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Grade 5 Esophagitis, CTCAE

MedGen UID:
327210
•Concept ID:
C1560347
•
Finding

Definition

Death [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 5 Esophagitis, CTCAE

Recent clinical studies

Etiology

Chemoradiation for elderly patients (≥ 65 years) with esophageal cancer: a retrospective single-center analysis.
Linde P, Mallmann M, Adams A, Wegen S, Rosenbrock J, Trommer M, Marnitz S, Baues C, Celik E
Radiat Oncol 2022 Nov 17;17(1):187. doi: 10.1186/s13014-022-02160-w. PMID: 36397163Free PMC Article
The efficacy and safety of definitive concurrent chemoradiotherapy for non-operable esophageal cancer.
Dreyfuss AD, Barsky AR, Wileyto EP, Eads JR, Kucharczuk JC, Williams NN, Karasic TB, Metz JM, Ben-Josef E, Plastaras JP, Wojcieszynski AP
Cancer Med 2021 Feb;10(4):1275-1288. Epub 2021 Jan 20 doi: 10.1002/cam4.3724. PMID: 33474812Free PMC Article
Risk factors for esophagitis after hypofractionated palliative (chemo) radiotherapy for non-small cell lung cancer.
Nieder C, Imingen KS, Mannsåker B, Yobuta R, Haukland E
Radiat Oncol 2020 May 1;15(1):91. doi: 10.1186/s13014-020-01550-2. PMID: 32357936Free PMC Article
Cisplatin and 5-fluorouracil with or without epidermal growth factor receptor inhibition panitumumab for patients with non-resectable, advanced or metastatic oesophageal squamous cell cancer: a prospective, open-label, randomised phase III AIO/EORTC trial (POWER).
Moehler M, Maderer A, Thuss-Patience PC, Brenner B, Meiler J, Ettrich TJ, Hofheinz RD, Al-Batran SE, Vogel A, Mueller L, Lutz MP, Lordick F, Alsina M, Borchert K, Greil R, Eisterer W, Schad A, Slotta-Huspenina J, Van Cutsem E, Lorenzen S
Ann Oncol 2020 Feb;31(2):228-235. Epub 2019 Dec 16 doi: 10.1016/j.annonc.2019.10.018. PMID: 31959339
Digestive toxicities after palliative three-dimensional conformal radiation therapy (3D-CRT) for cervico-thoracic spinal metastases.
Peyraga G, Caron D, Lizee T, Metayer Y, Septans AL, Pointreau Y, Denis F, Ganem G, Lafond C, Roche S, Dupuis O
Support Care Cancer 2018 Jun;26(6):1897-1903. Epub 2017 Dec 23 doi: 10.1007/s00520-017-4001-4. PMID: 29275524

Diagnosis

Cardiac substructures dosimetric predicts cardiac toxicity and prognosis in esophageal squamous cell cancer treated by radiotherapy.
Jin Z, Sun X, Zhou C, Yang H, Zhou S
Neoplasia 2024 Feb;48:100969. Epub 2024 Jan 10 doi: 10.1016/j.neo.2024.100969. PMID: 38199173Free PMC Article
Efficacy of Endoscopic Evaluation of Acute Radiation Esophagitis during Chemoradiotherapy with Proton Beam Therapy Boost for Esophageal Cancer.
Hasatani K, Tamamura H, Yamamoto K, Aoyagi H, Miyanaga T, Kaizaki Y, Sawada T
Digestion 2020;101(4):366-374. Epub 2019 May 8 doi: 10.1159/000500039. PMID: 31067539Free PMC Article
Simultaneous integrated boost intensity-modulated radiotherapy in esophageal carcinoma: early results of a phase II study.
Yu WW, Zhu ZF, Fu XL, Zhao KL, Mao JF, Wu KL, Yang HJ, Fan M, Zhao S, Welsh J
Strahlenther Onkol 2014 Oct;190(11):979-86. Epub 2014 Mar 8 doi: 10.1007/s00066-014-0636-y. PMID: 24609941
Fasting and cancer treatment in humans: A case series report.
Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD
Aging (Albany NY) 2009 Dec 31;1(12):988-1007. doi: 10.18632/aging.100114. PMID: 20157582Free PMC Article

