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Grade 5 Dysphagia, CTCAE

MedGen UID:
327208
•Concept ID:
C1560336
•
Finding
Synonym: CTCAE Grade 5 Dysphagia (difficulty swallowing)

Definition

Death [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 5 Dysphagia, CTCAE

Recent clinical studies

Etiology

Preliminary clinical outcomes of head and neck squamous cell carcinoma treated with particle beam radiation therapy.
Huang Q, Hu J, Hu W, Gao J, Yang J, Qiu X, Zhang H, Lu JJ, Kong L
Cancer Med 2023 Jun;12(11):12128-12138. Epub 2023 Apr 11 doi: 10.1002/cam4.5902. PMID: 37039275Free PMC Article
The efficacy and safety of definitive concurrent chemoradiotherapy for non-operable esophageal cancer.
Dreyfuss AD, Barsky AR, Wileyto EP, Eads JR, Kucharczuk JC, Williams NN, Karasic TB, Metz JM, Ben-Josef E, Plastaras JP, Wojcieszynski AP
Cancer Med 2021 Feb;10(4):1275-1288. Epub 2021 Jan 20 doi: 10.1002/cam4.3724. PMID: 33474812Free PMC Article
Cisplatin and 5-fluorouracil with or without epidermal growth factor receptor inhibition panitumumab for patients with non-resectable, advanced or metastatic oesophageal squamous cell cancer: a prospective, open-label, randomised phase III AIO/EORTC trial (POWER).
Moehler M, Maderer A, Thuss-Patience PC, Brenner B, Meiler J, Ettrich TJ, Hofheinz RD, Al-Batran SE, Vogel A, Mueller L, Lutz MP, Lordick F, Alsina M, Borchert K, Greil R, Eisterer W, Schad A, Slotta-Huspenina J, Van Cutsem E, Lorenzen S
Ann Oncol 2020 Feb;31(2):228-235. Epub 2019 Dec 16 doi: 10.1016/j.annonc.2019.10.018. PMID: 31959339
Dynamic Imaging Grade of Swallowing Toxicity (DIGEST): Scale development and validation.
Hutcheson KA, Barrow MP, Barringer DA, Knott JK, Lin HY, Weber RS, Fuller CD, Lai SY, Alvarez CP, Raut J, Lazarus CL, May A, Patterson J, Roe JW, Starmer HM, Lewin JS
Cancer 2017 Jan 1;123(1):62-70. Epub 2016 Aug 26 doi: 10.1002/cncr.30283. PMID: 27564246Free PMC Article
Acute toxicity in nasopharyngeal carcinoma patients treated with IMRT/VMAT.
Ozdemir S, Akin M, Coban Y, Yildirim C, Uzel O
Asian Pac J Cancer Prev 2015;16(5):1897-900. doi: 10.7314/apjcp.2015.16.5.1897. PMID: 25773841

Diagnosis

Primary and adjuvant intensity-modulated radiotherapy in oropharyngeal carcinoma patients from a single institution.
Hauswald H, Petrow E, Roeder F, Debus J, Zwicker F, Huber PE
J Cancer Res Ther 2024 Jan 1;20(1):375-382. Epub 2023 Apr 4 doi: 10.4103/jcrt.jcrt_2178_22. PMID: 38554349
Preliminary clinical outcomes of head and neck squamous cell carcinoma treated with particle beam radiation therapy.
Huang Q, Hu J, Hu W, Gao J, Yang J, Qiu X, Zhang H, Lu JJ, Kong L
Cancer Med 2023 Jun;12(11):12128-12138. Epub 2023 Apr 11 doi: 10.1002/cam4.5902. PMID: 37039275Free PMC Article
A randomized phase II/III study of adverse events between sequential (SEQ) versus simultaneous integrated boost (SIB) intensity modulated radiation therapy (IMRT) in nasopharyngeal carcinoma; preliminary result on acute adverse events.
Songthong AP, Kannarunimit D, Chakkabat C, Lertbutsayanukul C
Radiat Oncol 2015 Aug 8;10:166. doi: 10.1186/s13014-015-0472-y. PMID: 26253488Free PMC Article
Acute toxicity in nasopharyngeal carcinoma patients treated with IMRT/VMAT.
Ozdemir S, Akin M, Coban Y, Yildirim C, Uzel O
Asian Pac J Cancer Prev 2015;16(5):1897-900. doi: 10.7314/apjcp.2015.16.5.1897. PMID: 25773841
Evolution of neurological impairment in pediatric infratentorial ependymoma patients.
Morris EB, Li C, Khan RB, Sanford RA, Boop F, Pinlac R, Xiong X, Merchant TE
J Neurooncol 2009 Sep;94(3):391-8. Epub 2009 Mar 29 doi: 10.1007/s11060-009-9866-8. PMID: 19330288Free PMC Article

