U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Morning myoclonic jerks

MedGen UID:
335620
Concept ID:
C1847164
Finding
HPO: HP:0007000

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMorning myoclonic jerks

Conditions with this feature

Myoclonic epilepsy, juvenile, susceptibility to, 1
MedGen UID:
342587
Concept ID:
C1850778
Finding
Juvenile myoclonic epilepsy (EJM, JME) is a subtype of idiopathic generalized epilepsy (EIG; see 600669), affecting up to 26% of all individuals with EIG. Individuals with EJM have afebrile seizures only, with onset in adolescence of myoclonic jerks. Myoclonic jerks usually occur in the morning (Janz and Durner, 1997). Genetic Heterogeneity of Juvenile Myoclonic Seizures Susceptibility to EJM can be conferred by variation in several other genes: EJM5 (611136), by variation in the GABRA1 gene (137160) on 5q34; EJM6 (see 607682), by variation in the CACNB4 gene (601949) on 2q23; EJM7 (see 613060), by variation in the GABRD gene (137163) on 1p36; EJM8 (see 607628), by variation in the CLCN2 gene (600570) on 3q27; and EJM10 (617924), by variation in the ICK gene (612325) on chromosome 6p12. In addition, EJM loci have been identified by linkage analysis: EJM2 (see 604827) on 15q14, EJM3 (608816) on 6p21, EJM4 (611364) on 5q12-q14, and EJM9 (614280) on 2q33-q36.
Epilepsy, idiopathic generalized, susceptibility to, 9
MedGen UID:
413424
Concept ID:
C2750887
Finding
For a general phenotypic description and a discussion of genetic heterogeneity of idiopathic generalized epilepsy, see 600669. Juvenile myoclonic epilepsy is a subtype of idiopathic generalized epilepsy; see 254770 for a general phenotypic description and a discussion of genetic heterogeneity of JME.

Professional guidelines

PubMed

Sharpe C, Buchanan N
Med J Aust 1995 Feb 6;162(3):133-4. doi: 10.5694/j.1326-5377.1995.tb138476.x. PMID: 7854224

Recent clinical studies

Etiology

Shakeshaft A, Panjwani N, McDowall R, Crudgington H, Peña Ceballos J, Andrade DM, Beier CP, Fong CY, Gesche J, Greenberg DA, Hamandi K, Koht J, Lim KS, Orsini A, Rees MI, Rubboli G, Selmer KK, Smith AB, Striano P, Syvertsen M, Talvik I, Thomas RH, Zarubova J, Richardson MP, Strug LJ, Pal DK; BIOJUME Consortium
Ann Clin Transl Neurol 2021 Jan;8(1):138-152. Epub 2020 Dec 2 doi: 10.1002/acn3.51255. PMID: 33264519Free PMC Article
Wang X, Chen B, Jin L, Zhang W, Liu Y
Brain Dev 2021 Jan;43(1):160-165. Epub 2020 Aug 10 doi: 10.1016/j.braindev.2020.07.018. PMID: 32792174
Girard JM, Turnbull J, Ramachandran N, Minassian BA
Handb Clin Neurol 2013;113:1731-6. doi: 10.1016/B978-0-444-59565-2.00043-5. PMID: 23622396
Haba-Rubio J, Staner L, Krieger J, Macher JP
Neurophysiol Clin 2004 Dec;34(6):293-300. Epub 2004 Nov 23 doi: 10.1016/j.neucli.2004.10.001. PMID: 15890162
Moldofsky H, Lue FA, Saskin P
J Rheumatol 1987 Feb;14(1):124-8. PMID: 3572914

Diagnosis

Brown A, Esechie A, Gogia B, Shanina E
Clin Neuropharmacol 2021 Mar-Apr 01;44(2):75-76. doi: 10.1097/WNF.0000000000000434. PMID: 33480615
Genton P, Thomas P, Kasteleijn-Nolst Trenité DG, Medina MT, Salas-Puig J
Epilepsy Behav 2013 Jul;28 Suppl 1:S8-14. doi: 10.1016/j.yebeh.2012.10.034. PMID: 23756488
Girard JM, Turnbull J, Ramachandran N, Minassian BA
Handb Clin Neurol 2013;113:1731-6. doi: 10.1016/B978-0-444-59565-2.00043-5. PMID: 23622396
Mazza M, Della Marca G, De Risio S, Mennuni GF, Mazza S
Clin Ter 2004 Sep;155(9):391-4. PMID: 15700632
Porter RJ
Epilepsia 1993;34 Suppl 3:S42-8. doi: 10.1111/j.1528-1167.1993.tb06258.x. PMID: 8500432