Therapy

Perioperative therapy with FLOT4 significantly increases survival in patients with gastroesophageal and gastric cancer in a large real-world cohort.
Möhring C, Mańczak A, Timotheou A, Sadeghlar F, Zhou T, Mahn R, Monin MB, Toma M, Feldmann G, Brossart P, Köksal M, Sarria GR, Sommer N, Lingohr P, Jafari A, Kalff JC, Strassburg CP, Gonzalez-Carmona MA
Int J Cancer 2023 Aug 1;153(3):609-622. Epub 2023 May 5 doi: 10.1002/ijc.34511. PMID: 36919950
Chemoradiation for elderly patients (≥ 65 years) with esophageal cancer: a retrospective single-center analysis.
Linde P, Mallmann M, Adams A, Wegen S, Rosenbrock J, Trommer M, Marnitz S, Baues C, Celik E
Radiat Oncol 2022 Nov 17;17(1):187. doi: 10.1186/s13014-022-02160-w. PMID: 36397163Free PMC Article
Phase II Trial of Flaxseed to Prevent Acute Complications After Chemoradiation for Lung Cancer.
Lim TL, Pietrofesa RA, Arguiri E, Koumenis C, Feigenberg S, Simone CB 2nd, Rengan R, Cengel K, Levin WP, Christofidou-Solomidou M, Berman AT
J Altern Complement Med 2021 Oct;27(10):824-831. Epub 2021 Jun 23 doi: 10.1089/acm.2020.0542. PMID: 34161146
Patient-Reported Outcome Measures and Dosimetric Correlates for Early Detection of Acute Radiation Therapy-Related Esophagitis.
Voong KR, Han P, Hales R, Hill C, Friedes C, McNutt T, Lee S, Snyder C
Pract Radiat Oncol 2021 May-Jun;11(3):185-192. Epub 2020 Oct 31 doi: 10.1016/j.prro.2020.10.009. PMID: 33137465
Cisplatin and 5-fluorouracil with or without epidermal growth factor receptor inhibition panitumumab for patients with non-resectable, advanced or metastatic oesophageal squamous cell cancer: a prospective, open-label, randomised phase III AIO/EORTC trial (POWER).
Moehler M, Maderer A, Thuss-Patience PC, Brenner B, Meiler J, Ettrich TJ, Hofheinz RD, Al-Batran SE, Vogel A, Mueller L, Lutz MP, Lordick F, Alsina M, Borchert K, Greil R, Eisterer W, Schad A, Slotta-Huspenina J, Van Cutsem E, Lorenzen S
Ann Oncol 2020 Feb;31(2):228-235. Epub 2019 Dec 16 doi: 10.1016/j.annonc.2019.10.018. PMID: 31959339

