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Tubulointerstitial nephritis and uveitis syndrome(TINU)

MedGen UID:
334715
•Concept ID:
C1843273
•
Disease or Syndrome
Synonyms: TINU syndrome; Tubulointerstitial nephritis and uveitis; TUBULOINTERSTITIAL NEPHRITIS WITH UVEITIS
SNOMED CT: Tubulointerstitial nephritis with uveitis syndrome (418839003); TINU - Tubulointerstitial nephritis with uveitis syndrome (418839003)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on a mixture of major and minor genetic determinants possibly together with environmental factors. Diseases inherited in this manner are termed complex diseases.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0011885
OMIM®: 607665
Orphanet: ORPHA91500

Definition

A rare renal tubular disease characterized by early-onset tubulointerstitial nephritis associated with anterior uveitis. [from ORDO]

Clinical features

From HPO
Glomerulonephritis
MedGen UID:
6616
•Concept ID:
C0017658
•
Disease or Syndrome
Inflammation of the renal glomeruli.
See: Feature record | Search on this feature
Abnormality of the mouth
MedGen UID:
6447
•Concept ID:
C0026633
•
Congenital Abnormality
An abnormality of the mouth.
See: Feature record | Search on this feature
Panuveitis
MedGen UID:
45303
•Concept ID:
C0030343
•
Disease or Syndrome
Inflammation of the uveal tract in which inflammation affects the anterior chamber, vitreous, retina or choroid.
See: Feature record | Search on this feature
Uveitis
MedGen UID:
52961
•Concept ID:
C0042164
•
Disease or Syndrome
Inflammation of one or all portions of the uveal tract.
See: Feature record | Search on this feature
Anterior uveitis
MedGen UID:
22595
•Concept ID:
C0042165
•
Disease or Syndrome
Inflammation of the uveal tract in which the primary site of inflammation is the anterior chamber.
See: Feature record | Search on this feature
Elevated circulating creatinine concentration
MedGen UID:
148579
•Concept ID:
C0700225
•
Finding
An increased amount of creatinine in the blood.
See: Feature record | Search on this feature
Acute tubulointerstitial nephritis
MedGen UID:
334716
•Concept ID:
C1843274
•
Disease or Syndrome
Acute inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules.
See: Feature record | Search on this feature
Reversible renal failure
MedGen UID:
334717
•Concept ID:
C1843276
•
Disease or Syndrome
Acute renal failure with resolution of manifestations.
See: Feature record | Search on this feature
Circulating immune complexes
MedGen UID:
854473
•Concept ID:
C3887628
•
Finding
Persistence of immune complexes in the blood circulation.
See: Feature record | Search on this feature
Non-caseating epithelioid cell granulomatosis
MedGen UID:
868600
•Concept ID:
C4022999
•
Finding
The presence of multiple epithelioid cell granulomas consist of highly differentiated mononuclear phagocytes (epithelioid cells and giant cells) and lymphocytes, not exhibiting caseation (a form of necrosis in which the tissue changes into a dry, amorphous mass said to resemble cheese).
See: Feature record | Search on this feature
Glomerulonephritis
Abnormality of the mouth
Panuveitis
Uveitis
Anterior uveitis
Elevated circulating creatinine concentration
Acute tubulointerstitial nephritis
Reversible renal failure
Circulating immune complexes
Non-caseating epithelioid cell granulomatosis

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTubulointerstitial nephritis and uveitis syndrome
Follow this link to review classifications for Tubulointerstitial nephritis and uveitis syndrome in Orphanet.

Professional guidelines

PubMed

Aetiology, course and treatment of acute tubulointerstitial nephritis in paediatric patients: a cross-sectional web-based survey.
Wente-Schulz S, Aksenova M, Awan A, Ambarsari CG, Becherucci F, Emma F, Fila M, Francisco T, Gokce I, Gülhan B, Hansen M, Jahnukainen T, Kallash M, Kamperis K, Mason S, Mastrangelo A, Mencarelli F, Niwinska-Faryna B, Riordan M, Rus RR, Saygili S, Serdaroglu E, Taner S, Topaloglu R, Vidal E, Woroniecki R, Yel S, Zieg J, Pape L; international TIN study group
BMJ Open 2021 May 28;11(5):e047059. doi: 10.1136/bmjopen-2020-047059. PMID: 34049919Free PMC Article
Real-world evidence of treatment for relapse of noninfectious uveitis in tertiary centers in Japan: A multicenter study.
Takeuchi M, Kanda T, Kaburaki T, Tanaka R, Namba K, Kamoi K, Maruyama K, Shibuya E, Mizuki N
Medicine (Baltimore) 2019 Mar;98(9):e14668. doi: 10.1097/MD.0000000000014668. PMID: 30817592Free PMC Article
Enhanced recognition, treatment, and prognosis of tubulointerstitial nephritis and uveitis syndrome.
Mackensen F, Smith JR, Rosenbaum JT
Ophthalmology 2007 May;114(5):995-9. Epub 2007 Mar 26 doi: 10.1016/j.ophtha.2007.01.002. PMID: 17383731

