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Small Intestinal Mucinous Adenocarcinoma

MedGen UID:
328035
•Concept ID:
C1710109
•
Neoplastic Process

Definition

An invasive adenocarcinoma that arises from the small intestine. It is composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Mucinous Adenocarcinoma

Professional guidelines

PubMed

Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment.
Grützmann R, Niedergethmann M, Pilarsky C, Klöppel G, Saeger HD
Oncologist 2010;15(12):1294-309. Epub 2010 Dec 8 doi: 10.1634/theoncologist.2010-0151. PMID: 21147870Free PMC Article
Problems in the diagnosis and treatment of a so-called mucin-producing tumor of the pancreas.
Kimura W, Kuroda A, Makuuchi M
Pancreas 1998 Apr;16(3):363-9. doi: 10.1097/00006676-199804000-00025. PMID: 9548680
Clinical determinants of treatment failure in patients with pseudomyxoma peritonei.
Sugarbaker PH, Fernández-Trigo V, Shamsa F
Cancer Treat Res 1996;81:121-32. doi: 10.1007/978-1-4613-1245-1_11. PMID: 8834580

Recent clinical studies

Etiology

Predictors of Small Bowel Obstruction Post-Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.
Jedrzejko N, Wong A, MacNeill AJ, Hamilton TD
J Gastrointest Surg 2022 Oct;26(10):2176-2183. Epub 2022 Jun 29 doi: 10.1007/s11605-022-05394-x. PMID: 35852704
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Lynch syndrome-related small intestinal adenocarcinomas.
Jun SY, Lee EJ, Kim MJ, Chun SM, Bae YK, Hong SU, Choi J, Kim JM, Jang KT, Kim JY, Kim GI, Jung SJ, Yoon G, Hong SM
Oncotarget 2017 Mar 28;8(13):21483-21500. doi: 10.18632/oncotarget.15277. PMID: 28206961Free PMC Article
Mucinous phenotype and CD10 expression of primary adenocarcinoma of the small intestine.
Kumagai R, Kohashi K, Takahashi S, Yamamoto H, Hirahashi M, Taguchi K, Nishiyama K, Oda Y
World J Gastroenterol 2015 Mar 7;21(9):2700-10. doi: 10.3748/wjg.v21.i9.2700. PMID: 25759539Free PMC Article
Current understanding of precursors to pancreatic cancer.
Takaori K
J Hepatobiliary Pancreat Surg 2007;14(3):217-23. Epub 2007 May 29 doi: 10.1007/s00534-006-1165-6. PMID: 17520195

Diagnosis

Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Lynch syndrome-related small intestinal adenocarcinomas.
Jun SY, Lee EJ, Kim MJ, Chun SM, Bae YK, Hong SU, Choi J, Kim JM, Jang KT, Kim JY, Kim GI, Jung SJ, Yoon G, Hong SM
Oncotarget 2017 Mar 28;8(13):21483-21500. doi: 10.18632/oncotarget.15277. PMID: 28206961Free PMC Article
Mucinous phenotype and CD10 expression of primary adenocarcinoma of the small intestine.
Kumagai R, Kohashi K, Takahashi S, Yamamoto H, Hirahashi M, Taguchi K, Nishiyama K, Oda Y
World J Gastroenterol 2015 Mar 7;21(9):2700-10. doi: 10.3748/wjg.v21.i9.2700. PMID: 25759539Free PMC Article
Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment.
Grützmann R, Niedergethmann M, Pilarsky C, Klöppel G, Saeger HD
Oncologist 2010;15(12):1294-309. Epub 2010 Dec 8 doi: 10.1634/theoncologist.2010-0151. PMID: 21147870Free PMC Article
Gastrointestinal cancer.
Thomas RM, Sobin LH
Cancer 1995 Jan 1;75(1 Suppl):154-70. doi: 10.1002/1097-0142(19950101)75:1+<154::aid-cncr2820751305>3.0.co;2-z. PMID: 8000994

