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Extensively drug-resistant tuberculosis

MedGen UID:
321809
Concept ID:
C1827301
Disease or Syndrome
Synonyms: Drug-Resistant Tuberculoses, Extensively; Drug-Resistant Tuberculoses, Extremely; Drug-Resistant Tuberculosis, Extensively; Drug-Resistant Tuberculosis, Extremely; Extensively Drug Resistant Tuberculosis; Extensively Drug-Resistant Tuberculoses; Extensively Drug-Resistant Tuberculosis; Extremely Drug Resistant Tuberculosis; Extremely Drug-Resistant Tuberculoses; Extremely Drug-Resistant Tuberculosis; Tuberculoses, Extensively Drug-Resistant; Tuberculoses, Extremely Drug-Resistant; Tuberculosis, Extensively Drug Resistant; Tuberculosis, Extensively Drug-Resistant; Tuberculosis, Extremely Drug Resistant; Tuberculosis, Extremely Drug-Resistant; XDR-TB
SNOMED CT: Extreme drug resistant tuberculosis (422481005); Extremely drug resistant tuberculosis (422481005); Extensively drug resistant tuberculosis (710106005)
 
Monarch Initiative: MONDO:0100482

Definition

Extensively drug resistant TB are strains of TB that are resistant to at least rifampicin and isoniazid, and also resistant to a fluoroquinolone and to at least one of the three injectable TB drugs, capreomycin, kanamycin and amikacin. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtensively drug-resistant tuberculosis

Professional guidelines

PubMed

Vanino E, Granozzi B, Akkerman OW, Munoz-Torrico M, Palmieri F, Seaworth B, Tiberi S, Tadolini M
Int J Infect Dis 2023 May;130 Suppl 1:S12-S15. Epub 2023 Mar 12 doi: 10.1016/j.ijid.2023.03.013. PMID: 36918080
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838
Murray JF, Schraufnagel DE, Hopewell PC
Ann Am Thorac Soc 2015 Dec;12(12):1749-59. doi: 10.1513/AnnalsATS.201509-632PS. PMID: 26653188

Recent clinical studies

Etiology

Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
Conradie F, Diacon AH, Ngubane N, Howell P, Everitt D, Crook AM, Mendel CM, Egizi E, Moreira J, Timm J, McHugh TD, Wills GH, Bateson A, Hunt R, Van Niekerk C, Li M, Olugbosi M, Spigelman M; Nix-TB Trial Team
N Engl J Med 2020 Mar 5;382(10):893-902. doi: 10.1056/NEJMoa1901814. PMID: 32130813Free PMC Article
Pontali E, Raviglione MC, Migliori GB; and the writing group members of the Global TB Network Clinical Trials Committee
Eur Respir Rev 2019 Jun 30;28(152) Epub 2019 May 29 doi: 10.1183/16000617.0035-2019. PMID: 31142549Free PMC Article
Dean AS, Cox H, Zignol M
Adv Exp Med Biol 2017;1019:209-220. doi: 10.1007/978-3-319-64371-7_11. PMID: 29116637
Alsultan A, Peloquin CA
Drugs 2014 Jun;74(8):839-54. doi: 10.1007/s40265-014-0222-8. PMID: 24846578

Diagnosis

Tiberi S, Utjesanovic N, Galvin J, Centis R, D'Ambrosio L, van den Boom M, Zumla A, Migliori GB
Int J Infect Dis 2022 Nov;124 Suppl 1:S20-S25. Epub 2022 Mar 25 doi: 10.1016/j.ijid.2022.03.026. PMID: 35342000
Borah P, Deb PK, Venugopala KN, Al-Shar'i NA, Singh V, Deka S, Srivastava A, Tiwari V, Mailavaram RP
Curr Top Med Chem 2021;21(6):547-570. doi: 10.2174/1568026621999201211200447. PMID: 33319660
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838
Schito M, Migliori GB, Fletcher HA, McNerney R, Centis R, D'Ambrosio L, Bates M, Kibiki G, Kapata N, Corrah T, Bomanji J, Vilaplana C, Johnson D, Mwaba P, Maeurer M, Zumla A
Clin Infect Dis 2015 Oct 15;61Suppl 3(Suppl 3):S102-18. doi: 10.1093/cid/civ609. PMID: 26409271Free PMC Article
Seung KJ, Keshavjee S, Rich ML
Cold Spring Harb Perspect Med 2015 Apr 27;5(9):a017863. doi: 10.1101/cshperspect.a017863. PMID: 25918181Free PMC Article

