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Dyslexia, susceptibility to, 5(DYX5)

MedGen UID:
337746
•Concept ID:
C1847184
•
Finding
Synonym: Dyslexia 5
 
Monarch Initiative: MONDO:0011747
OMIM®: 606896

Recent clinical studies

Etiology

Sex-related differences in reading achievement.
Granocchio E, De Salvatore M, Bonanomi E, Sarti D
J Neurosci Res 2023 May;101(5):668-678. Epub 2021 Jul 9 doi: 10.1002/jnr.24913. PMID: 34240762
Tackling the 'dyslexia paradox': reading brain and behavior for early markers of developmental dyslexia.
Ozernov-Palchik O, Gaab N
Wiley Interdiscip Rev Cogn Sci 2016 Mar-Apr;7(2):156-76. Epub 2016 Feb 2 doi: 10.1002/wcs.1383. PMID: 26836227Free PMC Article
Empirically Based Profiles of the Early Literacy Skills of Children With Language Impairment in Early Childhood Special Education.
Justice L, Logan J, Kaderavek J, Schmitt MB, Tompkins V, Bartlett C
J Learn Disabil 2015 Sep-Oct;48(5):482-94. Epub 2013 Nov 14 doi: 10.1177/0022219413510179. PMID: 24232733
Imaging-genetics in dyslexia: connecting risk genetic variants to brain neuroimaging and ultimately to reading impairments.
Eicher JD, Gruen JR
Mol Genet Metab 2013 Nov;110(3):201-12. Epub 2013 Jul 17 doi: 10.1016/j.ymgme.2013.07.001. PMID: 23916419Free PMC Article
A review of association and linkage studies for genetical analyses of learning disorders.
Caylak E
Am J Med Genet B Neuropsychiatr Genet 2007 Oct 5;144B(7):923-43. doi: 10.1002/ajmg.b.30537. PMID: 17510947

Diagnosis

Sex-related differences in reading achievement.
Granocchio E, De Salvatore M, Bonanomi E, Sarti D
J Neurosci Res 2023 May;101(5):668-678. Epub 2021 Jul 9 doi: 10.1002/jnr.24913. PMID: 34240762
Patterns of Neural Functional Connectivity in Infants at Familial Risk of Developmental Dyslexia.
Yu X, Ferradal S, Dunstan J, Carruthers C, Sanfilippo J, Zuk J, Zöllei L, Gagoski B, Ou Y, Grant PE, Gaab N
JAMA Netw Open 2022 Oct 3;5(10):e2236102. doi: 10.1001/jamanetworkopen.2022.36102. PMID: 36301547Free PMC Article
Tackling the 'dyslexia paradox': reading brain and behavior for early markers of developmental dyslexia.
Ozernov-Palchik O, Gaab N
Wiley Interdiscip Rev Cogn Sci 2016 Mar-Apr;7(2):156-76. Epub 2016 Feb 2 doi: 10.1002/wcs.1383. PMID: 26836227Free PMC Article
Imaging-genetics in dyslexia: connecting risk genetic variants to brain neuroimaging and ultimately to reading impairments.
Eicher JD, Gruen JR
Mol Genet Metab 2013 Nov;110(3):201-12. Epub 2013 Jul 17 doi: 10.1016/j.ymgme.2013.07.001. PMID: 23916419Free PMC Article
Genetics of developmental dyslexia.
Scerri TS, Schulte-Körne G
Eur Child Adolesc Psychiatry 2010 Mar;19(3):179-97. Epub 2009 Nov 29 doi: 10.1007/s00787-009-0081-0. PMID: 20091194

Therapy

Genetic differential susceptibility in literacy-delayed children: a randomized controlled trial on emergent literacy in kindergarten.
Plak RD, Kegel CA, Bus AG
Dev Psychopathol 2015 Feb;27(1):69-79. doi: 10.1017/S0954579414001308. PMID: 25640831
Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample.
Ludwig KU, Schumacher J, Schulte-Körne G, König IR, Warnke A, Plume E, Anthoni H, Peyrard-Janvid M, Meng H, Ziegler A, Remschmidt H, Kere J, Gruen JR, Müller-Myhsok B, Nöthen MM, Hoffmann P
Psychiatr Genet 2008 Dec;18(6):310-2. doi: 10.1097/YPG.0b013e3283063a78. PMID: 19018237Free PMC Article
Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.
Harold D, Paracchini S, Scerri T, Dennis M, Cope N, Hill G, Moskvina V, Walter J, Richardson AJ, Owen MJ, Stein JF, Green ED, O'Donovan MC, Williams J, Monaco AP
Mol Psychiatry 2006 Dec;11(12):1085-91, 1061. Epub 2006 Oct 10 doi: 10.1038/sj.mp.4001904. PMID: 17033633
Coherent motion detection in preschool children at family risk for dyslexia.
Boets B, Wouters J, van Wieringen A, Ghesquière P
Vision Res 2006 Feb;46(4):527-35. Epub 2005 Oct 7 doi: 10.1016/j.visres.2005.08.023. PMID: 16214198
Hereditary partial transcobalamin II deficiency with neurologic, mental and hematologic abnormalities in children and adults.
Teplitsky V, Huminer D, Zoldan J, Pitlik S, Shohat M, Mittelman M
Isr Med Assoc J 2003 Dec;5(12):868-72. PMID: 14689755

