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Longitudinal vaginal septum

MedGen UID:
331104
Concept ID:
C1841680
Finding
Synonyms: longitudinal vaginal septum; Vertical vaginal septum
 
HPO: HP:0008740
Monarch Initiative: MONDO:0015849
Orphanet: ORPHA180157

Definition

The presence of a longitudinal vaginal septum, thereby creating a vaginal duplication. [from HPO]

Term Hierarchy

Conditions with this feature

Mullerian duct anomalies-limb anomalies syndrome
MedGen UID:
327078
Concept ID:
C1840335
Disease or Syndrome
Mullerian duct anomalies-limb anomalies syndrome is characterised by the association of mullerian duct and distal limb anomalies. It has been described in five individuals from one family. Females presented with anomalies ranging from a vaginal septum to complete duplication of uterus and vagina, and males presented with micropenis. The limb anomalies varied from postaxial polydactyly to severe upper limb hypoplasia with split hand. The mode of transmission is autosomal dominant.
Hand-foot-genital syndrome
MedGen UID:
331103
Concept ID:
C1841679
Disease or Syndrome
Hand-foot-genital syndrome (HFGS) is characterized by limb malformations and urogenital defects. Mild-to-severe bilateral shortening of the thumbs and great toes, caused primarily by shortening of the distal phalanx and/or the first metacarpal or metatarsal, is the most common limb malformation and results in impaired dexterity or apposition of the thumbs. Urogenital malformations include abnormalities of the ureters and urethra and various degrees of incomplete müllerian fusion in females, and hypospadias of variable severity with or without chordee in males. Vesicoureteral reflux, recurrent urinary tract infections, and chronic pyelonephritis may occur; fertility is normal.

Professional guidelines

PubMed

Obstet Gynecol 2019 Jun;133(6):e372-e376. doi: 10.1097/AOG.0000000000003283. PMID: 31135763
Obstet Gynecol 2019 Jun;133(6):1292-1293. doi: 10.1097/AOG.0000000000003284. PMID: 31135760
Patton PE, Novy MJ, Lee DM, Hickok LR
Am J Obstet Gynecol 2004 Jun;190(6):1669-75; discussion 1675-8. doi: 10.1016/j.ajog.2004.02.046. PMID: 15284765

Recent clinical studies

Etiology

Li L, Adeyemi-Fowode O, Bercaw-Pratt JL, Hakim J, Dietrich JE
J Pediatr Adolesc Gynecol 2024 Apr;37(2):198-204. Epub 2023 Dec 7 doi: 10.1016/j.jpag.2023.11.007. PMID: 38070700
Chu K, James D, McNamara K, Jongco B, Velcek F
J Pediatr Adolesc Gynecol 2020 Aug;33(4):435-437. Epub 2020 Mar 14 doi: 10.1016/j.jpag.2020.02.011. PMID: 32179069
Mazzon I, Gerli S, Di Angelo Antonio S, Assorgi C, Villani V, Favilli A
J Minim Invasive Gynecol 2020 Jan;27(1):60-64. Epub 2019 Mar 20 doi: 10.1016/j.jmig.2019.02.019. PMID: 30904487
Saygili-Yilmaz ES, Erman-Akar M, Bayar D, Yuksel B, Yilmaz Z
J Reprod Med 2004 Oct;49(10):833-6. PMID: 15568409
Haddad B, Louis-Sylvestre C, Poitout P, Paniel BJ
Eur J Obstet Gynecol Reprod Biol 1997 Aug;74(2):197-9. doi: 10.1016/s0301-2115(97)00105-x. PMID: 9306118

Diagnosis

Geng B, St Martin B, Harmanli O
J Minim Invasive Gynecol 2024 May;31(5):367. Epub 2024 Feb 5 doi: 10.1016/j.jmig.2024.01.020. PMID: 38325582
Li L, Adeyemi-Fowode O, Bercaw-Pratt JL, Hakim J, Dietrich JE
J Pediatr Adolesc Gynecol 2024 Apr;37(2):198-204. Epub 2023 Dec 7 doi: 10.1016/j.jpag.2023.11.007. PMID: 38070700
Mazzon I, Gerli S, Di Angelo Antonio S, Assorgi C, Villani V, Favilli A
J Minim Invasive Gynecol 2020 Jan;27(1):60-64. Epub 2019 Mar 20 doi: 10.1016/j.jmig.2019.02.019. PMID: 30904487
Ribeiro SC, Yamakami LY, Tormena RA, Pinheiro Wda S, Almeida JA, Baracat EC
Rev Assoc Med Bras (1992) 2010 Mar-Apr;56(2):254-6. doi: 10.1590/s0104-42302010000200029. PMID: 20499005
López C, Balogun M, Ganesan R, Olliff JF
Clin Radiol 2005 Jun;60(6):648-62. doi: 10.1016/j.crad.2005.02.010. PMID: 16038691

