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Nocturnal enuresis, 2(ENUR2)

MedGen UID:
331473
Concept ID:
C1833268
Disease or Syndrome
Synonym: Enuresis, Nocturnal, 2
 
Monarch Initiative: MONDO:0010941
OMIM®: 600808

Definition

Nocturnal enuresis where the child has been dry for at least 6 months but enuresis has recurred. [from MONDO]

Clinical features

From HPO
Nocturnal enuresis
MedGen UID:
124355
Concept ID:
C0270327
Mental or Behavioral Dysfunction
Nocturnal enuresis, or nightly bedwetting in children more than 7 years of age, affects about 10% of 7-year-old children, with a wide range of frequencies between populations. The affliction is often linked to major social maladjustments and occupies considerable time in general medical practice. From the age of 7, there is a spontaneous cure rate of 15% per year, such that few remain affected after the age of 16 years. There are 2 types of nocturnal enuresis: type I, the primary form (PNE), with at least 3 nightly episodes in children older than 7 years, where the child has always had the disorder, and type II, or secondary type, where the child has been dry for at least 6 months but enuresis has recurred (summary by Eiberg et al., 1995). Genetic Heterogeneity of Nocturnal Enuresis ENUR1 has been mapped to chromosome 13q, and ENUR2 has been mapped to chromosome 12q.

Professional guidelines

PubMed

Anwar T, Cooper CS, Lockwood G, Ferguson KJ, Barlow PB, Storm DW
J Pediatr Urol 2019 Oct;15(5):528.e1-528.e8. Epub 2019 Jul 27 doi: 10.1016/j.jpurol.2019.07.016. PMID: 31445857
von Gontard A
Eur Child Adolesc Psychiatry 2013 Feb;22 Suppl 1:S61-7. doi: 10.1007/s00787-012-0363-9. PMID: 23247389

Recent clinical studies

Etiology

Rodríguez-Ruiz M, Mendez-Gallart R, García Mérida M, Somoza-Argibay I
An Pediatr (Engl Ed) 2021 Aug;95(2):108-115. Epub 2021 May 10 doi: 10.1016/j.anpede.2020.06.011. PMID: 34373073
Taborga Díaz E, Martínez Suárez V, Alcántara-Canabal L, Suárez Castañón C, Cebrián Muíños C
An Pediatr (Engl Ed) 2021 Aug;95(2):101-107. Epub 2021 Jun 29 doi: 10.1016/j.anpede.2020.08.005. PMID: 34210621
Kiddoo D
BMJ Clin Evid 2011 Jan 31;2011 PMID: 21477399Free PMC Article
Kiddoo D
BMJ Clin Evid 2007 Oct 1;2007 PMID: 19450363Free PMC Article
Nevéus T, Läckgren G, Tuvemo T, Hetta J, Hjälmås K, Stenberg A
Scand J Urol Nephrol Suppl 2000;(206):1-44. PMID: 11196246

Diagnosis

Liu J, Zhang X, Zhao Y, Wang Y
PLoS One 2020;15(2):e0228533. Epub 2020 Feb 13 doi: 10.1371/journal.pone.0228533. PMID: 32053609Free PMC Article
Walker RA
Prim Care 2019 Jun;46(2):243-248. doi: 10.1016/j.pop.2019.02.005. PMID: 31030825
Kiddoo D
BMJ Clin Evid 2011 Jan 31;2011 PMID: 21477399Free PMC Article
Kiddoo D
BMJ Clin Evid 2007 Oct 1;2007 PMID: 19450363Free PMC Article
Schmitt BD
Pediatr Rev 1997 Jun;18(6):183-90; quiz 91. doi: 10.1542/pir.18-6-183. PMID: 9167432

Therapy

Purnomo AF, Daryanto B, Nurhadi P
Med Arch 2021 Dec;75(6):431-435. doi: 10.5455/medarh.2021.75.431-435. PMID: 35169370Free PMC Article
Prince E, Heys M
Drug Ther Bull 2020 Feb;58(2):25-29. doi: 10.1136/dtb.2018.000034. PMID: 32001450
Walker RA
Prim Care 2019 Jun;46(2):243-248. doi: 10.1016/j.pop.2019.02.005. PMID: 31030825
Parnell Prevost C, Gleberzon B, Carleo B, Anderson K, Cark M, Pohlman KA
BMC Complement Altern Med 2019 Mar 13;19(1):60. doi: 10.1186/s12906-019-2447-2. PMID: 30866915Free PMC Article
Kiddoo D
BMJ Clin Evid 2011 Jan 31;2011 PMID: 21477399Free PMC Article

Prognosis

Song QX, Wang L, Cheng X, Hao Y, Liu Z, Abrams P
BJU Int 2020 Oct;126(4):472-480. Epub 2020 Jul 24 doi: 10.1111/bju.15126. PMID: 32475016Free PMC Article
von Gontard A, Overs C, Moritz AM, Thomé-Granz S, Hussong J
Neurourol Urodyn 2019 Nov;38(8):2280-2287. Epub 2019 Aug 8 doi: 10.1002/nau.24134. PMID: 31397011
Ma Y, Shen Y, Liu X
Int Braz J Urol 2019 Jul-Aug;45(4):790-797. doi: 10.1590/S1677-5538.IBJU.2018.0603. PMID: 31184451Free PMC Article
Jeyakumar A, Rahman SI, Armbrecht ES, Mitchell R
Laryngoscope 2012 Aug;122(8):1873-7. Epub 2012 May 1 doi: 10.1002/lary.23323. PMID: 22549900
Nevéus T
Curr Opin Pediatr 2009 Apr;21(2):199-202. doi: 10.1097/MOP.0b013e3283229b12. PMID: 19307899

Clinical prediction guides

Rodríguez-Ruiz M, Mendez-Gallart R, García Mérida M, Somoza-Argibay I
An Pediatr (Engl Ed) 2021 Aug;95(2):108-115. Epub 2021 May 10 doi: 10.1016/j.anpede.2020.06.011. PMID: 34373073
Taborga Díaz E, Martínez Suárez V, Alcántara-Canabal L, Suárez Castañón C, Cebrián Muíños C
An Pediatr (Engl Ed) 2021 Aug;95(2):101-107. Epub 2021 Jun 29 doi: 10.1016/j.anpede.2020.08.005. PMID: 34210621
Liu J, Zhang X, Zhao Y, Wang Y
PLoS One 2020;15(2):e0228533. Epub 2020 Feb 13 doi: 10.1371/journal.pone.0228533. PMID: 32053609Free PMC Article
Kiddoo D
BMJ Clin Evid 2011 Jan 31;2011 PMID: 21477399Free PMC Article
Kiddoo D
BMJ Clin Evid 2007 Oct 1;2007 PMID: 19450363Free PMC Article

Recent systematic reviews

Liu J, Zhang X, Zhao Y, Wang Y
PLoS One 2020;15(2):e0228533. Epub 2020 Feb 13 doi: 10.1371/journal.pone.0228533. PMID: 32053609Free PMC Article
Parnell Prevost C, Gleberzon B, Carleo B, Anderson K, Cark M, Pohlman KA
BMC Complement Altern Med 2019 Mar 13;19(1):60. doi: 10.1186/s12906-019-2447-2. PMID: 30866915Free PMC Article
Kiddoo D
BMJ Clin Evid 2015 Jan 13;2015 PMID: 25585036Free PMC Article
Kiddoo D
BMJ Clin Evid 2011 Jan 31;2011 PMID: 21477399Free PMC Article
Kiddoo D
BMJ Clin Evid 2007 Oct 1;2007 PMID: 19450363Free PMC Article

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