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Cerebrospinal fluid rhinorrhoea

MedGen UID:
3331
•Concept ID:
C0007815
•
Disease or Syndrome
Synonyms: Cerebrospinal Fluid Rhinorrhea; Cerebrospinal Fluid Rhinorrheas; Cerebrospinal Rhinorrhea; Cerebrospinal Rhinorrheas; CSF Rhinorrhea; CSF Rhinorrheas; Rhinorrhea, Cerebrospinal; Rhinorrhea, Cerebrospinal Fluid; Rhinorrhea, CSF; Rhinorrheas, Cerebrospinal; Rhinorrheas, Cerebrospinal Fluid; Rhinorrheas, CSF
SNOMED CT: Cerebrospinal rhinorrhea (85638002); CSF - Cerebrospinal rhinorrhea (85638002); Cerebrospinal fluid rhinorrhea (85638002)
 
HPO: HP:0030998
Monarch Initiative: MONDO:0020773

Definition

Drainage of cerebrospinal fluid through the nose. This can occur when there is a fistula between the dura and the skull base and discharge of cerebrospinal fluid (CSF) from the nose. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebrospinal fluid rhinorrhoea

Professional guidelines

PubMed

Efficacy Of Conservative Management Of Early Post Traumatic Cerebrospinal Fluid Rhinorrhoea.
Khan SA, Ahmad B, Sajjad M, Ahmed M, Khan A, Ahsan A, Siddique AN, Khan AA
J Ayub Med Coll Abbottabad 2022 Jul-Sep;34(Suppl 1)(3):S691-S694. doi: 10.55519/JAMC-03-S1-10564. PMID: 36414592
Clivus pathologies from diagnosis to surgical multidisciplinary treatment. Review of the literature.
Pagella F, Ugolini S, Zoia C, Matti E, Carena P, Lizzio R, Benazzo M
Acta Otorhinolaryngol Ital 2021 Apr;41(Suppl. 1):S42-S50. doi: 10.14639/0392-100X-suppl.1-41-2021-04. PMID: 34060519Free PMC Article
Cerebrospinal fluid rhinorrhoea: diagnosis and management.
Abuabara A
Med Oral Patol Oral Cir Bucal 2007 Sep 1;12(5):E397-400. PMID: 17767107

Recent clinical studies

Etiology

Efficacy Of Conservative Management Of Early Post Traumatic Cerebrospinal Fluid Rhinorrhoea.
Khan SA, Ahmad B, Sajjad M, Ahmed M, Khan A, Ahsan A, Siddique AN, Khan AA
J Ayub Med Coll Abbottabad 2022 Jul-Sep;34(Suppl 1)(3):S691-S694. doi: 10.55519/JAMC-03-S1-10564. PMID: 36414592
Cerebrospinal fluid rhinorrhoea: does fibrin glue change the surgical outcome?
Ganesh PB, Basavarajaiah BM, Rudrappa BA, Kasaragod SK
J Laryngol Otol 2020 Jul;134(7):582-585. Epub 2020 Jul 16 doi: 10.1017/S0022215120000845. PMID: 32672143
Cerebrospinal fluid rhinorrhoea following transsphenoidal surgery for pituitary adenoma: experience in a Chinese centre.
Zhang C, Ding X, Lu Y, Hu L, Hu G
Acta Otorhinolaryngol Ital 2017 Aug;37(4):303-307. doi: 10.14639/0392-100X-1086. PMID: 28872159Free PMC Article
Cerebrospinal fluid rhinorrhoea after nasal packing for epistaxis: case report.
Edkins O, Nyamarebvu CT, Lubbe D
J Laryngol Otol 2012 Apr;126(4):421-3. Epub 2012 Feb 24 doi: 10.1017/S0022215112000187. PMID: 22361138
Cerebrospinal fluid rhinorrhoea: diagnosis and management.
Abuabara A
Med Oral Patol Oral Cir Bucal 2007 Sep 1;12(5):E397-400. PMID: 17767107

Diagnosis

Idiopathic Cerebrospinal Fluid Rhinorrhoea (An Uncommon Diagnosis): A case report and a Review of the Literature.
Ediale J, Onyema CO, Tobi KU
West Afr J Med 2018 Jan-Apr;35(1):33-36. PMID: 29607475
Cerebrospinal fluid rhinorrhoea: diagnosis and management.
Abuabara A
Med Oral Patol Oral Cir Bucal 2007 Sep 1;12(5):E397-400. PMID: 17767107
Optimum imaging and diagnosis of cerebrospinal fluid rhinorrhoea.
Lund VJ, Savy L, Lloyd G, Howard D
J Laryngol Otol 2000 Dec;114(12):988-92. doi: 10.1258/0022215001904572. PMID: 11177378
Cerebrospinal fluid rhinorrhoea.
Walsh M, Curran AJ
Br J Neurosurg 1997 Jun;11(3):189-90. doi: 10.1080/02688699746221. PMID: 9231004
Non-traumatic cerebrospinal fluid rhinorrhoea.
Ommaya AK, Di Chiro G, Baldwin M, Pennybacker JB
J Neurol Neurosurg Psychiatry 1968 Jun;31(3):214-25. doi: 10.1136/jnnp.31.3.214. PMID: 5303103Free PMC Article

