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Grade 2 Proctitis, CTCAE

MedGen UID:
326134
•Concept ID:
C1559352
•
Finding

Definition

Symptomatic (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental ADL [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Proctitis, CTCAE

Recent clinical studies

Etiology

Comparing symptom reporting by prostate cancer patients and healthcare professionals in the international multicentre REQUITE study.
Heumann P, Aguado-Barrera ME, Avuzzi B, Azria D, Briers E, Bultijnck R, Choudhury A, De Ruysscher D, Farcy-Jacquet MP, Fonteyne V, Gómez Caamaño A, Helmbold I, Johnson K, Kerns SL, Lambrecht M, Lingard Z, Rancati T, Rosenstein BS, Sperk E, Paul Symonds R, Talbot C, Valdagni R, Vega A, Veldeman L, Ward T, Webb A, West CM, Chang-Claude J, Seibold P; REQUITE Consortium
Radiother Oncol 2023 Jan;178:109426. Epub 2022 Nov 25 doi: 10.1016/j.radonc.2022.11.015. PMID: 36442608
Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future.
Spampinato S, Jensen NBK, Pötter R, Fokdal LU, Chargari C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Hoskin P, Segedin B, Rai B, Bruheim K, Wiebe E, Van der Steen-Banasik E, Cooper R, Van Limbergen E, Sundset M, Pieters BR, Lutgens LCHW, Tan LT, Villafranca E, Smet S, Jastaniyah N, Nout RA, Kirisits C, Chopra S, Kirchheiner K, Tanderup K, Embrace Collaborative Group
Int J Radiat Oncol Biol Phys 2022 Mar 1;112(3):681-693. Epub 2021 Oct 20 doi: 10.1016/j.ijrobp.2021.09.055. PMID: 34678431
MRI- and PET-Guided Interstitial Brachytherapy for Postsurgical Vaginal Recurrences of Cervical Cancer: Results of Phase II Study.
Chopra S, Engineer R, Shah S, Shukla R, Dora T, Gupta P, Paul SN, Popat P, Swamidas J, Mahantshetty U, Varghese L, Gupta S, Rangrajan V, Shrivastava S
Int J Radiat Oncol Biol Phys 2020 Feb 1;106(2):310-319. Epub 2019 Nov 1 doi: 10.1016/j.ijrobp.2019.10.037. PMID: 31682968
Late toxicities of prostate cancer radiotherapy with and without hydrogel SpaceAOR insertion.
Te Velde BL, Westhuyzen J, Awad N, Wood M, Shakespeare TP
J Med Imaging Radiat Oncol 2019 Dec;63(6):836-841. Epub 2019 Sep 13 doi: 10.1111/1754-9485.12945. PMID: 31520465
Iodine-125 seed brachytherapy for early stage prostate cancer: a single-institution review.
Zuber S, Weiß S, Baaske D, Schöpe M, Stevens S, Bodis S, Zwahlen DR
Radiat Oncol 2015 Feb 22;10:49. doi: 10.1186/s13014-015-0349-0. PMID: 25880809Free PMC Article

Diagnosis

Comparing symptom reporting by prostate cancer patients and healthcare professionals in the international multicentre REQUITE study.
Heumann P, Aguado-Barrera ME, Avuzzi B, Azria D, Briers E, Bultijnck R, Choudhury A, De Ruysscher D, Farcy-Jacquet MP, Fonteyne V, Gómez Caamaño A, Helmbold I, Johnson K, Kerns SL, Lambrecht M, Lingard Z, Rancati T, Rosenstein BS, Sperk E, Paul Symonds R, Talbot C, Valdagni R, Vega A, Veldeman L, Ward T, Webb A, West CM, Chang-Claude J, Seibold P; REQUITE Consortium
Radiother Oncol 2023 Jan;178:109426. Epub 2022 Nov 25 doi: 10.1016/j.radonc.2022.11.015. PMID: 36442608
Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant.
Schirmer MA, Mergler CP, Rave-Fränk M, Herrmann MK, Hennies S, Gaedcke J, Conradi LC, Jo P, Beissbarth T, Hess CF, Becker H, Ghadimi M, Brockmöller J, Christiansen H, Wolff HA
Int J Radiat Oncol Biol Phys 2012 May 1;83(1):149-57. Epub 2011 Oct 12 doi: 10.1016/j.ijrobp.2011.05.063. PMID: 22000747
Rectal toxicity profile after transperineal interstitial permanent prostate brachytherapy: use of a comprehensive toxicity scoring system and identification of rectal dosimetric toxicity predictors.
Shah JN, Ennis RD
Int J Radiat Oncol Biol Phys 2006 Mar 1;64(3):817-24. Epub 2005 Nov 16 doi: 10.1016/j.ijrobp.2005.08.042. PMID: 16297567

