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Fibrinolytic defect

MedGen UID:
338221
•Concept ID:
C1851184
•
Disease or Syndrome
Synonym: Fibrinolytic Defect
 
Monarch Initiative: MONDO:0007605
OMIM®: 134900

Clinical features

From HPO
Hyperextensible skin
MedGen UID:
66023
•Concept ID:
C0241074
•
Finding
A condition in which the skin can be stretched beyond normal, and then returns to its initial position.
See: Feature record | Search on this feature
Spontaneous hematomas
MedGen UID:
306397
•Concept ID:
C1697453
•
Disease or Syndrome
Spontaneous development of hematomas (hematoma) or bruises without significant trauma.
See: Feature record | Search on this feature

Recent clinical studies

Etiology

Alterations in the lipid profile associate with a dysregulated inflammatory, prothrombotic, anti-fibrinolytic state and development of severe acute kidney injury in coronavirus disease 2019 (COVID-19): A study from Cincinnati, USA.
Henry BM, Szergyuk I, de Oliveira MHS, Abosamak MF, Benoit SW, Benoit JL, Lippi G
Diabetes Metab Syndr 2021 May-Jun;15(3):863-868. Epub 2021 Apr 14 doi: 10.1016/j.dsx.2021.04.011. PMID: 33878674Free PMC Article
Traumatic-Induced Coagulopathy as a Systems Failure: A New Window into Hemostasis.
Dobson GP, Morris JL, Davenport LM, Letson HL
Semin Thromb Hemost 2020 Mar;46(2):199-214. Epub 2020 Feb 18 doi: 10.1055/s-0039-1701018. PMID: 32069514
Mixed Fibrinolytic Phenotypes in Decompensated Cirrhosis and Acute-on-Chronic Liver Failure with Hypofibrinolysis in Those With Complications and Poor Survival.
Blasi A, Patel VC, Adelmeijer J, Azarian S, Hernandez Tejero M, Calvo A, Fernández J, Bernal W, Lisman T
Hepatology 2020 Apr;71(4):1381-1390. Epub 2019 Oct 24 doi: 10.1002/hep.30915. PMID: 31465557Free PMC Article
Adverse effects of glucocorticoids: coagulopathy.
Coelho MC, Santos CV, Vieira Neto L, Gadelha MR
Eur J Endocrinol 2015 Oct;173(4):M11-21. Epub 2015 May 13 doi: 10.1530/EJE-15-0198. PMID: 25971647
Thrombophilia in ethnic Arabs in Kuwait.
Mohanty D, Das KC, al-Hussain H, Naglen P, Eklof B, Marouf R, Khamis A, al-Majdi M
Ann Hematol 1996 Dec;73(6):283-90. doi: 10.1007/s002770050242. PMID: 9003158

Diagnosis

Rare inherited coagulation and fibrinolytic defects that challenge diagnostic laboratories.
Mathews N, Tasneem S, Hayward CPM
Int J Lab Hematol 2023 Jun;45 Suppl 2:30-43. Epub 2023 May 21 doi: 10.1111/ijlh.14084. PMID: 37211424
Association Between PAI-1 Activity Levels and t-PA Antigen with Glycemic Status in Prediabetic Population.
Benyamin AF, Bayu D, Minhajat R
Acta Med Indones 2016 Jul;48(3):200-206. PMID: 27840354
Menorrhagia due to a qualitative deficiency of plasminogen activator inhibitor-1: case report and literature review.
Repine T, Osswald M
Clin Appl Thromb Hemost 2004 Jul;10(3):293-6. doi: 10.1177/107602960401000316. PMID: 15247991
Fibrinolytic defect and chronic low-back pain.
Previnaire JG, Plaghki L, Col-de Beys C, Pardonge E
Acta Belg Med Phys 1990 Oct-Dec;13(4):229-33. PMID: 2151500

Therapy

Decreased fibrinolytic potential and morphological changes of fibrin structure in dermatitis herpetiformis.
Görög A, Németh K, Szabó L, Mayer B, Silló P, Kolev K, Kárpáti S
J Dermatol Sci 2016 Oct;84(1):17-23. Epub 2016 Jul 6 doi: 10.1016/j.jdermsci.2016.07.005. PMID: 27440075
Adverse effects of glucocorticoids: coagulopathy.
Coelho MC, Santos CV, Vieira Neto L, Gadelha MR
Eur J Endocrinol 2015 Oct;173(4):M11-21. Epub 2015 May 13 doi: 10.1530/EJE-15-0198. PMID: 25971647
Coagulation, fibrinolysis, and fibrin deposition in acute lung injury.
Idell S
Crit Care Med 2003 Apr;31(4 Suppl):S213-20. doi: 10.1097/01.CCM.0000057846.21303.AB. PMID: 12682443
Adult respiratory distress syndrome: do selective anticoagulants help?
Idell S
Am J Respir Med 2002;1(6):383-91. doi: 10.1007/BF03257165. PMID: 14720025
Impaired fibrinolysis and insulin resistance in patients with hypertension.
Jeng JR, Sheu WH, Jeng CY, Huang SH, Shieh SM
Am J Hypertens 1996 May;9(5):484-90. doi: 10.1016/0895-7061(95)00442-4. PMID: 8735180

Prognosis

Alterations in the lipid profile associate with a dysregulated inflammatory, prothrombotic, anti-fibrinolytic state and development of severe acute kidney injury in coronavirus disease 2019 (COVID-19): A study from Cincinnati, USA.
Henry BM, Szergyuk I, de Oliveira MHS, Abosamak MF, Benoit SW, Benoit JL, Lippi G
Diabetes Metab Syndr 2021 May-Jun;15(3):863-868. Epub 2021 Apr 14 doi: 10.1016/j.dsx.2021.04.011. PMID: 33878674Free PMC Article
Fibrinolysis during liver transplantation in humans: role of tissue-type plasminogen activator.
Dzik WH, Arkin CF, Jenkins RL, Stump DC
Blood 1988 Apr;71(4):1090-5. PMID: 3128347

Clinical prediction guides

Mixed Fibrinolytic Phenotypes in Decompensated Cirrhosis and Acute-on-Chronic Liver Failure with Hypofibrinolysis in Those With Complications and Poor Survival.
Blasi A, Patel VC, Adelmeijer J, Azarian S, Hernandez Tejero M, Calvo A, Fernández J, Bernal W, Lisman T
Hepatology 2020 Apr;71(4):1381-1390. Epub 2019 Oct 24 doi: 10.1002/hep.30915. PMID: 31465557Free PMC Article
Association Between PAI-1 Activity Levels and t-PA Antigen with Glycemic Status in Prediabetic Population.
Benyamin AF, Bayu D, Minhajat R
Acta Med Indones 2016 Jul;48(3):200-206. PMID: 27840354
Decreased fibrinolytic potential and morphological changes of fibrin structure in dermatitis herpetiformis.
Görög A, Németh K, Szabó L, Mayer B, Silló P, Kolev K, Kárpáti S
J Dermatol Sci 2016 Oct;84(1):17-23. Epub 2016 Jul 6 doi: 10.1016/j.jdermsci.2016.07.005. PMID: 27440075
Coagulation, fibrinolysis, and fibrin deposition in acute lung injury.
Idell S
Crit Care Med 2003 Apr;31(4 Suppl):S213-20. doi: 10.1097/01.CCM.0000057846.21303.AB. PMID: 12682443
Adult respiratory distress syndrome: do selective anticoagulants help?
Idell S
Am J Respir Med 2002;1(6):383-91. doi: 10.1007/BF03257165. PMID: 14720025

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