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Cerebral infarction

MedGen UID:
3321
•Concept ID:
C0007785
•
Disease or Syndrome
Synonym: Cerebral infarct
SNOMED CT: Cerebral infarction (432504007)
 
HPO: HP:0025722
Monarch Initiative: MONDO:0002679
OMIM®: 601367

Definition

A necrotic lesion in the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors. [from HPO]

Professional guidelines

PubMed

Contemporary antiplatelet therapy for secondary stroke prevention: a narrative review of current literature and guidelines.
Shah J, Liu S, Yu W
Stroke Vasc Neurol 2022 Oct;7(5):406-414. Epub 2022 Apr 7 doi: 10.1136/svn-2021-001166. PMID: 35393359Free PMC Article
Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review).
Zhao Y, Zhang X, Chen X, Wei Y
Int J Mol Med 2022 Feb;49(2) Epub 2021 Dec 8 doi: 10.3892/ijmm.2021.5070. PMID: 34878154Free PMC Article
Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.
Demaerschalk BM, Kleindorfer DO, Adeoye OM, Demchuk AM, Fugate JE, Grotta JC, Khalessi AA, Levy EI, Palesch YY, Prabhakaran S, Saposnik G, Saver JL, Smith EE; American Heart Association Stroke Council and Council on Epidemiology and Prevention
Stroke 2016 Feb;47(2):581-641. Epub 2015 Dec 22 doi: 10.1161/STR.0000000000000086. PMID: 26696642

Recent clinical studies

Etiology

HMGB1, angel or devil, in ischemic stroke.
Gao B, Wang S, Li J, Han N, Ge H, Zhang G, Chang M
Brain Behav 2023 May;13(5):e2987. Epub 2023 Apr 16 doi: 10.1002/brb3.2987. PMID: 37062906Free PMC Article
Postprandial cerebral infarction.
Ikenouchi H, Yoshimoto T, Ihara M
J Clin Neurosci 2021 Dec;94:38-40. Epub 2021 Oct 6 doi: 10.1016/j.jocn.2021.09.034. PMID: 34863460
Chlamydia pneumoniae infection and cerebral infarction risk: a meta-analysis.
Su X, Chen HL
Int J Stroke 2014 Apr;9(3):356-64. Epub 2014 Mar 5 doi: 10.1111/ijs.12248. PMID: 24597545
Neonatal cerebral infarction.
Miller V
Semin Pediatr Neurol 2000 Dec;7(4):278-88. doi: 10.1053/spen.2000.20076. PMID: 11205717
Classification and natural history of clinically identifiable subtypes of cerebral infarction.
Bamford J, Sandercock P, Dennis M, Burn J, Warlow C
Lancet 1991 Jun 22;337(8756):1521-6. doi: 10.1016/0140-6736(91)93206-o. PMID: 1675378

Diagnosis

Pulmonary Vein Stump Thrombosis and Cerebral Infarction after Left Upper Lobectomy.
Yasuura Y, Kayata H, Konno H, Kojima H, Mizuno T, Isaka M, Ohde Y
Thorac Cardiovasc Surg 2023 Oct;71(7):589-594. Epub 2023 Feb 3 doi: 10.1055/s-0043-1761274. PMID: 36736369
Associations between the size and location of myocardial infarction and cerebral infarction.
Merkler AE, Alakbarli J, Barbar T, Baradaran H, Adejumo O, Navi BB, Kamel H, Kim J, Okin PM, Gupta A, Weinsaft JW
J Neurol Sci 2020 Dec 15;419:117182. Epub 2020 Oct 13 doi: 10.1016/j.jns.2020.117182. PMID: 33099172
Management of Hemispheric Infarction and Ischemic Swelling.
Sheth KN
Continuum (Minneap Minn) 2015 Oct;21(5 Neurocritical Care):1346-61. doi: 10.1212/CON.0000000000000219. PMID: 26426234
Chlamydia pneumoniae infection and cerebral infarction risk: a meta-analysis.
Su X, Chen HL
Int J Stroke 2014 Apr;9(3):356-64. Epub 2014 Mar 5 doi: 10.1111/ijs.12248. PMID: 24597545
Neonatal cerebral infarction.
Miller V
Semin Pediatr Neurol 2000 Dec;7(4):278-88. doi: 10.1053/spen.2000.20076. PMID: 11205717

Therapy

Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial.
Wolf S, Mielke D, Barner C, Malinova V, Kerz T, Wostrack M, Czorlich P, Salih F, Engel DC, Ehlert A, Staykov D, Alturki AY, Sure U, Bardutzky J, Schroeder HWS, Schürer L, Beck J, Juratli TA, Fritsch M, Lemcke J, Pohrt A, Meyer B, Schwab S, Rohde V, Vajkoczy P; EARLYDRAIN Study Group
JAMA Neurol 2023 Aug 1;80(8):833-842. doi: 10.1001/jamaneurol.2023.1792. PMID: 37330974Free PMC Article
Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial.
Jiang JL, Zhang L, He LL, Yu H, Li XF, Dai SH, Yu H
Anesth Analg 2023 Jan 1;136(1):60-69. Epub 2022 Oct 27 doi: 10.1213/ANE.0000000000006257. PMID: 36301724
A Comparison Between Enteral and Intravenous Nimodipine in Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis.
Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, Disarò L, Carere A, Cacco N, Navalesi P, Munari M
Neurocrit Care 2022 Jun;36(3):1071-1079. Epub 2022 Apr 13 doi: 10.1007/s12028-022-01493-4. PMID: 35419702
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
JAMA 1995 May 10;273(18):1421-8. PMID: 7723155
Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.
Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd
Stroke 1993 Jan;24(1):35-41. doi: 10.1161/01.str.24.1.35. PMID: 7678184

