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Grade 4 Other Gastrointestinal, CTCAE

MedGen UID:
327235
•Concept ID:
C1560445
•
Finding
Synonym: CTCAE Grade 4 Gastrointestinal - Other

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Other Gastrointestinal, CTCAE

Professional guidelines

PubMed

Highly conformal combined radiotherapy with cisplatin and gemcitabine for treatment of loco-regionally advanced cervical cancer - a retrospective study.
Cihoric N, Tsikkinis A, Vlaskou Badra E, Glatzer M, Novak U, Scherz A, Shelan M, Soldatovic I, Yojena CKK, Aebersold DM, Lössl K
Radiat Oncol 2017 Dec 22;12(1):202. doi: 10.1186/s13014-017-0938-1. PMID: 29273076Free PMC Article
Chemoradiation treatment with gemcitabine plus stereotactic body radiotherapy for unresectable, non-metastatic, locally advanced hilar cholangiocarcinoma. Results of a five year experience.
Polistina FA, Guglielmi R, Baiocchi C, Francescon P, Scalchi P, Febbraro A, Costantin G, Ambrosino G
Radiother Oncol 2011 May;99(2):120-3. Epub 2011 May 27 doi: 10.1016/j.radonc.2011.05.016. PMID: 21621289

Recent clinical studies

Etiology

Safety and Efficacy Study of Neoadjuvant Radiohormonal Therapy for Oligometastatic Prostate Cancer: Protocol of an Open-Label, Dose-Escalation, Single-Centre Phase I/II Clinical Trial.
Zhao X, Xiao YT, Yang Y, Ye Y, Chang Y, Jiang L, Eftekhar M, Ren S, Zhang H
Cancer Control 2022 Jan-Dec;29:10732748221120462. doi: 10.1177/10732748221120462. PMID: 35980734Free PMC Article
Outcomes of Squamous Cell Carcinoma Anal Canal treated with IMRT-VMAT-based Concurrent Chemoradiation: a Single Institutional Experience.
Singh K, Sathyamurthy A, Ramireddy JK, Ram TS
J Gastrointest Cancer 2022 Mar;53(1):161-169. Epub 2021 Jan 5 doi: 10.1007/s12029-020-00580-z. PMID: 33400211
Combined use of 177Lu-DOTATATE and metronomic capecitabine (Lu-X) in FDG-positive gastro-entero-pancreatic neuroendocrine tumors.
Nicolini S, Bodei L, Bongiovanni A, Sansovini M, Grassi I, Ibrahim T, Monti M, Caroli P, Sarnelli A, Diano D, Di Iorio V, Grana CM, Cittanti C, Pieri F, Severi S, Paganelli G
Eur J Nucl Med Mol Imaging 2021 Sep;48(10):3260-3267. Epub 2021 Feb 18 doi: 10.1007/s00259-021-05236-z. PMID: 33604690Free PMC Article
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584
A nomogram to predict 5-fluorouracil toxicity: when pharmacogenomics meets the patient.
Botticelli A, Onesti CE, Strigari L, Occhipinti M, Di Pietro FR, Cerbelli B, Petremolo A, Anselmi E, Macrini S, Roberto M, Falcone R, Lionetto L, Borro M, Milano A, Gentile G, Simmaco M, Marchetti P, Mazzuca F
Anticancer Drugs 2017 Jun;28(5):551-556. doi: 10.1097/CAD.0000000000000492. PMID: 28296649

