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DNA Degradation, Necrotic

MedGen UID:
319061
•Concept ID:
C1721093
•
Cell or Molecular Dysfunction
Synonym: Necrotic DNA Degradation

Definition

The random catabolism of DNA accompanying the irreversible damage to tissue which leads to the pathological death of one or more cells. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDNA Degradation, Necrotic

Professional guidelines

PubMed

Encoding of low-quality DNA profiles as genotype probability matrices for improved profile comparisons, relatedness evaluation and database searches.
Ryan K, Williams DG, Balding DJ
Forensic Sci Int Genet 2016 Nov;25:227-239. Epub 2016 Sep 21 doi: 10.1016/j.fsigen.2016.09.004. PMID: 27768939
Assessment of apoptosis and necrosis by DNA fragmentation and morphological criteria.
Zhivotosky B, Orrenius S
Curr Protoc Cell Biol 2001 Nov;Chapter 18:18.3.1-18.3.23. doi: 10.1002/0471143030.cb1803s12. PMID: 18228342
Morphologic criteria and detection of apoptosis.
Saraste A
Herz 1999 May;24(3):189-95. doi: 10.1007/BF03044961. PMID: 10412642

Recent clinical studies

Etiology

Whole human blood DNA degradation associated with artificial ultraviolet and solar radiations as a function of exposure time.
Rahi GS, Adams JL, Yuan J, Devone DJ, Lodhi KM
Forensic Sci Int 2021 Feb;319:110674. Epub 2020 Dec 24 doi: 10.1016/j.forsciint.2020.110674. PMID: 33422800
UV-Visible spectroscopic effect on Haemoglobin & DNA degradation: A forensic approach.
Kaur S, Saini V, Dalal R
Forensic Sci Int 2020 Feb;307:110078. Epub 2019 Dec 31 doi: 10.1016/j.forsciint.2019.110078. PMID: 31923852
Evaluation of InnoQuant(®) HY and InnoTyper(®) 21 kits in the DNA analysis of rootless hair samples.
Martins C, Ferreira PM, Carvalho R, Costa SC, Farinha C, Azevedo L, Amorim A, Oliveira M
Forensic Sci Int Genet 2019 Mar;39:61-65. Epub 2018 Dec 17 doi: 10.1016/j.fsigen.2018.12.005. PMID: 30578984
Forensic genetic analysis of bone remain samples.
Siriboonpiputtana T, Rinthachai T, Shotivaranon J, Peonim V, Rerkamnuaychoke B
Forensic Sci Int 2018 Mar;284:167-175. Epub 2018 Jan 8 doi: 10.1016/j.forsciint.2017.12.045. PMID: 29408726
DNA reviews: DNA identification following CBRN incidents.
Socratous E, Graham EA
Forensic Sci Med Pathol 2008;4(4):255-8. Epub 2008 Nov 18 doi: 10.1007/s12024-008-9066-4. PMID: 19291448

Diagnosis

Detecting DNA damage in stored blood samples.
Schulze Johann K, Bauer H, Wiegand P, Pfeiffer H, Vennemann M
Forensic Sci Med Pathol 2023 Mar;19(1):50-59. Epub 2022 Nov 10 doi: 10.1007/s12024-022-00549-3. PMID: 36355320Free PMC Article
Role of molecular techniques in PMI estimation: An update.
Sangwan A, Singh SP, Singh P, Gupta OP, Manas A, Gupta S
J Forensic Leg Med 2021 Oct;83:102251. Epub 2021 Sep 23 doi: 10.1016/j.jflm.2021.102251. PMID: 34592482
SD quants-Sensitive detection tetraplex-system for nuclear and mitochondrial DNA quantification and degradation inference.
Xavier C, Eduardoff M, Strobl C, Parson W
Forensic Sci Int Genet 2019 Sep;42:39-44. Epub 2019 Jun 10 doi: 10.1016/j.fsigen.2019.06.004. PMID: 31216503
Human DNA degradation assessment and male DNA detection by quantitative-PCR followed by high-resolution melting analysis.
Ginart S, Caputo M, Corach D, Sala A
Forensic Sci Int 2019 Feb;295:1-7. Epub 2018 Nov 29 doi: 10.1016/j.forsciint.2018.11.013. PMID: 30550960
Use of flow cytometry in forensic medicine: Current scenario and future prospects.
Bakdash A, Kumar S, Gautam KA, Mishra VC
J Forensic Leg Med 2018 Nov;60:42-44. Epub 2018 Oct 1 doi: 10.1016/j.jflm.2018.09.010. PMID: 30296631

