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Grade 1 Colitis, CTCAE

MedGen UID:
326116
•Concept ID:
C1559277
•
Finding

Definition

Asymptomatic; clinical or diagnostic observations only; intervention not indicated [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 1 Colitis, CTCAE

Professional guidelines

PubMed

Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis.
Alexander JL, Ibraheim H, Richards C, Shum B, Pavlidis P, Hunter N, Teare JP, Wotherspoon A, Furness A, Turajlic S, Pickering L, Larkin J, Speight A, Papa S, Powell N
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005490. PMID: 36113896Free PMC Article
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article

Recent clinical studies

Etiology

Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis.
Alexander JL, Ibraheim H, Richards C, Shum B, Pavlidis P, Hunter N, Teare JP, Wotherspoon A, Furness A, Turajlic S, Pickering L, Larkin J, Speight A, Papa S, Powell N
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005490. PMID: 36113896Free PMC Article
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab.
Alexander JL, Ibraheim H, Sheth B, Little J, Khan MS, Richards C, Hunter N, Chauhan D, Ratnakumaran R, McHugh K, Pinato DJ, Nathan P, Choy J, Crusz SM, Furness A, Turajlic S, Pickering L, Larkin J, Teare JP, Papa S, Speight A, Sharma A, Powell N
J Immunother Cancer 2021 Jul;9(7) doi: 10.1136/jitc-2021-002742. PMID: 34233964Free PMC Article
A real-world data of Immune checkpoint inhibitors in solid tumors from India.
Noronha V, Abraham G, Patil V, Joshi A, Menon N, Mahajan A, Janu A, Jain S, Talreja VT, Kapoor A, Kumar Singh G, Khaddar S, Gupta K, Rathinasamy N, Srinivas S, Agrawal A, Ventrapati P, Prabhash K
Cancer Med 2021 Mar;10(5):1525-1534. Epub 2021 Feb 16 doi: 10.1002/cam4.3617. PMID: 33591635Free PMC Article
Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study.
Heppt MV, Amaral T, Kähler KC, Heinzerling L, Hassel JC, Meissner M, Kreuzberg N, Loquai C, Reinhardt L, Utikal J, Dabrowski E, Gesierich A, Pföhler C, Terheyden P, Thoms KM, Zimmer L, Eigentler TK, Kirchberger MC, Stege HM, Meier F, Schlaak M, Berking C
J Immunother Cancer 2019 Nov 13;7(1):299. doi: 10.1186/s40425-019-0800-0. PMID: 31722735Free PMC Article

Diagnosis

Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review.
Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y
J Immunother 2022 Oct 1;45(8):363-369. Epub 2022 Aug 16 doi: 10.1097/CJI.0000000000000435. PMID: 35972801
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
The Effect of Concurrent Stereotactic Body Radiation and Anti-PD-1 Therapy for Recurrent Metastatic Sarcoma.
Callaghan CM, Seyedin SN, Mohiuddin IH, Hawkes KL, Petronek MS, Anderson CM, Buatti JM, Milhem MM, Monga V, Allen BG
Radiat Res 2020 Aug 1;194(2):124-132. doi: 10.1667/RADE-20-00017. PMID: 32845986Free PMC Article
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Cheung VTF, Gupta T, Olsson-Brown A, Subramanian S, Sasson SC, Heseltine J, Fryer E, Collantes E, Sacco JJ, Pirmohamed M, Simmons A, Klenerman P, Tuthill M, Protheroe AS, Chitnis M, Fairfax BP, Payne MJ, Middleton MR, Brain O
Br J Cancer 2020 Jul;123(2):207-215. Epub 2020 May 18 doi: 10.1038/s41416-020-0882-y. PMID: 32418993Free PMC Article
Colitis after checkpoint blockade: A retrospective cohort study of melanoma patients requiring admission for symptom control.
Hughes MS, Zheng H, Zubiri L, Molina GE, Chen ST, Mooradian MJ, Allen IM, Reynolds KL, Dougan M
Cancer Med 2019 Sep;8(11):4986-4999. Epub 2019 Jul 9 doi: 10.1002/cam4.2397. PMID: 31286682Free PMC Article