Prognosis

Phase II Trial of Flaxseed to Prevent Acute Complications After Chemoradiation for Lung Cancer.
Lim TL, Pietrofesa RA, Arguiri E, Koumenis C, Feigenberg S, Simone CB 2nd, Rengan R, Cengel K, Levin WP, Christofidou-Solomidou M, Berman AT
J Altern Complement Med 2021 Oct;27(10):824-831. Epub 2021 Jun 23 doi: 10.1089/acm.2020.0542. PMID: 34161146
The efficacy and safety of definitive concurrent chemoradiotherapy for non-operable esophageal cancer.
Dreyfuss AD, Barsky AR, Wileyto EP, Eads JR, Kucharczuk JC, Williams NN, Karasic TB, Metz JM, Ben-Josef E, Plastaras JP, Wojcieszynski AP
Cancer Med 2021 Feb;10(4):1275-1288. Epub 2021 Jan 20 doi: 10.1002/cam4.3724. PMID: 33474812Free PMC Article
Risk factors for esophagitis after hypofractionated palliative (chemo) radiotherapy for non-small cell lung cancer.
Nieder C, Imingen KS, Mannsåker B, Yobuta R, Haukland E
Radiat Oncol 2020 May 1;15(1):91. doi: 10.1186/s13014-020-01550-2. PMID: 32357936Free PMC Article
Lymphopenia during radiotherapy in patients with oropharyngeal cancer.
Ng SP, Bahig H, Jethanandani A, Pollard C, Berends J, Sturgis EM, Johnson FM, Elgohari B, Elhalawani H, Rosenthal DI, Skinner HD, Gunn GB, Phan J, Frank SJ, Mohamed ASR, Fuller CD, Garden AS
Radiother Oncol 2020 Apr;145:95-100. Epub 2020 Jan 10 doi: 10.1016/j.radonc.2019.12.023. PMID: 31931292Free PMC Article
Tolerability and efficacy of concurrent chemoradiotherapy comparing carboplatin/paclitaxel versus platinum/5-FU regimen for locally advanced esophageal and esophagogastric junction cancers.
Tamtai A, Jiarpinitnun C, Hiranyatheb P, Unwanatham N, Sirachainun E, Supsamutchai C, Pattaranutaporn P, Ngamphaiboon N
Med Oncol 2017 Sep;34(9):157. Epub 2017 Aug 7 doi: 10.1007/s12032-017-1017-z. PMID: 28785986

Clinical prediction guides

Chemoradiation for elderly patients (≥ 65 years) with esophageal cancer: a retrospective single-center analysis.
Linde P, Mallmann M, Adams A, Wegen S, Rosenbrock J, Trommer M, Marnitz S, Baues C, Celik E
Radiat Oncol 2022 Nov 17;17(1):187. doi: 10.1186/s13014-022-02160-w. PMID: 36397163Free PMC Article
Clinical Outcome After Esophagectomy or Definitive Chemoradiotherapy in Elderly Patients (≥80 Years) With Esophageal Cancer.
Shimonosono M, Sasaki K, Tsuruda Y, Noda M, Uchikado Y, Arigami T, Matsushita D, Mori S, Kurahara H, Nakajo A, Ohtsuka T
Anticancer Res 2022 Aug;42(8):3953-3961. doi: 10.21873/anticanres.15890. PMID: 35896243
Risk factors for esophagitis after hypofractionated palliative (chemo) radiotherapy for non-small cell lung cancer.
Nieder C, Imingen KS, Mannsåker B, Yobuta R, Haukland E
Radiat Oncol 2020 May 1;15(1):91. doi: 10.1186/s13014-020-01550-2. PMID: 32357936Free PMC Article
Lymphopenia during radiotherapy in patients with oropharyngeal cancer.
Ng SP, Bahig H, Jethanandani A, Pollard C, Berends J, Sturgis EM, Johnson FM, Elgohari B, Elhalawani H, Rosenthal DI, Skinner HD, Gunn GB, Phan J, Frank SJ, Mohamed ASR, Fuller CD, Garden AS
Radiother Oncol 2020 Apr;145:95-100. Epub 2020 Jan 10 doi: 10.1016/j.radonc.2019.12.023. PMID: 31931292Free PMC Article
Continuous hyperfractionated accelerated radiotherapy - Escalated dose (CHART-ED): A phase I study.
Hatton MQ, Hill R, Fenwick JD, Morgan SA, Wilson PC, Atherton PJ, Dickson J, Murray KE, Paul J
Radiother Oncol 2016 Mar;118(3):471-7. Epub 2015 Dec 11 doi: 10.1016/j.radonc.2015.11.015. PMID: 26687902

Recent systematic reviews

Radiation Pneumonitis after Intensity-Modulated Radiotherapy for Esophageal Cancer: Institutional Data and a Systematic Review.
Tonison JJ, Fischer SG, Viehrig M, Welz S, Boeke S, Zwirner K, Klumpp B, Braun LH, Zips D, Gani C
Sci Rep 2019 Feb 19;9(1):2255. doi: 10.1038/s41598-018-38414-5. PMID: 30783157Free PMC Article

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