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Insect Stings, hypersensitivity to

MedGen UID:
327045
•Concept ID:
C1840171
•
Finding
Synonym: INSECT STINGS, HYPERSENSITIVITY TO
 
Monarch Initiative: MONDO:0007831
OMIM®: 147540

Clinical features

From HPO
Abnormality of the skin
MedGen UID:
1845238
•Concept ID:
C5848159
•
Anatomical Abnormality
An abnormality of the skin.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Anaphylaxis: A 2023 practice parameter update.
Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Abrams EM, Bernstein JA, Chu DK, Horner CC, Rank MA, Stukus DR; Collaborators, Burrows AG, Cruickshank H; Workgroup Contributors, Golden DBK, Wang J, Akin C, Campbell RL, Ellis AK, Greenhawt M, Lang DM, Ledford DK, Lieberman J, Oppenheimer J, Shaker MS, Wallace DV, Waserman S; Joint Task Force on Practice Parameters Reviewers, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Horner CC, Ledford DK, Lieberman J, Rank MA, Shaker MS, Stukus DR, Wang J
Ann Allergy Asthma Immunol 2024 Feb;132(2):124-176. Epub 2023 Dec 18 doi: 10.1016/j.anai.2023.09.015. PMID: 38108678
Update on mosquito bite reaction: Itch and hypersensitivity, pathophysiology, prevention, and treatment.
Vander Does A, Labib A, Yosipovitch G
Front Immunol 2022;13:1024559. Epub 2022 Sep 21 doi: 10.3389/fimmu.2022.1024559. PMID: 36211437Free PMC Article
Allergen immunotherapy: a practice parameter third update.
Cox L, Nelson H, Lockey R, Calabria C, Chacko T, Finegold I, Nelson M, Weber R, Bernstein DI, Blessing-Moore J, Khan DA, Lang DM, Nicklas RA, Oppenheimer J, Portnoy JM, Randolph C, Schuller DE, Spector SL, Tilles S, Wallace D
J Allergy Clin Immunol 2011 Jan;127(1 Suppl):S1-55. Epub 2010 Dec 3 doi: 10.1016/j.jaci.2010.09.034. PMID: 21122901

Recent clinical studies

Etiology

Approach to Patients with Stinging Insect Allergy.
Abrams EM, Golden DBK
Med Clin North Am 2020 Jan;104(1):129-143. Epub 2019 Oct 28 doi: 10.1016/j.mcna.2019.08.006. PMID: 31757231
Eosinophilic dermatoses.
Peckruhn M, Elsner P, Tittelbach J
J Dtsch Dermatol Ges 2019 Oct;17(10):1039-1051. Epub 2019 Sep 27 doi: 10.1111/ddg.13943. PMID: 31562692
Who needs to carry an epinephrine autoinjector?
Song TT, Lieberman P
Cleve Clin J Med 2019 Jan;86(1):66-72. doi: 10.3949/ccjm.86a.17123. PMID: 30624186
Hymenoptera venom immunotherapy.
Bilò BM, Bonifazi F
Immunotherapy 2011 Feb;3(2):229-46. doi: 10.2217/imt.10.88. PMID: 21322761
Hymenoptera venom allergy.
Przybilla B, Ruëff F
J Dtsch Dermatol Ges 2010 Feb;8(2):114-27; quiz 128-30. Epub 2009 Sep 14 doi: 10.1111/j.1610-0387.2009.07125.x. PMID: 19751222

Diagnosis

What's Eating You? Mosquitoes (Culicidae).
Andrews L, Ellis CR, Elston DM
Cutis 2022 Mar;109(3):126-128. doi: 10.12788/cutis.0472. PMID: 35659146
Approach to Patients with Stinging Insect Allergy.
Abrams EM, Golden DBK
Med Clin North Am 2020 Jan;104(1):129-143. Epub 2019 Oct 28 doi: 10.1016/j.mcna.2019.08.006. PMID: 31757231
Honeybee and wasp venom allergy: Sensitization and immunotherapy.
Adib-Tezer H, Bayerl C
J Dtsch Dermatol Ges 2018 Oct;16(10):1228-1247. doi: 10.1111/ddg.13670. PMID: 30300499
Venom Allergy.
Stitt J, Katial R
J Allergy Clin Immunol Pract 2016 Jan-Feb;4(1):184-5; quiz 186. doi: 10.1016/j.jaip.2015.09.016. PMID: 26772932
Mosquito allergy.
Crisp HC, Johnson KS
Ann Allergy Asthma Immunol 2013 Feb;110(2):65-9. doi: 10.1016/j.anai.2012.07.023. PMID: 23352522

