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Global systolic dysfunction

MedGen UID:
339750
•Concept ID:
C1847397
•
Finding
HPO: HP:0005185

Definition

A reduced ejection fraction and an enlarged left ventricle chamber, the latter by an increased resistance to filling with increased filling pressures. Systolic dysfunction is clinically associated with left ventricular failure in the presence of marked cardiomegaly. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlobal systolic dysfunction

Conditions with this feature

Cardioneuromyopathy with hyaline masses and nemaline rods
MedGen UID:
339747
•Concept ID:
C1847387
•
Disease or Syndrome
See: Condition Record
Cardioneuromyopathy with hyaline masses and nemaline rods

Professional guidelines

PubMed

Evaluation and Management of Cardiac Sarcoidosis with Advanced Imaging.
Shrivastav R, Hajra A, Krishnan S, Bandyopadhyay D, Ranjan P, Fuisz A
Heart Fail Clin 2023 Oct;19(4):475-489. Epub 2023 Jul 23 doi: 10.1016/j.hfc.2023.06.002. PMID: 37714588
How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).
Pieske B, Tschöpe C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP, Lancellotti P, Melenovsky V, Morris DA, Nagel E, Pieske-Kraigher E, Ponikowski P, Solomon SD, Vasan RS, Rutten FH, Voors AA, Ruschitzka F, Paulus WJ, Seferovic P, Filippatos G
Eur Heart J 2019 Oct 21;40(40):3297-3317. doi: 10.1093/eurheartj/ehz641. PMID: 31504452
Acromegalic cardiomyopathy: Epidemiology, diagnosis, and management.
Sharma AN, Tan M, Amsterdam EA, Singh GD
Clin Cardiol 2018 Mar;41(3):419-425. Epub 2018 Mar 25 doi: 10.1002/clc.22867. PMID: 29574794Free PMC Article

Recent clinical studies

Etiology

Study on the correlation between cardiac function indices measured by velocity vector imaging and disease severity in patients with Parkinson disease.
Shi J, Du L, He W, Zheng S, Xu X
J Clin Ultrasound 2023 Oct;51(8):1289-1297. Epub 2023 Aug 26 doi: 10.1002/jcu.23527. PMID: 37632405
Left ventricular global systolic dysfunction has a significant role in the development of diastolic heart failure in patients with systemic hypertension.
Kono M, Kisanuki A, Ueya N, Kubota K, Kuwahara E, Takasaki K, Yuasa T, Mizukami N, Miyata M, Tei C
Hypertens Res 2010 Nov;33(11):1167-73. Epub 2010 Aug 19 doi: 10.1038/hr.2010.142. PMID: 20720552
Relation of circulating markers of fibrosis and progression of left and right ventricular dysfunction in hypertensive patients with heart failure.
Plaksej R, Kosmala W, Frantz S, Herrmann S, Niemann M, Störk S, Wachter R, Angermann CE, Ertl G, Bijnens B, Weidemann F
J Hypertens 2009 Dec;27(12):2483-91. doi: 10.1097/HJH.0b013e3283316c4d. PMID: 19887955
Heart failure following anterior myocardial infarction: an indication for ventricular restoration, a surgical method to reverse post-infarction remodeling.
Stanley AW Jr, Athanasuleas CL, Buckberg GD; RESTORE Group
Heart Fail Rev 2004 Oct;9(4):241-54. doi: 10.1007/s10741-005-6802-7. PMID: 15886971
Effect of oscillatory breathing on the variability of the RR Intervals and its prognostic importance in individuals with left ventricular global systolic dysfunction.
Benchimol Barbosa PR, Barbosa Filho J, Cordovil I
Arq Bras Cardiol 2003 May;80(5):544-57. Epub 2003 May 30 doi: 10.1590/s0066-782x2003000500007. PMID: 12792719

Diagnosis

Focused Cardiac Ultrasound Diagnosis of Dilated Cardiomyopathy.
Perera AND, Noorbakhsh KA, Marin JR, Azhdam DB
Pediatr Emerg Care 2024 Feb 1;40(2):164-165. doi: 10.1097/PEC.0000000000003123. PMID: 38295197
Use of Cardiac Point-of-Care Ultrasound in the Pediatric Emergency Department.
Miller AF, Arichai P, Gravel CA, Vieira RL, Neal JT, Neuman MI, Monuteaux MC, Levy JA
Pediatr Emerg Care 2022 Jan 1;38(1):e300-e305. doi: 10.1097/PEC.0000000000002271. PMID: 33122503
Multidirectional global left ventricular systolic function in normal subjects and patients with hypertension: multicenter evaluation.
Morris DA, Otani K, Bekfani T, Takigiku K, Izumi C, Yuda S, Sakata K, Ohte N, Tanabe K, Friedrich K, Kühnle Y, Nakatani S, Otsuji Y, Haverkamp W, Boldt LH, Takeuchi M
J Am Soc Echocardiogr 2014 May;27(5):493-500. Epub 2014 Feb 26 doi: 10.1016/j.echo.2014.01.017. PMID: 24582162
Myocardial systolic activation delay in patients with left bundle branch block and either normal or impaired left ventricular function.
Caso P, D'Andrea A, Martiniello AR, Severino S, Cioppa C, Iengo R, Di Salvo G, Ascione L, Scherillo M, Calabrò R
Echocardiography 2006 Jan;23(1):14-23. doi: 10.1111/j.1540-8175.2006.00177.x. PMID: 16412178
Anthracycline-induced cardiomyopathy.
Keefe DL
Semin Oncol 2001 Aug;28(4 Suppl 12):2-7. PMID: 11552224

