genetic analysis of bone remain samples.
Siriboonpiputtana T, Rinthachai T, Shotivaranon J, Peonim V, Rerkamnuaychoke B
Forensic Sci Int 2018 Mar;284:167-175. Epub 2018 Jan 8 doi: 10.1016/j.forsciint.2017.12.045. PMID: 29408726
Human DNA quantification and sample quality assessment: Developmental validation of the PowerQuant(®) system.
Ewing MM, Thompson JM, McLaren RS, Purpero VM, Thomas KJ, Dobrowski PA, DeGroot GA, Romsos EL, Storts DR
Forensic Sci Int Genet 2016 Jul;23:166-177. Epub 2016 Apr 16 doi: 10.1016/j.fsigen.2016.04.007. PMID: 27206225
Study of short- and long-term storage of teeth and its influence on DNA.
Rubio L, Martinez LJ, Martinez E, Martin de las Heras S
J Forensic Sci 2009 Nov;54(6):1411-3. Epub 2009 Oct 5 doi: 10.1111/j.1556-4029.2009.01159.x. PMID: 19804532
DNA reviews: DNA identification following CBRN incidents.
Socratous E, Graham EA
Forensic Sci Med Pathol 2008;4(4):255-8. Epub 2008 Nov 18 doi: 10.1007/s12024-008-9066-4. PMID: 19291448

Diagnosis

Detecting DNA damage in stored blood samples.
Schulze Johann K, Bauer H, Wiegand P, Pfeiffer H, Vennemann M
Forensic Sci Med Pathol 2023 Mar;19(1):50-59. Epub 2022 Nov 10 doi: 10.1007/s12024-022-00549-3. PMID: 36355320Free PMC Article
Role of molecular techniques in PMI estimation: An update.
Sangwan A, Singh SP, Singh P, Gupta OP, Manas A, Gupta S
J Forensic Leg Med 2021 Oct;83:102251. Epub 2021 Sep 23 doi: 10.1016/j.jflm.2021.102251. PMID: 34592482
SD quants-Sensitive detection tetraplex-system for nuclear and mitochondrial DNA quantification and degradation inference.
Xavier C, Eduardoff M, Strobl C, Parson W
Forensic Sci Int Genet 2019 Sep;42:39-44. Epub 2019 Jun 10 doi: 10.1016/j.fsigen.2019.06.004. PMID: 31216503
Human DNA degradation assessment and male DNA detection by quantitative-PCR followed by high-resolution melting analysis.
Ginart S, Caputo M, Corach D, Sala A
Forensic Sci Int 2019 Feb;295:1-7. Epub 2018 Nov 29 doi: 10.1016/j.forsciint.2018.11.013. PMID: 30550960
The forensic spleen: Morphological, radiological, and toxicological investigations.
Palmiere C, Tettamanti C, Scarpelli MP, Tse R
Forensic Sci Int 2018 Oct;291:94-99. Epub 2018 Aug 18 doi: 10.1016/j.forsciint.2018.08.012. PMID: 30173072

Therapy

Inhibition of Drug-Induced Liver Injury in Mice Using a Positively Charged Peptide That Binds DNA.
Marques PE, Vandendriessche S, de Oliveira THC, Crijns H, Lopes ME, Blanter M, Schuermans S, Yu K, Poosti F, Vanheule V, Janssens R, Boff D, Kungl AJ, Menezes GB, Teixeira MM, Proost P
Hepatol Commun 2021 Oct;5(10):1737-1754. Epub 2021 Jul 1 doi: 10.1002/hep4.1759. PMID: 34532999Free PMC Article
Whole human blood DNA degradation associated with artificial ultraviolet and solar radiations as a function of exposure time.
Rahi GS, Adams JL, Yuan J, Devone DJ, Lodhi KM
Forensic Sci Int 2021 Feb;319:110674. Epub 2020 Dec 24 doi: 10.1016/j.forsciint.2020.110674. PMID: 33422800
Development and validation of a novel multiplexed DNA analysis system, InnoTyper(®) 21.
Brown H, Thompson R, Murphy G, Peters D, La Rue B, King J, Montgomery AH, Carroll M, Baus J, Sinha S, Wendt FR, Song B, Chakraborty R, Budowle B, Sinha SK
Forensic Sci Int Genet 2017 Jul;29:80-99. Epub 2017 Mar 18 doi: 10.1016/j.fsigen.2017.03.017. PMID: 28391141
Pathogenesis, developmental consequences, and clinical correlations of human embryo fragmentation.
Fujimoto VY, Browne RW, Bloom MS, Sakkas D, Alikani M
Fertil Steril 2011 Mar 15;95(4):1197-204. Epub 2010 Dec 13 doi: 10.1016/j.fertnstert.2010.11.033. PMID: 21146166
Developmental validation of the Quantifiler Duo DNA Quantification kit for simultaneous quantification of total human and human male DNA and detection of PCR inhibitors in biological samples.
Barbisin M, Fang R, O'Shea CE, Calandro LM, Furtado MR, Shewale JG
J Forensic Sci 2009 Mar;54(2):305-19. Epub 2009 Jan 27 doi: 10.1111/j.1556-4029.2008.00951.x. PMID: 19175708

