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Portal vein, cavernous transformation of

MedGen UID:
331396
•Concept ID:
C1832917
•
Disease or Syndrome
Synonym: Portal Vein, Cavernous Transformation Of
 
Monarch Initiative: MONDO:0010978
OMIM®: 601004

Clinical features

From HPO
Extrahepatic portal hypertension
MedGen UID:
870811
•Concept ID:
C4025268
•
Disease or Syndrome
Increased pressure in the pre-hepatic portal vein.
See: Feature record | Search on this feature

Recent clinical studies

Etiology

Transjugular intrahepatic collateral-systemic shunt is effective for cavernous transformation of the portal vein with variceal bleeding.
Tie J, Gou X, He C, Li K, Yuan X, Jia W, Niu J, Han N, Xu J, Zhu Y, Wang W
Hepatol Int 2023 Aug;17(4):979-988. Epub 2023 Apr 25 doi: 10.1007/s12072-023-10522-z. PMID: 37097537Free PMC Article
Combined transjugular/percutaneous intrahepatic portosystemic shunts (cTIPS) for cavernous transformation of the portal vein after conventional transjugular approach TIPS failure.
Bi Y, Ren J, Han X, Guo K, Tu X
Medicine (Baltimore) 2023 Apr 21;102(16):e33608. doi: 10.1097/MD.0000000000033608. PMID: 37083811Free PMC Article
Portal Vein Recanalization for Noncirrhotic Portal Vein Cavernous Transformation: Transjugular Intrahepatic Portosystemic Shunt Creation versus Portal Vein Stent Placement.
Wei B, Huang Z, Wu H, Tai Y, Tong H, Li Q, Wang Z, Yang R, Tang C
J Vasc Interv Radiol 2023 Feb;34(2):187-194. Epub 2022 Nov 7 doi: 10.1016/j.jvir.2022.10.039. PMID: 36356710
Portal cavernoma or chronic non cirrhotic extrahepatic portal vein obstruction.
Elkrief L, Houssel-Debry P, Ackermann O, Franchi-Abella S, Branchereau S, Valla D, Hillaire S, Dutheil D, Plessier A, Hernandez-Gea V, Bureau C
Clin Res Hepatol Gastroenterol 2020 Sep;44(4):491-496. Epub 2020 Aug 17 doi: 10.1016/j.clinre.2020.03.016. PMID: 32819872
The keys to successful TIPS in patients with portal vein thrombosis and cavernous transformation.
Lombardo S, Espejo JJ, Pérez-Montilla ME, Zurera LJ, González-Galilea Á
Radiologia (Engl Ed) 2018 Mar-Apr;60(2):94-104. Epub 2017 Nov 6 doi: 10.1016/j.rx.2017.08.006. PMID: 29122309

Diagnosis

Combined transjugular/percutaneous intrahepatic portosystemic shunts (cTIPS) for cavernous transformation of the portal vein after conventional transjugular approach TIPS failure.
Bi Y, Ren J, Han X, Guo K, Tu X
Medicine (Baltimore) 2023 Apr 21;102(16):e33608. doi: 10.1097/MD.0000000000033608. PMID: 37083811Free PMC Article
Portal cavernoma or chronic non cirrhotic extrahepatic portal vein obstruction.
Elkrief L, Houssel-Debry P, Ackermann O, Franchi-Abella S, Branchereau S, Valla D, Hillaire S, Dutheil D, Plessier A, Hernandez-Gea V, Bureau C
Clin Res Hepatol Gastroenterol 2020 Sep;44(4):491-496. Epub 2020 Aug 17 doi: 10.1016/j.clinre.2020.03.016. PMID: 32819872
Choledochal varices: An uncommon cholangioscopic finding.
Senra Lorenzana F, Navaratne L, Martínez Isla A
Cir Esp (Engl Ed) 2020 Jun-Jul;98(6):361. Epub 2020 Feb 17 doi: 10.1016/j.ciresp.2019.12.010. PMID: 32081376
Portal biliary ductopathy caused by cavernous transformation of the portal vein.
Chong JC, Boyapati R, Rusli F
BMJ Case Rep 2013 Jan 31;2013 doi: 10.1136/bcr-2012-008339. PMID: 23376675Free PMC Article
Editor's quiz: GI snapshot. A case of jaundice in portal hypertension.
Kashikar SV, Tham TC, Bansal M, Lakhkar B, Manikpure GP
Gut 2013 Dec;62(12):1763, 1816. Epub 2013 Jan 7 doi: 10.1136/gutjnl-2012-303817. PMID: 23300137

