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Debrisoquine, poor metabolism of

MedGen UID:
332377
•Concept ID:
C1837156
•
Finding
Synonym: DEBRISOQUINE, POOR METABOLISM OF
 
OMIM®: 124030; 608902

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Potential genetic causes of heterogeneity of treatment effects.
Goldstein DB, Need AC, Singh R, Sisodiya SM
Am J Med 2007 Apr;120(4 Suppl 1):S21-5. doi: 10.1016/j.amjmed.2007.02.004. PMID: 17403378
Clinical importance of non-genetic and genetic cytochrome P450 function tests in liver disease.
Tanaka E
J Clin Pharm Ther 1998 Jun;23(3):161-70. doi: 10.1046/j.1365-2710.1998.00135.x. PMID: 9831966
A risk-benefit assessment of mirtazapine in the treatment of depression.
Kasper S, Praschak-Rieder N, Tauscher J, Wolf R
Drug Saf 1997 Oct;17(4):251-64. doi: 10.2165/00002018-199717040-00005. PMID: 9352961

Recent clinical studies

Etiology

CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans.
Llerena A, Dorado P, Ramírez R, González I, Alvarez M, Peñas-Lledó EM, Pérez B, Calzadilla LR
Pharmacogenomics J 2012 Apr;12(2):176-83. Epub 2010 Dec 7 doi: 10.1038/tpj.2010.85. PMID: 21135868
Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity.
Llerena A, Dorado P, Peñas-Lledó EM
Pharmacogenomics 2009 Jan;10(1):17-28. doi: 10.2217/14622416.10.1.17. PMID: 19102711
Populations and genetic polymorphisms.
Weber WW
Mol Diagn 1999 Dec;4(4):299-307. doi: 10.154/MODI00400299. PMID: 10671640
Polymorphic drug metabolism.
Relling MV
Clin Pharm 1989 Dec;8(12):852-63. PMID: 2689060
Clinical pharmacokinetics of encainide.
Roden DM, Woosley RL
Clin Pharmacokinet 1988 Mar;14(3):141-7. doi: 10.2165/00003088-198814030-00002. PMID: 3131058

Diagnosis

Potential genetic causes of heterogeneity of treatment effects.
Goldstein DB, Need AC, Singh R, Sisodiya SM
Am J Med 2007 Apr;120(4 Suppl 1):S21-5. doi: 10.1016/j.amjmed.2007.02.004. PMID: 17403378
On the assessment of drug metabolism by assays of codeine and its main metabolites.
Haffen E, Paintaud G, Berard M, Masuyer C, Bechtel Y, Bechtel PR
Ther Drug Monit 2000 Jun;22(3):258-65. doi: 10.1097/00007691-200006000-00005. PMID: 10850391
Populations and genetic polymorphisms.
Weber WW
Mol Diagn 1999 Dec;4(4):299-307. doi: 10.154/MODI00400299. PMID: 10671640
Correlation of polymorphic expression of CYP2D6 mRNA in bladder mucosa and tumor tissue to in vivo debrisoquine hydroxylase activity.
Romkes-Sparks M, Mnuskin A, Chern HD, Persad R, Fleming C, Sibley GN, Smith P, Wilkinson GR, Branch RA
Carcinogenesis 1994 Sep;15(9):1955-61. doi: 10.1093/carcin/15.9.1955. PMID: 7923590
Role of genetics and drug metabolism in human cancer risk.
Nebert DW
Mutat Res 1991 Apr;247(2):267-81. doi: 10.1016/0027-5107(91)90022-g. PMID: 2011144

Therapy

Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity.
Llerena A, Dorado P, Peñas-Lledó EM
Pharmacogenomics 2009 Jan;10(1):17-28. doi: 10.2217/14622416.10.1.17. PMID: 19102711
A risk-benefit assessment of mirtazapine in the treatment of depression.
Kasper S, Praschak-Rieder N, Tauscher J, Wolf R
Drug Saf 1997 Oct;17(4):251-64. doi: 10.2165/00002018-199717040-00005. PMID: 9352961
Amitriptyline-induced prolonged cholestasis.
Larrey D, Amouyal G, Pessayre D, Degott C, Danne O, Machayekhi JP, Feldmann G, Benhamou JP
Gastroenterology 1988 Jan;94(1):200-3. doi: 10.1016/0016-5085(88)90631-2. PMID: 3335290
Clinical pharmacokinetics of encainide.
Roden DM, Woosley RL
Clin Pharmacokinet 1988 Mar;14(3):141-7. doi: 10.2165/00003088-198814030-00002. PMID: 3131058
Oxidation phenotype and the metabolism and action of beta-blockers.
Lennard MS
Klin Wochenschr 1985 Apr 1;63(7):285-92. doi: 10.1007/BF01731972. PMID: 2860267

Prognosis

Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity.
Llerena A, Dorado P, Peñas-Lledó EM
Pharmacogenomics 2009 Jan;10(1):17-28. doi: 10.2217/14622416.10.1.17. PMID: 19102711
Molecular mechanisms of genetic polymorphisms of drug metabolism.
Meyer UA, Zanger UM
Annu Rev Pharmacol Toxicol 1997;37:269-96. doi: 10.1146/annurev.pharmtox.37.1.269. PMID: 9131254
Propafenone in the treatment of cardiac arrhythmias. A risk-benefit appraisal.
Capucci A, Boriani G
Drug Saf 1995 Jan;12(1):55-72. doi: 10.2165/00002018-199512010-00005. PMID: 7741984
Role of genetics and drug metabolism in human cancer risk.
Nebert DW
Mutat Res 1991 Apr;247(2):267-81. doi: 10.1016/0027-5107(91)90022-g. PMID: 2011144
Amitriptyline-induced prolonged cholestasis.
Larrey D, Amouyal G, Pessayre D, Degott C, Danne O, Machayekhi JP, Feldmann G, Benhamou JP
Gastroenterology 1988 Jan;94(1):200-3. doi: 10.1016/0016-5085(88)90631-2. PMID: 3335290

Clinical prediction guides

CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans.
Llerena A, Dorado P, Ramírez R, González I, Alvarez M, Peñas-Lledó EM, Pérez B, Calzadilla LR
Pharmacogenomics J 2012 Apr;12(2):176-83. Epub 2010 Dec 7 doi: 10.1038/tpj.2010.85. PMID: 21135868
Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity.
Llerena A, Dorado P, Peñas-Lledó EM
Pharmacogenomics 2009 Jan;10(1):17-28. doi: 10.2217/14622416.10.1.17. PMID: 19102711
Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives.
Lötsch J, Skarke C, Liefhold J, Geisslinger G
Clin Pharmacokinet 2004;43(14):983-1013. doi: 10.2165/00003088-200443140-00003. PMID: 15530129
Molecular mechanisms of genetic polymorphisms of drug metabolism.
Meyer UA, Zanger UM
Annu Rev Pharmacol Toxicol 1997;37:269-96. doi: 10.1146/annurev.pharmtox.37.1.269. PMID: 9131254
Amitriptyline-induced prolonged cholestasis.
Larrey D, Amouyal G, Pessayre D, Degott C, Danne O, Machayekhi JP, Feldmann G, Benhamou JP
Gastroenterology 1988 Jan;94(1):200-3. doi: 10.1016/0016-5085(88)90631-2. PMID: 3335290

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