U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tubulointerstitial nephritis and uveitis syndrome(TINU)

MedGen UID:
334715
•Concept ID:
C1843273
•
Disease or Syndrome
Synonyms: TINU syndrome; Tubulointerstitial nephritis and uveitis; TUBULOINTERSTITIAL NEPHRITIS WITH UVEITIS
SNOMED CT: Tubulointerstitial nephritis with uveitis syndrome (418839003); TINU - Tubulointerstitial nephritis with uveitis syndrome (418839003)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0011885
OMIM®: 607665
Orphanet: ORPHA91500

Definition

A rare renal tubular disease characterized by early-onset tubulointerstitial nephritis associated with anterior uveitis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTubulointerstitial nephritis and uveitis syndrome
Follow this link to review classifications for Tubulointerstitial nephritis and uveitis syndrome in Orphanet.

Professional guidelines

PubMed

Aetiology, course and treatment of acute tubulointerstitial nephritis in paediatric patients: a cross-sectional web-based survey.
Wente-Schulz S, Aksenova M, Awan A, Ambarsari CG, Becherucci F, Emma F, Fila M, Francisco T, Gokce I, Gülhan B, Hansen M, Jahnukainen T, Kallash M, Kamperis K, Mason S, Mastrangelo A, Mencarelli F, Niwinska-Faryna B, Riordan M, Rus RR, Saygili S, Serdaroglu E, Taner S, Topaloglu R, Vidal E, Woroniecki R, Yel S, Zieg J, Pape L; international TIN study group
BMJ Open 2021 May 28;11(5):e047059. doi: 10.1136/bmjopen-2020-047059. PMID: 34049919Free PMC Article
Real-world evidence of treatment for relapse of noninfectious uveitis in tertiary centers in Japan: A multicenter study.
Takeuchi M, Kanda T, Kaburaki T, Tanaka R, Namba K, Kamoi K, Maruyama K, Shibuya E, Mizuki N
Medicine (Baltimore) 2019 Mar;98(9):e14668. doi: 10.1097/MD.0000000000014668. PMID: 30817592Free PMC Article
Enhanced recognition, treatment, and prognosis of tubulointerstitial nephritis and uveitis syndrome.
Mackensen F, Smith JR, Rosenbaum JT
Ophthalmology 2007 May;114(5):995-9. Epub 2007 Mar 26 doi: 10.1016/j.ophtha.2007.01.002. PMID: 17383731

Recent clinical studies

Etiology

Genome-Wide Association Study in Acute Tubulointerstitial Nephritis.
Zhou XJ, Su T, Xie J, Xie QH, Wang LZ, Hu Y, Chen G, Jia Y, Huang JW, Li G, Liu Y, Yu XJ, Nath SK, Tsoi LC, Patrick MT, Berthier CC, Liu G, Wang SX, Xu H, Chen N, Hao CM, Zhang H, Yang L
J Am Soc Nephrol 2023 May 1;34(5):895-908. Epub 2023 Feb 2 doi: 10.1681/ASN.0000000000000091. PMID: 36749126Free PMC Article
Renal outcomes in tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review and meta-analysis.
Southgate G, Clarke P, Harmer MJ
J Nephrol 2023 Mar;36(2):507-519. Epub 2022 Nov 18 doi: 10.1007/s40620-022-01478-8. PMID: 36396848
Tubulointerstitial nephritis and uveitis syndrome: a systematic review.
Regusci A, Lava SAG, Milani GP, Bianchetti MG, Simonetti GD, Vanoni F
Nephrol Dial Transplant 2022 Apr 25;37(5):876-886. doi: 10.1093/ndt/gfab030. PMID: 33561271
Tubulointerstitial Nephritis and Uveitis Syndrome: Characterization of Clinical Features.
Koreishi AF, Zhou M, Goldstein DA
Ocul Immunol Inflamm 2021 Nov 17;29(7-8):1312-1317. Epub 2020 May 28 doi: 10.1080/09273948.2020.1736311. PMID: 32463299
Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographics and risk factors.
Okafor LO, Hewins P, Murray PI, Denniston AK
Orphanet J Rare Dis 2017 Jul 14;12(1):128. doi: 10.1186/s13023-017-0677-2. PMID: 28709457Free PMC Article