Therapy

Brown A, Esechie A, Gogia B, Shanina E
Clin Neuropharmacol 2021 Mar-Apr 01;44(2):75-76. doi: 10.1097/WNF.0000000000000434. PMID: 33480615
Genton P, Thomas P, Kasteleijn-Nolst Trenité DG, Medina MT, Salas-Puig J
Epilepsy Behav 2013 Jul;28 Suppl 1:S8-14. doi: 10.1016/j.yebeh.2012.10.034. PMID: 23756488
Kasteleijn-Nolst Trenité DG, de Weerd A, Beniczky S
Epilepsy Behav 2013 Jul;28 Suppl 1:S25-9. doi: 10.1016/j.yebeh.2012.11.045. PMID: 23756476
Mazza M, Della Marca G, De Risio S, Mennuni GF, Mazza S
Clin Ter 2004 Sep;155(9):391-4. PMID: 15700632
Porter RJ
Epilepsia 1993;34 Suppl 3:S42-8. doi: 10.1111/j.1528-1167.1993.tb06258.x. PMID: 8500432

Prognosis

Wang X, Chen B, Jin L, Zhang W, Liu Y
Brain Dev 2021 Jan;43(1):160-165. Epub 2020 Aug 10 doi: 10.1016/j.braindev.2020.07.018. PMID: 32792174
O'Brien LM, Koo J, Fan L, Owusu JT, Chotinaiwattarakul W, Felt BT, Chervin RD
J Clin Sleep Med 2009 Dec 15;5(6):525-31. PMID: 20465018Free PMC Article
Brubacher JR, Hoffman RS, Lurin MJ
Vet Hum Toxicol 1996 Oct;38(5):358-61. PMID: 8888541
Sharpe C, Buchanan N
Med J Aust 1995 Feb 6;162(3):133-4. doi: 10.5694/j.1326-5377.1995.tb138476.x. PMID: 7854224
Porter RJ
Epilepsia 1993;34 Suppl 3:S42-8. doi: 10.1111/j.1528-1167.1993.tb06258.x. PMID: 8500432

Clinical prediction guides

Brown A, Esechie A, Gogia B, Shanina E
Clin Neuropharmacol 2021 Mar-Apr 01;44(2):75-76. doi: 10.1097/WNF.0000000000000434. PMID: 33480615
Shakeshaft A, Panjwani N, McDowall R, Crudgington H, Peña Ceballos J, Andrade DM, Beier CP, Fong CY, Gesche J, Greenberg DA, Hamandi K, Koht J, Lim KS, Orsini A, Rees MI, Rubboli G, Selmer KK, Smith AB, Striano P, Syvertsen M, Talvik I, Thomas RH, Zarubova J, Richardson MP, Strug LJ, Pal DK; BIOJUME Consortium
Ann Clin Transl Neurol 2021 Jan;8(1):138-152. Epub 2020 Dec 2 doi: 10.1002/acn3.51255. PMID: 33264519Free PMC Article
Karthik N, Kulkarni GB, Taly AB, Rao S, Sinha S
J Neurol Sci 2012 Oct 15;321(1-2):73-6. Epub 2012 Aug 9 doi: 10.1016/j.jns.2012.07.057. PMID: 22877507
O'Brien LM, Koo J, Fan L, Owusu JT, Chotinaiwattarakul W, Felt BT, Chervin RD
J Clin Sleep Med 2009 Dec 15;5(6):525-31. PMID: 20465018Free PMC Article
Porter RJ
Epilepsia 1993;34 Suppl 3:S42-8. doi: 10.1111/j.1528-1167.1993.tb06258.x. PMID: 8500432

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...