Prognosis

QIAGEN's Investigator(®) Quantiplex(®) Pro Kit.
Bonnette MD
Methods Mol Biol 2023;2685:189-204. doi: 10.1007/978-1-0716-3295-6_12. PMID: 37439983
Role of molecular techniques in PMI estimation: An update.
Sangwan A, Singh SP, Singh P, Gupta OP, Manas A, Gupta S
J Forensic Leg Med 2021 Oct;83:102251. Epub 2021 Sep 23 doi: 10.1016/j.jflm.2021.102251. PMID: 34592482
Characterization of degradation and heterozygote balance by simulation of the forensic DNA analysis process.
Hansson O, Egeland T, Gill P
Int J Legal Med 2017 Mar;131(2):303-317. Epub 2016 Nov 3 doi: 10.1007/s00414-016-1453-x. PMID: 27807625Free PMC Article
Quantifiler® Trio Kit and forensic samples management: a matter of degradation.
Vernarecci S, Ottaviani E, Agostino A, Mei E, Calandro L, Montagna P
Forensic Sci Int Genet 2015 May;16:77-85. Epub 2014 Dec 24 doi: 10.1016/j.fsigen.2014.12.005. PMID: 25544252
Assessment of DNA degradation and the genotyping success of highly degraded samples.
Hughes-Stamm SR, Ashton KJ, van Daal A
Int J Legal Med 2011 May;125(3):341-8. Epub 2010 Apr 24 doi: 10.1007/s00414-010-0455-3. PMID: 20419381

Clinical prediction guides

QIAGEN's Investigator(®) Quantiplex(®) Pro Kit.
Bonnette MD
Methods Mol Biol 2023;2685:189-204. doi: 10.1007/978-1-0716-3295-6_12. PMID: 37439983
Detecting DNA damage in stored blood samples.
Schulze Johann K, Bauer H, Wiegand P, Pfeiffer H, Vennemann M
Forensic Sci Med Pathol 2023 Mar;19(1):50-59. Epub 2022 Nov 10 doi: 10.1007/s12024-022-00549-3. PMID: 36355320Free PMC Article
Role of molecular techniques in PMI estimation: An update.
Sangwan A, Singh SP, Singh P, Gupta OP, Manas A, Gupta S
J Forensic Leg Med 2021 Oct;83:102251. Epub 2021 Sep 23 doi: 10.1016/j.jflm.2021.102251. PMID: 34592482
Intrinsic and extrinsic factors that may influence DNA preservation in skeletal remains: A review.
Raffone C, Baeta M, Lambacher N, Granizo-Rodríguez E, Etxeberria F, de Pancorbo MM
Forensic Sci Int 2021 Aug;325:110859. Epub 2021 Jun 5 doi: 10.1016/j.forsciint.2021.110859. PMID: 34098475
Assessment of DNA degradation and the genotyping success of highly degraded samples.
Hughes-Stamm SR, Ashton KJ, van Daal A
Int J Legal Med 2011 May;125(3):341-8. Epub 2010 Apr 24 doi: 10.1007/s00414-010-0455-3. PMID: 20419381

Recent systematic reviews

The Role of DNA Degradation in the Estimation of Post-Mortem Interval: A Systematic Review of the Current Literature.
Tozzo P, Scrivano S, Sanavio M, Caenazzo L
Int J Mol Sci 2020 May 17;21(10) doi: 10.3390/ijms21103540. PMID: 32429539Free PMC Article

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