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Coronary artery disease, autosomal dominant, 1(ADCAD1)

MedGen UID:
330802
•Concept ID:
C1842247
•
Disease or Syndrome
Synonyms: ADCAD1; CORONARY ARTERY DISEASE WITH MYOCARDIAL INFARCTION
 
Gene (location): MEF2A (15q26.3)
 
Monarch Initiative: MONDO:0012011
OMIM®: 608320

Definition

Coronary artery disease (CAD) and its most important complication, acute myocardial infarction (MI), are leading causes of death and disability in the developed world. Multiple risk factors for CAD/MI have been identified, including family history, hypertension, hypercholesterolemia, obesity, smoking, and diabetes. Several genomewide scans of affected sib pairs have identified susceptibility loci for CAD, e.g., 607339 and 300464. [from OMIM]

Clinical features

From HPO
Chest pain
MedGen UID:
2992
•Concept ID:
C0008031
•
Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.
See: Feature record | Search on this feature
Hypertensive disorder
MedGen UID:
6969
•Concept ID:
C0020538
•
Disease or Syndrome
The presence of chronic increased pressure in the systemic arterial system.
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Myocardial infarction
MedGen UID:
10150
•Concept ID:
C0027051
•
Disease or Syndrome
Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin.
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Premature coronary artery atherosclerosis
MedGen UID:
356830
•Concept ID:
C1867743
•
Disease or Syndrome
Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries before age of 45.
See: Feature record | Search on this feature
Obesity
MedGen UID:
18127
•Concept ID:
C0028754
•
Disease or Syndrome
Accumulation of substantial excess body fat.
See: Feature record | Search on this feature
Diabetes mellitus
MedGen UID:
8350
•Concept ID:
C0011849
•
Disease or Syndrome
A group of abnormalities characterized by hyperglycemia and glucose intolerance.
See: Feature record | Search on this feature
Hypercholesterolemia
MedGen UID:
5687
•Concept ID:
C0020443
•
Disease or Syndrome
An increased concentration of cholesterol in the blood.
See: Feature record | Search on this feature
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Recent clinical studies

Etiology

FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells.
Wong D, Auguste G, Lino Cardenas CL, Turner AW, Chen Y, Song Y, Ma L, Perry RN, Aherrahrou R, Kuppusamy M, Yang C, Mosquera JV, Dube CJ, Khan MD, Palmore M, Kalra J, Kavousi M, Peyser PA, Matic L, Hedin U, Manichaikul A, Sonkusare SK, Civelek M, Kovacic JC, Björkegren JLM, Malhotra R, Miller CL
Circ Res 2023 Apr 28;132(9):1144-1161. Epub 2023 Apr 5 doi: 10.1161/CIRCRESAHA.122.321692. PMID: 37017084Free PMC Article
Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population.
Loh WJ, Chang X, Aw TC, Phua SK, Low AF, Chan MY, Watts GF, Heng CK
Atherosclerosis 2022 May;349:160-165. Epub 2021 Nov 26 doi: 10.1016/j.atherosclerosis.2021.11.018. PMID: 34887076
Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study.
Li GH, Cheung CL, Chung AK, Cheung BM, Wong IC, Fok MLY, Au PC, Sham PC
Psychol Med 2022 Jul;52(9):1765-1776. Epub 2020 Oct 9 doi: 10.1017/S0033291720003566. PMID: 33032663
Systematic use of cardiac magnetic resonance imaging in MINOCA led to a five-fold increase in the detection rate of myocarditis: a retrospective study.
Heidecker B, Ruedi G, Baltensperger N, Gresser E, Kottwitz J, Berg J, Manka R, Landmesser U, Lüscher TF, Patriki D
Swiss Med Wkly 2019 Jul 1;149:w20098. Epub 2019 Jul 3 doi: 10.4414/smw.2019.20098. PMID: 31269222
A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease in Saudi Arabs.
Wakil SM, Ram R, Muiya NP, Mehta M, Andres E, Mazhar N, Baz B, Hagos S, Alshahid M, Meyer BF, Morahan G, Dzimiri N
Atherosclerosis 2016 Feb;245:62-70. Epub 2015 Nov 22 doi: 10.1016/j.atherosclerosis.2015.11.019. PMID: 26708285

