U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Thyroid gland squamous cell carcinoma

MedGen UID:
328050
•Concept ID:
C1710177
•
Neoplastic Process
Synonyms: squamous cell thyroid gland carcinoma; Thyroid Gland Anaplastic Carcinoma, Squamous Cell Carcinoma Pattern; Thyroid Gland Squamous Cell Carcinoma; thyroid gland squamous cell carcinoma
 
Monarch Initiative: MONDO:0006467

Definition

Thyroid gland anaplastic carcinoma with focal or complete squamous differentiation. Primary thyroid gland squamous cell carcinomas have similar poor overall survival rates as compared to conventional anaplastic thyroid gland carcinomas and are now considered a subtype of the latter. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid gland squamous cell carcinoma

Professional guidelines

PubMed

Primary Total Laryngectomy for Endolaryngeal cT3-4M0 Squamous Cell Carcinoma: A STROBE Analysis.
Laccourreye O, Garcia D, Haroun F, Nguyen DH, Giraud P, Mirghani H
Laryngoscope 2024 May;134(5):2288-2294. Epub 2023 Nov 3 doi: 10.1002/lary.31129. PMID: 37921374
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Squamous cell carcinoma of the thyroid gland: primary or secondary disease?
Syed MI, Stewart M, Syed S, Dahill S, Adams C, McLellan DR, Clark LJ
J Laryngol Otol 2011 Jan;125(1):3-9. Epub 2010 Oct 18 doi: 10.1017/S0022215110002070. PMID: 20950510

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Thyroid gland invasion in total laryngectomy: A systematic review and meta-analysis.
Xie J, Wu P, Liu H, Zhang S, Lu Z
Int J Surg 2022 Mar;99:106262. Epub 2022 Feb 13 doi: 10.1016/j.ijsu.2022.106262. PMID: 35172203
The incidence of thyroid gland invasion in advanced laryngeal squamous cell carcinoma.
Al-Hakami HA, Al Garni MA, AlSubayea H, AlOtaibi Y, Neazy A, Jameel W, Albouq M, Alnufaie A, Fatani N
Braz J Otorhinolaryngol 2021 Sep-Oct;87(5):533-537. Epub 2019 Dec 9 doi: 10.1016/j.bjorl.2019.11.003. PMID: 31879196Free PMC Article
Metastasis of squamous cell carcinoma of the head and neck to the thyroid: a single institution's experience with a review of relevant publications.
Vatsyayan A, Mandlik D, Patel P, Patel P, Sharma N, Joshipura A, Patel M, Odedra P, Dubbal JC, Shah DS, Kanhere SA, Sanghvi KJ, Patel K
Br J Oral Maxillofac Surg 2019 Sep;57(7):609-615. Epub 2019 Jun 10 doi: 10.1016/j.bjoms.2019.05.012. PMID: 31196573
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406

Diagnosis

Top 10 Clear Cell Head and Neck Lesions to Contemplate.
Cipriani NA, Kakkar A
Head Neck Pathol 2023 Mar;17(1):33-52. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01518-6. PMID: 36928734Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Annexin A4 and cancer.
Wei B, Guo C, Liu S, Sun MZ
Clin Chim Acta 2015 Jul 20;447:72-8. Epub 2015 Jun 3 doi: 10.1016/j.cca.2015.05.016. PMID: 26048190
Thyroglossal duct carcinoma.
Motamed M, McGlashan JA
Curr Opin Otolaryngol Head Neck Surg 2004 Apr;12(2):106-9. doi: 10.1097/00020840-200404000-00009. PMID: 15167046

Therapy

Multi-organ carcinogenicity by inhalation exposure to 2-Bromopropane in rats.
Senoh H, Kasai T, Hirai S, Furukawa Y, Misumi K, Goto Y, Takanobu K, Matsumoto M, Fukushima S, Aiso S
J Occup Health 2023 Jan;65(1):e12388. doi: 10.1002/1348-9585.12388. PMID: 36756793Free PMC Article
Emerging tyrosine kinase inhibitors for head and neck cancer.
Long Z, Grandis JR, Johnson DE
Expert Opin Emerg Drugs 2022 Sep;27(3):333-344. Epub 2022 Sep 21 doi: 10.1080/14728214.2022.2125954. PMID: 36131561Free PMC Article
Thyroid gland invasion in total laryngectomy: A systematic review and meta-analysis.
Xie J, Wu P, Liu H, Zhang S, Lu Z
Int J Surg 2022 Mar;99:106262. Epub 2022 Feb 13 doi: 10.1016/j.ijsu.2022.106262. PMID: 35172203
The Role of Adipokines in the Establishment and Progression of Head and Neck Neoplasms.
Tzanavari T, Tasoulas J, Vakaki C, Mihailidou C, Tsourouflis G, Theocharis S
Curr Med Chem 2019;26(25):4726-4748. doi: 10.2174/0929867325666180713154505. PMID: 30009699
Diffusion-weighted and PET/MR Imaging after Radiation Therapy for Malignant Head and Neck Tumors.
Varoquaux A, Rager O, Dulguerov P, Burkhardt K, Ailianou A, Becker M
Radiographics 2015 Sep-Oct;35(5):1502-27. Epub 2015 Aug 7 doi: 10.1148/rg.2015140029. PMID: 26252192

