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Lack of peer relationships

MedGen UID:
335162
Concept ID:
C1845337
Finding
HPO: HP:0002332

Definition

The state of not having relationships with peers outside of school or organized activity appropriate to developmental level. This may be caused by behavioral or physical barriers. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLack of peer relationships

Conditions with this feature

Autism, susceptibility to, X-linked 3
MedGen UID:
335161
Concept ID:
C1845336
Finding
The spectrum of MECP2-related phenotypes in females ranges from classic Rett syndrome to variant Rett syndrome with a broader clinical phenotype (either milder or more severe than classic Rett syndrome) to mild learning disabilities; the spectrum in males ranges from severe neonatal encephalopathy to pyramidal signs, parkinsonism, and macroorchidism (PPM-X) syndrome to severe syndromic/nonsyndromic intellectual disability. Females: Classic Rett syndrome, a progressive neurodevelopmental disorder primarily affecting girls, is characterized by apparently normal psychomotor development during the first six to 18 months of life, followed by a short period of developmental stagnation, then rapid regression in language and motor skills, followed by long-term stability. During the phase of rapid regression, repetitive, stereotypic hand movements replace purposeful hand use. Additional findings include fits of screaming and inconsolable crying, autistic features, panic-like attacks, bruxism, episodic apnea and/or hyperpnea, gait ataxia and apraxia, tremors, seizures, and acquired microcephaly. Males: Severe neonatal-onset encephalopathy, the most common phenotype in affected males, is characterized by a relentless clinical course that follows a metabolic-degenerative type of pattern, abnormal tone, involuntary movements, severe seizures, and breathing abnormalities. Death often occurs before age two years.
Autism, susceptibility to, X-linked 2
MedGen UID:
336964
Concept ID:
C1845539
Finding
Autism, the prototypic pervasive developmental disorder (PDD), is usually apparent by 3 years of age. It is characterized by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypic, and ritualized patterns of interests and behavior (Bailey et al., 1996; Risch et al., 1999). 'Autism spectrum disorder,' sometimes referred to as ASD, is a broader phenotype encompassing the less severe disorders Asperger syndrome (see ASPG1; 608638) and pervasive developmental disorder, not otherwise specified (PDD-NOS). 'Broad autism phenotype' includes individuals with some symptoms of autism, but who do not meet the full criteria for autism or other disorders. Impaired intellectual development coexists in approximately two-thirds of individuals with ASD, except for Asperger syndrome, in which intellectual disability is conspicuously absent (Jones et al., 2008). Genetic studies in autism often include family members with these less stringent diagnoses (Schellenberg et al., 2006). For a discussion of genetic heterogeneity of autism, see 209850.
Autism, susceptibility to, X-linked 1
MedGen UID:
335205
Concept ID:
C1845540
Finding
Autism, the prototypic pervasive developmental disorder (PDD), is usually apparent by 3 years of age. It is characterized by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypic, and ritualized patterns of interests and behavior (Bailey et al., 1996; Risch et al., 1999). 'Autism spectrum disorder,' sometimes referred to as ASD, is a broader phenotype encompassing the less severe disorders Asperger syndrome (see ASPG1; 608638) and pervasive developmental disorder, not otherwise specified (PDD-NOS). 'Broad autism phenotype' includes individuals with some symptoms of autism, but who do not meet the full criteria for autism or other disorders. Mental retardation coexists in approximately two-thirds of individuals with ASD, except for Asperger syndrome, in which mental retardation is conspicuously absent (Jones et al., 2008). Genetic studies in autism often include family members with these less stringent diagnoses (Schellenberg et al., 2006). For a discussion of genetic heterogeneity of autism, see 209850.

