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Heartburn or Dyspepsia, CTCAE

MedGen UID:: 327236
•Concept ID:: C1560447
•: Finding

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHeartburn or Dyspepsia, CTCAE

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Cause
    - Adverse Event
      - Adverse Event by CTCAE Category
        Adverse Event Associated with the Gastrointestinal System
        Heartburn or Dyspepsia, CTCAE
        Grade 1 Heartburn or Dyspepsia, CTCAE
        Grade 2 Heartburn or Dyspepsia, CTCAE
        Grade 3 Heartburn or Dyspepsia, CTCAE

Professional guidelines

PubMed

Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021.

Iwakiri K, Fujiwara Y, Manabe N, Ihara E, Kuribayashi S, Akiyama J, Kondo T, Yamashita H, Ishimura N, Kitasako Y, Iijima K, Koike T, Omura N, Nomura T, Kawamura O, Ohara S, Ozawa S, Kinoshita Y, Mochida S, Enomoto N, Shimosegawa T, Koike K
J Gastroenterol 2022 Apr;57(4):267-285. Epub 2022 Feb 28 doi: 10.1007/s00535-022-01861-z. PMID: 35226174 Free PMC Article

AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review.

Yadlapati R, Gyawali CP, Pandolfino JE; CGIT GERD Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 May;20(5):984-994.e1. Epub 2022 Feb 2 doi: 10.1016/j.cgh.2022.01.025. PMID: 35123084 Free PMC Article

Gastroesophageal Reflux Disease: Pathophysiology, Diagnosis, and Treatment.

Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703

See all (431)

Recent clinical studies

Etiology

Poliprotect vs Omeprazole in the Relief of Heartburn, Epigastric Pain, and Burning in Patients Without Erosive Esophagitis and Gastroduodenal Lesions: A Randomized, Controlled Trial.

Corazziari ES, Gasbarrini A, D'Alba L, D'Ovidio V, Riggio O, Passaretti S, Annibale B, Cicala M, Repici A, Bassotti G, Ciacci C, Di Sabatino A, Neri M, Bragazzi MC, Ribichini E, Radocchia G, Iovino P, Marazzato M, Schippa S, Badiali D
Am J Gastroenterol 2023 Nov 1;118(11):2014-2024. Epub 2023 Jun 13 doi: 10.14309/ajg.0000000000002360. PMID: 37307528 Free PMC Article

The Effects of Modifying Amount and Type of Dietary Carbohydrate on Esophageal Acid Exposure Time and Esophageal Reflux Symptoms: A Randomized Controlled Trial.

Gu C, Olszewski T, King KL, Vaezi MF, Niswender KD, Silver HJ
Am J Gastroenterol 2022 Oct 1;117(10):1655-1667. Epub 2022 Jun 21 doi: 10.14309/ajg.0000000000001889. PMID: 35973185 Free PMC Article

AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review.

Presentation and Epidemiology of Gastroesophageal Reflux Disease.

Richter JE, Rubenstein JH
Gastroenterology 2018 Jan;154(2):267-276. Epub 2017 Aug 3 doi: 10.1053/j.gastro.2017.07.045. PMID: 28780072 Free PMC Article

Diagnosis and Management of Functional Heartburn.

Hachem C, Shaheen NJ
Am J Gastroenterol 2016 Jan;111(1):53-61; quiz 62. Epub 2016 Jan 5 doi: 10.1038/ajg.2015.376. PMID: 26729546

See all (2935)

Diagnosis

The Effects of Modifying Amount and Type of Dietary Carbohydrate on Esophageal Acid Exposure Time and Esophageal Reflux Symptoms: A Randomized Controlled Trial.

Gu C, Olszewski T, King KL, Vaezi MF, Niswender KD, Silver HJ
Am J Gastroenterol 2022 Oct 1;117(10):1655-1667. Epub 2022 Jun 21 doi: 10.14309/ajg.0000000000001889. PMID: 35973185 Free PMC Article

AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review.

Chronic Abdominal Pain: Gastroenterologist Approach.

Lukic S, Mijac D, Filipovic B, Sokic-Milutinovic A, Tomasevic R, Krstic M, Milosavljevic T
Dig Dis 2022;40(2):181-186. Epub 2021 May 4 doi: 10.1159/000516977. PMID: 33946069

Functional Dyspepsia: Advances in Diagnosis and Therapy.

Talley NJ
Gut Liver 2017 May 15;11(3):349-357. doi: 10.5009/gnl16055. PMID: 28452210 Free PMC Article

Diagnosis and Management of Functional Heartburn.

Hachem C, Shaheen NJ
Am J Gastroenterol 2016 Jan;111(1):53-61; quiz 62. Epub 2016 Jan 5 doi: 10.1038/ajg.2015.376. PMID: 26729546

See all (2312)

Therapy

Poliprotect vs Omeprazole in the Relief of Heartburn, Epigastric Pain, and Burning in Patients Without Erosive Esophagitis and Gastroduodenal Lesions: A Randomized, Controlled Trial.

The Effects of Modifying Amount and Type of Dietary Carbohydrate on Esophageal Acid Exposure Time and Esophageal Reflux Symptoms: A Randomized Controlled Trial.

Gu C, Olszewski T, King KL, Vaezi MF, Niswender KD, Silver HJ
Am J Gastroenterol 2022 Oct 1;117(10):1655-1667. Epub 2022 Jun 21 doi: 10.14309/ajg.0000000000001889. PMID: 35973185 Free PMC Article

Antacids revisited: review on contemporary facts and relevance for self-management.