Prognosis

Orthographic Depth May Influence the Degree of Severity of Maze Learning Performance in Children at Risk for Reading Disorder.
Gabel LA, Battison A, Truong DT, Lindström ER, Voss K, Yu YC, Roongruengratanakul S, Shyntassov K, Riebesell S, Toumanios N, Nielsen-Pheiffer CM, Paniagua S, Gruen JR
Dev Neurosci 2022;44(6):651-670. Epub 2022 Oct 12 doi: 10.1159/000527480. PMID: 36223729Free PMC Article
Long-term effects of the home literacy environment on reading development: Familial risk for dyslexia as a moderator.
Torppa M, Vasalampi K, Eklund K, Niemi P
J Exp Child Psychol 2022 Mar;215:105314. Epub 2021 Nov 16 doi: 10.1016/j.jecp.2021.105314. PMID: 34798592
ATP2C2 and DYX1C1 are putative modulators of dyslexia-related MMR.
Müller B, Schaadt G, Boltze J, Emmrich F; LEGASCREEN Consortium, Skeide MA, Neef NE, Kraft I, Brauer J, Friederici AD, Kirsten H, Wilcke A
Brain Behav 2017 Nov;7(11):e00851. Epub 2017 Oct 18 doi: 10.1002/brb3.851. PMID: 29201552Free PMC Article
Late-Emerging and Resolving Dyslexia: A Follow-Up Study from Age 3 to 14.
Torppa M, Eklund K, van Bergen E, Lyytinen H
J Abnorm Child Psychol 2015 Oct;43(7):1389-401. doi: 10.1007/s10802-015-0003-1. PMID: 25772426
Towards a further characterization of phonological and literacy problems in Dutch-speaking children with dyslexia.
Boets B, De Smedt B, Cleuren L, Vandewalle E, Wouters J, Ghesquière P
Br J Dev Psychol 2010 Mar;28(Pt 1):5-31. doi: 10.1348/026151010x485223. PMID: 20306623

Clinical prediction guides

A rare missense variant in the ATP2C2 gene is associated with language impairment and related measures.
Martinelli A, Rice ML, Talcott JB, Diaz R, Smith S, Raza MH, Snowling MJ, Hulme C, Stein J, Hayiou-Thomas ME, Hawi Z, Kent L, Pitt SJ, Newbury DF, Paracchini S
Hum Mol Genet 2021 Jun 9;30(12):1160-1171. doi: 10.1093/hmg/ddab111. PMID: 33864365Free PMC Article
ATP2C2 and DYX1C1 are putative modulators of dyslexia-related MMR.
Müller B, Schaadt G, Boltze J, Emmrich F; LEGASCREEN Consortium, Skeide MA, Neef NE, Kraft I, Brauer J, Friederici AD, Kirsten H, Wilcke A
Brain Behav 2017 Nov;7(11):e00851. Epub 2017 Oct 18 doi: 10.1002/brb3.851. PMID: 29201552Free PMC Article
Translating dyslexia across species.
Gabel LA, Manglani M, Escalona N, Cysner J, Hamilton R, Pfaffmann J, Johnson E
Ann Dyslexia 2016 Oct;66(3):319-336. Epub 2016 Mar 24 doi: 10.1007/s11881-016-0125-3. PMID: 27013331
Empirically Based Profiles of the Early Literacy Skills of Children With Language Impairment in Early Childhood Special Education.
Justice L, Logan J, Kaderavek J, Schmitt MB, Tompkins V, Bartlett C
J Learn Disabil 2015 Sep-Oct;48(5):482-94. Epub 2013 Nov 14 doi: 10.1177/0022219413510179. PMID: 24232733
The influence of different diagnostic approaches on familial aggregation of spelling disability.
Remschmidt H, Hennighausen K, Schulte-Körne G, Deimel W, Warnke A
Eur Child Adolesc Psychiatry 1999;8 Suppl 3:13-20. doi: 10.1007/s007870050122. PMID: 10638364

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