U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hypertension, pregnancy-induced, susceptibility to

MedGen UID:
320277
•Concept ID:
C1834154
•
Finding
Synonym: HYPERTENSION, PREGNANCY-INDUCED, SUSCEPTIBILITY TO
 
OMIM®: 163729

Professional guidelines

PubMed

Endothelial nitric oxide synthase gene G894T polymorphism and risk assessment for pregnancy-induced hypertension: evidence from 11 700 subjects.
Ma Q, Lv J, Huang K, Guo H, Yang W, Luo W, Qiu J, Yang L
Hypertens Res 2016 Dec;39(12):899-906. Epub 2016 Jul 28 doi: 10.1038/hr.2016.95. PMID: 27465577
Universal screening of gestational diabetes mellitus: prevalence and diagnostic value of clinical risk factors.
Arora D, Arora R, Sangthong S, Leelaporn W, Sangratanathongchai J
J Med Assoc Thai 2013 Mar;96(3):266-71. PMID: 23539927
Vascular endothelial growth factor genotypes and haplotypes are associated with pre-eclampsia but not with gestational hypertension.
Sandrim VC, Palei AC, Cavalli RC, Araújo FM, Ramos ES, Duarte G, Tanus-Santos JE
Mol Hum Reprod 2009 Feb;15(2):115-20. Epub 2008 Dec 5 doi: 10.1093/molehr/gan076. PMID: 19060000

Curated

UK NICE guideline (NG133), Hypertension in pregnancy: diagnosis and management, 2023

Recent clinical studies

Etiology

Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy.
Tyrmi JS, Kaartokallio T, Lokki AI, Jääskeläinen T, Kortelainen E, Ruotsalainen S, Karjalainen J, Ripatti S, Kivioja A, Laisk T, Kettunen J, Pouta A, Kivinen K, Kajantie E, Heinonen S, Kere J, Laivuori H; FINNPEC Study Group, FinnGen Project, and the Estonian Biobank Research Team
JAMA Cardiol 2023 Jul 1;8(7):674-683. doi: 10.1001/jamacardio.2023.1312. PMID: 37285119Free PMC Article
Ozone Exposure During Pregnancy and Risk of Gestational Hypertension or Preeclampsia in China.
Cheng Y, Wang P, Zhang L, Shi H, Li J, Meng X, Xiao X, Dai H, Zhang Y
JAMA Netw Open 2023 Apr 3;6(4):e236347. doi: 10.1001/jamanetworkopen.2023.6347. PMID: 37010870Free PMC Article
The genetic risk factors for pregnancy-induced hypertension: Evidence from genetic polymorphisms.
Wei W, Wang X, Zhou Y, Shang X, Yu H
FASEB J 2022 Jul;36(7):e22413. doi: 10.1096/fj.202101853RR. PMID: 35696055
Vitamin D and risk of pregnancy related hypertensive disorders: mendelian randomisation study.
Magnus MC, Miliku K, Bauer A, Engel SM, Felix JF, Jaddoe VWV, Lawlor DA, London SJ, Magnus P, McGinnis R, Nystad W, Page CM, Rivadeneira F, Stene LC, Tapia G, Williams N, Bonilla C, Fraser A
BMJ 2018 Jun 20;361:k2167. doi: 10.1136/bmj.k2167. PMID: 29925546Free PMC Article
Bronchopulmonary dysplasia: A review of pathogenesis and pathophysiology.
Kalikkot Thekkeveedu R, Guaman MC, Shivanna B
Respir Med 2017 Nov;132:170-177. Epub 2017 Oct 24 doi: 10.1016/j.rmed.2017.10.014. PMID: 29229093Free PMC Article