Diagnosis

Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population.
Loh WJ, Chang X, Aw TC, Phua SK, Low AF, Chan MY, Watts GF, Heng CK
Atherosclerosis 2022 May;349:160-165. Epub 2021 Nov 26 doi: 10.1016/j.atherosclerosis.2021.11.018. PMID: 34887076
Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study.
Li GH, Cheung CL, Chung AK, Cheung BM, Wong IC, Fok MLY, Au PC, Sham PC
Psychol Med 2022 Jul;52(9):1765-1776. Epub 2020 Oct 9 doi: 10.1017/S0033291720003566. PMID: 33032663
Case report of a 66-year-old woman with atypical takotsubo syndrome and concomitant coronary artery disease.
Niederseer D, Ghadri JR, Manka R, Templin C
BMJ Case Rep 2020 Feb 13;13(2) doi: 10.1136/bcr-2019-230164. PMID: 32060106Free PMC Article
Non-ST elevation myocardial infarction, non-obstructive coronary arteries and severe regional microvascular dysfunction in a patient with dilated cardiomyopathy.
Kite TA, Marrow BA, Nduwayo S, McCann GP
BMJ Case Rep 2019 Oct 23;12(10) doi: 10.1136/bcr-2019-231731. PMID: 31645381Free PMC Article
Systematic use of cardiac magnetic resonance imaging in MINOCA led to a five-fold increase in the detection rate of myocarditis: a retrospective study.
Heidecker B, Ruedi G, Baltensperger N, Gresser E, Kottwitz J, Berg J, Manka R, Landmesser U, Lüscher TF, Patriki D
Swiss Med Wkly 2019 Jul 1;149:w20098. Epub 2019 Jul 3 doi: 10.4414/smw.2019.20098. PMID: 31269222

Therapy

Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study.
Li GH, Cheung CL, Chung AK, Cheung BM, Wong IC, Fok MLY, Au PC, Sham PC
Psychol Med 2022 Jul;52(9):1765-1776. Epub 2020 Oct 9 doi: 10.1017/S0033291720003566. PMID: 33032663
Complete versus culprit-only revascularization for ST-segment-elevation myocardial infarction and multivessel disease: a meta-analysis and trial sequential analysis of randomized trials.
Bangalore S, Toklu B, Wetterslev J
Circ Cardiovasc Interv 2015 Apr;8(4) doi: 10.1161/CIRCINTERVENTIONS.114.002142. PMID: 25873730
Clinical outcomes of everolimus- and zotarolimus-eluting stents in patients with acute myocardial infarction for small coronary artery disease.
Cho SC, Jeong MH, Kim W, Ahn Y, Hong YJ, Kim YJ, Kim CJ, Cho MC, Han KR, Kim HS; Korea Acute Myocardial Infarction Registry Investigators
J Cardiol 2014 Jun;63(6):409-17. Epub 2013 Dec 5 doi: 10.1016/j.jjcc.2013.10.016. PMID: 24314902
Stent thrombosis after primary angioplasty for STEMI in relation to non-adherence to dual antiplatelet therapy over time: results of the HORIZONS-AMI trial.
Dangas GD, Claessen BE, Mehran R, Xu K, Stone GW
EuroIntervention 2013 Jan 22;8(9):1033-9. doi: 10.4244/EIJV8I9A159. PMID: 23339809

