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Metatarsal diaphyseal endosteal sclerosis

MedGen UID:
Concept ID:
HPO: HP:0008114


Osteosclerosis of the endosteal surface of the diaphyses (shafts) of the metatarsal bones. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetatarsal diaphyseal endosteal sclerosis

Conditions with this feature

Worth disease
MedGen UID:
Concept ID:
Disease or Syndrome
Autosomal dominant endosteal hyperostosis is a generalized bone dysplasia characterized by a cortical thickening of the long bones, with no alteration in external shape, and a remarkable resistance of the bone to fracture. The skeleton is normal in childhood. Facial metamorphoses occur in adolescence, as the forehead flattens, the mandible becomes elongated, and the gonial angle decreases. An enlarging osseous prominence (torus palatinus) develops in the hard palate, which may lead to malocclusion or loss of teeth (summary by Van Wesenbeeck et al., 2003).

Recent clinical studies


Gorlin RJ, Glass L
Radiology 1977 Nov;125(2):547-8. doi: 10.1148/125.2.547. PMID: 198847

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