Diagnosis

Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy.
Tyrmi JS, Kaartokallio T, Lokki AI, Jääskeläinen T, Kortelainen E, Ruotsalainen S, Karjalainen J, Ripatti S, Kivioja A, Laisk T, Kettunen J, Pouta A, Kivinen K, Kajantie E, Heinonen S, Kere J, Laivuori H; FINNPEC Study Group, FinnGen Project, and the Estonian Biobank Research Team
JAMA Cardiol 2023 Jul 1;8(7):674-683. doi: 10.1001/jamacardio.2023.1312. PMID: 37285119Free PMC Article
Ozone Exposure During Pregnancy and Risk of Gestational Hypertension or Preeclampsia in China.
Cheng Y, Wang P, Zhang L, Shi H, Li J, Meng X, Xiao X, Dai H, Zhang Y
JAMA Netw Open 2023 Apr 3;6(4):e236347. doi: 10.1001/jamanetworkopen.2023.6347. PMID: 37010870Free PMC Article
Heightened susceptibility: A review of how pregnancy and chemical exposures influence maternal health.
Varshavsky J, Smith A, Wang A, Hom E, Izano M, Huang H, Padula A, Woodruff TJ
Reprod Toxicol 2020 Mar;92:14-56. Epub 2019 May 2 doi: 10.1016/j.reprotox.2019.04.004. PMID: 31055053Free PMC Article
New Models of Pregnancy-Associated Hypertension.
Cushen SC, Goulopoulou S
Am J Hypertens 2017 Nov 1;30(11):1053-1062. doi: 10.1093/ajh/hpx063. PMID: 28472224
Epidemiology of pregnancy-induced hypertension.
Zhang J, Zeisler J, Hatch MC, Berkowitz G
Epidemiol Rev 1997;19(2):218-32. doi: 10.1093/oxfordjournals.epirev.a017954. PMID: 9494784

Therapy

Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study.
Tschiderer L, van der Schouw YT, Burgess S, Bloemenkamp KWM, Seekircher L, Willeit P, Onland-Moret C, Peters SAE
Heart 2024 Apr 25;110(10):710-717. doi: 10.1136/heartjnl-2023-323490. PMID: 38148158Free PMC Article
Ozone Exposure During Pregnancy and Risk of Gestational Hypertension or Preeclampsia in China.
Cheng Y, Wang P, Zhang L, Shi H, Li J, Meng X, Xiao X, Dai H, Zhang Y
JAMA Netw Open 2023 Apr 3;6(4):e236347. doi: 10.1001/jamanetworkopen.2023.6347. PMID: 37010870Free PMC Article
Heightened susceptibility: A review of how pregnancy and chemical exposures influence maternal health.
Varshavsky J, Smith A, Wang A, Hom E, Izano M, Huang H, Padula A, Woodruff TJ
Reprod Toxicol 2020 Mar;92:14-56. Epub 2019 May 2 doi: 10.1016/j.reprotox.2019.04.004. PMID: 31055053Free PMC Article
Vitamin D and risk of pregnancy related hypertensive disorders: mendelian randomisation study.
Magnus MC, Miliku K, Bauer A, Engel SM, Felix JF, Jaddoe VWV, Lawlor DA, London SJ, Magnus P, McGinnis R, Nystad W, Page CM, Rivadeneira F, Stene LC, Tapia G, Williams N, Bonilla C, Fraser A
BMJ 2018 Jun 20;361:k2167. doi: 10.1136/bmj.k2167. PMID: 29925546Free PMC Article
Genetic and molecular aspects of hypertension.
Padmanabhan S, Caulfield M, Dominiczak AF
Circ Res 2015 Mar 13;116(6):937-59. doi: 10.1161/CIRCRESAHA.116.303647. PMID: 25767282

Prognosis

Genetics of hypertension-related sex differences and hypertensive disorders of pregnancy.
Nurkkala J, Vaura F, Toivonen J, Niiranen T
Blood Press 2024 Dec;33(1):2408574. Epub 2024 Oct 7 doi: 10.1080/08037051.2024.2408574. PMID: 39371034
Ozone Exposure During Pregnancy and Risk of Gestational Hypertension or Preeclampsia in China.
Cheng Y, Wang P, Zhang L, Shi H, Li J, Meng X, Xiao X, Dai H, Zhang Y
JAMA Netw Open 2023 Apr 3;6(4):e236347. doi: 10.1001/jamanetworkopen.2023.6347. PMID: 37010870Free PMC Article
Bronchopulmonary dysplasia: A review of pathogenesis and pathophysiology.
Kalikkot Thekkeveedu R, Guaman MC, Shivanna B
Respir Med 2017 Nov;132:170-177. Epub 2017 Oct 24 doi: 10.1016/j.rmed.2017.10.014. PMID: 29229093Free PMC Article
Pheochromocytoma and pregnancy: a deceptive connection.
Lenders JW
Eur J Endocrinol 2012 Feb;166(2):143-50. Epub 2011 Sep 2 doi: 10.1530/EJE-11-0528. PMID: 21890650
Pathophysiology of placentation abnormalities in pregnancy-induced hypertension.
Furuya M, Ishida J, Aoki I, Fukamizu A
Vasc Health Risk Manag 2008;4(6):1301-13. doi: 10.2147/vhrm.s4009. PMID: 19337544Free PMC Article