Diagnosis

Safety profile of G-CSF in chemotherapy-induced neutropenia: A prospective observational study in Eastern India.
Deb U, Mukhopadhyay S, Banerjee S, Biswas S
Indian J Cancer 2022 Oct-Dec;59(4):493-498. doi: 10.4103/ijc.IJC_982_19. PMID: 33753622
A placebo-controlled, double-blind, randomized study of recombinant thrombomodulin (ART-123) to prevent oxaliplatin-induced peripheral neuropathy.
Kotaka M, Saito Y, Kato T, Satake H, Makiyama A, Tsuji Y, Shinozaki K, Fujiwara T, Mizushima T, Harihara Y, Nagata N, Kurihara N, Ando M, Kusakawa G, Sakai T, Uchida Y, Takamoto M, Kimoto S, Hyodo I
Cancer Chemother Pharmacol 2020 Nov;86(5):607-618. Epub 2020 Sep 23 doi: 10.1007/s00280-020-04135-8. PMID: 32965539Free PMC Article
Pattern and impact of hepatic adverse events encountered during immune checkpoint inhibitors - A territory-wide cohort study.
Chan SL, Yip TC, Wong VW, Tse YK, Yuen BW, Luk HW, Lui RN, Chan HL, Mok TS, Wong GL
Cancer Med 2020 Oct;9(19):7052-7061. Epub 2020 Aug 11 doi: 10.1002/cam4.3378. PMID: 32780516Free PMC Article
Gastroduodenal complications after concurrent chemoradiation therapy in patients with hepatocellular carcinoma: endoscopic findings and risk factors.
Chon YE, Seong J, Kim BK, Cha J, Kim SU, Park JY, Ahn SH, Han KH, Chon CY, Shin SK, Kim DY
Int J Radiat Oncol Biol Phys 2011 Dec 1;81(5):1343-51. Epub 2010 Oct 8 doi: 10.1016/j.ijrobp.2010.07.1986. PMID: 20934268
Fasting and cancer treatment in humans: A case series report.
Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD
Aging (Albany NY) 2009 Dec 31;1(12):988-1007. doi: 10.18632/aging.100114. PMID: 20157582Free PMC Article

Therapy

Magnetic Resonance Imaging-Guided vs Computed Tomography-Guided Stereotactic Body Radiotherapy for Prostate Cancer: The MIRAGE Randomized Clinical Trial.
Kishan AU, Ma TM, Lamb JM, Casado M, Wilhalme H, Low DA, Sheng K, Sharma S, Nickols NG, Pham J, Yang Y, Gao Y, Neylon J, Basehart V, Cao M, Steinberg ML
JAMA Oncol 2023 Mar 1;9(3):365-373. doi: 10.1001/jamaoncol.2022.6558. PMID: 36633877Free PMC Article
Safety and Efficacy Study of Neoadjuvant Radiohormonal Therapy for Oligometastatic Prostate Cancer: Protocol of an Open-Label, Dose-Escalation, Single-Centre Phase I/II Clinical Trial.
Zhao X, Xiao YT, Yang Y, Ye Y, Chang Y, Jiang L, Eftekhar M, Ren S, Zhang H
Cancer Control 2022 Jan-Dec;29:10732748221120462. doi: 10.1177/10732748221120462. PMID: 35980734Free PMC Article
Phase II Study of Copanlisib in Patients With Tumors With PIK3CA Mutations: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1F.
Damodaran S, Zhao F, Deming DA, Mitchell EP, Wright JJ, Gray RJ, Wang V, McShane LM, Rubinstein LV, Patton DR, Williams PM, Hamilton SR, Suga JM, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT
J Clin Oncol 2022 May 10;40(14):1552-1561. Epub 2022 Feb 8 doi: 10.1200/JCO.21.01648. PMID: 35133871Free PMC Article
Combined use of 177Lu-DOTATATE and metronomic capecitabine (Lu-X) in FDG-positive gastro-entero-pancreatic neuroendocrine tumors.
Nicolini S, Bodei L, Bongiovanni A, Sansovini M, Grassi I, Ibrahim T, Monti M, Caroli P, Sarnelli A, Diano D, Di Iorio V, Grana CM, Cittanti C, Pieri F, Severi S, Paganelli G
Eur J Nucl Med Mol Imaging 2021 Sep;48(10):3260-3267. Epub 2021 Feb 18 doi: 10.1007/s00259-021-05236-z. PMID: 33604690Free PMC Article
A nomogram to predict 5-fluorouracil toxicity: when pharmacogenomics meets the patient.
Botticelli A, Onesti CE, Strigari L, Occhipinti M, Di Pietro FR, Cerbelli B, Petremolo A, Anselmi E, Macrini S, Roberto M, Falcone R, Lionetto L, Borro M, Milano A, Gentile G, Simmaco M, Marchetti P, Mazzuca F
Anticancer Drugs 2017 Jun;28(5):551-556. doi: 10.1097/CAD.0000000000000492. PMID: 28296649