Therapy

Endonasal endoscopic management of spontaneous cerebrospinal fluid rhinorrhoea: The Birmingham UK experience.
Jolly K, Gupta KK, Bhamra N, Aslanidou A, Batra R, Ahmed SK
Asian J Endosc Surg 2023 Jan;16(1):68-76. Epub 2022 Sep 18 doi: 10.1111/ases.13125. PMID: 36116916
Cerebrospinal fluid rhinorrhoea: does fibrin glue change the surgical outcome?
Ganesh PB, Basavarajaiah BM, Rudrappa BA, Kasaragod SK
J Laryngol Otol 2020 Jul;134(7):582-585. Epub 2020 Jul 16 doi: 10.1017/S0022215120000845. PMID: 32672143
Cerebrospinal fluid rhinorrhoea as a complication of endoscopic endonasal reduction of blowout fractures.
Lee DG, Cho KS, Kim HJ, Roh HJ
J Laryngol Otol 2012 Sep;126(9):942-5. Epub 2012 Jul 12 doi: 10.1017/S0022215112001399. PMID: 22784813
Cerebrospinal fluid rhinorrhoea after nasal packing for epistaxis: case report.
Edkins O, Nyamarebvu CT, Lubbe D
J Laryngol Otol 2012 Apr;126(4):421-3. Epub 2012 Feb 24 doi: 10.1017/S0022215112000187. PMID: 22361138
Spontaneous cerebrospinal-fluid rhinorrhoea.
Nussey AM
Br Med J 1966 Jun 25;1(5503):1579-80. doi: 10.1136/bmj.1.5503.1579. PMID: 5940224Free PMC Article

Prognosis

Efficacy Of Conservative Management Of Early Post Traumatic Cerebrospinal Fluid Rhinorrhoea.
Khan SA, Ahmad B, Sajjad M, Ahmed M, Khan A, Ahsan A, Siddique AN, Khan AA
J Ayub Med Coll Abbottabad 2022 Jul-Sep;34(Suppl 1)(3):S691-S694. doi: 10.55519/JAMC-03-S1-10564. PMID: 36414592
Cerebrospinal fluid rhinorrhoea following transsphenoidal surgery for pituitary adenoma: experience in a Chinese centre.
Zhang C, Ding X, Lu Y, Hu L, Hu G
Acta Otorhinolaryngol Ital 2017 Aug;37(4):303-307. doi: 10.14639/0392-100X-1086. PMID: 28872159Free PMC Article
Cerebrospinal fluid (CSF) rhinorrhoea and/or otorrhoea in patients with head injury.
Ologe FE, Odebode TO
Afr J Med Med Sci 2005 Jun;34(2):173-5. PMID: 16749343
Optimum imaging and diagnosis of cerebrospinal fluid rhinorrhoea.
Lund VJ, Savy L, Lloyd G, Howard D
J Laryngol Otol 2000 Dec;114(12):988-92. doi: 10.1258/0022215001904572. PMID: 11177378
Non-traumatic cerebrospinal fluid rhinorrhoea.
Ommaya AK, Di Chiro G, Baldwin M, Pennybacker JB
J Neurol Neurosurg Psychiatry 1968 Jun;31(3):214-25. doi: 10.1136/jnnp.31.3.214. PMID: 5303103Free PMC Article

Clinical prediction guides

Aetiology of cerebrospinal fluid rhinorrhoea in a Dutch retrospective cohort from two tertiary referral centres.
de Jong WB, Hoogmoed J, Adriaensen GFJPM, Nagtegaal AP, Reitsma S
Rhinology 2024 Apr 1;62(2):208-215. doi: 10.4193/Rhin23.158. PMID: 38073582
Efficacy Of Conservative Management Of Early Post Traumatic Cerebrospinal Fluid Rhinorrhoea.
Khan SA, Ahmad B, Sajjad M, Ahmed M, Khan A, Ahsan A, Siddique AN, Khan AA
J Ayub Med Coll Abbottabad 2022 Jul-Sep;34(Suppl 1)(3):S691-S694. doi: 10.55519/JAMC-03-S1-10564. PMID: 36414592
New insights into the glucose oxidase stick test for cerebrospinal fluid rhinorrhoea.
Baker EH, Wood DM, Brennan AL, Baines DL, Philips BJ
Emerg Med J 2005 Aug;22(8):556-7. doi: 10.1136/emj.2004.022111. PMID: 16046755Free PMC Article
Optimum imaging and diagnosis of cerebrospinal fluid rhinorrhoea.
Lund VJ, Savy L, Lloyd G, Howard D
J Laryngol Otol 2000 Dec;114(12):988-92. doi: 10.1258/0022215001904572. PMID: 11177378
Should prophylactic antibiotics be used in the management of cerebrospinal fluid rhinorrhoea following endoscopic sinus surgery? A review of the literature.
Moralee SJ
Clin Otolaryngol Allied Sci 1995 Apr;20(2):100-2. doi: 10.1111/j.1365-2273.1995.tb00023.x. PMID: 7634512

Recent systematic reviews

Skull base repair following endonasal pituitary and skull base tumour resection: a systematic review.
Khan DZ, Ali AMS, Koh CH, Dorward NL, Grieve J, Layard Horsfall H, Muirhead W, Santarius T, Van Furth WR, Zamanipoor Najafabadi AH, Marcus HJ
Pituitary 2021 Oct;24(5):698-713. Epub 2021 May 10 doi: 10.1007/s11102-021-01145-4. PMID: 33973152Free PMC Article

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