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Cheilitis

MedGen UID:
3349
Concept ID:
C0007971
Disease or Syndrome
Synonym: Cheilitides
SNOMED CT: Cheilitis (7847004)
 
HPO: HP:0100825
Monarch Initiative: MONDO:0002102

Definition

Inflammation of the lip. [from HPO]

Conditions with this feature

Actinic prurigo
MedGen UID:
98348
Concept ID:
C0406217
Disease or Syndrome
Hereditary polymorphic light eruption is a form of photosensitivity found in the American Indians of the central plains of Canada and the United States and in the Indians of Central and South America. The disorder has also been called familial actinic prurigo, solar dermatitis, and hydroa aestivale. In northern latitudes, skin lesions appear on exposed areas early in spring, become severe during the summer, and abate in the fall. Usually the disorder appears in childhood with eczematous crusted eruptions on the face and arms. Fissured, crusted exudative cheilitis develops on the lips, especially the lower lip. The dorsum of the hands, the laterodorsal aspects of the forearms, and the lower half of the arms often show excoriated papular and nodular lesions. Children frequently have complicating pyoderma. Adults usually exhibit an erythematous plaquelike eruption on the face and other exposed areas. The disease is more severe in children than in adults. Glomerulonephritis can follow streptococcal pyoderma (summary by Fusaro and Johnson, 1980).
Candidiasis, familial, 8
MedGen UID:
811541
Concept ID:
C3714992
Disease or Syndrome
Chronic mucocutaneous candidiasis is characterized by recurrent or persistent infections of the skin, nails, and oral and genital mucosae with Candida albicans, and sometimes by staphylococcal skin infections (summary by Boisson et al., 2013). For a discussion of genetic heterogeneity of familial candidiasis, see CANDF1 (114580).
Combined immunodeficiency due to MALT1 deficiency
MedGen UID:
815913
Concept ID:
C3809583
Disease or Syndrome
Combined immunodeficiency due to MALT1 deficiency is a rare, genetic form of primary immunodeficiency characterized by growth retardation, early recurrent pulmonary infections leading to bronchiectasis, inflammatory gastrointestinal disease, and other symptoms, such as rash, dermatitis, skin infections.
Peeling skin-leukonuchia-acral punctate keratoses-cheilitis-knuckle pads syndrome
MedGen UID:
902464
Concept ID:
C4225381
Disease or Syndrome
A rare genetic skin disease characterized by generalized skin peeling, leukonychia, acral punctate keratoses coalescing into focal keratoderma on the weight-bearing areas, angular cheilitis and knuckle pads with multiple hyperkeratotic micropapules. The skin appears dry and scaly with superficial exfoliation and underlying erythema. Histopathologic examination of affected skin areas shows hyperkeratosis, acanthosis and intraepidermal clefting with irregular acantholysis. Additional systemic abnormalities are absent.
Olmsted syndrome 2
MedGen UID:
1779902
Concept ID:
C5543096
Disease or Syndrome
Olmsted syndrome-2 (OLMS2) is characterized by mutilating hyperkeratotic skin lesions, primarily on the palms and soles, but also extending onto dorsal surfaces of the hands and feet and distal extremities. The lesions are progressive, becoming thicker with verrucous fissures on the palms and soles over time. In addition, affected individuals exhibit perioral hyperkeratosis, and may have lesions around other orifices as well, such as the nostrils, perineum, and anus. Most patients also have hyperkeratotic nails and light-colored woolly hair (Duchatelet et al., 2019). Some patients may experience flexion contractures of the digits due to the severity of the keratoderma, and intractable pruritus and alopecia universalis have been observed (Dai et al., 2020). For a general phenotypic description and discussion of genetic heterogeneity of Olmsted disease, see OLMS1 (614594).

