U.S. flag

An official website of the United States government


Send to:

Choose Destination

Gait instability, worse in the dark

MedGen UID:
Concept ID:
Synonym: Unstable walking, worse in the dark
HPO: HP:0006962

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGait instability, worse in the dark

Conditions with this feature

Autosomal dominant sensory ataxia 1
MedGen UID:
Concept ID:
Disease or Syndrome
Autosomal dominant sensory ataxia-1 (SNAX1) is a peripheral neuropathy resulting from the degeneration of dorsal root ganglia that affects both central and peripheral neurites of sensory neurons. Affected individuals show adult onset of slowly progressive clumsiness, gait ataxia, walking difficulties, and distal sensory loss which may be associated with abnormal sensory nerve conduction values. Some patients have vestibular ocular dysfunction. Muscle weakness and atrophy are not observed, and brain imaging is normal (summary by Cortese et al., 2020).

Recent clinical studies


Seichepine DR, Neargarder S, Miller IN, Riedel TM, Gilmore GC, Cronin-Golomb A
J Int Neuropsychol Soc 2011 Sep;17(5):841-52. Epub 2011 Aug 4 doi: 10.1017/S1355617711000853. PMID: 21813030Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...