Therapy

Tsai S, Romanski PA, Bortoletto P, Pfeifer SM
Fertil Steril 2024 Jan;121(1):128-130. Epub 2023 Oct 26 doi: 10.1016/j.fertnstert.2023.10.022. PMID: 37898469
Ludwin A, Lindheim SR, Bhagavath B, Martins WP, Ludwin I
Fertil Steril 2020 Oct;114(4):899-901. Epub 2020 Aug 18 doi: 10.1016/j.fertnstert.2020.06.014. PMID: 32826051
Mazzon I, Gerli S, Di Angelo Antonio S, Assorgi C, Villani V, Favilli A
J Minim Invasive Gynecol 2020 Jan;27(1):60-64. Epub 2019 Mar 20 doi: 10.1016/j.jmig.2019.02.019. PMID: 30904487
Batioglu S, Zeyneloglu HB
Gynecol Obstet Invest 1999;47(2):144-6. doi: 10.1159/000010079. PMID: 9949287
Damario MA, Holcomb K, Bodack MP
J Am Assoc Gynecol Laparosc 1996 Nov;4(1):69-72. doi: 10.1016/s1074-3804(96)80112-5. PMID: 9050715

Prognosis

Tsai S, Romanski PA, Bortoletto P, Pfeifer SM
Fertil Steril 2024 Jan;121(1):128-130. Epub 2023 Oct 26 doi: 10.1016/j.fertnstert.2023.10.022. PMID: 37898469
Shavell VI, Montgomery SE, Johnson SC, Diamond MP, Berman JM
Arch Gynecol Obstet 2009 Sep;280(3):449-52. Epub 2009 Jan 9 doi: 10.1007/s00404-008-0919-6. PMID: 19132379
Saygili-Yilmaz ES, Erman-Akar M, Bayar D, Yuksel B, Yilmaz Z
J Reprod Med 2004 Oct;49(10):833-6. PMID: 15568409
Patton PE, Novy MJ, Lee DM, Hickok LR
Am J Obstet Gynecol 2004 Jun;190(6):1669-75; discussion 1675-8. doi: 10.1016/j.ajog.2004.02.046. PMID: 15284765
Heinonen PK
Eur J Obstet Gynecol Reprod Biol 2000 Aug;91(2):183-90. doi: 10.1016/s0301-2115(99)00259-6. PMID: 10869793

Clinical prediction guides

Li L, Adeyemi-Fowode O, Bercaw-Pratt JL, Hakim J, Dietrich JE
J Pediatr Adolesc Gynecol 2024 Apr;37(2):198-204. Epub 2023 Dec 7 doi: 10.1016/j.jpag.2023.11.007. PMID: 38070700
Bindra V, Reddy CA, Swetha P, Madhavi N
Fertil Steril 2022 Oct;118(4):808-809. Epub 2022 Aug 8 doi: 10.1016/j.fertnstert.2022.06.027. PMID: 35953315
Di Spiezio Sardo A, Manzi A, Zizolfi B, Giampaolino P, Carugno J, Grimbizis G
Fertil Steril 2021 Aug;116(2):602-604. Epub 2021 May 8 doi: 10.1016/j.fertnstert.2021.04.011. PMID: 33975726
Grynberg M, Gervaise A, Faivre E, Deffieux X, Frydman R, Fernandez H
J Minim Invasive Gynecol 2012 Jan-Feb;19(1):34-9. Epub 2011 Oct 22 doi: 10.1016/j.jmig.2011.08.726. PMID: 22020009
Heinonen PK
Fertil Steril 2006 Mar;85(3):700-5. doi: 10.1016/j.fertnstert.2005.08.039. PMID: 16500341

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