Professional guidelines

PubMed

Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Labadie JG, Ibrahim SA, Worley B, Kang BY, Rakita U, Rigali S, Arndt KA, Bernstein E, Brauer JA, Chandra S, Didwania A, DiGiorgio C, Donelan M, Dover JS, Galadari H, Geronemus RG, Goldman MP, Haedersdal M, Hruza G, Ibrahimi OA, Kauvar A, Kelly KM, Krakowski AC, Miest R, Orringer JS, Ozog DM, Ross EV, Shumaker PR, Sobanko JF, Suozzi K, Taylor MB, Teng JMC, Uebelhoer NS, Waibel J, Wanner M, Ratchev I, Christensen RE, Poon E, Miller CH, Alam M
JAMA Dermatol 2022 Oct 1;158(10):1193-1201. doi: 10.1001/jamadermatol.2022.3234. PMID: 35976634
Lugović-Mihić L, Pilipović K, Crnarić I, Šitum M, Duvančić T
Acta Clin Croat 2018 Jun;57(2):342-351. doi: 10.20471/acc.2018.57.02.16. PMID: 30431729Free PMC Article

Recent clinical studies

Etiology

McReynolds DE, Moorthy A, Moneley JO, Jabra-Rizk MA, Sultan AS
J Prosthodont 2023 Aug;32(7):560-570. Epub 2023 Apr 18 doi: 10.1111/jopr.13687. PMID: 36988151
Lugović-Mihić L, Pilipović K, Crnarić I, Šitum M, Duvančić T
Acta Clin Croat 2018 Jun;57(2):342-351. doi: 10.20471/acc.2018.57.02.16. PMID: 30431729Free PMC Article
Muhvić-Urek M, Tomac-Stojmenović M, Mijandrušić-Sinčić B
World J Gastroenterol 2016 Jul 7;22(25):5655-67. doi: 10.3748/wjg.v22.i25.5655. PMID: 27433081Free PMC Article
Gonçalves Jde A, Moreira EA, Trindade EB, Fiates GM
Rev Paul Pediatr 2013 Jan-Mar;31(1):96-103. doi: 10.1590/s0103-05822013000100016. PMID: 23703051
Akpan A, Morgan R
Postgrad Med J 2002 Aug;78(922):455-9. doi: 10.1136/pmj.78.922.455. PMID: 12185216Free PMC Article

Diagnosis

Lugović-Mihić L, Pilipović K, Crnarić I, Šitum M, Duvančić T
Acta Clin Croat 2018 Jun;57(2):342-351. doi: 10.20471/acc.2018.57.02.16. PMID: 30431729Free PMC Article
Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799
Muhvić-Urek M, Tomac-Stojmenović M, Mijandrušić-Sinčić B
World J Gastroenterol 2016 Jul 7;22(25):5655-67. doi: 10.3748/wjg.v22.i25.5655. PMID: 27433081Free PMC Article
Millsop JW, Fazel N
Clin Dermatol 2016 Jul-Aug;34(4):487-94. Epub 2016 Mar 2 doi: 10.1016/j.clindermatol.2016.02.022. PMID: 27343964
Akpan A, Morgan R
Postgrad Med J 2002 Aug;78(922):455-9. doi: 10.1136/pmj.78.922.455. PMID: 12185216Free PMC Article

Therapy

Reinhart JP, Stoopler ET, Crawford GH
Dermatol Clin 2020 Oct;38(4):467-476. Epub 2020 Aug 11 doi: 10.1016/j.det.2020.05.007. PMID: 32892855
Costa CS, Bagatin E, Martimbianco ALC, da Silva EM, Lúcio MM, Magin P, Riera R
Cochrane Database Syst Rev 2018 Nov 24;11(11):CD009435. doi: 10.1002/14651858.CD009435.pub2. PMID: 30484286Free PMC Article
Wehl G, Rauchenzauner M
Curr Pediatr Rev 2018;14(3):196-203. doi: 10.2174/1573396314666180515113941. PMID: 29766816
Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799
Muhvić-Urek M, Tomac-Stojmenović M, Mijandrušić-Sinčić B
World J Gastroenterol 2016 Jul 7;22(25):5655-67. doi: 10.3748/wjg.v22.i25.5655. PMID: 27433081Free PMC Article

