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Grade 4 Vomiting, CTCAE

MedGen UID:
326183
•Concept ID:
C1559522
•
Finding

Definition

Life-threatening consequences [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Vomiting, CTCAE

Professional guidelines

PubMed

Clinicians versus patients subjective adverse events assessment: based on patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE).
Liu L, Suo T, Shen Y, Geng C, Song Z, Liu F, Wang J, Xie Y, Zhang Y, Tang T, Zhang L, Wang W
Qual Life Res 2020 Nov;29(11):3009-3015. Epub 2020 Jun 20 doi: 10.1007/s11136-020-02558-7. PMID: 32564293
Toxicity profile of temozolomide in the treatment of 300 malignant glioma patients in Korea.
Bae SH, Park MJ, Lee MM, Kim TM, Lee SH, Cho SY, Kim YH, Kim YJ, Park CK, Kim CY
J Korean Med Sci 2014 Jul;29(7):980-4. Epub 2014 Jul 11 doi: 10.3346/jkms.2014.29.7.980. PMID: 25045231Free PMC Article
A prospective study on the efficacy of octreotide in the management of malignant bowel obstruction in gynecologic cancer.
Watari H, Hosaka M, Wakui Y, Nomura E, Hareyama H, Tanuma F, Hattori R, Azuma M, Kato H, Takeda N, Ariga S, Sakuragi N
Int J Gynecol Cancer 2012 May;22(4):692-6. doi: 10.1097/IGC.0b013e318244ce93. PMID: 22343971

Recent clinical studies

Etiology

Hypnosis on patients treated with adjuvant chemotherapy for breast cancer: A feasibility study.
Fabbro M, Jacot W, Jarlier M, Guiu S, D'Hondt V, Pouderoux S, Champoiral P, Janiszewski C, Nicklès I
Cancer Rep (Hoboken) 2023 Jan;6(1):e1732. Epub 2022 Oct 27 doi: 10.1002/cnr2.1732. PMID: 36302744Free PMC Article
A phase I trial of lurbinectedin in combination with cisplatin in patients with advanced solid tumors.
Metaxas Y, Kahatt C, Alfaro V, Fudio S, Zeaiter A, Plummer R, Sessa C, Von Moos R, Forster M, Stathis A
Invest New Drugs 2022 Feb;40(1):91-98. Epub 2021 Aug 28 doi: 10.1007/s10637-021-01142-1. PMID: 34453241
Olanzapine for the prophylaxis and rescue of chemotherapy-induced nausea and vomiting: a systematic review, meta-analysis, cumulative meta-analysis and fragility assessment of the literature.
Chow R, Herrstedt J, Aapro M, Chiu L, Lam H, Prsic E, Lock M, DeAngelis C, Navari RM
Support Care Cancer 2021 Jul;29(7):3439-3459. Epub 2021 Jan 13 doi: 10.1007/s00520-020-05935-7. PMID: 33442782Free PMC Article
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584
Digestive toxicities after palliative three-dimensional conformal radiation therapy (3D-CRT) for cervico-thoracic spinal metastases.
Peyraga G, Caron D, Lizee T, Metayer Y, Septans AL, Pointreau Y, Denis F, Ganem G, Lafond C, Roche S, Dupuis O
Support Care Cancer 2018 Jun;26(6):1897-1903. Epub 2017 Dec 23 doi: 10.1007/s00520-017-4001-4. PMID: 29275524