Prognosis

Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population.
Loh WJ, Chang X, Aw TC, Phua SK, Low AF, Chan MY, Watts GF, Heng CK
Atherosclerosis 2022 May;349:160-165. Epub 2021 Nov 26 doi: 10.1016/j.atherosclerosis.2021.11.018. PMID: 34887076
A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease in Saudi Arabs.
Wakil SM, Ram R, Muiya NP, Mehta M, Andres E, Mazhar N, Baz B, Hagos S, Alshahid M, Meyer BF, Morahan G, Dzimiri N
Atherosclerosis 2016 Feb;245:62-70. Epub 2015 Nov 22 doi: 10.1016/j.atherosclerosis.2015.11.019. PMID: 26708285
Time-dependent effect of preinfarction angina pectoris and intermittent claudication on mortality following myocardial infarction: A Danish nationwide cohort study.
Schmidt M, Horváth-Puhó E, Pedersen L, Sørensen HT, Bøtker HE
Int J Cardiol 2015;187:462-9. Epub 2015 Mar 21 doi: 10.1016/j.ijcard.2015.03.328. PMID: 25846654
Clinical outcomes of everolimus- and zotarolimus-eluting stents in patients with acute myocardial infarction for small coronary artery disease.
Cho SC, Jeong MH, Kim W, Ahn Y, Hong YJ, Kim YJ, Kim CJ, Cho MC, Han KR, Kim HS; Korea Acute Myocardial Infarction Registry Investigators
J Cardiol 2014 Jun;63(6):409-17. Epub 2013 Dec 5 doi: 10.1016/j.jjcc.2013.10.016. PMID: 24314902
Stent thrombosis after primary angioplasty for STEMI in relation to non-adherence to dual antiplatelet therapy over time: results of the HORIZONS-AMI trial.
Dangas GD, Claessen BE, Mehran R, Xu K, Stone GW
EuroIntervention 2013 Jan 22;8(9):1033-9. doi: 10.4244/EIJV8I9A159. PMID: 23339809

Clinical prediction guides

FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells.
Wong D, Auguste G, Lino Cardenas CL, Turner AW, Chen Y, Song Y, Ma L, Perry RN, Aherrahrou R, Kuppusamy M, Yang C, Mosquera JV, Dube CJ, Khan MD, Palmore M, Kalra J, Kavousi M, Peyser PA, Matic L, Hedin U, Manichaikul A, Sonkusare SK, Civelek M, Kovacic JC, Björkegren JLM, Malhotra R, Miller CL
Circ Res 2023 Apr 28;132(9):1144-1161. Epub 2023 Apr 5 doi: 10.1161/CIRCRESAHA.122.321692. PMID: 37017084Free PMC Article
Lipoprotein(a) as predictor of coronary artery disease and myocardial infarction in a multi-ethnic Asian population.
Loh WJ, Chang X, Aw TC, Phua SK, Low AF, Chan MY, Watts GF, Heng CK
Atherosclerosis 2022 May;349:160-165. Epub 2021 Nov 26 doi: 10.1016/j.atherosclerosis.2021.11.018. PMID: 34887076
Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study.
Li GH, Cheung CL, Chung AK, Cheung BM, Wong IC, Fok MLY, Au PC, Sham PC
Psychol Med 2022 Jul;52(9):1765-1776. Epub 2020 Oct 9 doi: 10.1017/S0033291720003566. PMID: 33032663
A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease in Saudi Arabs.
Wakil SM, Ram R, Muiya NP, Mehta M, Andres E, Mazhar N, Baz B, Hagos S, Alshahid M, Meyer BF, Morahan G, Dzimiri N
Atherosclerosis 2016 Feb;245:62-70. Epub 2015 Nov 22 doi: 10.1016/j.atherosclerosis.2015.11.019. PMID: 26708285
Clinical outcomes of everolimus- and zotarolimus-eluting stents in patients with acute myocardial infarction for small coronary artery disease.
Cho SC, Jeong MH, Kim W, Ahn Y, Hong YJ, Kim YJ, Kim CJ, Cho MC, Han KR, Kim HS; Korea Acute Myocardial Infarction Registry Investigators
J Cardiol 2014 Jun;63(6):409-17. Epub 2013 Dec 5 doi: 10.1016/j.jjcc.2013.10.016. PMID: 24314902

Supplemental Content

Table of contents

    Clinical resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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