Therapy

Inhibition of Drug-Induced Liver Injury in Mice Using a Positively Charged Peptide That Binds DNA.
Marques PE, Vandendriessche S, de Oliveira THC, Crijns H, Lopes ME, Blanter M, Schuermans S, Yu K, Poosti F, Vanheule V, Janssens R, Boff D, Kungl AJ, Menezes GB, Teixeira MM, Proost P
Hepatol Commun 2021 Oct;5(10):1737-1754. Epub 2021 Jul 1 doi: 10.1002/hep4.1759. PMID: 34532999Free PMC Article
Whole human blood DNA degradation associated with artificial ultraviolet and solar radiations as a function of exposure time.
Rahi GS, Adams JL, Yuan J, Devone DJ, Lodhi KM
Forensic Sci Int 2021 Feb;319:110674. Epub 2020 Dec 24 doi: 10.1016/j.forsciint.2020.110674. PMID: 33422800
A single nucleotide polymorphism panel for individual identification and ancestry assignment in Caucasians and four East and Southeast Asian populations using a machine learning classifier.
Hwa HL, Wu MY, Lin CP, Hsieh WH, Yin HI, Lee TT, Lee JC
Forensic Sci Med Pathol 2019 Mar;15(1):67-74. Epub 2019 Jan 16 doi: 10.1007/s12024-018-0071-y. PMID: 30649693
Development and validation of a novel multiplexed DNA analysis system, InnoTyper(®) 21.
Brown H, Thompson R, Murphy G, Peters D, La Rue B, King J, Montgomery AH, Carroll M, Baus J, Sinha S, Wendt FR, Song B, Chakraborty R, Budowle B, Sinha SK
Forensic Sci Int Genet 2017 Jul;29:80-99. Epub 2017 Mar 18 doi: 10.1016/j.fsigen.2017.03.017. PMID: 28391141
Comparing Standard and Selective Degradation DNA Extraction Methods: Results from a Field Experiment with Sexual Assault Kits<sup/>.
Campbell R, Pierce SJ, Sharma DB, Shaw J, Feeney H, Nye J, Schelling K, Fehler-Cabral G
J Forensic Sci 2017 Jan;62(1):213-222. Epub 2016 Nov 25 doi: 10.1111/1556-4029.13251. PMID: 27885653

Prognosis

QIAGEN's Investigator(®) Quantiplex(®) Pro Kit.
Bonnette MD
Methods Mol Biol 2023;2685:189-204. doi: 10.1007/978-1-0716-3295-6_12. PMID: 37439983
Role of molecular techniques in PMI estimation: An update.
Sangwan A, Singh SP, Singh P, Gupta OP, Manas A, Gupta S
J Forensic Leg Med 2021 Oct;83:102251. Epub 2021 Sep 23 doi: 10.1016/j.jflm.2021.102251. PMID: 34592482
The challenge of predicting human pigmentation traits in degraded bone samples with the MPS-based HIrisPlex-S system.
Kukla-Bartoszek M, Szargut M, Pośpiech E, Diepenbroek M, Zielińska G, Jarosz A, Piniewska-Róg D, Arciszewska J, Cytacka S, Spólnicka M, Branicki W, Ossowski A
Forensic Sci Int Genet 2020 Jul;47:102301. Epub 2020 Apr 21 doi: 10.1016/j.fsigen.2020.102301. PMID: 32387914
Quantifiler® Trio Kit and forensic samples management: a matter of degradation.
Vernarecci S, Ottaviani E, Agostino A, Mei E, Calandro L, Montagna P
Forensic Sci Int Genet 2015 May;16:77-85. Epub 2014 Dec 24 doi: 10.1016/j.fsigen.2014.12.005. PMID: 25544252
Assessment of DNA degradation and the genotyping success of highly degraded samples.
Hughes-Stamm SR, Ashton KJ, van Daal A
Int J Legal Med 2011 May;125(3):341-8. Epub 2010 Apr 24 doi: 10.1007/s00414-010-0455-3. PMID: 20419381

Clinical prediction guides

QIAGEN's Investigator(®) Quantiplex(®) Pro Kit.
Bonnette MD
Methods Mol Biol 2023;2685:189-204. doi: 10.1007/978-1-0716-3295-6_12. PMID: 37439983
Role of molecular techniques in PMI estimation: An update.
Sangwan A, Singh SP, Singh P, Gupta OP, Manas A, Gupta S
J Forensic Leg Med 2021 Oct;83:102251. Epub 2021 Sep 23 doi: 10.1016/j.jflm.2021.102251. PMID: 34592482
Intrinsic and extrinsic factors that may influence DNA preservation in skeletal remains: A review.
Raffone C, Baeta M, Lambacher N, Granizo-Rodríguez E, Etxeberria F, de Pancorbo MM
Forensic Sci Int 2021 Aug;325:110859. Epub 2021 Jun 5 doi: 10.1016/j.forsciint.2021.110859. PMID: 34098475
Impact of DNA degradation on massively parallel sequencing-based autosomal STR, iiSNP, and mitochondrial DNA typing systems.
Zavala EI, Rajagopal S, Perry GH, Kruzic I, Bašić Ž, Parsons TJ, Holland MM
Int J Legal Med 2019 Sep;133(5):1369-1380. Epub 2019 Jul 2 doi: 10.1007/s00414-019-02110-4. PMID: 31267160
RIPK3 in cell death and inflammation: the good, the bad, and the ugly.
Orozco S, Oberst A
Immunol Rev 2017 May;277(1):102-112. doi: 10.1111/imr.12536. PMID: 28462521Free PMC Article

Recent systematic reviews

The Role of DNA Degradation in the Estimation of Post-Mortem Interval: A Systematic Review of the Current Literature.
Tozzo P, Scrivano S, Sanavio M, Caenazzo L
Int J Mol Sci 2020 May 17;21(10) doi: 10.3390/ijms21103540. PMID: 32429539Free PMC Article

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