Diagnosis

Hypnosis on patients treated with adjuvant chemotherapy for breast cancer: A feasibility study.
Fabbro M, Jacot W, Jarlier M, Guiu S, D'Hondt V, Pouderoux S, Champoiral P, Janiszewski C, Nicklès I
Cancer Rep (Hoboken) 2023 Jan;6(1):e1732. Epub 2022 Oct 27 doi: 10.1002/cnr2.1732. PMID: 36302744Free PMC Article
Lack of Concordance in Symptomatic Adverse Event Reporting by Children, Clinicians, and Caregivers: Implications for Cancer Clinical Trials.
Freyer DR, Lin L, Mack JW, Maurer SH, McFatrich M, Baker JN, Jacobs SS, Lucas N, Withycombe JS, Tomlinson D, Villabroza KR, Waldron MK, Hinds PS, Reeve BB
J Clin Oncol 2022 May 20;40(15):1623-1634. Epub 2022 Mar 16 doi: 10.1200/JCO.21.02669. PMID: 35294262Free PMC Article
Clinicians versus patients subjective adverse events assessment: based on patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE).
Liu L, Suo T, Shen Y, Geng C, Song Z, Liu F, Wang J, Xie Y, Zhang Y, Tang T, Zhang L, Wang W
Qual Life Res 2020 Nov;29(11):3009-3015. Epub 2020 Jun 20 doi: 10.1007/s11136-020-02558-7. PMID: 32564293
Efficacy of venlafaxine for the relief of taxane and oxaliplatin-induced acute neurotoxicity: a single-center retrospective case-control study.
Kus T, Aktas G, Alpak G, Kalender ME, Sevinc A, Kul S, Temizer M, Camci C
Support Care Cancer 2016 May;24(5):2085-2091. Epub 2015 Nov 7 doi: 10.1007/s00520-015-3009-x. PMID: 26546457
Gastroduodenal complications after concurrent chemoradiation therapy in patients with hepatocellular carcinoma: endoscopic findings and risk factors.
Chon YE, Seong J, Kim BK, Cha J, Kim SU, Park JY, Ahn SH, Han KH, Chon CY, Shin SK, Kim DY
Int J Radiat Oncol Biol Phys 2011 Dec 1;81(5):1343-51. Epub 2010 Oct 8 doi: 10.1016/j.ijrobp.2010.07.1986. PMID: 20934268

Therapy

Pooled Safety Analysis of Single-Agent Lurbinectedin in Patients With Advanced Solid Tumours.
Leary A, Oaknin A, Trigo JM, Moreno V, Delord JP, Boni V, Braña I, Fernández C, Kahatt C, Nieto A, Cullell-Young M, Zeaiter A, Subbiah V
Eur J Cancer 2023 Oct;192:113259. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113259. PMID: 37634282
Phase I/II study of streptozocin monotherapy in Japanese patients with unresectable or metastatic gastroenteropancreatic neuroendocrine tumors.
Komoto I, Kokudo N, Aoki T, Morizane C, Ito T, Hashimoto T, Kimura W, Inoue N, Hasegawa K, Kondo S, Ueno H, Igarashi H, Oono T, Makuuchi M, Takamoto T, Hirai I, Takeshita A, Imamura M
Jpn J Clin Oncol 2022 Jul 8;52(7):716-724. doi: 10.1093/jjco/hyac048. PMID: 35411926Free PMC Article
A phase I trial of lurbinectedin in combination with cisplatin in patients with advanced solid tumors.
Metaxas Y, Kahatt C, Alfaro V, Fudio S, Zeaiter A, Plummer R, Sessa C, Von Moos R, Forster M, Stathis A
Invest New Drugs 2022 Feb;40(1):91-98. Epub 2021 Aug 28 doi: 10.1007/s10637-021-01142-1. PMID: 34453241
Olanzapine for the prophylaxis and rescue of chemotherapy-induced nausea and vomiting: a systematic review, meta-analysis, cumulative meta-analysis and fragility assessment of the literature.
Chow R, Herrstedt J, Aapro M, Chiu L, Lam H, Prsic E, Lock M, DeAngelis C, Navari RM
Support Care Cancer 2021 Jul;29(7):3439-3459. Epub 2021 Jan 13 doi: 10.1007/s00520-020-05935-7. PMID: 33442782Free PMC Article
Efficacy and safety of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis.
Yoodee J, Permsuwan U, Nimworapan M
Crit Rev Oncol Hematol 2017 Apr;112:113-125. Epub 2017 Feb 20 doi: 10.1016/j.critrevonc.2017.02.017. PMID: 28325253