Therapy

Venom immunotherapy: What is the rush?
Golden DBK, Tracy JM
Ann Allergy Asthma Immunol 2024 Oct;133(4):360-361. doi: 10.1016/j.anai.2024.07.021. PMID: 39293900
Approach to Patients with Stinging Insect Allergy.
Abrams EM, Golden DBK
Med Clin North Am 2020 Jan;104(1):129-143. Epub 2019 Oct 28 doi: 10.1016/j.mcna.2019.08.006. PMID: 31757231
Venom Allergy.
Stitt J, Katial R
J Allergy Clin Immunol Pract 2016 Jan-Feb;4(1):184-5; quiz 186. doi: 10.1016/j.jaip.2015.09.016. PMID: 26772932
Allergen immunotherapy: a practice parameter third update.
Cox L, Nelson H, Lockey R, Calabria C, Chacko T, Finegold I, Nelson M, Weber R, Bernstein DI, Blessing-Moore J, Khan DA, Lang DM, Nicklas RA, Oppenheimer J, Portnoy JM, Randolph C, Schuller DE, Spector SL, Tilles S, Wallace D
J Allergy Clin Immunol 2011 Jan;127(1 Suppl):S1-55. Epub 2010 Dec 3 doi: 10.1016/j.jaci.2010.09.034. PMID: 21122901
Lepidopterism.
Lancet 1979 Mar 3;1(8114):480-1. PMID: 85063

Prognosis

Venom immunotherapy: an updated review.
Antolín-Amérigo D, Moreno Aguilar C, Vega A, Alvarez-Mon M
Curr Allergy Asthma Rep 2014 Jul;14(7):449. doi: 10.1007/s11882-014-0449-1. PMID: 24934908
Hymenoptera venom allergy.
Przybilla B, Ruëff F
J Dtsch Dermatol Ges 2010 Feb;8(2):114-27; quiz 128-30. Epub 2009 Sep 14 doi: 10.1111/j.1610-0387.2009.07125.x. PMID: 19751222
Cardiovascular disease and anaphylaxis.
Mueller UR
Curr Opin Allergy Clin Immunol 2007 Aug;7(4):337-41. doi: 10.1097/ACI.0b013e328259c328. PMID: 17620826
Insect sting allergy.
Graft DF
Med Clin North Am 2006 Jan;90(1):211-32. doi: 10.1016/j.mcna.2005.08.006. PMID: 16310531
Anaphylaxis.
Sheffer AL
J Allergy Clin Immunol 1985 Feb;75(2):227-33. doi: 10.1016/0091-6749(85)90048-x. PMID: 3968334

Clinical prediction guides

Venom allergen immunotherapy.
Golden DBK
Allergy Asthma Proc 2022 Jul 1;43(4):339-343. doi: 10.2500/aap.2022.43.210109. PMID: 35818146
Hymenoptera venom allergy.
Przybilla B, Ruëff F
J Dtsch Dermatol Ges 2010 Feb;8(2):114-27; quiz 128-30. Epub 2009 Sep 14 doi: 10.1111/j.1610-0387.2009.07125.x. PMID: 19751222
Insect sting allergy.
Graft DF
Med Clin North Am 2006 Jan;90(1):211-32. doi: 10.1016/j.mcna.2005.08.006. PMID: 16310531
A practical guide to anaphylaxis.
Tang AW
Am Fam Physician 2003 Oct 1;68(7):1325-32. PMID: 14567487
Wasp sting anaphylaxis.
Ratnoff OD, Nossel HL
Blood 1983 Jan;61(1):132-9. PMID: 6336652

Recent systematic reviews

Evidence-based data support strategies for the prevention of Hymenoptera venom anaphylaxis.
Kamga A, Bourrain JL, Demoly P, Tanno LK
Curr Opin Allergy Clin Immunol 2024 Oct 1;24(5):330-340. Epub 2024 Jul 22 doi: 10.1097/ACI.0000000000001011. PMID: 39052760
Allergen immunotherapy for insect venom allergy: a systematic review and meta-analysis.
Dhami S, Zaman H, Varga EM, Sturm GJ, Muraro A, Akdis CA, Antolín-Amérigo D, Bilò MB, Bokanovic D, Calderon MA, Cichocka-Jarosz E, Oude Elberink JN, Gawlik R, Jakob T, Kosnik M, Lange J, Mingomataj E, Mitsias DI, Mosbech H, Ollert M, Pfaar O, Pitsios C, Pravettoni V, Roberts G, Ruëff F, Sin BA, Asaria M, Netuveli G, Sheikh A
Allergy 2017 Mar;72(3):342-365. Epub 2017 Jan 25 doi: 10.1111/all.13077. PMID: 28120424
Insect bite reactions.
Singh S, Mann BK
Indian J Dermatol Venereol Leprol 2013 Mar-Apr;79(2):151-64. doi: 10.4103/0378-6323.107629. PMID: 23442453
Safety of hymenoptera venom immunotherapy: a systematic review.
Incorvaia C, Frati F, Dell'Albani I, Robino A, Cattaneo E, Mauro M, David M, Qualizza R, Pastorello E
Expert Opin Pharmacother 2011 Nov;12(16):2527-32. Epub 2011 Sep 2 doi: 10.1517/14656566.2011.616494. PMID: 21883032
Specific immunotherapy using Hymenoptera venom: systematic review.
Watanabe AS, Fonseca LA, Galvão CE, Kalil J, Castro FF
Sao Paulo Med J 2010 Jan;128(1):30-7. doi: 10.1590/s1516-31802010000100007. PMID: 20512278Free PMC Article

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