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consanguinity

MedGen UID:
3213
Concept ID:
C0009789
Finding
Synonyms: Consanguinities; Consanguinity
SNOMED CT: Consanguinity (842009)

Definition

The magnitude of INBREEDING in humans. [from MeSH]

Professional guidelines

PubMed

Gonzales PR, Andersen EF, Brown TR, Horner VL, Horwitz J, Rehder CW, Rudy NL, Robin NH, Thorland EC, On Behalf Of The Acmg Laboratory Quality Assurance Committee
Genet Med 2022 Feb;24(2):255-261. Epub 2021 Dec 3 doi: 10.1016/j.gim.2021.10.004. PMID: 34906464
Al-Herz W, Aldhekri H, Barbouche MR, Rezaei N
Hum Hered 2014;77(1-4):138-43. Epub 2014 Jul 29 doi: 10.1159/000357710. PMID: 25060276
Wimmer K, Kratz CP, Vasen HF, Caron O, Colas C, Entz-Werle N, Gerdes AM, Goldberg Y, Ilencikova D, Muleris M, Duval A, Lavoine N, Ruiz-Ponte C, Slavc I, Burkhardt B, Brugieres L; EU-Consortium Care for CMMRD (C4CMMRD)
J Med Genet 2014 Jun;51(6):355-65. Epub 2014 Apr 15 doi: 10.1136/jmedgenet-2014-102284. PMID: 24737826

Recent clinical studies

Etiology

Roy N, Ghaziuddin M, Mohiuddin S
Curr Psychiatry Rep 2020 Jan 13;22(1):3. doi: 10.1007/s11920-019-1124-y. PMID: 31933025
Fareed M, Afzal M
Ann Hum Biol 2017 Mar;44(2):99-107. Epub 2016 Dec 14 doi: 10.1080/03014460.2016.1265148. PMID: 27892699
Sirdah MM
Eur J Med Genet 2014 Feb;57(2-3):90-4. Epub 2014 Jan 25 doi: 10.1016/j.ejmg.2014.01.003. PMID: 24468669
Lancet 1991 Jul 13;338(8759):85-6. PMID: 1676472
Nobel M
J Med Ethics 1978 Jun;4(2):64-70. doi: 10.1136/jme.4.2.64. PMID: 671473Free PMC Article

Diagnosis

Gonzales PR, Andersen EF, Brown TR, Horner VL, Horwitz J, Rehder CW, Rudy NL, Robin NH, Thorland EC, On Behalf Of The Acmg Laboratory Quality Assurance Committee
Genet Med 2022 Feb;24(2):255-261. Epub 2021 Dec 3 doi: 10.1016/j.gim.2021.10.004. PMID: 34906464
van Zelm MC, Condino-Neto A, Barbouche MR
Front Immunol 2019;10:3148. Epub 2020 Jan 22 doi: 10.3389/fimmu.2019.03148. PMID: 32038648Free PMC Article
Al-Dewik N, Mohd H, Al-Mureikhi M, Ali R, Al-Mesaifri F, Mahmoud L, Shahbeck N, El-Akouri K, Almulla M, Al Sulaiman R, Musa S, Al-Marri AA, Richard G, Juusola J, Solomon BD, Alkuraya FS, Ben-Omran T
Am J Med Genet A 2019 Jun;179(6):927-935. Epub 2019 Mar 27 doi: 10.1002/ajmg.a.61126. PMID: 30919572Free PMC Article
Jan AU, Ahmad S, Cheema TA, Ullah F, Waqar M, Hussain B
J Ayub Med Coll Abbottabad 2018 Jul-Sep;30(3):473-475. PMID: 30465389
Al-Herz W, Aldhekri H, Barbouche MR, Rezaei N
Hum Hered 2014;77(1-4):138-43. Epub 2014 Jul 29 doi: 10.1159/000357710. PMID: 25060276

Therapy

Tein I
Epilepsy Behav 2023 Aug;145:109338. Epub 2023 Jul 13 doi: 10.1016/j.yebeh.2023.109338. PMID: 37453291
Majid H, Ahmed S, Muneer S, Hamid R, Jafri L, Khan AH
J Coll Physicians Surg Pak 2022 Jun;32(6):823-825. doi: 10.29271/jcpsp.2022.06.823. PMID: 35686422
Crawford AZ, Zhang J, Gokul A, McGhee CNJ, Ormonde SE
Asia Pac J Ophthalmol (Phila) 2020 Dec;9(6):549-556. doi: 10.1097/APO.0000000000000334. PMID: 33284230
al-Mondhiry H, Ehmann WC
Am J Hematol 1994 Aug;46(4):343-7. doi: 10.1002/ajh.2830460416. PMID: 8037188
J Pediatr 1969 Apr;74(4):655-7. doi: 10.1016/s0022-3476(69)80055-7. PMID: 4304438