Garg V, Narang P, Taneja R
J Int Med Res 2022 Mar;50(3):3000605221086457. doi: 10.1177/03000605221086457. PMID: 35343261 Free PMC Article

AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review.

Gastroesophageal reflux disease-related and functional heartburn: pathophysiology and treatment.

Miwa H, Kondo T, Oshima T
Curr Opin Gastroenterol 2016 Jul;32(4):344-52. doi: 10.1097/MOG.0000000000000282. PMID: 27206157

See all (2661)

Prognosis

Overlap of heartburn, functional dyspepsia, and irritable bowel syndrome in a population sample: Prevalence, temporal stability, and associated comorbidities.

Jones MP, Shah A, Walker MM, Koloski NA, Holtmann G, Talley NJ
Neurogastroenterol Motil 2022 Sep;34(9):e14349. Epub 2022 Mar 16 doi: 10.1111/nmo.14349. PMID: 35293084

The management of neuroendocrine tumours: A nutritional viewpoint.

Gallo M, Muscogiuri G, Pizza G, Ruggeri RM, Barrea L, Faggiano A, Colao A; NIKE Group
Crit Rev Food Sci Nutr 2019;59(7):1046-1057. Epub 2017 Nov 29 doi: 10.1080/10408398.2017.1390729. PMID: 29020456

Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review.

El-Serag HB, Sweet S, Winchester CC, Dent J
Gut 2014 Jun;63(6):871-80. Epub 2013 Jul 13 doi: 10.1136/gutjnl-2012-304269. PMID: 23853213 Free PMC Article

Gastroesophageal reflux disease.

Fock KM, Poh CH
J Gastroenterol 2010 Aug;45(8):808-15. Epub 2010 Jun 29 doi: 10.1007/s00535-010-0274-9. PMID: 20585811

Dyspepsia: current understanding and management.

Agréus L, Talley NJ
Annu Rev Med 1998;49:475-93. doi: 10.1146/annurev.med.49.1.475. PMID: 9509276

See all (1198)

Clinical prediction guides

Poliprotect vs Omeprazole in the Relief of Heartburn, Epigastric Pain, and Burning in Patients Without Erosive Esophagitis and Gastroduodenal Lesions: A Randomized, Controlled Trial.

Evidence-based treatment recommendations for gastroesophageal reflux disease during pregnancy: A review.

Altuwaijri M
Medicine (Baltimore) 2022 Sep 2;101(35):e30487. doi: 10.1097/MD.0000000000030487. PMID: 36107559 Free PMC Article

Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn.

Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, Sanchez VM, Dunbar KB, Pham TH, Murthy UK, Kim T, Jackson CS, Wallen JM, von Rosenvinge EC, Pearl JP, Laine L, Kim AW, Kaz AM, Tatum RP, Gellad ZF, Lagoo-Deenadayalan S, Rubenstein JH, Ghaferi AA, Lo WK, Fernando RS, Chan BS, Paski SC, Provenzale D, Castell DO, Lieberman D, Souza RF, Chey WD, Warren SR, Davis-Karim A, Melton SD, Genta RM, Serpi T, Biswas K, Huang GD
N Engl J Med 2019 Oct 17;381(16):1513-1523. doi: 10.1056/NEJMoa1811424. PMID: 31618539

Functional Dyspepsia: Advances in Diagnosis and Therapy.

Talley NJ
Gut Liver 2017 May 15;11(3):349-357. doi: 10.5009/gnl16055. PMID: 28452210 Free PMC Article

Between GERD and NERD: the relevance of weakly acidic reflux.

de Bortoli N, Ottonello A, Zerbib F, Sifrim D, Gyawali CP, Savarino E
Ann N Y Acad Sci 2016 Sep;1380(1):218-229. Epub 2016 Jul 29 doi: 10.1111/nyas.13169. PMID: 27472432

See all (1821)

Recent systematic reviews

Gastroesophageal Reflux Disease and Probiotics: A Systematic Review.

Cheng J, Ouwehand AC
Nutrients 2020 Jan 2;12(1) doi: 10.3390/nu12010132. PMID: 31906573 Free PMC Article

Enteral nutritional therapy for induction of remission in Crohn's disease.

Narula N, Dhillon A, Zhang D, Sherlock ME, Tondeur M, Zachos M
Cochrane Database Syst Rev 2018 Apr 1;4(4):CD000542. doi: 10.1002/14651858.CD000542.pub3. PMID: 29607496 Free PMC Article

Lifestyle Intervention in Gastroesophageal Reflux Disease.

Ness-Jensen E, Hveem K, El-Serag H, Lagergren J
Clin Gastroenterol Hepatol 2016 Feb;14(2):175-82.e1-3. Epub 2015 May 6 doi: 10.1016/j.cgh.2015.04.176. PMID: 25956834 Free PMC Article

A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting.

Viljoen E, Visser J, Koen N, Musekiwa A
Nutr J 2014 Mar 19;13:20. doi: 10.1186/1475-2891-13-20. PMID: 24642205 Free PMC Article

Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review.

El-Serag HB, Sweet S, Winchester CC, Dent J
Gut 2014 Jun;63(6):871-80. Epub 2013 Jul 13 doi: 10.1136/gutjnl-2012-304269. PMID: 23853213 Free PMC Article

See all (119)

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Heartburn or Dyspepsia, CTCAE

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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