Therapy

Tiberi S, Utjesanovic N, Galvin J, Centis R, D'Ambrosio L, van den Boom M, Zumla A, Migliori GB
Int J Infect Dis 2022 Nov;124 Suppl 1:S20-S25. Epub 2022 Mar 25 doi: 10.1016/j.ijid.2022.03.026. PMID: 35342000
Conradie F, Diacon AH, Ngubane N, Howell P, Everitt D, Crook AM, Mendel CM, Egizi E, Moreira J, Timm J, McHugh TD, Wills GH, Bateson A, Hunt R, Van Niekerk C, Li M, Olugbosi M, Spigelman M; Nix-TB Trial Team
N Engl J Med 2020 Mar 5;382(10):893-902. doi: 10.1056/NEJMoa1901814. PMID: 32130813Free PMC Article
Pontali E, Raviglione MC, Migliori GB; and the writing group members of the Global TB Network Clinical Trials Committee
Eur Respir Rev 2019 Jun 30;28(152) Epub 2019 May 29 doi: 10.1183/16000617.0035-2019. PMID: 31142549Free PMC Article
Schito M, Migliori GB, Fletcher HA, McNerney R, Centis R, D'Ambrosio L, Bates M, Kibiki G, Kapata N, Corrah T, Bomanji J, Vilaplana C, Johnson D, Mwaba P, Maeurer M, Zumla A
Clin Infect Dis 2015 Oct 15;61Suppl 3(Suppl 3):S102-18. doi: 10.1093/cid/civ609. PMID: 26409271Free PMC Article
Seung KJ, Keshavjee S, Rich ML
Cold Spring Harb Perspect Med 2015 Apr 27;5(9):a017863. doi: 10.1101/cshperspect.a017863. PMID: 25918181Free PMC Article

Prognosis

Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838
Seaworth BJ, Griffith DE
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0042-2017. PMID: 28361737
Maitre T, Aubry A, Jarlier V, Robert J, Veziris N; CNR-MyRMA
Med Mal Infect 2017 Feb;47(1):3-10. doi: 10.1016/j.medmal.2016.07.006. PMID: 27637852
Murray JF, Schraufnagel DE, Hopewell PC
Ann Am Thorac Soc 2015 Dec;12(12):1749-59. doi: 10.1513/AnnalsATS.201509-632PS. PMID: 26653188

Clinical prediction guides

Tiberi S, Utjesanovic N, Galvin J, Centis R, D'Ambrosio L, van den Boom M, Zumla A, Migliori GB
Int J Infect Dis 2022 Nov;124 Suppl 1:S20-S25. Epub 2022 Mar 25 doi: 10.1016/j.ijid.2022.03.026. PMID: 35342000
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
Conradie F, Diacon AH, Ngubane N, Howell P, Everitt D, Crook AM, Mendel CM, Egizi E, Moreira J, Timm J, McHugh TD, Wills GH, Bateson A, Hunt R, Van Niekerk C, Li M, Olugbosi M, Spigelman M; Nix-TB Trial Team
N Engl J Med 2020 Mar 5;382(10):893-902. doi: 10.1056/NEJMoa1901814. PMID: 32130813Free PMC Article
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Respirology 2018 Jul;23(7):656-673. Epub 2018 Apr 11 doi: 10.1111/resp.13304. PMID: 29641838
Treat Guidel Med Lett 2012 Mar;10(116):29-36; quiz 37-8. PMID: 22450707

Recent systematic reviews

Pedersen OS, Holmgaard FB, Mikkelsen MKD, Lange C, Sotgiu G, Lillebaek T, Andersen AB, Wejse CM, Dahl VN
J Infect 2023 Sep;87(3):177-189. Epub 2023 Jun 23 doi: 10.1016/j.jinf.2023.06.014. PMID: 37356629
Antimicrobial Resistance Collaborators
Lancet 2022 Feb 12;399(10325):629-655. Epub 2022 Jan 19 doi: 10.1016/S0140-6736(21)02724-0. PMID: 35065702Free PMC Article
Song WM, Li YF, Liu YX, Liu Y, Yu CB, Liu JY, Li HC
Front Public Health 2021;9:721817. Epub 2021 Aug 18 doi: 10.3389/fpubh.2021.721817. PMID: 34490197Free PMC Article
Natarajan A, Beena PM, Devnikar AV, Mali S
Indian J Tuberc 2020 Jul;67(3):295-311. Epub 2020 Feb 28 doi: 10.1016/j.ijtb.2020.02.005. PMID: 32825856
Sotgiu G, D'Ambrosio L, Centis R, Tiberi S, Esposito S, Dore S, Spanevello A, Migliori GB
Int J Mol Sci 2016 Mar 12;17(3):373. doi: 10.3390/ijms17030373. PMID: 26985890Free PMC Article

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