Therapy

Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis.
Alexander JL, Ibraheim H, Richards C, Shum B, Pavlidis P, Hunter N, Teare JP, Wotherspoon A, Furness A, Turajlic S, Pickering L, Larkin J, Speight A, Papa S, Powell N
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005490. PMID: 36113896Free PMC Article
COLAR: open-label clinical study of IL-6 blockade with tocilizumab for the treatment of immune checkpoint inhibitor-induced colitis and arthritis.
Holmstroem RB, Nielsen OH, Jacobsen S, Riis LB, Theile S, Bjerrum JT, Vilmann P, Johansen JS, Boisen MK, Eefsen RHL, Marie Svane I, Nielsen DL, Chen IM
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005111. PMID: 36096534Free PMC Article
Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review.
Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y
J Immunother 2022 Oct 1;45(8):363-369. Epub 2022 Aug 16 doi: 10.1097/CJI.0000000000000435. PMID: 35972801
The Effect of Concurrent Stereotactic Body Radiation and Anti-PD-1 Therapy for Recurrent Metastatic Sarcoma.
Callaghan CM, Seyedin SN, Mohiuddin IH, Hawkes KL, Petronek MS, Anderson CM, Buatti JM, Milhem MM, Monga V, Allen BG
Radiat Res 2020 Aug 1;194(2):124-132. doi: 10.1667/RADE-20-00017. PMID: 32845986Free PMC Article
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Cheung VTF, Gupta T, Olsson-Brown A, Subramanian S, Sasson SC, Heseltine J, Fryer E, Collantes E, Sacco JJ, Pirmohamed M, Simmons A, Klenerman P, Tuthill M, Protheroe AS, Chitnis M, Fairfax BP, Payne MJ, Middleton MR, Brain O
Br J Cancer 2020 Jul;123(2):207-215. Epub 2020 May 18 doi: 10.1038/s41416-020-0882-y. PMID: 32418993Free PMC Article

Prognosis

Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review.
Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y
J Immunother 2022 Oct 1;45(8):363-369. Epub 2022 Aug 16 doi: 10.1097/CJI.0000000000000435. PMID: 35972801
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
A real-world data of Immune checkpoint inhibitors in solid tumors from India.
Noronha V, Abraham G, Patil V, Joshi A, Menon N, Mahajan A, Janu A, Jain S, Talreja VT, Kapoor A, Kumar Singh G, Khaddar S, Gupta K, Rathinasamy N, Srinivas S, Agrawal A, Ventrapati P, Prabhash K
Cancer Med 2021 Mar;10(5):1525-1534. Epub 2021 Feb 16 doi: 10.1002/cam4.3617. PMID: 33591635Free PMC Article
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Cheung VTF, Gupta T, Olsson-Brown A, Subramanian S, Sasson SC, Heseltine J, Fryer E, Collantes E, Sacco JJ, Pirmohamed M, Simmons A, Klenerman P, Tuthill M, Protheroe AS, Chitnis M, Fairfax BP, Payne MJ, Middleton MR, Brain O
Br J Cancer 2020 Jul;123(2):207-215. Epub 2020 May 18 doi: 10.1038/s41416-020-0882-y. PMID: 32418993Free PMC Article
Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study.
Heppt MV, Amaral T, Kähler KC, Heinzerling L, Hassel JC, Meissner M, Kreuzberg N, Loquai C, Reinhardt L, Utikal J, Dabrowski E, Gesierich A, Pföhler C, Terheyden P, Thoms KM, Zimmer L, Eigentler TK, Kirchberger MC, Stege HM, Meier F, Schlaak M, Berking C
J Immunother Cancer 2019 Nov 13;7(1):299. doi: 10.1186/s40425-019-0800-0. PMID: 31722735Free PMC Article

Clinical prediction guides

Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis.
Alexander JL, Ibraheim H, Richards C, Shum B, Pavlidis P, Hunter N, Teare JP, Wotherspoon A, Furness A, Turajlic S, Pickering L, Larkin J, Speight A, Papa S, Powell N
J Immunother Cancer 2022 Sep;10(9) doi: 10.1136/jitc-2022-005490. PMID: 36113896Free PMC Article
Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review.
Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y
J Immunother 2022 Oct 1;45(8):363-369. Epub 2022 Aug 16 doi: 10.1097/CJI.0000000000000435. PMID: 35972801
Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease.
Lischalk JW, Blacksburg S, Mendez C, Repka M, Sanchez A, Carpenter T, Witten M, Garbus JE, Evans A, Collins SP, Katz A, Haas J
Radiat Oncol 2021 Jul 9;16(1):126. doi: 10.1186/s13014-021-01850-1. PMID: 34243797Free PMC Article
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Cheung VTF, Gupta T, Olsson-Brown A, Subramanian S, Sasson SC, Heseltine J, Fryer E, Collantes E, Sacco JJ, Pirmohamed M, Simmons A, Klenerman P, Tuthill M, Protheroe AS, Chitnis M, Fairfax BP, Payne MJ, Middleton MR, Brain O
Br J Cancer 2020 Jul;123(2):207-215. Epub 2020 May 18 doi: 10.1038/s41416-020-0882-y. PMID: 32418993Free PMC Article
Efficacy and safety of a standardized extract from Achillea wilhelmsii C. Koch in patients with ulcerative colitis: A randomized double blind placebo-controlled clinical trial.
Amiri M, Navabi J, Shokoohinia Y, Heydarpour F, Bahrami G, Behbood L, Derakhshandeh P, Momtaz S, Farzaei MH
Complement Ther Med 2019 Aug;45:262-268. Epub 2019 May 2 doi: 10.1016/j.ctim.2019.05.001. PMID: 31331572

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