Therapy

Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future.
Spampinato S, Jensen NBK, Pötter R, Fokdal LU, Chargari C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Hoskin P, Segedin B, Rai B, Bruheim K, Wiebe E, Van der Steen-Banasik E, Cooper R, Van Limbergen E, Sundset M, Pieters BR, Lutgens LCHW, Tan LT, Villafranca E, Smet S, Jastaniyah N, Nout RA, Kirisits C, Chopra S, Kirchheiner K, Tanderup K, Embrace Collaborative Group
Int J Radiat Oncol Biol Phys 2022 Mar 1;112(3):681-693. Epub 2021 Oct 20 doi: 10.1016/j.ijrobp.2021.09.055. PMID: 34678431
MRI- and PET-Guided Interstitial Brachytherapy for Postsurgical Vaginal Recurrences of Cervical Cancer: Results of Phase II Study.
Chopra S, Engineer R, Shah S, Shukla R, Dora T, Gupta P, Paul SN, Popat P, Swamidas J, Mahantshetty U, Varghese L, Gupta S, Rangrajan V, Shrivastava S
Int J Radiat Oncol Biol Phys 2020 Feb 1;106(2):310-319. Epub 2019 Nov 1 doi: 10.1016/j.ijrobp.2019.10.037. PMID: 31682968
Sequential short-course radiation therapy and chemotherapy in the neoadjuvant treatment of rectal adenocarcinoma.
Jia AY, Narang A, Safar B, Zaheer A, Murphy A, Azad NS, Gearhart S, Fang S, Efron J, Warczynski T, Hacker-Prietz A, Meyer J
Radiat Oncol 2019 Aug 19;14(1):147. doi: 10.1186/s13014-019-1358-1. PMID: 31426827Free PMC Article
Iodine-125 seed brachytherapy for early stage prostate cancer: a single-institution review.
Zuber S, Weiß S, Baaske D, Schöpe M, Stevens S, Bodis S, Zwahlen DR
Radiat Oncol 2015 Feb 22;10:49. doi: 10.1186/s13014-015-0349-0. PMID: 25880809Free PMC Article
Proctitis following stereotactic body radiation therapy for prostate cancer.
Joh DY, Chen LN, Porter G, Bhagat A, Sood S, Kim JS, Moures R, Yung T, Lei S, Collins BT, Ju AW, Suy S, Carroll J, Lynch JH, Dritschilo A, Collins SP
Radiat Oncol 2014 Dec 12;9:277. doi: 10.1186/s13014-014-0277-4. PMID: 25497602Free PMC Article