Therapy

Simultaneous integrated boost concepts in definitive radiation therapy for esophageal cancer: outcomes and toxicity.
Ristau J, Thiel M, Katayama S, Schlampp I, Lang K, Häfner MF, Herfarth K, Debus J, Koerber SA
Radiat Oncol 2021 Feb 1;16(1):23. doi: 10.1186/s13014-021-01749-x. PMID: 33522923Free PMC Article
The efficacy and safety of definitive concurrent chemoradiotherapy for non-operable esophageal cancer.
Dreyfuss AD, Barsky AR, Wileyto EP, Eads JR, Kucharczuk JC, Williams NN, Karasic TB, Metz JM, Ben-Josef E, Plastaras JP, Wojcieszynski AP
Cancer Med 2021 Feb;10(4):1275-1288. Epub 2021 Jan 20 doi: 10.1002/cam4.3724. PMID: 33474812Free PMC Article
Patient-Reported Outcome Measures and Dosimetric Correlates for Early Detection of Acute Radiation Therapy-Related Esophagitis.
Voong KR, Han P, Hales R, Hill C, Friedes C, McNutt T, Lee S, Snyder C
Pract Radiat Oncol 2021 May-Jun;11(3):185-192. Epub 2020 Oct 31 doi: 10.1016/j.prro.2020.10.009. PMID: 33137465
Cisplatin and 5-fluorouracil with or without epidermal growth factor receptor inhibition panitumumab for patients with non-resectable, advanced or metastatic oesophageal squamous cell cancer: a prospective, open-label, randomised phase III AIO/EORTC trial (POWER).
Moehler M, Maderer A, Thuss-Patience PC, Brenner B, Meiler J, Ettrich TJ, Hofheinz RD, Al-Batran SE, Vogel A, Mueller L, Lutz MP, Lordick F, Alsina M, Borchert K, Greil R, Eisterer W, Schad A, Slotta-Huspenina J, Van Cutsem E, Lorenzen S
Ann Oncol 2020 Feb;31(2):228-235. Epub 2019 Dec 16 doi: 10.1016/j.annonc.2019.10.018. PMID: 31959339
Dynamic Imaging Grade of Swallowing Toxicity (DIGEST): Scale development and validation.
Hutcheson KA, Barrow MP, Barringer DA, Knott JK, Lin HY, Weber RS, Fuller CD, Lai SY, Alvarez CP, Raut J, Lazarus CL, May A, Patterson J, Roe JW, Starmer HM, Lewin JS
Cancer 2017 Jan 1;123(1):62-70. Epub 2016 Aug 26 doi: 10.1002/cncr.30283. PMID: 27564246Free PMC Article