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Thyroid gland invasion in total laryngectomy: A systematic review and meta-analysis.
Xie J, Wu P, Liu H, Zhang S, Lu Z
Int J Surg 2022 Mar;99:106262. Epub 2022 Feb 13 doi: 10.1016/j.ijsu.2022.106262. PMID: 35172203
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Annexin A4 and cancer.
Wei B, Guo C, Liu S, Sun MZ
Clin Chim Acta 2015 Jul 20;447:72-8. Epub 2015 Jun 3 doi: 10.1016/j.cca.2015.05.016. PMID: 26048190
Thyroglossal duct carcinoma.
Motamed M, McGlashan JA
Curr Opin Otolaryngol Head Neck Surg 2004 Apr;12(2):106-9. doi: 10.1097/00020840-200404000-00009. PMID: 15167046

Clinical prediction guides

Thyroid gland invasion in total laryngectomy: A systematic review and meta-analysis.
Xie J, Wu P, Liu H, Zhang S, Lu Z
Int J Surg 2022 Mar;99:106262. Epub 2022 Feb 13 doi: 10.1016/j.ijsu.2022.106262. PMID: 35172203
Applications of Computational Pathology in Head and Neck Cytopathology.
Lollie TK, Krane JF
Acta Cytol 2021;65(4):330-334. Epub 2021 Feb 23 doi: 10.1159/000513286. PMID: 33621977
The Role of Adipokines in the Establishment and Progression of Head and Neck Neoplasms.
Tzanavari T, Tasoulas J, Vakaki C, Mihailidou C, Tsourouflis G, Theocharis S
Curr Med Chem 2019;26(25):4726-4748. doi: 10.2174/0929867325666180713154505. PMID: 30009699
Thyroid gland management in total laryngectomy: meta-analysis and surgical recommendations.
Mendelson AA, Al-Khatib TA, Julien M, Payne RJ, Black MJ, Hier MP
Otolaryngol Head Neck Surg 2009 Mar;140(3):298-305. doi: 10.1016/j.otohns.2008.10.031. PMID: 19248932
Orbital syndromes.
Bhatti MT
Semin Neurol 2007 Jul;27(3):269-87. doi: 10.1055/s-2007-979685. PMID: 17577868

Recent systematic reviews

Thyroid gland invasion in total laryngectomy: A systematic review and meta-analysis.
Xie J, Wu P, Liu H, Zhang S, Lu Z
Int J Surg 2022 Mar;99:106262. Epub 2022 Feb 13 doi: 10.1016/j.ijsu.2022.106262. PMID: 35172203
Cervical esophageal cancer: a gap in cancer knowledge.
Hoeben A, Polak J, Van De Voorde L, Hoebers F, Grabsch HI, de Vos-Geelen J
Ann Oncol 2016 Sep;27(9):1664-74. Epub 2016 Apr 26 doi: 10.1093/annonc/mdw183. PMID: 27117535
Primary squamous cell carcinomas in the thyroid gland: an individual participant data meta-analysis.
Cho JK, Woo SH, Park J, Kim MJ, Jeong HS
Cancer Med 2014 Oct;3(5):1396-403. Epub 2014 Jul 4 doi: 10.1002/cam4.287. PMID: 24995699Free PMC Article
Thyroid gland invasion in total laryngectomy and total laryngopharyngectomy: a systematic review and meta-analysis of the English literature.
Kumar R, Drinnan M, Robinson M, Meikle D, Stafford F, Welch A, Zammit-Maempel I, Paleri V
Clin Otolaryngol 2013 Oct;38(5):372-8. doi: 10.1111/coa.12165. PMID: 23998197
Thyroid gland management in total laryngectomy: meta-analysis and surgical recommendations.
Mendelson AA, Al-Khatib TA, Julien M, Payne RJ, Black MJ, Hier MP
Otolaryngol Head Neck Surg 2009 Mar;140(3):298-305. doi: 10.1016/j.otohns.2008.10.031. PMID: 19248932

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...