Recent clinical studies

Etiology

Genome-Wide Association Study in Acute Tubulointerstitial Nephritis.
Zhou XJ, Su T, Xie J, Xie QH, Wang LZ, Hu Y, Chen G, Jia Y, Huang JW, Li G, Liu Y, Yu XJ, Nath SK, Tsoi LC, Patrick MT, Berthier CC, Liu G, Wang SX, Xu H, Chen N, Hao CM, Zhang H, Yang L
J Am Soc Nephrol 2023 May 1;34(5):895-908. Epub 2023 Feb 2 doi: 10.1681/ASN.0000000000000091. PMID: 36749126Free PMC Article
Renal outcomes in tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review and meta-analysis.
Southgate G, Clarke P, Harmer MJ
J Nephrol 2023 Mar;36(2):507-519. Epub 2022 Nov 18 doi: 10.1007/s40620-022-01478-8. PMID: 36396848
Tubulointerstitial nephritis and uveitis syndrome: a systematic review.
Regusci A, Lava SAG, Milani GP, Bianchetti MG, Simonetti GD, Vanoni F
Nephrol Dial Transplant 2022 Apr 25;37(5):876-886. doi: 10.1093/ndt/gfab030. PMID: 33561271
Tubulointerstitial Nephritis and Uveitis Syndrome: Characterization of Clinical Features.
Koreishi AF, Zhou M, Goldstein DA
Ocul Immunol Inflamm 2021 Nov 17;29(7-8):1312-1317. Epub 2020 May 28 doi: 10.1080/09273948.2020.1736311. PMID: 32463299
Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographics and risk factors.
Okafor LO, Hewins P, Murray PI, Denniston AK
Orphanet J Rare Dis 2017 Jul 14;12(1):128. doi: 10.1186/s13023-017-0677-2. PMID: 28709457Free PMC Article

Diagnosis

Renal outcomes in tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review and meta-analysis.
Southgate G, Clarke P, Harmer MJ
J Nephrol 2023 Mar;36(2):507-519. Epub 2022 Nov 18 doi: 10.1007/s40620-022-01478-8. PMID: 36396848
Tubulointerstitial nephritis and uveitis syndrome: a systematic review.
Regusci A, Lava SAG, Milani GP, Bianchetti MG, Simonetti GD, Vanoni F
Nephrol Dial Transplant 2022 Apr 25;37(5):876-886. doi: 10.1093/ndt/gfab030. PMID: 33561271
Tubulointerstitial Nephritis and Uveitis Syndrome: Characterization of Clinical Features.
Koreishi AF, Zhou M, Goldstein DA
Ocul Immunol Inflamm 2021 Nov 17;29(7-8):1312-1317. Epub 2020 May 28 doi: 10.1080/09273948.2020.1736311. PMID: 32463299
Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographics and risk factors.
Okafor LO, Hewins P, Murray PI, Denniston AK
Orphanet J Rare Dis 2017 Jul 14;12(1):128. doi: 10.1186/s13023-017-0677-2. PMID: 28709457Free PMC Article
Tubulointerstitial nephritis and uveitis syndrome.
Mackensen F, Billing H
Curr Opin Ophthalmol 2009 Nov;20(6):525-31. doi: 10.1097/ICU.0b013e3283318f9a. PMID: 19752730

Therapy

Renal outcomes in tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review and meta-analysis.
Southgate G, Clarke P, Harmer MJ
J Nephrol 2023 Mar;36(2):507-519. Epub 2022 Nov 18 doi: 10.1007/s40620-022-01478-8. PMID: 36396848
Subclinical Choroidal Inflammation Revealed by Indocyanine Green Angiography in Tubulointerstitial Nephritis and Uveitis Syndrome.
Scifo L, Willermain F, Postelmans L, Pozdzik A, Lolin Sekelj K, Zampieri M, de Jong C, Makhoul D
Ocul Immunol Inflamm 2022 Jul;30(5):1190-1198. Epub 2021 Jun 30 doi: 10.1080/09273948.2020.1869267. PMID: 34191677
Tubulointerstitial Nephritis and Uveitis Syndrome: Characterization of Clinical Features.
Koreishi AF, Zhou M, Goldstein DA
Ocul Immunol Inflamm 2021 Nov 17;29(7-8):1312-1317. Epub 2020 May 28 doi: 10.1080/09273948.2020.1736311. PMID: 32463299
Tubulointerstitial Nephritis and Uveitis Syndrome: Case Report and Review of the Literature.
Aguilar MC, Lonngi M, de-la-Torre A
Ocul Immunol Inflamm 2016 Aug;24(4):415-21. Epub 2015 Sep 23 doi: 10.3109/09273948.2015.1034374. PMID: 26400208
Tubulointerstitial nephritis and uveitis syndrome in children: a prospective multicenter study.
Saarela V, Nuutinen M, Ala-Houhala M, Arikoski P, Rönnholm K, Jahnukainen T
Ophthalmology 2013 Jul;120(7):1476-81. Epub 2013 Mar 16 doi: 10.1016/j.ophtha.2012.12.039. PMID: 23511116