Professional guidelines

PubMed

Hirsch KG, Abella BS, Amorim E, Bader MK, Barletta JF, Berg K, Callaway CW, Friberg H, Gilmore EJ, Greer DM, Kern KB, Livesay S, May TL, Neumar RW, Nolan JP, Oddo M, Peberdy MA, Poloyac SM, Seder D, Taccone FS, Uzendu A, Walsh B, Zimmerman JL, Geocadin RG; American Heart Association, Neurocritical Care Society
Neurocrit Care 2024 Feb;40(1):1-37. Epub 2023 Dec 1 doi: 10.1007/s12028-023-01871-6. PMID: 38040992Free PMC Article
Morgan PJ, Young MD, Lloyd AB, Wang ML, Eather N, Miller A, Murtagh EM, Barnes AT, Pagoto SL
Pediatrics 2017 Feb;139(2) doi: 10.1542/peds.2016-2635. PMID: 28130430Free PMC Article
van Loenen T, van den Berg MJ, Westert GP, Faber MJ
Fam Pract 2014 Oct;31(5):502-16. Epub 2014 Sep 12 doi: 10.1093/fampra/cmu053. PMID: 25216664

Recent clinical studies

Etiology

Chetan MR, Gleeson FV
Eur Radiol 2021 Feb;31(2):1049-1058. Epub 2020 Aug 18 doi: 10.1007/s00330-020-07141-9. PMID: 32809167Free PMC Article
Cooke KJ, Patt DA, Prabhu RS
Am Soc Clin Oncol Educ Book 2017;37:788-792. doi: 10.1200/EDBK_175193. PMID: 28561670
Donnelly JE, Hillman CH, Castelli D, Etnier JL, Lee S, Tomporowski P, Lambourne K, Szabo-Reed AN
Med Sci Sports Exerc 2016 Jun;48(6):1197-222. doi: 10.1249/MSS.0000000000000901. PMID: 27182986Free PMC Article
Duffy A, Dawson DL, das Nair R
J Sex Med 2016 May;13(5):760-77. doi: 10.1016/j.jsxm.2016.03.002. PMID: 27114191
Deliens T, Clarys P, De Bourdeaudhuij I, Deforche B
BMC Public Health 2014 Jan 18;14:53. doi: 10.1186/1471-2458-14-53. PMID: 24438555Free PMC Article

Diagnosis

Palmieri V, Montisci A, Vietri MT, Colombo PC, Sala S, Maiello C, Coscioni E, Donatelli F, Napoli C
Int J Med Inform 2023 Aug;176:105110. Epub 2023 May 25 doi: 10.1016/j.ijmedinf.2023.105110. PMID: 37285695
Reeder SB, Yokoo T, França M, Hernando D, Alberich-Bayarri Á, Alústiza JM, Gandon Y, Henninger B, Hillenbrand C, Jhaveri K, Karçaaltıncaba M, Kühn JP, Mojtahed A, Serai SD, Ward R, Wood JC, Yamamura J, Martí-Bonmatí L
Radiology 2023 Apr;307(1):e221856. Epub 2023 Feb 21 doi: 10.1148/radiol.221856. PMID: 36809220Free PMC Article
Chetan MR, Gleeson FV
Eur Radiol 2021 Feb;31(2):1049-1058. Epub 2020 Aug 18 doi: 10.1007/s00330-020-07141-9. PMID: 32809167Free PMC Article
Duffy A, Dawson DL, das Nair R
J Sex Med 2016 May;13(5):760-77. doi: 10.1016/j.jsxm.2016.03.002. PMID: 27114191
Tyrrell M
J Sch Nurs 2005 Jun;21(3):147-51. doi: 10.1177/10598405050210030401. PMID: 15898849

Therapy

RECOVERY Collaborative Group
Lancet 2022 Jul 30;400(10349):359-368. doi: 10.1016/S0140-6736(22)01109-6. PMID: 35908569Free PMC Article
Jain R, Bolch C, Al-Nakkash L, Sweazea KL
Am J Physiol Regul Integr Comp Physiol 2022 Sep 1;323(3):R279-R288. Epub 2022 Jul 11 doi: 10.1152/ajpregu.00236.2021. PMID: 35816719
O'Mathúna DP
Front Public Health 2022;10:788972. Epub 2022 Mar 1 doi: 10.3389/fpubh.2022.788972. PMID: 35299698Free PMC Article
Le V, Crouser ED
Expert Opin Biol Ther 2018 Apr;18(4):399-407. Epub 2018 Jan 17 doi: 10.1080/14712598.2018.1427727. PMID: 29327613Free PMC Article
Donnelly JE, Hillman CH, Castelli D, Etnier JL, Lee S, Tomporowski P, Lambourne K, Szabo-Reed AN
Med Sci Sports Exerc 2016 Jun;48(6):1197-222. doi: 10.1249/MSS.0000000000000901. PMID: 27182986Free PMC Article

