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Zinc deficiency, transient neonatal(TNZD)

MedGen UID:
330858
Concept ID:
C1842486
Disease or Syndrome
Synonyms: TNZD; ZINC DEFICIENCY, NEONATAL, DUE TO LOW BREAST MILK ZINC
 
Gene (location): SLC30A2 (1p36.11)
 
Monarch Initiative: MONDO:0011973
OMIM®: 608118

Definition

Transient neonatal zinc deficiency occurs in breast-fed infants as a consequence of low milk zinc concentration in their nursing mothers, which cannot be corrected by maternal zinc supplementation. A large amount of zinc, an essential trace mineral, is required for normal growth particularly in infants, and breast milk normally contains adequate zinc to meet the requirement for infants up to 4 to 6 months of age. Zinc deficiency can lead to dermatitis, alopecia, decreased growth, and impaired immune function. The disorder shows autosomal dominant inheritance with incomplete penetrance (summary by Chowanadisai et al., 2006). Some aspects of TNZD resemble the more severe disorder acrodermatitis enteropathica (AEZ; 201100), an autosomal recessive disorder caused by mutation in the zinc transporter SLC39A4 (607059). However, infants with transient neonatal zinc deficiency do not require zinc supplementation following weaning and have normal zinc absorption, whereas those with AEZ require lifelong zinc supplementation (summary by Chowanadisai et al., 2006). [from OMIM]

Clinical features

From HPO
Eczematoid dermatitis
MedGen UID:
3968
Concept ID:
C0013595
Disease or Syndrome
Eczema is a form of dermatitis that is characterized by scaly, pruritic, erythematous lesions located on flexural surfaces.
Decreased serum zinc
MedGen UID:
1642863
Concept ID:
C4703561
Finding
A reduced concentration of zinc in the blood.
Alopecia
MedGen UID:
7982
Concept ID:
C0002170
Finding
A noncongenital process of hair loss, which may progress to partial or complete baldness.

Recent clinical studies

Etiology

Burcham LR, Burcham ZM, Akbari MS, Metcalf JL, Doran KS
mSphere 2022 Aug 31;7(4):e0026422. Epub 2022 Aug 9 doi: 10.1128/msphere.00264-22. PMID: 35943198Free PMC Article
Golan Y, Lehvy A, Horev G, Assaraf YG
J Cell Mol Med 2019 Feb;23(2):828-840. Epub 2018 Nov 18 doi: 10.1111/jcmm.13982. PMID: 30450693Free PMC Article
Watson L, Cartwright D, Jardine LA, Pincus D, Koorts P, Kury S, Bezieau S, George S, Moloney S, Holt J, Coman D
J Paediatr Child Health 2018 Mar;54(3):319-322. Epub 2017 Nov 16 doi: 10.1111/jpc.13780. PMID: 29143460
Kasana S, Din J, Maret W
J Trace Elem Med Biol 2015 Jan;29:47-62. doi: 10.1016/j.jtemb.2014.10.003. PMID: 25468189
Ustundag B, Yilmaz E, Dogan Y, Akarsu S, Canatan H, Halifeoglu I, Cikim G, Aygun AD
Mediators Inflamm 2005 Dec 14;2005(6):331-6. doi: 10.1155/MI.2005.331. PMID: 16489252Free PMC Article

Diagnosis

King NY, Gach JE
Clin Exp Dermatol 2021 Dec;46(8):1650-1652. Epub 2021 Jun 18 doi: 10.1111/ced.14755. PMID: 34142742
Golan Y, Lehvy A, Horev G, Assaraf YG
J Cell Mol Med 2019 Feb;23(2):828-840. Epub 2018 Nov 18 doi: 10.1111/jcmm.13982. PMID: 30450693Free PMC Article
Golan Y, Kambe T, Assaraf YG
Metallomics 2017 Oct 18;9(10):1352-1366. doi: 10.1039/c7mt00162b. PMID: 28665435
Golan Y, Itsumura N, Glaser F, Berman B, Kambe T, Assaraf YG
J Biol Chem 2016 Jun 24;291(26):13546-59. Epub 2016 May 2 doi: 10.1074/jbc.M116.732693. PMID: 27137936Free PMC Article
Krieger I, Alpern BE, Cunnane SC
Am J Clin Nutr 1986 Jun;43(6):955-8. doi: 10.1093/ajcn/43.6.955. PMID: 3717070

Therapy

King NY, Gach JE
Clin Exp Dermatol 2021 Dec;46(8):1650-1652. Epub 2021 Jun 18 doi: 10.1111/ced.14755. PMID: 34142742
Mohammed J, Mehrotra S, Schulz H, Lim R
Pediatr Emerg Care 2017 Aug;33(8):582-584. doi: 10.1097/PEC.0000000000001218. PMID: 28697160
Kambe T, Fukue K, Ishida R, Miyazaki S
J Nutr Sci Vitaminol (Tokyo) 2015;61 Suppl:S44-6. doi: 10.3177/jnsv.61.S44. PMID: 26598882
Zattra E, Belloni Fortina A
G Ital Dermatol Venereol 2013 Dec;148(6):699-702. PMID: 24442054
Krieger I, Alpern BE, Cunnane SC
Am J Clin Nutr 1986 Jun;43(6):955-8. doi: 10.1093/ajcn/43.6.955. PMID: 3717070

Prognosis

Burcham LR, Burcham ZM, Akbari MS, Metcalf JL, Doran KS
mSphere 2022 Aug 31;7(4):e0026422. Epub 2022 Aug 9 doi: 10.1128/msphere.00264-22. PMID: 35943198Free PMC Article
Golan Y, Lehvy A, Horev G, Assaraf YG
J Cell Mol Med 2019 Feb;23(2):828-840. Epub 2018 Nov 18 doi: 10.1111/jcmm.13982. PMID: 30450693Free PMC Article
Coelho S, Fernandes B, Rodrigues F, Reis JP, Moreno A, Figueiredo A
Eur J Dermatol 2006 Mar-Apr;16(2):193-5. PMID: 16581577
Stapleton KM, O'Loughlin E, Relic JP
Australas J Dermatol 1995 Aug;36(3):157-9. doi: 10.1111/j.1440-0960.1995.tb00959.x. PMID: 7487743
Yang DR, Huie ML, Hirschhorn R
Clin Immunol Immunopathol 1994 Feb;70(2):171-5. doi: 10.1006/clin.1994.1026. PMID: 8299233

Clinical prediction guides

Burcham LR, Burcham ZM, Akbari MS, Metcalf JL, Doran KS
mSphere 2022 Aug 31;7(4):e0026422. Epub 2022 Aug 9 doi: 10.1128/msphere.00264-22. PMID: 35943198Free PMC Article
Golan Y, Lehvy A, Horev G, Assaraf YG
J Cell Mol Med 2019 Feb;23(2):828-840. Epub 2018 Nov 18 doi: 10.1111/jcmm.13982. PMID: 30450693Free PMC Article
Kasana S, Din J, Maret W
J Trace Elem Med Biol 2015 Jan;29:47-62. doi: 10.1016/j.jtemb.2014.10.003. PMID: 25468189
Zattra E, Belloni Fortina A
G Ital Dermatol Venereol 2013 Dec;148(6):699-702. PMID: 24442054
Krieger I, Alpern BE, Cunnane SC
Am J Clin Nutr 1986 Jun;43(6):955-8. doi: 10.1093/ajcn/43.6.955. PMID: 3717070

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