Prognosis

Tubulointerstitial nephritis and uveitis syndrome in an adolescent female: a case report.
Petek T, Frelih M, Marčun Varda N
J Med Case Rep 2021 Sep 4;15(1):443. doi: 10.1186/s13256-021-03017-8. PMID: 34479628Free PMC Article
Tubulointerstitial nephritis and uveitis syndrome in a female adult.
Carvalho TJ, Calça R, Cassis J, Mendes A
BMJ Case Rep 2019 Jan 29;12(1) doi: 10.1136/bcr-2018-227688. PMID: 30700465Free PMC Article
Long-term Follow-up of Patients with Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome.
Sobolewska B, Bayyoud T, Deuter C, Doycheva D, Zierhut M
Ocul Immunol Inflamm 2018;26(4):601-607. Epub 2016 Dec 12 doi: 10.1080/09273948.2016.1247872. PMID: 27937079
Tubulointerstitial nephritis and uveitis syndrome in children: a prospective multicenter study.
Saarela V, Nuutinen M, Ala-Houhala M, Arikoski P, Rönnholm K, Jahnukainen T
Ophthalmology 2013 Jul;120(7):1476-81. Epub 2013 Mar 16 doi: 10.1016/j.ophtha.2012.12.039. PMID: 23511116
The tubulointerstitial nephritis and uveitis syndrome.
Mandeville JT, Levinson RD, Holland GN
Surv Ophthalmol 2001 Nov-Dec;46(3):195-208. doi: 10.1016/s0039-6257(01)00261-2. PMID: 11738428

Clinical prediction guides

Long-term clinical characteristics and renal prognosis of children with tubulointerstitial nephritis and uveitis syndrome.
Hayashi A, Takahashi T, Ueda Y, Sato Y, Okamoto T
Pediatr Nephrol 2021 Aug;36(8):2319-2325. Epub 2021 Feb 3 doi: 10.1007/s00467-021-04956-6. PMID: 33534000
Clinical Features and Visual Outcome of Uveitis in Japanese Patients Younger than 18 Years.
Kitano M, Tanaka R, Kaburaki T, Nakahara H, Shirahama S, Suzuki T, Komae K, Aihara M
Ocul Immunol Inflamm 2021 Nov 17;29(7-8):1280-1286. Epub 2020 Mar 12 doi: 10.1080/09273948.2020.1726972. PMID: 32162972
Tubulointerstitial nephritis and uveitis syndrome in children: a prospective multicenter study.
Saarela V, Nuutinen M, Ala-Houhala M, Arikoski P, Rönnholm K, Jahnukainen T
Ophthalmology 2013 Jul;120(7):1476-81. Epub 2013 Mar 16 doi: 10.1016/j.ophtha.2012.12.039. PMID: 23511116
Tubulointerstitial nephritis and uveitis syndrome in Southern Spain.
Sanchez-Burson J, Garcia-Porrua C, Montero-Granados R, Gonzalez-Escribano F, Gonzalez-Gay MA
Semin Arthritis Rheum 2002 Oct;32(2):125-9. doi: 10.1053/sarh.2002.33718. PMID: 12430100
Fluorescein angiographic features of tubulointerstitial nephritis and uveitis syndrome.
Matsuo T
Ophthalmology 2002 Jan;109(1):132-6. doi: 10.1016/s0161-6420(01)00850-8. PMID: 11772592

Recent systematic reviews

Renal outcomes in tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review and meta-analysis.
Southgate G, Clarke P, Harmer MJ
J Nephrol 2023 Mar;36(2):507-519. Epub 2022 Nov 18 doi: 10.1007/s40620-022-01478-8. PMID: 36396848
Tubulointerstitial nephritis and uveitis syndrome: a systematic review.
Regusci A, Lava SAG, Milani GP, Bianchetti MG, Simonetti GD, Vanoni F
Nephrol Dial Transplant 2022 Apr 25;37(5):876-886. doi: 10.1093/ndt/gfab030. PMID: 33561271
Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographics and risk factors.
Okafor LO, Hewins P, Murray PI, Denniston AK
Orphanet J Rare Dis 2017 Jul 14;12(1):128. doi: 10.1186/s13023-017-0677-2. PMID: 28709457Free PMC Article

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