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Helicobacter pylori infection, susceptibility to

MedGen UID:
325004
Concept ID:
C1838332
Disease or Syndrome
Synonym: HELICOBACTER PYLORI INFECTION, SUSCEPTIBILITY TO
 
Gene (location): IFNGR1 (6q23.3)
 
Monarch Initiative: MONDO:0010853
OMIM®: 600263

Definition

Helicobacter pylori is a microaerophilic, gram-negative bacterium that colonizes the gastric mucosa of approximately 50% of the world's population, and is a primary pathogenic factor in benign and malignant gastroduodenal disease (Warren and Marshall, 1983; Blaser and Parsonnet, 1994). Tomb et al. (1997) reported the complete sequence of the circular genome of H. pylori. The 1,667,867-bp genome contains 1,590 predicted coding sequences (genes). Sequence analysis of these genes indicated that the organism has systems for motility, for scavenging iron, and for DNA restriction and modification. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH. [from OMIM]

Clinical features

From HPO
Helicobacter pylori infection
MedGen UID:
208857
Concept ID:
C0850666
Disease or Syndrome
A recurrent infection of the GI tract with helicobacter pylori, a gram-negative, microaerophilic bacterium usually found in the stomach.

Professional guidelines

PubMed

Moss SF, Shah SC, Tan MC, El-Serag HB
Gastroenterology 2024 Feb;166(2):267-283. Epub 2023 Oct 6 doi: 10.1053/j.gastro.2023.09.047. PMID: 37806461Free PMC Article
Argueta EA, Moss SF
Curr Opin Gastroenterol 2020 Nov;36(6):518-524. doi: 10.1097/MOG.0000000000000678. PMID: 32868505
Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, Czinn S, Gold BD, Guarner J, Elitsur Y, Homan M, Kalach N, Kori M, Madrazo A, Megraud F, Papadopoulou A, Rowland M; ESPGHAN, NASPGHAN
J Pediatr Gastroenterol Nutr 2017 Jun;64(6):991-1003. doi: 10.1097/MPG.0000000000001594. PMID: 28541262

Curated

UK NICE Clinical Guideline CG184, Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management, 2019

Recent clinical studies

Etiology

Moss SF, Shah SC, Tan MC, El-Serag HB
Gastroenterology 2024 Feb;166(2):267-283. Epub 2023 Oct 6 doi: 10.1053/j.gastro.2023.09.047. PMID: 37806461Free PMC Article
Usui Y, Taniyama Y, Endo M, Koyanagi YN, Kasugai Y, Oze I, Ito H, Imoto I, Tanaka T, Tajika M, Niwa Y, Iwasaki Y, Aoi T, Hakozaki N, Takata S, Suzuki K, Terao C, Hatakeyama M, Hirata M, Sugano K, Yoshida T, Kamatani Y, Nakagawa H, Matsuda K, Murakami Y, Spurdle AB, Matsuo K, Momozawa Y
N Engl J Med 2023 Mar 30;388(13):1181-1190. doi: 10.1056/NEJMoa2211807. PMID: 36988593
Wu Y, Murray GK, Byrne EM, Sidorenko J, Visscher PM, Wray NR
Nat Commun 2021 Feb 19;12(1):1146. doi: 10.1038/s41467-021-21280-7. PMID: 33608531Free PMC Article
Burucoa C, Axon A
Helicobacter 2017 Sep;22 Suppl 1 doi: 10.1111/hel.12403. PMID: 28891138
Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, Czinn S, Gold BD, Guarner J, Elitsur Y, Homan M, Kalach N, Kori M, Madrazo A, Megraud F, Papadopoulou A, Rowland M; ESPGHAN, NASPGHAN
J Pediatr Gastroenterol Nutr 2017 Jun;64(6):991-1003. doi: 10.1097/MPG.0000000000001594. PMID: 28541262

Diagnosis

Moss SF, Shah SC, Tan MC, El-Serag HB
Gastroenterology 2024 Feb;166(2):267-283. Epub 2023 Oct 6 doi: 10.1053/j.gastro.2023.09.047. PMID: 37806461Free PMC Article
Malfertheiner P, Camargo MC, El-Omar E, Liou JM, Peek R, Schulz C, Smith SI, Suerbaum S
Nat Rev Dis Primers 2023 Apr 20;9(1):19. doi: 10.1038/s41572-023-00431-8. PMID: 37081005
Pohl D, Keller PM, Bordier V, Wagner K
World J Gastroenterol 2019 Aug 28;25(32):4629-4660. doi: 10.3748/wjg.v25.i32.4629. PMID: 31528091Free PMC Article
Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, Czinn S, Gold BD, Guarner J, Elitsur Y, Homan M, Kalach N, Kori M, Madrazo A, Megraud F, Papadopoulou A, Rowland M; ESPGHAN, NASPGHAN
J Pediatr Gastroenterol Nutr 2017 Jun;64(6):991-1003. doi: 10.1097/MPG.0000000000001594. PMID: 28541262
Patel SK, Pratap CB, Jain AK, Gulati AK, Nath G
World J Gastroenterol 2014 Sep 28;20(36):12847-59. doi: 10.3748/wjg.v20.i36.12847. PMID: 25278682Free PMC Article