Prognosis

Sequential short-course radiation therapy and chemotherapy in the neoadjuvant treatment of rectal adenocarcinoma.
Jia AY, Narang A, Safar B, Zaheer A, Murphy A, Azad NS, Gearhart S, Fang S, Efron J, Warczynski T, Hacker-Prietz A, Meyer J
Radiat Oncol 2019 Aug 19;14(1):147. doi: 10.1186/s13014-019-1358-1. PMID: 31426827Free PMC Article
Rectal retractor application during image-guided dose-escalated prostate radiotherapy.
Mahdavi SR, Ghaffari H, Mofid B, Rostami A, Reiazi R, Janani L
Strahlenther Onkol 2019 Oct;195(10):923-933. Epub 2019 Mar 1 doi: 10.1007/s00066-019-01445-6. PMID: 30824942
Randomized, double-blind, placebo-controlled phase II trial of nanocurcumin in prostate cancer patients undergoing radiotherapy.
Saadipoor A, Razzaghdoust A, Simforoosh N, Mahdavi A, Bakhshandeh M, Moghadam M, Abdollahi H, Mofid B
Phytother Res 2019 Feb;33(2):370-378. Epub 2018 Nov 14 doi: 10.1002/ptr.6230. PMID: 30427093
Iodine-125 seed brachytherapy for early stage prostate cancer: a single-institution review.
Zuber S, Weiß S, Baaske D, Schöpe M, Stevens S, Bodis S, Zwahlen DR
Radiat Oncol 2015 Feb 22;10:49. doi: 10.1186/s13014-015-0349-0. PMID: 25880809Free PMC Article
Proctitis following stereotactic body radiation therapy for prostate cancer.
Joh DY, Chen LN, Porter G, Bhagat A, Sood S, Kim JS, Moures R, Yung T, Lei S, Collins BT, Ju AW, Suy S, Carroll J, Lynch JH, Dritschilo A, Collins SP
Radiat Oncol 2014 Dec 12;9:277. doi: 10.1186/s13014-014-0277-4. PMID: 25497602Free PMC Article

Clinical prediction guides

Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future.
Spampinato S, Jensen NBK, Pötter R, Fokdal LU, Chargari C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Hoskin P, Segedin B, Rai B, Bruheim K, Wiebe E, Van der Steen-Banasik E, Cooper R, Van Limbergen E, Sundset M, Pieters BR, Lutgens LCHW, Tan LT, Villafranca E, Smet S, Jastaniyah N, Nout RA, Kirisits C, Chopra S, Kirchheiner K, Tanderup K, Embrace Collaborative Group
Int J Radiat Oncol Biol Phys 2022 Mar 1;112(3):681-693. Epub 2021 Oct 20 doi: 10.1016/j.ijrobp.2021.09.055. PMID: 34678431
MRI- and PET-Guided Interstitial Brachytherapy for Postsurgical Vaginal Recurrences of Cervical Cancer: Results of Phase II Study.
Chopra S, Engineer R, Shah S, Shukla R, Dora T, Gupta P, Paul SN, Popat P, Swamidas J, Mahantshetty U, Varghese L, Gupta S, Rangrajan V, Shrivastava S
Int J Radiat Oncol Biol Phys 2020 Feb 1;106(2):310-319. Epub 2019 Nov 1 doi: 10.1016/j.ijrobp.2019.10.037. PMID: 31682968
Sequential short-course radiation therapy and chemotherapy in the neoadjuvant treatment of rectal adenocarcinoma.
Jia AY, Narang A, Safar B, Zaheer A, Murphy A, Azad NS, Gearhart S, Fang S, Efron J, Warczynski T, Hacker-Prietz A, Meyer J
Radiat Oncol 2019 Aug 19;14(1):147. doi: 10.1186/s13014-019-1358-1. PMID: 31426827Free PMC Article
Iodine-125 seed brachytherapy for early stage prostate cancer: a single-institution review.
Zuber S, Weiß S, Baaske D, Schöpe M, Stevens S, Bodis S, Zwahlen DR
Radiat Oncol 2015 Feb 22;10:49. doi: 10.1186/s13014-015-0349-0. PMID: 25880809Free PMC Article
Proctitis following stereotactic body radiation therapy for prostate cancer.
Joh DY, Chen LN, Porter G, Bhagat A, Sood S, Kim JS, Moures R, Yung T, Lei S, Collins BT, Ju AW, Suy S, Carroll J, Lynch JH, Dritschilo A, Collins SP
Radiat Oncol 2014 Dec 12;9:277. doi: 10.1186/s13014-014-0277-4. PMID: 25497602Free PMC Article

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