Prognosis

Hirsch KG, Abella BS, Amorim E, Bader MK, Barletta JF, Berg K, Callaway CW, Friberg H, Gilmore EJ, Greer DM, Kern KB, Livesay S, May TL, Neumar RW, Nolan JP, Oddo M, Peberdy MA, Poloyac SM, Seder D, Taccone FS, Uzendu A, Walsh B, Zimmerman JL, Geocadin RG; American Heart Association, Neurocritical Care Society
Neurocrit Care 2024 Feb;40(1):1-37. Epub 2023 Dec 1 doi: 10.1007/s12028-023-01871-6. PMID: 38040992Free PMC Article
Boucher V, Frenette J, Neveu X, Tardif PA, Mercier É, Chauny JM, Berthelot S, Archambault P, Lee J, Perry JJ, McRae A, Lang E, Moore L, Cameron P, Ouellet MC, de Guise E, Swaine B, Émond M, Le Sage N
J Clin Neurosci 2023 Dec;118:34-43. Epub 2023 Oct 17 doi: 10.1016/j.jocn.2023.10.007. PMID: 37857062
Palmieri V, Montisci A, Vietri MT, Colombo PC, Sala S, Maiello C, Coscioni E, Donatelli F, Napoli C
Int J Med Inform 2023 Aug;176:105110. Epub 2023 May 25 doi: 10.1016/j.ijmedinf.2023.105110. PMID: 37285695
Chetan MR, Gleeson FV
Eur Radiol 2021 Feb;31(2):1049-1058. Epub 2020 Aug 18 doi: 10.1007/s00330-020-07141-9. PMID: 32809167Free PMC Article
Rubin KH, Coplan RJ, Bowker JC
Annu Rev Psychol 2009;60:141-71. doi: 10.1146/annurev.psych.60.110707.163642. PMID: 18851686Free PMC Article

Clinical prediction guides

Luo Y, Acevedo D, Vlagea A, Codina A, García-García A, Deyà-Martínez A, Martí-Castellote C, Esteve-Solé A, Alsina L
Front Immunol 2023;14:1283981. Epub 2023 Nov 21 doi: 10.3389/fimmu.2023.1283981. PMID: 38077340Free PMC Article
Palmieri V, Montisci A, Vietri MT, Colombo PC, Sala S, Maiello C, Coscioni E, Donatelli F, Napoli C
Int J Med Inform 2023 Aug;176:105110. Epub 2023 May 25 doi: 10.1016/j.ijmedinf.2023.105110. PMID: 37285695
Parekh KD, Wong WB, Zullig LL
Am J Manag Care 2022 May 1;28(5):e189-e197. doi: 10.37765/ajmc.2022.89151. PMID: 35546593
Chetan MR, Gleeson FV
Eur Radiol 2021 Feb;31(2):1049-1058. Epub 2020 Aug 18 doi: 10.1007/s00330-020-07141-9. PMID: 32809167Free PMC Article
Rubin KH, Coplan RJ, Bowker JC
Annu Rev Psychol 2009;60:141-71. doi: 10.1146/annurev.psych.60.110707.163642. PMID: 18851686Free PMC Article

Recent systematic reviews

Donnelly JE, Hillman CH, Castelli D, Etnier JL, Lee S, Tomporowski P, Lambourne K, Szabo-Reed AN
Med Sci Sports Exerc 2016 Jun;48(6):1197-222. doi: 10.1249/MSS.0000000000000901. PMID: 27182986Free PMC Article
Duffy A, Dawson DL, das Nair R
J Sex Med 2016 May;13(5):760-77. doi: 10.1016/j.jsxm.2016.03.002. PMID: 27114191
Brundisini F, Giacomini M, DeJean D, Vanstone M, Winsor S, Smith A
Ont Health Technol Assess Ser 2013;13(15):1-33. Epub 2013 Sep 1 PMID: 24228078Free PMC Article
Lin GH, Chan HL, Wang HL
J Periodontol 2013 Dec;84(12):1755-67. Epub 2013 Mar 1 doi: 10.1902/jop.2013.120688. PMID: 23451989
Roy T, Lloyd CE
J Affect Disord 2012 Oct;142 Suppl:S8-21. doi: 10.1016/S0165-0327(12)70004-6. PMID: 23062861

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