Therapy

Moss SF, Shah SC, Tan MC, El-Serag HB
Gastroenterology 2024 Feb;166(2):267-283. Epub 2023 Oct 6 doi: 10.1053/j.gastro.2023.09.047. PMID: 37806461Free PMC Article
Pohl D, Keller PM, Bordier V, Wagner K
World J Gastroenterol 2019 Aug 28;25(32):4629-4660. doi: 10.3748/wjg.v25.i32.4629. PMID: 31528091Free PMC Article
Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, Czinn S, Gold BD, Guarner J, Elitsur Y, Homan M, Kalach N, Kori M, Madrazo A, Megraud F, Papadopoulou A, Rowland M; ESPGHAN, NASPGHAN
J Pediatr Gastroenterol Nutr 2017 Jun;64(6):991-1003. doi: 10.1097/MPG.0000000000001594. PMID: 28541262
Hu Y, Zhu Y, Lu NH
Front Cell Infect Microbiol 2017;7:168. Epub 2017 May 5 doi: 10.3389/fcimb.2017.00168. PMID: 28529929Free PMC Article
Yonezawa H, Osaki T, Kamiya S
Biomed Res Int 2015;2015:914791. Epub 2015 May 19 doi: 10.1155/2015/914791. PMID: 26078970Free PMC Article

Prognosis

Zu M, Hao X, Ning J, Zhou X, Gong Y, Lang Y, Xu W, Zhang J, Ding S
Biomed Pharmacother 2023 Jul;163:114751. Epub 2023 Apr 26 doi: 10.1016/j.biopha.2023.114751. PMID: 37105073
Poonyam P, Chotivitayatarakorn P, Vilaichone RK
Asian Pac J Cancer Prev 2019 Sep 1;20(9):2859-2864. doi: 10.31557/APJCP.2019.20.9.2859. PMID: 31554388Free PMC Article
Dutta U, Bush N, Kalsi D, Popli P, Kapoor VK
Chin Clin Oncol 2019 Aug;8(4):33. doi: 10.21037/cco.2019.08.03. PMID: 31484488
Argueta EA, Moss SF
Curr Opin Gastroenterol 2019 Nov;35(6):544-550. doi: 10.1097/MOG.0000000000000578. PMID: 31433314
Patel SK, Pratap CB, Jain AK, Gulati AK, Nath G
World J Gastroenterol 2014 Sep 28;20(36):12847-59. doi: 10.3748/wjg.v20.i36.12847. PMID: 25278682Free PMC Article

Clinical prediction guides

Mannion A, Dzink-Fox J, Shen Z, Piazuelo MB, Wilson KT, Correa P, Peek RM Jr, Camargo MC, Fox JG
J Clin Microbiol 2021 Apr 20;59(5) doi: 10.1128/JCM.03203-20. PMID: 33692136Free PMC Article
Savoldi A, Carrara E, Graham DY, Conti M, Tacconelli E
Gastroenterology 2018 Nov;155(5):1372-1382.e17. Epub 2018 Jul 7 doi: 10.1053/j.gastro.2018.07.007. PMID: 29990487Free PMC Article
Hu Y, Zhu Y, Lu NH
Front Cell Infect Microbiol 2017;7:168. Epub 2017 May 5 doi: 10.3389/fcimb.2017.00168. PMID: 28529929Free PMC Article
Yonezawa H, Osaki T, Kamiya S
Biomed Res Int 2015;2015:914791. Epub 2015 May 19 doi: 10.1155/2015/914791. PMID: 26078970Free PMC Article
Patel SK, Pratap CB, Jain AK, Gulati AK, Nath G
World J Gastroenterol 2014 Sep 28;20(36):12847-59. doi: 10.3748/wjg.v20.i36.12847. PMID: 25278682Free PMC Article

Recent systematic reviews

de Moraes Andrade PV, Monteiro YM, Chehter EZ
World J Gastroenterol 2023 Jan 14;29(2):390-409. doi: 10.3748/wjg.v29.i2.390. PMID: 36687120Free PMC Article
Savoldi A, Carrara E, Graham DY, Conti M, Tacconelli E
Gastroenterology 2018 Nov;155(5):1372-1382.e17. Epub 2018 Jul 7 doi: 10.1053/j.gastro.2018.07.007. PMID: 29990487Free PMC Article
Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, Czinn S, Gold BD, Guarner J, Elitsur Y, Homan M, Kalach N, Kori M, Madrazo A, Megraud F, Papadopoulou A, Rowland M; ESPGHAN, NASPGHAN
J Pediatr Gastroenterol Nutr 2017 Jun;64(6):991-1003. doi: 10.1097/MPG.0000000000001594. PMID: 28541262
Dhurandhar NV, Bailey D, Thomas D
Obes Rev 2015 Dec;16(12):1017-29. Epub 2015 Sep 10 doi: 10.1111/obr.12320. PMID: 26354800
O'Connor A, Vaira D, Gisbert JP, O'Morain C
Helicobacter 2014 Sep;19 Suppl 1:38-45. doi: 10.1111/hel.12163. PMID: 25167944

Supplemental Content

Table of contents

    Clinical resources

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    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2019
      UK NICE Clinical Guideline CG184, Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management, 2019

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