Diagnosis

Tubulointerstitial Nephritis and Uveitis Syndrome in Pediatric Patients.
Janetos TM, Lee PHA, Goldstein DA
Ocul Immunol Inflamm 2023 Dec;31(10):1955-1964. Epub 2023 Dec 14 doi: 10.1080/09273948.2023.2279689. PMID: 37983806
A case of tubulointerstitial nephritis and uveitis syndrome accompanied by subclinical choroiditis.
Arita T, Namba K, Iwata D, Suzuki K, Ogino Y, Mizuuchi K, Hiraoka M, Kitaichi N, Ishida S
BMC Ophthalmol 2023 Oct 20;23(1):424. doi: 10.1186/s12886-023-03172-0. PMID: 37864178Free PMC Article
Renal outcomes in tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review and meta-analysis.
Southgate G, Clarke P, Harmer MJ
J Nephrol 2023 Mar;36(2):507-519. Epub 2022 Nov 18 doi: 10.1007/s40620-022-01478-8. PMID: 36396848
Tubulointerstitial nephritis and uveitis syndrome: a systematic review.
Regusci A, Lava SAG, Milani GP, Bianchetti MG, Simonetti GD, Vanoni F
Nephrol Dial Transplant 2022 Apr 25;37(5):876-886. doi: 10.1093/ndt/gfab030. PMID: 33561271
Tubulointerstitial nephritis and uveitis syndrome.
Mackensen F, Billing H
Curr Opin Ophthalmol 2009 Nov;20(6):525-31. doi: 10.1097/ICU.0b013e3283318f9a. PMID: 19752730

Therapy

A case of tubulointerstitial nephritis and uveitis syndrome accompanied by subclinical choroiditis.
Arita T, Namba K, Iwata D, Suzuki K, Ogino Y, Mizuuchi K, Hiraoka M, Kitaichi N, Ishida S
BMC Ophthalmol 2023 Oct 20;23(1):424. doi: 10.1186/s12886-023-03172-0. PMID: 37864178Free PMC Article
Renal outcomes in tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review and meta-analysis.
Southgate G, Clarke P, Harmer MJ
J Nephrol 2023 Mar;36(2):507-519. Epub 2022 Nov 18 doi: 10.1007/s40620-022-01478-8. PMID: 36396848
Tubulointerstitial Nephritis and Uveitis Syndrome: Characterization of Clinical Features.
Koreishi AF, Zhou M, Goldstein DA
Ocul Immunol Inflamm 2021 Nov 17;29(7-8):1312-1317. Epub 2020 May 28 doi: 10.1080/09273948.2020.1736311. PMID: 32463299
Tubulointerstitial Nephritis and Uveitis Syndrome: Case Report and Review of the Literature.
Aguilar MC, Lonngi M, de-la-Torre A
Ocul Immunol Inflamm 2016 Aug;24(4):415-21. Epub 2015 Sep 23 doi: 10.3109/09273948.2015.1034374. PMID: 26400208
Tubulointerstitial nephritis and uveitis syndrome in children: a prospective multicenter study.
Saarela V, Nuutinen M, Ala-Houhala M, Arikoski P, Rönnholm K, Jahnukainen T
Ophthalmology 2013 Jul;120(7):1476-81. Epub 2013 Mar 16 doi: 10.1016/j.ophtha.2012.12.039. PMID: 23511116