Therapy

Predictors of Small Bowel Obstruction Post-Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.
Jedrzejko N, Wong A, MacNeill AJ, Hamilton TD
J Gastrointest Surg 2022 Oct;26(10):2176-2183. Epub 2022 Jun 29 doi: 10.1007/s11605-022-05394-x. PMID: 35852704
Anti epidermal growth factor receptor therapy in small bowel adenocarcinoma: Case report and literature review.
Falcone R, Roberto M, Filetti M, Anselmi E, Marchetti P
Medicine (Baltimore) 2018 Jan;97(3):e9672. doi: 10.1097/MD.0000000000009672. PMID: 29505011Free PMC Article
Adenocarcinoma in a Blind Loop of the Ileum 53 Years After an Ileotransversostomy Procedure.
Takei R, Onishi I, Zaimoku R, Makita N, Yagi Y, Kayahara M
Am J Case Rep 2018 Feb 6;19:133-136. doi: 10.12659/ajcr.907144. PMID: 29402880Free PMC Article
Dermatitis Herpetiformis Refractory to Gluten-free Dietary Treatment.
Hervonen K, Salmi TT, Ilus T, Paasikivi K, Vornanen M, Laurila K, Lindfors K, Viiri K, Saavalainen P, Collin P, Kaukinen K, Reunala T
Acta Derm Venereol 2016 Jan;96(1):82-6. doi: 10.2340/00015555-2184. PMID: 26084552
Rapid growth of residual colonic tumor after incomplete mucosal resection.
Matsuda K, Masaki T, Abo Y, Uchida H, Watanabe T, Muto T
J Gastroenterol 1999 Apr;34(2):260-3. doi: 10.1007/s005350050254. PMID: 10213129

Prognosis

Consequence of distinctive expression of MUC2 in colorectal cancers: How much is actually bad?
Gundamaraju R, Chong WC
Biochim Biophys Acta Rev Cancer 2021 Aug;1876(1):188579. Epub 2021 Jun 15 doi: 10.1016/j.bbcan.2021.188579. PMID: 34139275
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Lynch syndrome-related small intestinal adenocarcinomas.
Jun SY, Lee EJ, Kim MJ, Chun SM, Bae YK, Hong SU, Choi J, Kim JM, Jang KT, Kim JY, Kim GI, Jung SJ, Yoon G, Hong SM
Oncotarget 2017 Mar 28;8(13):21483-21500. doi: 10.18632/oncotarget.15277. PMID: 28206961Free PMC Article
Mucinous phenotype and CD10 expression of primary adenocarcinoma of the small intestine.
Kumagai R, Kohashi K, Takahashi S, Yamamoto H, Hirahashi M, Taguchi K, Nishiyama K, Oda Y
World J Gastroenterol 2015 Mar 7;21(9):2700-10. doi: 10.3748/wjg.v21.i9.2700. PMID: 25759539Free PMC Article
Gastrointestinal cancer.
Thomas RM, Sobin LH
Cancer 1995 Jan 1;75(1 Suppl):154-70. doi: 10.1002/1097-0142(19950101)75:1+<154::aid-cncr2820751305>3.0.co;2-z. PMID: 8000994

Clinical prediction guides

Predictors of Small Bowel Obstruction Post-Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.
Jedrzejko N, Wong A, MacNeill AJ, Hamilton TD
J Gastrointest Surg 2022 Oct;26(10):2176-2183. Epub 2022 Jun 29 doi: 10.1007/s11605-022-05394-x. PMID: 35852704
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Dual loss of USP10 and p14ARF protein expression is associated with poor prognosis in patients with small intestinal adenocarcinoma.
Song JS, Yi JM, Cho H, Choi CH, Park Y, Chung EJ, Song J, Chung JY, Hong SM
Tumour Biol 2018 Oct;40(10):1010428318808678. doi: 10.1177/1010428318808678. PMID: 30375264
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948
Intestinal mucinous substances in gastric intestinal metaplasia and carcinoma studied by immunofluorescence.
Ma J, De Boer WG, Nayman J
Cancer 1982 Apr 15;49(8):1664-7. doi: 10.1002/1097-0142(19820415)49:8<1664::aid-cncr2820490822>3.0.co;2-o. PMID: 6279272

Recent systematic reviews

Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358

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