Therapy

Computed tomography imaging features to evaluate the severity of portal hypertension and predict the rebleeding risk after endoscopic treatment in cirrhotic patients with variceal hemorrhage.
Rao C, Chen J, Wang W, Xue C, Wu L, Huang X, Chen S, Rao S, Li F
Eur J Radiol 2023 Jun;163:110841. Epub 2023 Apr 23 doi: 10.1016/j.ejrad.2023.110841. PMID: 37104896
Transjugular intrahepatic collateral-systemic shunt is effective for cavernous transformation of the portal vein with variceal bleeding.
Tie J, Gou X, He C, Li K, Yuan X, Jia W, Niu J, Han N, Xu J, Zhu Y, Wang W
Hepatol Int 2023 Aug;17(4):979-988. Epub 2023 Apr 25 doi: 10.1007/s12072-023-10522-z. PMID: 37097537Free PMC Article
Portal Vein Recanalization for Noncirrhotic Portal Vein Cavernous Transformation: Transjugular Intrahepatic Portosystemic Shunt Creation versus Portal Vein Stent Placement.
Wei B, Huang Z, Wu H, Tai Y, Tong H, Li Q, Wang Z, Yang R, Tang C
J Vasc Interv Radiol 2023 Feb;34(2):187-194. Epub 2022 Nov 7 doi: 10.1016/j.jvir.2022.10.039. PMID: 36356710
Choledochal varices: An uncommon cholangioscopic finding.
Senra Lorenzana F, Navaratne L, Martínez Isla A
Cir Esp (Engl Ed) 2020 Jun-Jul;98(6):361. Epub 2020 Feb 17 doi: 10.1016/j.ciresp.2019.12.010. PMID: 32081376
Transjugular intrahepatic portosystemic shunt prevents rebleeding in cirrhotic patients having cavernous transformation of the portal vein without improving their survival.
Li LN, Sun XY, Wang GC, Tian XG, Zhang MY, Jiang KT, Zhang CQ
J Dig Dis 2019 Feb;20(2):89-96. Epub 2019 Mar 3 doi: 10.1111/1751-2980.12702. PMID: 30629804

Prognosis

Computed tomography imaging features to evaluate the severity of portal hypertension and predict the rebleeding risk after endoscopic treatment in cirrhotic patients with variceal hemorrhage.
Rao C, Chen J, Wang W, Xue C, Wu L, Huang X, Chen S, Rao S, Li F
Eur J Radiol 2023 Jun;163:110841. Epub 2023 Apr 23 doi: 10.1016/j.ejrad.2023.110841. PMID: 37104896
Portal cavernoma or chronic non cirrhotic extrahepatic portal vein obstruction.
Elkrief L, Houssel-Debry P, Ackermann O, Franchi-Abella S, Branchereau S, Valla D, Hillaire S, Dutheil D, Plessier A, Hernandez-Gea V, Bureau C
Clin Res Hepatol Gastroenterol 2020 Sep;44(4):491-496. Epub 2020 Aug 17 doi: 10.1016/j.clinre.2020.03.016. PMID: 32819872
Pancreatic Surgery in Chronic Pancreatitis Complicated by Extrahepatic Portal Hypertension or Cavernous Transformation of the Portal Vein: A Systematic Review.
Latorre Fragua RA, Manuel Vázquez A, López Marcano AJ, Gijón De La Santa L, de la Plaza Llamas R, Ramia Ángel JM
Scand J Surg 2020 Sep;109(3):177-186. Epub 2019 Jun 23 doi: 10.1177/1457496919857260. PMID: 31232190
Cholangiopathy in children with extrahepatic portal venous obstruction.
Sen Sarma M, Yachha SK, Rai P, Neyaz Z, Srivastava A, Poddar U
J Hepatobiliary Pancreat Sci 2018 Oct;25(10):440-447. Epub 2018 Oct 16 doi: 10.1002/jhbp.582. PMID: 30259697
Short-Term Outcome of Patients with Cirrhosis and Concurrent Portal Cavernoma Presenting with Acute Variceal Bleeding.
Luo X, Wang W, Fan X, Zhao Y, Wang X, Yang J, Yang L
Can J Gastroenterol Hepatol 2018;2018:9491856. Epub 2018 Jan 24 doi: 10.1155/2018/9491856. PMID: 29623267Free PMC Article