Prognosis

Tubulointerstitial Nephritis and Uveitis Syndrome in Pediatric Patients.
Janetos TM, Lee PHA, Goldstein DA
Ocul Immunol Inflamm 2023 Dec;31(10):1955-1964. Epub 2023 Dec 14 doi: 10.1080/09273948.2023.2279689. PMID: 37983806
Tubulointerstitial nephritis and uveitis syndrome in an adolescent female: a case report.
Petek T, Frelih M, Marčun Varda N
J Med Case Rep 2021 Sep 4;15(1):443. doi: 10.1186/s13256-021-03017-8. PMID: 34479628Free PMC Article
Tubulointerstitial nephritis and uveitis syndrome in a female adult.
Carvalho TJ, Calça R, Cassis J, Mendes A
BMJ Case Rep 2019 Jan 29;12(1) doi: 10.1136/bcr-2018-227688. PMID: 30700465Free PMC Article
Tubulointerstitial nephritis and uveitis syndrome in children: a prospective multicenter study.
Saarela V, Nuutinen M, Ala-Houhala M, Arikoski P, Rönnholm K, Jahnukainen T
Ophthalmology 2013 Jul;120(7):1476-81. Epub 2013 Mar 16 doi: 10.1016/j.ophtha.2012.12.039. PMID: 23511116
The tubulointerstitial nephritis and uveitis syndrome.
Mandeville JT, Levinson RD, Holland GN
Surv Ophthalmol 2001 Nov-Dec;46(3):195-208. doi: 10.1016/s0039-6257(01)00261-2. PMID: 11738428

Clinical prediction guides

Tubulointerstitial Nephritis and Uveitis Syndrome During the COVID-19 Pandemic: A Case Series.
Özdemir Yalçınsoy K, Güngör A, Karakaya D, Özdal L, Kılıç M, Özdamar Erol Y, Çakar Özdal P
Turk J Ophthalmol 2024 Feb 22;54(1):5-10. doi: 10.4274/tjo.galenos.2023.24280. PMID: 38385308Free PMC Article
A case of tubulointerstitial nephritis and uveitis syndrome accompanied by subclinical choroiditis.
Arita T, Namba K, Iwata D, Suzuki K, Ogino Y, Mizuuchi K, Hiraoka M, Kitaichi N, Ishida S
BMC Ophthalmol 2023 Oct 20;23(1):424. doi: 10.1186/s12886-023-03172-0. PMID: 37864178Free PMC Article
Clinical Features and Visual Outcome of Uveitis in Japanese Patients Younger than 18 Years.
Kitano M, Tanaka R, Kaburaki T, Nakahara H, Shirahama S, Suzuki T, Komae K, Aihara M
Ocul Immunol Inflamm 2021 Nov 17;29(7-8):1280-1286. Epub 2020 Mar 12 doi: 10.1080/09273948.2020.1726972. PMID: 32162972
Tubulointerstitial nephritis and uveitis syndrome in children: a prospective multicenter study.
Saarela V, Nuutinen M, Ala-Houhala M, Arikoski P, Rönnholm K, Jahnukainen T
Ophthalmology 2013 Jul;120(7):1476-81. Epub 2013 Mar 16 doi: 10.1016/j.ophtha.2012.12.039. PMID: 23511116
Fluorescein angiographic features of tubulointerstitial nephritis and uveitis syndrome.
Matsuo T
Ophthalmology 2002 Jan;109(1):132-6. doi: 10.1016/s0161-6420(01)00850-8. PMID: 11772592

Recent systematic reviews

Clinical manifestations and outcomes in tubulointerstitial nephritis and uveitis syndrome: a case report and a systematic review in China.
Shi J, Xu S, Chen J, Wu H
Int Urol Nephrol 2024 Apr;56(4):1415-1427. Epub 2023 Sep 27 doi: 10.1007/s11255-023-03797-6. PMID: 37755610Free PMC Article
Renal outcomes in tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review and meta-analysis.
Southgate G, Clarke P, Harmer MJ
J Nephrol 2023 Mar;36(2):507-519. Epub 2022 Nov 18 doi: 10.1007/s40620-022-01478-8. PMID: 36396848
Tubulointerstitial nephritis and uveitis syndrome: a systematic review.
Regusci A, Lava SAG, Milani GP, Bianchetti MG, Simonetti GD, Vanoni F
Nephrol Dial Transplant 2022 Apr 25;37(5):876-886. doi: 10.1093/ndt/gfab030. PMID: 33561271
Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographics and risk factors.
Okafor LO, Hewins P, Murray PI, Denniston AK
Orphanet J Rare Dis 2017 Jul 14;12(1):128. doi: 10.1186/s13023-017-0677-2. PMID: 28709457Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...