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Grade 3 Dysphagia, CTCAE

MedGen UID:
327207
•Concept ID:
C1560334
•
Finding
Synonym: CTCAE Grade 3 Dysphagia (difficulty swallowing)

Definition

Severely altered eating/swallowing; tube feeding, TPN, or hospitalization indicated [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Dysphagia, CTCAE

Professional guidelines

PubMed

Effects of treatment intensification on acute local toxicity during radiotherapy for head and neck cancer: prospective observational study validating CTCAE, version 3.0, scoring system.
Palazzi M, Tomatis S, Orlandi E, Guzzo M, Sangalli C, Potepan P, Fantini S, Bergamini C, Gavazzi C, Licitra L, Scaramellini G, Cantu' G, Olmi P
Int J Radiat Oncol Biol Phys 2008 Feb 1;70(2):330-7. Epub 2007 Sep 19 doi: 10.1016/j.ijrobp.2007.06.022. PMID: 17881148

Recent clinical studies

Etiology

Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1.
Forner LE, Dieleman FJ, Shaw RJ, Kanatas A, Butterworth CJ, Kjeller G, Alsner J, Overgaard J, Hillerup S, Hyldegaard O, Arnell P, von Buchwald C, Kaanders JHAM, Smeele LE, Specht L, Johansen J, Witjes MJH, Merkx MAW, Jansen EC
Radiother Oncol 2022 Jan;166:137-144. Epub 2021 Nov 26 doi: 10.1016/j.radonc.2021.11.021. PMID: 34843843
The efficacy and safety of definitive concurrent chemoradiotherapy for non-operable esophageal cancer.
Dreyfuss AD, Barsky AR, Wileyto EP, Eads JR, Kucharczuk JC, Williams NN, Karasic TB, Metz JM, Ben-Josef E, Plastaras JP, Wojcieszynski AP
Cancer Med 2021 Feb;10(4):1275-1288. Epub 2021 Jan 20 doi: 10.1002/cam4.3724. PMID: 33474812Free PMC Article
Radiotherapy for cutaneous head and neck cancer and parotid tumours: a prospective investigation of treatment-related acute swallowing and toxicity patterns.
Moroney LB, Helios J, Ward EC, Crombie J, Burns CL, Yeo SQ, Pelecanos A, Spurgin AL, Blake C, Kenny L, Chua B, Hughes BGM
Support Care Cancer 2019 Feb;27(2):573-581. Epub 2018 Jul 17 doi: 10.1007/s00520-018-4352-5. PMID: 30019149
Grading Dysphagia as a Toxicity of Head and Neck Cancer: Differences in Severity Classification Based on MBS DIGEST and Clinical CTCAE Grades.
Goepfert RP, Lewin JS, Barrow MP, Warneke CL, Fuller CD, Lai SY, Weber RS, Hutcheson KA
Dysphagia 2018 Apr;33(2):185-191. Epub 2017 Aug 23 doi: 10.1007/s00455-017-9843-x. PMID: 28836005Free PMC Article
Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT±concurrent chemotherapy.
Moroney LB, Helios J, Ward EC, Crombie J, Wockner LF, Burns CL, Spurgin AL, Blake C, Kenny L, Hughes BG
Oral Oncol 2017 Jan;64:1-8. Epub 2016 Nov 25 doi: 10.1016/j.oraloncology.2016.11.009. PMID: 28024718