Prognosis

Primary and adjuvant intensity-modulated radiotherapy in oropharyngeal carcinoma patients from a single institution.
Hauswald H, Petrow E, Roeder F, Debus J, Zwicker F, Huber PE
J Cancer Res Ther 2024 Jan 1;20(1):375-382. Epub 2023 Apr 4 doi: 10.4103/jcrt.jcrt_2178_22. PMID: 38554349
Preliminary clinical outcomes of head and neck squamous cell carcinoma treated with particle beam radiation therapy.
Huang Q, Hu J, Hu W, Gao J, Yang J, Qiu X, Zhang H, Lu JJ, Kong L
Cancer Med 2023 Jun;12(11):12128-12138. Epub 2023 Apr 11 doi: 10.1002/cam4.5902. PMID: 37039275Free PMC Article
The efficacy and safety of definitive concurrent chemoradiotherapy for non-operable esophageal cancer.
Dreyfuss AD, Barsky AR, Wileyto EP, Eads JR, Kucharczuk JC, Williams NN, Karasic TB, Metz JM, Ben-Josef E, Plastaras JP, Wojcieszynski AP
Cancer Med 2021 Feb;10(4):1275-1288. Epub 2021 Jan 20 doi: 10.1002/cam4.3724. PMID: 33474812Free PMC Article
Helical intensity-modulated radiotherapy with concurrent chemotherapy for oropharyngeal squamous cell carcinoma: A prospective investigation of acute swallowing and toxicity patterns.
Moroney LB, Helios J, Ward EC, Crombie J, Pelecanos A, Burns CL, Spurgin AL, Blake C, Kenny L, Chua B, Hughes BGM
Head Neck 2018 Sep;40(9):1955-1966. Epub 2018 May 13 doi: 10.1002/hed.25182. PMID: 29756244
Dynamic Imaging Grade of Swallowing Toxicity (DIGEST): Scale development and validation.
Hutcheson KA, Barrow MP, Barringer DA, Knott JK, Lin HY, Weber RS, Fuller CD, Lai SY, Alvarez CP, Raut J, Lazarus CL, May A, Patterson J, Roe JW, Starmer HM, Lewin JS
Cancer 2017 Jan 1;123(1):62-70. Epub 2016 Aug 26 doi: 10.1002/cncr.30283. PMID: 27564246Free PMC Article

Clinical prediction guides

Toxicities and clinical outcome of adjuvant dysphagia optimized versus standard intensity-modulated radiotherapy for post-operative oral cavity cancers: A prospective comparative study.
Patni A, Rastogi M, Gandhi AK, Mishra VK, Srivastava AK, Sharma V, Agarwal A, Khurana R, Hadi R, Sapru S, Mishra SP
Head Neck 2023 Dec;45(12):3119-3128. Epub 2023 Oct 10 doi: 10.1002/hed.27541. PMID: 37814926
Preliminary clinical outcomes of head and neck squamous cell carcinoma treated with particle beam radiation therapy.
Huang Q, Hu J, Hu W, Gao J, Yang J, Qiu X, Zhang H, Lu JJ, Kong L
Cancer Med 2023 Jun;12(11):12128-12138. Epub 2023 Apr 11 doi: 10.1002/cam4.5902. PMID: 37039275Free PMC Article
Dynamic Imaging Grade of Swallowing Toxicity (DIGEST): Scale development and validation.
Hutcheson KA, Barrow MP, Barringer DA, Knott JK, Lin HY, Weber RS, Fuller CD, Lai SY, Alvarez CP, Raut J, Lazarus CL, May A, Patterson J, Roe JW, Starmer HM, Lewin JS
Cancer 2017 Jan 1;123(1):62-70. Epub 2016 Aug 26 doi: 10.1002/cncr.30283. PMID: 27564246Free PMC Article
Continuous hyperfractionated accelerated radiotherapy - Escalated dose (CHART-ED): A phase I study.
Hatton MQ, Hill R, Fenwick JD, Morgan SA, Wilson PC, Atherton PJ, Dickson J, Murray KE, Paul J
Radiother Oncol 2016 Mar;118(3):471-7. Epub 2015 Dec 11 doi: 10.1016/j.radonc.2015.11.015. PMID: 26687902
Acute toxicity in nasopharyngeal carcinoma patients treated with IMRT/VMAT.
Ozdemir S, Akin M, Coban Y, Yildirim C, Uzel O
Asian Pac J Cancer Prev 2015;16(5):1897-900. doi: 10.7314/apjcp.2015.16.5.1897. PMID: 25773841

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