Prognosis

Combined use of 177Lu-DOTATATE and metronomic capecitabine (Lu-X) in FDG-positive gastro-entero-pancreatic neuroendocrine tumors.
Nicolini S, Bodei L, Bongiovanni A, Sansovini M, Grassi I, Ibrahim T, Monti M, Caroli P, Sarnelli A, Diano D, Di Iorio V, Grana CM, Cittanti C, Pieri F, Severi S, Paganelli G
Eur J Nucl Med Mol Imaging 2021 Sep;48(10):3260-3267. Epub 2021 Feb 18 doi: 10.1007/s00259-021-05236-z. PMID: 33604690Free PMC Article
A placebo-controlled, double-blind, randomized study of recombinant thrombomodulin (ART-123) to prevent oxaliplatin-induced peripheral neuropathy.
Kotaka M, Saito Y, Kato T, Satake H, Makiyama A, Tsuji Y, Shinozaki K, Fujiwara T, Mizushima T, Harihara Y, Nagata N, Kurihara N, Ando M, Kusakawa G, Sakai T, Uchida Y, Takamoto M, Kimoto S, Hyodo I
Cancer Chemother Pharmacol 2020 Nov;86(5):607-618. Epub 2020 Sep 23 doi: 10.1007/s00280-020-04135-8. PMID: 32965539Free PMC Article
Pattern and impact of hepatic adverse events encountered during immune checkpoint inhibitors - A territory-wide cohort study.
Chan SL, Yip TC, Wong VW, Tse YK, Yuen BW, Luk HW, Lui RN, Chan HL, Mok TS, Wong GL
Cancer Med 2020 Oct;9(19):7052-7061. Epub 2020 Aug 11 doi: 10.1002/cam4.3378. PMID: 32780516Free PMC Article
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584
A nomogram to predict 5-fluorouracil toxicity: when pharmacogenomics meets the patient.
Botticelli A, Onesti CE, Strigari L, Occhipinti M, Di Pietro FR, Cerbelli B, Petremolo A, Anselmi E, Macrini S, Roberto M, Falcone R, Lionetto L, Borro M, Milano A, Gentile G, Simmaco M, Marchetti P, Mazzuca F
Anticancer Drugs 2017 Jun;28(5):551-556. doi: 10.1097/CAD.0000000000000492. PMID: 28296649

Clinical prediction guides

Magnetic Resonance Imaging-Guided vs Computed Tomography-Guided Stereotactic Body Radiotherapy for Prostate Cancer: The MIRAGE Randomized Clinical Trial.
Kishan AU, Ma TM, Lamb JM, Casado M, Wilhalme H, Low DA, Sheng K, Sharma S, Nickols NG, Pham J, Yang Y, Gao Y, Neylon J, Basehart V, Cao M, Steinberg ML
JAMA Oncol 2023 Mar 1;9(3):365-373. doi: 10.1001/jamaoncol.2022.6558. PMID: 36633877Free PMC Article
Phase II Study of Copanlisib in Patients With Tumors With PIK3CA Mutations: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1F.
Damodaran S, Zhao F, Deming DA, Mitchell EP, Wright JJ, Gray RJ, Wang V, McShane LM, Rubinstein LV, Patton DR, Williams PM, Hamilton SR, Suga JM, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT
J Clin Oncol 2022 May 10;40(14):1552-1561. Epub 2022 Feb 8 doi: 10.1200/JCO.21.01648. PMID: 35133871Free PMC Article
Combined use of 177Lu-DOTATATE and metronomic capecitabine (Lu-X) in FDG-positive gastro-entero-pancreatic neuroendocrine tumors.
Nicolini S, Bodei L, Bongiovanni A, Sansovini M, Grassi I, Ibrahim T, Monti M, Caroli P, Sarnelli A, Diano D, Di Iorio V, Grana CM, Cittanti C, Pieri F, Severi S, Paganelli G
Eur J Nucl Med Mol Imaging 2021 Sep;48(10):3260-3267. Epub 2021 Feb 18 doi: 10.1007/s00259-021-05236-z. PMID: 33604690Free PMC Article
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584
A nomogram to predict 5-fluorouracil toxicity: when pharmacogenomics meets the patient.
Botticelli A, Onesti CE, Strigari L, Occhipinti M, Di Pietro FR, Cerbelli B, Petremolo A, Anselmi E, Macrini S, Roberto M, Falcone R, Lionetto L, Borro M, Milano A, Gentile G, Simmaco M, Marchetti P, Mazzuca F
Anticancer Drugs 2017 Jun;28(5):551-556. doi: 10.1097/CAD.0000000000000492. PMID: 28296649

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