Clinical prediction guides

Genetics of hypertension-related sex differences and hypertensive disorders of pregnancy.
Nurkkala J, Vaura F, Toivonen J, Niiranen T
Blood Press 2024 Dec;33(1):2408574. Epub 2024 Oct 7 doi: 10.1080/08037051.2024.2408574. PMID: 39371034
Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study.
Tschiderer L, van der Schouw YT, Burgess S, Bloemenkamp KWM, Seekircher L, Willeit P, Onland-Moret C, Peters SAE
Heart 2024 Apr 25;110(10):710-717. doi: 10.1136/heartjnl-2023-323490. PMID: 38148158Free PMC Article
Ozone Exposure During Pregnancy and Risk of Gestational Hypertension or Preeclampsia in China.
Cheng Y, Wang P, Zhang L, Shi H, Li J, Meng X, Xiao X, Dai H, Zhang Y
JAMA Netw Open 2023 Apr 3;6(4):e236347. doi: 10.1001/jamanetworkopen.2023.6347. PMID: 37010870Free PMC Article
Vitamin D and risk of pregnancy related hypertensive disorders: mendelian randomisation study.
Magnus MC, Miliku K, Bauer A, Engel SM, Felix JF, Jaddoe VWV, Lawlor DA, London SJ, Magnus P, McGinnis R, Nystad W, Page CM, Rivadeneira F, Stene LC, Tapia G, Williams N, Bonilla C, Fraser A
BMJ 2018 Jun 20;361:k2167. doi: 10.1136/bmj.k2167. PMID: 29925546Free PMC Article
Pheochromocytoma and pregnancy: a deceptive connection.
Lenders JW
Eur J Endocrinol 2012 Feb;166(2):143-50. Epub 2011 Sep 2 doi: 10.1530/EJE-11-0528. PMID: 21890650

Recent systematic reviews

Association between Vitamin D receptor (VDR) gene polymorphisms and hypertensive disorders of pregnancy: a systematic review and meta-analysis.
Guo Y, Zhang Y, Tang X, Liu X, Xu H
PeerJ 2023;11:e15181. Epub 2023 Apr 25 doi: 10.7717/peerj.15181. PMID: 37123013Free PMC Article
Maternal Mercury Exposure and Hypertensive Disorders of Pregnancy: A Systematic Review.
Dantas AO, Castro TDSDS, Câmara VM, Santos ASE, Asmus CIRF, Vianna ADS
Rev Bras Ginecol Obstet 2022 Dec;44(12):1126-1133. Epub 2022 Dec 29 doi: 10.1055/s-0042-1760215. PMID: 36580940Free PMC Article
NTP monograph on the systematic review of traffic-related air pollution and hypertensive disorders of pregnancy.
National Toxicology Program
NTP Monogr 2019 Dec;(7) doi: 10.22427/NTP-MGRAPH-7. PMID: 33560269Free PMC Article
Vascular endothelial growth factor gene polymorphisms and hypertensive disorder of pregnancy: A meta-analysis.
Su M, Hu Z, Dong C, Xu X
Pregnancy Hypertens 2019 Jul;17:191-196. Epub 2019 May 9 doi: 10.1016/j.preghy.2019.05.012. PMID: 31487639

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE guideline (NG133), Hypertension in pregnancy: diagnosis and management, 2023

    Consumer resources

    Reviews

    Related information

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...