Prognosis

McReynolds DE, Moorthy A, Moneley JO, Jabra-Rizk MA, Sultan AS
J Prosthodont 2023 Aug;32(7):560-570. Epub 2023 Apr 18 doi: 10.1111/jopr.13687. PMID: 36988151
García-Ríos P, Pecci-Lloret MP, Oñate-Sánchez RE
Int J Environ Res Public Health 2022 Sep 21;19(19) doi: 10.3390/ijerph191911910. PMID: 36231212Free PMC Article
Costa CS, Bagatin E, Martimbianco ALC, da Silva EM, Lúcio MM, Magin P, Riera R
Cochrane Database Syst Rev 2018 Nov 24;11(11):CD009435. doi: 10.1002/14651858.CD009435.pub2. PMID: 30484286Free PMC Article
Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799
Akpan A, Morgan R
Postgrad Med J 2002 Aug;78(922):455-9. doi: 10.1136/pmj.78.922.455. PMID: 12185216Free PMC Article

Clinical prediction guides

Paglioni MP, Khurram SA, Ruiz BII, Lauby-Secretan B, Normando AG, Ribeiro ACP, Brandão TB, Palmier NR, Lopes MA, da Silva Guerra EN, Meleti M, Migliorati CA, Carvalho AL, de Matos LL, Kowalski LP, Santos-Silva AR
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Nov;134(5):573-587. Epub 2022 Jul 21 doi: 10.1016/j.oooo.2022.07.006. PMID: 36153299
Pathania YS
Int J Dermatol 2022 Jun;61(6):755-759. Epub 2022 Feb 17 doi: 10.1111/ijd.16126. PMID: 35174873
Ramassamy S, Van HTA, Chuang JY, Wu YH
Am J Dermatopathol 2022 Feb 1;44(2):83-91. doi: 10.1097/DAD.0000000000001952. PMID: 33878045
Costa CS, Bagatin E, Martimbianco ALC, da Silva EM, Lúcio MM, Magin P, Riera R
Cochrane Database Syst Rev 2018 Nov 24;11(11):CD009435. doi: 10.1002/14651858.CD009435.pub2. PMID: 30484286Free PMC Article
Novacek G
Orphanet J Rare Dis 2006 Sep 15;1:36. doi: 10.1186/1750-1172-1-36. PMID: 16978405Free PMC Article

Recent systematic reviews

García-Ríos P, Pecci-Lloret MP, Oñate-Sánchez RE
Int J Environ Res Public Health 2022 Sep 21;19(19) doi: 10.3390/ijerph191911910. PMID: 36231212Free PMC Article
Ralho A, Coelho A, Ribeiro M, Paula A, Amaro I, Sousa J, Marto C, Ferreira M, Carrilho E
J Evid Based Dent Pract 2019 Dec;19(4):101318. Epub 2019 Apr 8 doi: 10.1016/j.jebdp.2019.04.002. PMID: 31843181
Costa CS, Bagatin E, Martimbianco ALC, da Silva EM, Lúcio MM, Magin P, Riera R
Cochrane Database Syst Rev 2018 Nov 24;11(11):CD009435. doi: 10.1002/14651858.CD009435.pub2. PMID: 30484286Free PMC Article
Wehl G, Rauchenzauner M
Curr Pediatr Rev 2018;14(3):196-203. doi: 10.2174/1573396314666180515113941. PMID: 29766816
Vallerand IA, Lewinson RT, Farris MS, Sibley CD, Ramien ML, Bulloch AGM, Patten SB
Br J Dermatol 2018 Jan;178(1):76-85. Epub 2017 Dec 8 doi: 10.1111/bjd.15668. PMID: 28542914

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