Diagnosis

Primary and adjuvant intensity-modulated radiotherapy in oropharyngeal carcinoma patients from a single institution.
Hauswald H, Petrow E, Roeder F, Debus J, Zwicker F, Huber PE
J Cancer Res Ther 2024 Jan 1;20(1):375-382. Epub 2023 Apr 4 doi: 10.4103/jcrt.jcrt_2178_22. PMID: 38554349
Preliminary clinical outcomes of head and neck squamous cell carcinoma treated with particle beam radiation therapy.
Huang Q, Hu J, Hu W, Gao J, Yang J, Qiu X, Zhang H, Lu JJ, Kong L
Cancer Med 2023 Jun;12(11):12128-12138. Epub 2023 Apr 11 doi: 10.1002/cam4.5902. PMID: 37039275Free PMC Article
Grading Dysphagia as a Toxicity of Head and Neck Cancer: Differences in Severity Classification Based on MBS DIGEST and Clinical CTCAE Grades.
Goepfert RP, Lewin JS, Barrow MP, Warneke CL, Fuller CD, Lai SY, Weber RS, Hutcheson KA
Dysphagia 2018 Apr;33(2):185-191. Epub 2017 Aug 23 doi: 10.1007/s00455-017-9843-x. PMID: 28836005Free PMC Article
Acute toxicity in nasopharyngeal carcinoma patients treated with IMRT/VMAT.
Ozdemir S, Akin M, Coban Y, Yildirim C, Uzel O
Asian Pac J Cancer Prev 2015;16(5):1897-900. doi: 10.7314/apjcp.2015.16.5.1897. PMID: 25773841
Evolution of neurological impairment in pediatric infratentorial ependymoma patients.
Morris EB, Li C, Khan RB, Sanford RA, Boop F, Pinlac R, Xiong X, Merchant TE
J Neurooncol 2009 Sep;94(3):391-8. Epub 2009 Mar 29 doi: 10.1007/s11060-009-9866-8. PMID: 19330288Free PMC Article

Therapy

Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1.
Forner LE, Dieleman FJ, Shaw RJ, Kanatas A, Butterworth CJ, Kjeller G, Alsner J, Overgaard J, Hillerup S, Hyldegaard O, Arnell P, von Buchwald C, Kaanders JHAM, Smeele LE, Specht L, Johansen J, Witjes MJH, Merkx MAW, Jansen EC
Radiother Oncol 2022 Jan;166:137-144. Epub 2021 Nov 26 doi: 10.1016/j.radonc.2021.11.021. PMID: 34843843
The efficacy and safety of definitive concurrent chemoradiotherapy for non-operable esophageal cancer.
Dreyfuss AD, Barsky AR, Wileyto EP, Eads JR, Kucharczuk JC, Williams NN, Karasic TB, Metz JM, Ben-Josef E, Plastaras JP, Wojcieszynski AP
Cancer Med 2021 Feb;10(4):1275-1288. Epub 2021 Jan 20 doi: 10.1002/cam4.3724. PMID: 33474812Free PMC Article
Patient-Reported Outcome Measures and Dosimetric Correlates for Early Detection of Acute Radiation Therapy-Related Esophagitis.
Voong KR, Han P, Hales R, Hill C, Friedes C, McNutt T, Lee S, Snyder C
Pract Radiat Oncol 2021 May-Jun;11(3):185-192. Epub 2020 Oct 31 doi: 10.1016/j.prro.2020.10.009. PMID: 33137465
Grading Dysphagia as a Toxicity of Head and Neck Cancer: Differences in Severity Classification Based on MBS DIGEST and Clinical CTCAE Grades.
Goepfert RP, Lewin JS, Barrow MP, Warneke CL, Fuller CD, Lai SY, Weber RS, Hutcheson KA
Dysphagia 2018 Apr;33(2):185-191. Epub 2017 Aug 23 doi: 10.1007/s00455-017-9843-x. PMID: 28836005Free PMC Article
Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT±concurrent chemotherapy.
Moroney LB, Helios J, Ward EC, Crombie J, Wockner LF, Burns CL, Spurgin AL, Blake C, Kenny L, Hughes BG
Oral Oncol 2017 Jan;64:1-8. Epub 2016 Nov 25 doi: 10.1016/j.oraloncology.2016.11.009. PMID: 28024718

