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Orthostatic hypotensive disorder, Streeten type

MedGen UID:
327101
Concept ID:
C1840438
Disease or Syndrome
Synonyms: HYPERBRADYKININISM; ORTHOSTATIC HYPOTENSIVE DISORDER
 
Monarch Initiative: MONDO:0007746
OMIM®: 143850

Clinical features

From HPO
Syncope
MedGen UID:
21443
Concept ID:
C0039070
Sign or Symptom
Syncope is a syndrome in which loss of consciousness is of relatively sudden onset, temporary (usually less than 1 to 2 minutes), self-terminating, and of usually rapid recovery. Syncope leads to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow.
Orthostatic hypotension
MedGen UID:
43803
Concept ID:
C0020651
Disease or Syndrome
A form of hypotension characterized by a sudden fall in blood pressure that occurs when a person assumes a standing position.
Facial erythema
MedGen UID:
65986
Concept ID:
C0239488
Finding
Redness of the skin of the face, caused by hyperemia of the capillaries in the lower layers of the skin.
Bruising susceptibility
MedGen UID:
140849
Concept ID:
C0423798
Finding
An ecchymosis (bruise) refers to the skin discoloration caused by the escape of blood into the tissues from ruptured blood vessels. This term refers to an abnormally increased susceptibility to bruising. The corresponding phenotypic abnormality is generally elicited on medical history as a report of frequent ecchymoses or bruising without adequate trauma.

Professional guidelines

PubMed

Eschlböck S, Wenning G, Fanciulli A
J Neural Transm (Vienna) 2017 Dec;124(12):1567-1605. Epub 2017 Oct 22 doi: 10.1007/s00702-017-1791-y. PMID: 29058089Free PMC Article

Recent clinical studies

Diagnosis

Maerckx C, Tondreau T, Berardis S, van Pelt J, Najimi M, Sokal E
World J Gastroenterol 2014 Aug 14;20(30):10553-63. doi: 10.3748/wjg.v20.i30.10553. PMID: 25132775Free PMC Article

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