Prognosis

Mansouritorghabeh H
Expert Rev Hematol 2021 May;14(5):467-472. Epub 2021 May 10 doi: 10.1080/17474086.2021.1923476. PMID: 33910448
McLean J, Katebian R, Suh E, Mirza K, Amin S
Neoreviews 2019 Jun;20(6):e316-e325. doi: 10.1542/neo.20-6-e316. PMID: 31261095
Siddique AW, Ahmed Z, Haider A, Khalid H, Karim T
J Ayub Med Coll Abbottabad 2019 Apr-Jun;31(2):290-292. PMID: 31094135
Oniya O, Neves K, Ahmed B, Konje JC
Eur J Obstet Gynecol Reprod Biol 2019 Jan;232:87-96. Epub 2018 Nov 1 doi: 10.1016/j.ejogrb.2018.10.042. PMID: 30502592
al-Mondhiry H, Ehmann WC
Am J Hematol 1994 Aug;46(4):343-7. doi: 10.1002/ajh.2830460416. PMID: 8037188

Clinical prediction guides

Khatri ML
Int J Dermatol 2021 Mar;60(3):314-320. Epub 2021 Feb 4 doi: 10.1111/ijd.15395. PMID: 33538348
Al-Dewik N, Mohd H, Al-Mureikhi M, Ali R, Al-Mesaifri F, Mahmoud L, Shahbeck N, El-Akouri K, Almulla M, Al Sulaiman R, Musa S, Al-Marri AA, Richard G, Juusola J, Solomon BD, Alkuraya FS, Ben-Omran T
Am J Med Genet A 2019 Jun;179(6):927-935. Epub 2019 Mar 27 doi: 10.1002/ajmg.a.61126. PMID: 30919572Free PMC Article
Claerhout H, Witters P, Régal L, Jansen K, Van Hoestenberghe MR, Breckpot J, Vermeersch P
J Inherit Metab Dis 2018 Jan;41(1):101-108. Epub 2017 Oct 4 doi: 10.1007/s10545-017-0089-4. PMID: 28980090
Nybo Andersen AM, Gundlund A, Villadsen SF
Best Pract Res Clin Obstet Gynaecol 2016 Apr;32:50-9. Epub 2015 Oct 19 doi: 10.1016/j.bpobgyn.2015.09.004. PMID: 26545588
Wimmer K, Kratz CP, Vasen HF, Caron O, Colas C, Entz-Werle N, Gerdes AM, Goldberg Y, Ilencikova D, Muleris M, Duval A, Lavoine N, Ruiz-Ponte C, Slavc I, Burkhardt B, Brugieres L; EU-Consortium Care for CMMRD (C4CMMRD)
J Med Genet 2014 Jun;51(6):355-65. Epub 2014 Apr 15 doi: 10.1136/jmedgenet-2014-102284. PMID: 24737826

Recent systematic reviews

Greenberg ABW, Mehta NH, Allington G, Jin SC, Moreno-De-Luca A, Kahle KT
JAMA Netw Open 2023 Nov 1;6(11):e2343384. doi: 10.1001/jamanetworkopen.2023.43384. PMID: 37991765Free PMC Article
Al-Kouatly HB, Shivashankar K, Mossayebi MH, Makhamreh M, Critchlow E, Gao Z, Fasehun LK, Alkuraya FS, Ryan EE, Hegde M, Wodoslawsky S, Hughes J, Berger SI
Clin Genet 2023 May;103(5):503-512. Epub 2023 Feb 26 doi: 10.1111/cge.14309. PMID: 36757664
Pournasiri Z, Madani A, Nazarpack F, Sayer JA, Chavoshzadeh Z, Nili F, Tran P, Saba JD, Jamee M
World J Pediatr 2023 May;19(5):425-437. Epub 2022 Nov 12 doi: 10.1007/s12519-022-00615-4. PMID: 36371483
Zhao CY, Murrell DF
Curr Opin Pediatr 2016 Aug;28(4):500-6. doi: 10.1097/MOP.0000000000000381. PMID: 27386969
Sabbagh HJ, Hassan MH, Innes NP, Baik AA, Mossey PA
Cleft Palate Craniofac J 2014 Sep;51(5):501-13. Epub 2013 May 2 doi: 10.1597/12-209. PMID: 23638915

Supplemental Content

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    Clinical resources

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