Clinical prediction guides

Efficacy and safety of precision-guided transjugular extrahepatic portosystemic shunt (TEPS) in the management of cavernous transformation of the portal vein with portal hypertension: a case series.
Zhang L, Zhu YJ, Wang XQ, Wang RF, Dong L, Yin L, Lv WF, Cheng DL, Zhou CZ
Hepatol Int 2024 Aug;18(4):1227-1237. Epub 2024 Apr 9 doi: 10.1007/s12072-024-10656-8. PMID: 38594475Free PMC Article
Intrahepatic portal venous systems in adult patients with cavernous transformation of portal vein: Imaging features and a new classification.
Huang X, Lu Q, Zhang YW, Zhang L, Ren ZZ, Yang XW, Liu Y, Tang R
Hepatobiliary Pancreat Dis Int 2024 Oct;23(5):481-486. Epub 2023 Jan 14 doi: 10.1016/j.hbpd.2023.01.002. PMID: 36693772
Computed tomography imaging features to evaluate the severity of portal hypertension and predict the rebleeding risk after endoscopic treatment in cirrhotic patients with variceal hemorrhage.
Rao C, Chen J, Wang W, Xue C, Wu L, Huang X, Chen S, Rao S, Li F
Eur J Radiol 2023 Jun;163:110841. Epub 2023 Apr 23 doi: 10.1016/j.ejrad.2023.110841. PMID: 37104896
Cholangiopathy in children with extrahepatic portal venous obstruction.
Sen Sarma M, Yachha SK, Rai P, Neyaz Z, Srivastava A, Poddar U
J Hepatobiliary Pancreat Sci 2018 Oct;25(10):440-447. Epub 2018 Oct 16 doi: 10.1002/jhbp.582. PMID: 30259697
Short-Term Outcome of Patients with Cirrhosis and Concurrent Portal Cavernoma Presenting with Acute Variceal Bleeding.
Luo X, Wang W, Fan X, Zhao Y, Wang X, Yang J, Yang L
Can J Gastroenterol Hepatol 2018;2018:9491856. Epub 2018 Jan 24 doi: 10.1155/2018/9491856. PMID: 29623267Free PMC Article

Recent systematic reviews

Pancreatic Surgery in Chronic Pancreatitis Complicated by Extrahepatic Portal Hypertension or Cavernous Transformation of the Portal Vein: A Systematic Review.
Latorre Fragua RA, Manuel Vázquez A, López Marcano AJ, Gijón De La Santa L, de la Plaza Llamas R, Ramia Ángel JM
Scand J Surg 2020 Sep;109(3):177-186. Epub 2019 Jun 23 doi: 10.1177/1457496919857260. PMID: 31232190
Therapeutic approaches for portal biliopathy: A systematic review.
Franceschet I, Zanetto A, Ferrarese A, Burra P, Senzolo M
World J Gastroenterol 2016 Dec 7;22(45):9909-9920. doi: 10.3748/wjg.v22.i45.9909. PMID: 28018098Free PMC Article

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