Prognosis

Adverse drug events and contributing factors among pediatric cancer patients at Jimma University medical center, Southwest Ethiopia.
Tola WO, Melaku T, Fufa D, Sheleme T
BMC Pediatr 2023 Feb 13;23(1):77. doi: 10.1186/s12887-023-03891-9. PMID: 36782170Free PMC Article
Lack of Concordance in Symptomatic Adverse Event Reporting by Children, Clinicians, and Caregivers: Implications for Cancer Clinical Trials.
Freyer DR, Lin L, Mack JW, Maurer SH, McFatrich M, Baker JN, Jacobs SS, Lucas N, Withycombe JS, Tomlinson D, Villabroza KR, Waldron MK, Hinds PS, Reeve BB
J Clin Oncol 2022 May 20;40(15):1623-1634. Epub 2022 Mar 16 doi: 10.1200/JCO.21.02669. PMID: 35294262Free PMC Article
Phase II study of chidamide in combination with cisplatin in patients with metastatic triple-negative breast cancer.
Meng Y, Jin J, Gong C, Miao H, Tao Z, Li T, Cao J, Wang L, Wang B, Zhang J, Hu X
Ann Palliat Med 2021 Nov;10(11):11255-11264. Epub 2021 Oct 8 doi: 10.21037/apm-21-1139. PMID: 34670391
A phase I dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors.
Ferrarotto R, Eckhardt G, Patnaik A, LoRusso P, Faoro L, Heymach JV, Kapoun AM, Xu L, Munster P
Ann Oncol 2018 Jul 1;29(7):1561-1568. doi: 10.1093/annonc/mdy171. PMID: 29726923
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584

Clinical prediction guides

Hypnosis on patients treated with adjuvant chemotherapy for breast cancer: A feasibility study.
Fabbro M, Jacot W, Jarlier M, Guiu S, D'Hondt V, Pouderoux S, Champoiral P, Janiszewski C, Nicklès I
Cancer Rep (Hoboken) 2023 Jan;6(1):e1732. Epub 2022 Oct 27 doi: 10.1002/cnr2.1732. PMID: 36302744Free PMC Article
A phase I trial of lurbinectedin in combination with cisplatin in patients with advanced solid tumors.
Metaxas Y, Kahatt C, Alfaro V, Fudio S, Zeaiter A, Plummer R, Sessa C, Von Moos R, Forster M, Stathis A
Invest New Drugs 2022 Feb;40(1):91-98. Epub 2021 Aug 28 doi: 10.1007/s10637-021-01142-1. PMID: 34453241
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584
Efficacy and safety of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis.
Yoodee J, Permsuwan U, Nimworapan M
Crit Rev Oncol Hematol 2017 Apr;112:113-125. Epub 2017 Feb 20 doi: 10.1016/j.critrevonc.2017.02.017. PMID: 28325253
Palonosetron and dexamethasone for the prevention of nausea and vomiting in patients receiving allogeneic hematopoietic stem cell transplantation.
Yeh SP, Lo WC, Hsieh CY, Bai LY, Lin CC, Lin PH, Lin CY, Liao YM, Chiu CF
Support Care Cancer 2014 May;22(5):1199-206. Epub 2013 Dec 7 doi: 10.1007/s00520-013-2072-4. PMID: 24317849

Recent systematic reviews

Olanzapine for the prophylaxis and rescue of chemotherapy-induced nausea and vomiting: a systematic review, meta-analysis, cumulative meta-analysis and fragility assessment of the literature.
Chow R, Herrstedt J, Aapro M, Chiu L, Lam H, Prsic E, Lock M, DeAngelis C, Navari RM
Support Care Cancer 2021 Jul;29(7):3439-3459. Epub 2021 Jan 13 doi: 10.1007/s00520-020-05935-7. PMID: 33442782Free PMC Article
Efficacy and safety of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis.
Yoodee J, Permsuwan U, Nimworapan M
Crit Rev Oncol Hematol 2017 Apr;112:113-125. Epub 2017 Feb 20 doi: 10.1016/j.critrevonc.2017.02.017. PMID: 28325253

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