Therapy

Value of the CHA(2)DS(2)-VASc score and Fabry-specific score for predicting new-onset or recurrent stroke/TIA in Fabry disease patients without atrial fibrillation.
Liu D, Hu K, Schmidt M, Müntze J, Maniuc O, Gensler D, Oder D, Salinger T, Weidemann F, Ertl G, Frantz S, Wanner C, Nordbeck P
Clin Res Cardiol 2018 Dec;107(12):1111-1121. Epub 2018 May 24 doi: 10.1007/s00392-018-1285-4. PMID: 29797054Free PMC Article
Multidirectional global left ventricular systolic function in normal subjects and patients with hypertension: multicenter evaluation.
Morris DA, Otani K, Bekfani T, Takigiku K, Izumi C, Yuda S, Sakata K, Ohte N, Tanabe K, Friedrich K, Kühnle Y, Nakatani S, Otsuji Y, Haverkamp W, Boldt LH, Takeuchi M
J Am Soc Echocardiogr 2014 May;27(5):493-500. Epub 2014 Feb 26 doi: 10.1016/j.echo.2014.01.017. PMID: 24582162
Myocardial systolic activation delay in patients with left bundle branch block and either normal or impaired left ventricular function.
Caso P, D'Andrea A, Martiniello AR, Severino S, Cioppa C, Iengo R, Di Salvo G, Ascione L, Scherillo M, Calabrò R
Echocardiography 2006 Jan;23(1):14-23. doi: 10.1111/j.1540-8175.2006.00177.x. PMID: 16412178
Cardiac diphtheria in a previously immunized individual.
Munford L, Jones J, Landrum L, O'Connell J, Ayers E
J Natl Med Assoc 2003 Sep;95(9):875-8. PMID: 14527057Free PMC Article
Anthracycline-induced cardiomyopathy.
Keefe DL
Semin Oncol 2001 Aug;28(4 Suppl 12):2-7. PMID: 11552224

Prognosis

Study on the correlation between cardiac function indices measured by velocity vector imaging and disease severity in patients with Parkinson disease.
Shi J, Du L, He W, Zheng S, Xu X
J Clin Ultrasound 2023 Oct;51(8):1289-1297. Epub 2023 Aug 26 doi: 10.1002/jcu.23527. PMID: 37632405
Prognostic implications of left ventricular dyssynchrony early after non-ST elevation myocardial infarction without congestive heart failure.
Ng AC, Tran da T, Allman C, Vidaic J, Leung DY
Eur Heart J 2010 Feb;31(3):298-308. Epub 2009 Nov 18 doi: 10.1093/eurheartj/ehp488. PMID: 19933227
Relation of circulating markers of fibrosis and progression of left and right ventricular dysfunction in hypertensive patients with heart failure.
Plaksej R, Kosmala W, Frantz S, Herrmann S, Niemann M, Störk S, Wachter R, Angermann CE, Ertl G, Bijnens B, Weidemann F
J Hypertens 2009 Dec;27(12):2483-91. doi: 10.1097/HJH.0b013e3283316c4d. PMID: 19887955
Effect of oscillatory breathing on the variability of the RR Intervals and its prognostic importance in individuals with left ventricular global systolic dysfunction.
Benchimol Barbosa PR, Barbosa Filho J, Cordovil I
Arq Bras Cardiol 2003 May;80(5):544-57. Epub 2003 May 30 doi: 10.1590/s0066-782x2003000500007. PMID: 12792719
Echocardiographic features of idiopathic hemochromatosis.
Olson LJ, Baldus WP, Tajik AJ
Am J Cardiol 1987 Oct 1;60(10):885-9. doi: 10.1016/0002-9149(87)91041-1. PMID: 2959141

Clinical prediction guides

Study on the correlation between cardiac function indices measured by velocity vector imaging and disease severity in patients with Parkinson disease.
Shi J, Du L, He W, Zheng S, Xu X
J Clin Ultrasound 2023 Oct;51(8):1289-1297. Epub 2023 Aug 26 doi: 10.1002/jcu.23527. PMID: 37632405
Multidirectional global left ventricular systolic function in normal subjects and patients with hypertension: multicenter evaluation.
Morris DA, Otani K, Bekfani T, Takigiku K, Izumi C, Yuda S, Sakata K, Ohte N, Tanabe K, Friedrich K, Kühnle Y, Nakatani S, Otsuji Y, Haverkamp W, Boldt LH, Takeuchi M
J Am Soc Echocardiogr 2014 May;27(5):493-500. Epub 2014 Feb 26 doi: 10.1016/j.echo.2014.01.017. PMID: 24582162
Clinical significance of global two-dimensional strain as a surrogate parameter of myocardial fibrosis and cardiac events in patients with hypertrophic cardiomyopathy.
Saito M, Okayama H, Yoshii T, Higashi H, Morioka H, Hiasa G, Sumimoto T, Inaba S, Nishimura K, Inoue K, Ogimoto A, Shigematsu Y, Hamada M, Higaki J
Eur Heart J Cardiovasc Imaging 2012 Jul;13(7):617-23. Epub 2012 Jan 12 doi: 10.1093/ejechocard/jer318. PMID: 22271116
Prognostic implications of left ventricular dyssynchrony early after non-ST elevation myocardial infarction without congestive heart failure.
Ng AC, Tran da T, Allman C, Vidaic J, Leung DY
Eur Heart J 2010 Feb;31(3):298-308. Epub 2009 Nov 18 doi: 10.1093/eurheartj/ehp488. PMID: 19933227
Effect of oscillatory breathing on the variability of the RR Intervals and its prognostic importance in individuals with left ventricular global systolic dysfunction.
Benchimol Barbosa PR, Barbosa Filho J, Cordovil I
Arq Bras Cardiol 2003 May;80(5):544-57. Epub 2003 May 30 doi: 10.1590/s0066-782x2003000500007. PMID: 12792719

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