Prognosis

Triglyceride glucose index is a significant predictor of severe disturbance of consciousness and all-cause mortality in critical cerebrovascular disease patients.
Chen T, Qian Y, Deng X
Cardiovasc Diabetol 2023 Jun 29;22(1):156. doi: 10.1186/s12933-023-01893-6. PMID: 37386419Free PMC Article
Effect of hip fracture on prognosis of acute cerebral infarction.
Yuan J, Zhu G, Zhao Y, Huang J
Clinics (Sao Paulo) 2021;76:e3059. Epub 2021 Dec 13 doi: 10.6061/clinics/2021/e3059. PMID: 34909940Free PMC Article
High-dose versus standard-dose twice-daily thoracic radiotherapy for patients with limited stage small-cell lung cancer: an open-label, randomised, phase 2 trial.
Grønberg BH, Killingberg KT, Fløtten Ø, Brustugun OT, Hornslien K, Madebo T, Langer SW, Schytte T, Nyman J, Risum S, Tsakonas G, Engleson J, Halvorsen TO
Lancet Oncol 2021 Mar;22(3):321-331. doi: 10.1016/S1470-2045(20)30742-7. PMID: 33662285
Exercise as stroke prophylaxis.
Reimers CD, Knapp G, Reimers AK
Dtsch Arztebl Int 2009 Oct;106(44):715-21. Epub 2009 Oct 30 doi: 10.3238/arztbl.2009.0715. PMID: 19997550Free PMC Article
Classification and natural history of clinically identifiable subtypes of cerebral infarction.
Bamford J, Sandercock P, Dennis M, Burn J, Warlow C
Lancet 1991 Jun 22;337(8756):1521-6. doi: 10.1016/0140-6736(91)93206-o. PMID: 1675378

Clinical prediction guides

Associations between the size and location of myocardial infarction and cerebral infarction.
Merkler AE, Alakbarli J, Barbar T, Baradaran H, Adejumo O, Navi BB, Kamel H, Kim J, Okin PM, Gupta A, Weinsaft JW
J Neurol Sci 2020 Dec 15;419:117182. Epub 2020 Oct 13 doi: 10.1016/j.jns.2020.117182. PMID: 33099172
A Nomogram for Predicting Stroke Recurrence Among Young Adults.
Yuan K, Chen J, Xu P, Zhang X, Gong X, Wu M, Xie Y, Wang H, Xu G, Liu X
Stroke 2020 Jun;51(6):1865-1867. Epub 2020 May 11 doi: 10.1161/STROKEAHA.120.029740. PMID: 32390546
ERASER.
Fiehler J, Thomalla G, Bernhardt M, Kniep H, Berlis A, Dorn F, Eckert B, Kemmling A, Langner S, Remonda L, Reith W, Rohde S, Möhlenbruch M, Bendszus M, Forkert ND, Gellissen S
Stroke 2019 May;50(5):1275-1278. doi: 10.1161/STROKEAHA.119.024858. PMID: 31009356
Machine Learning-Based Model for Prediction of Outcomes in Acute Stroke.
Heo J, Yoon JG, Park H, Kim YD, Nam HS, Heo JH
Stroke 2019 May;50(5):1263-1265. doi: 10.1161/STROKEAHA.118.024293. PMID: 30890116
Prediction Factors of Recurrent Stroke among Chinese Adults Using Retinal Vasculature Characteristics.
Zhuo Y, Yu H, Yang Z, Zee B, Lee J, Kuang L
J Stroke Cerebrovasc Dis 2017 Apr;26(4):679-685. Epub 2017 Feb 21 doi: 10.1016/j.jstrokecerebrovasdis.2017.01.020. PMID: 28233623

Recent systematic reviews

Endovascular Therapy for Stroke Presenting Beyond 24 Hours: A Systematic Review and Meta-analysis.
Kobeissi H, Ghozy S, Adusumilli G, Kadirvel R, Brinjikji W, Rabinstein AA, Kallmes DF
JAMA Netw Open 2023 May 1;6(5):e2311768. doi: 10.1001/jamanetworkopen.2023.11768. PMID: 37140919Free PMC Article
CT Perfusion vs Noncontrast CT for Late Window Stroke Thrombectomy: A Systematic Review and Meta-analysis.
Kobeissi H, Ghozy S, Adusumilli G, Bilgin C, Tolba H, Amoukhteh M, Kadirvel R, Brinjikji W, Heit JJ, Rabinstein AA, Kallmes DF
Neurology 2023 May 30;100(22):e2304-e2311. Epub 2023 Mar 29 doi: 10.1212/WNL.0000000000207262. PMID: 36990720Free PMC Article
A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury.
Yang K, Zeng L, Ge A, Wang S, Zeng J, Yuan X, Mei Z, Wang G, Ge J
Front Immunol 2022;13:930171. Epub 2022 Oct 7 doi: 10.3389/fimmu.2022.930171. PMID: 36275741Free PMC Article
A Comparison Between Enteral and Intravenous Nimodipine in Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis.
Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, Disarò L, Carere A, Cacco N, Navalesi P, Munari M
Neurocrit Care 2022 Jun;36(3):1071-1079. Epub 2022 Apr 13 doi: 10.1007/s12028-022-01493-4. PMID: 35419702
Contemporary antiplatelet therapy for secondary stroke prevention: a narrative review of current literature and guidelines.
Shah J, Liu S, Yu W
Stroke Vasc Neurol 2022 Oct;7(5):406-414. Epub 2022 Apr 7 doi: 10.1136/svn-2021-001166. PMID: 35393359Free PMC Article

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