Prognosis

Primary and adjuvant intensity-modulated radiotherapy in oropharyngeal carcinoma patients from a single institution.
Hauswald H, Petrow E, Roeder F, Debus J, Zwicker F, Huber PE
J Cancer Res Ther 2024 Jan 1;20(1):375-382. Epub 2023 Apr 4 doi: 10.4103/jcrt.jcrt_2178_22. PMID: 38554349
Preliminary clinical outcomes of head and neck squamous cell carcinoma treated with particle beam radiation therapy.
Huang Q, Hu J, Hu W, Gao J, Yang J, Qiu X, Zhang H, Lu JJ, Kong L
Cancer Med 2023 Jun;12(11):12128-12138. Epub 2023 Apr 11 doi: 10.1002/cam4.5902. PMID: 37039275Free PMC Article
The efficacy and safety of definitive concurrent chemoradiotherapy for non-operable esophageal cancer.
Dreyfuss AD, Barsky AR, Wileyto EP, Eads JR, Kucharczuk JC, Williams NN, Karasic TB, Metz JM, Ben-Josef E, Plastaras JP, Wojcieszynski AP
Cancer Med 2021 Feb;10(4):1275-1288. Epub 2021 Jan 20 doi: 10.1002/cam4.3724. PMID: 33474812Free PMC Article
Helical intensity-modulated radiotherapy with concurrent chemotherapy for oropharyngeal squamous cell carcinoma: A prospective investigation of acute swallowing and toxicity patterns.
Moroney LB, Helios J, Ward EC, Crombie J, Pelecanos A, Burns CL, Spurgin AL, Blake C, Kenny L, Chua B, Hughes BGM
Head Neck 2018 Sep;40(9):1955-1966. Epub 2018 May 13 doi: 10.1002/hed.25182. PMID: 29756244
Effects of treatment intensification on acute local toxicity during radiotherapy for head and neck cancer: prospective observational study validating CTCAE, version 3.0, scoring system.
Palazzi M, Tomatis S, Orlandi E, Guzzo M, Sangalli C, Potepan P, Fantini S, Bergamini C, Gavazzi C, Licitra L, Scaramellini G, Cantu' G, Olmi P
Int J Radiat Oncol Biol Phys 2008 Feb 1;70(2):330-7. Epub 2007 Sep 19 doi: 10.1016/j.ijrobp.2007.06.022. PMID: 17881148

Clinical prediction guides

Preliminary clinical outcomes of head and neck squamous cell carcinoma treated with particle beam radiation therapy.
Huang Q, Hu J, Hu W, Gao J, Yang J, Qiu X, Zhang H, Lu JJ, Kong L
Cancer Med 2023 Jun;12(11):12128-12138. Epub 2023 Apr 11 doi: 10.1002/cam4.5902. PMID: 37039275Free PMC Article
Radiotherapy for cutaneous head and neck cancer and parotid tumours: a prospective investigation of treatment-related acute swallowing and toxicity patterns.
Moroney LB, Helios J, Ward EC, Crombie J, Burns CL, Yeo SQ, Pelecanos A, Spurgin AL, Blake C, Kenny L, Chua B, Hughes BGM
Support Care Cancer 2019 Feb;27(2):573-581. Epub 2018 Jul 17 doi: 10.1007/s00520-018-4352-5. PMID: 30019149
Patterns of dysphagia and acute toxicities in patients with head and neck cancer undergoing helical IMRT±concurrent chemotherapy.
Moroney LB, Helios J, Ward EC, Crombie J, Wockner LF, Burns CL, Spurgin AL, Blake C, Kenny L, Hughes BG
Oral Oncol 2017 Jan;64:1-8. Epub 2016 Nov 25 doi: 10.1016/j.oraloncology.2016.11.009. PMID: 28024718
Continuous hyperfractionated accelerated radiotherapy - Escalated dose (CHART-ED): A phase I study.
Hatton MQ, Hill R, Fenwick JD, Morgan SA, Wilson PC, Atherton PJ, Dickson J, Murray KE, Paul J
Radiother Oncol 2016 Mar;118(3):471-7. Epub 2015 Dec 11 doi: 10.1016/j.radonc.2015.11.015. PMID: 26687902
Acute toxicity in nasopharyngeal carcinoma patients treated with IMRT/VMAT.
Ozdemir S, Akin M, Coban Y, Yildirim C, Uzel O
Asian Pac J Cancer Prev 2015;16(5):1897-900. doi: 10.7314/apjcp.2015.16.5.1897. PMID: 25773841

Recent systematic reviews

Dysphagia optimized radiotherapy to reduce swallowing dysfunction severity in patients undergoing treatment for head and neck cancer: A systematized scoping review.
Hutchison AR, Cartmill B, Wall LR, Ward EC
Head Neck 2019 Jun;41(6):2024-2033. Epub 2019 Feb 5 doi: 10.1002/hed.25688. PMID: 30723986

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